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李偉

（吉林農業大學中藥材學院）

鎖定
李偉，吉林農業大學中藥材學院教授，男，1980年11月出生，遼寧北鎮市人，滿族，中共黨員，醫學博士，教授，博士生導師，澳大利亞昆士蘭大學訪問學者，現任中藥材學院副院長。為吉林省第五批拔尖創新人才，吉林省中青年科技創新人才及團隊帶頭人，擔任中華中醫藥學會中藥資源學分會常委，中國植物學會藥用植物與植物藥專委會委員，中國中藥協會人蔘屬藥用植物研究發展專委會委員，全國工商聯醫藥業商會理事會專家，吉林省藥理學會中藥與天然藥藥理專委會副主任委員，吉林省中醫藥學會中藥專委會副主任委員，吉林省青年科技工作者協會常務理事，《吉林農業大學學報》編委等，主要從事藥用植物資源開發與利用研究工作。 [1]  。
中文名
李偉
國    籍
中國
民    族
滿族
出生地
遼寧省北鎮市
出生日期
1980年11月9日
畢業院校
吉林大學
學位/學歷
博士/研究生
職    業
教師
專業方向
藥用資源開發利用
學術代表作
《金銀花標準化加工與利用》、《中國藥用植物誌》 [1] 

目錄

  1. 1 人物經歷
  2. 2 研究方向
  3. 3 主要作品
  4. 4 榮譽成就

李偉人物經歷

近年來，先後對人蔘、桔梗、五味子等多種長白山藥用植物進行化學成分及藥理活性研究，在《J Agr Food Chem》，《Food Chem Toxicol》和《Phytotherapy Res》等國內外期刊發表學術論文100餘篇，其中SCI收錄100餘篇，累計IF>200，他引1600餘次，H指數23，包括ESI高被引論文（Highly Cited Paper）5篇；主/參編《金銀花標準化加工與利用》、《中國藥用植物誌》等多部著作及教材 [1] 
2000.09-2004.07 吉林農業大學中藥材學院，中藥學專業，獲得理學學士學位
2004.09-2007.07 吉林農業大學中藥材學院，中藥學專業，醫學碩士，主要從事植物化學成分分離與鑑定，導師，鄭毅男，教授
2009.07-2012.06 吉林大學白求恩醫學院，藥理學，醫學博士，主要從事內分泌藥理學，導師，陳立，教授
2012.08-2014.08 中國農業科學研特產研究所，博士後，主要從事人蔘次生代謝產物及生物活性，導師，王英平，研究員
2014.08-2015.08 澳大利亞The University of Queensland訪問學者，研究方向，天然產物分子內分泌，合作導師Chen chen教授。 [2] 
2007.09-現在 吉林農業大學中藥材學院，中藥學專業，講師，副教授，教授（破格） [1] 

李偉研究方向

1、藥用資源開發利用

李偉主要作品

代表性論文
  1. Zhou Yan-dan, Hou Jin-gang, Liu Wei, Ren Shen, Wang Ying-ping, Zhang Rui, Chen Chen, Wang Zi*, Li Wei*. 20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. International Immunopharmacology, 2018, 59, 21-30.
  2. Li Wei*, Chen Chen. Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem. 2018, 66(7):1734-1735.
  3. Hu Jun-Nan, Xu Xing-Yue,Li Wei*, Wang Yi-Ming, Liu Ying, Wang Zi, Wang Ying-Ping. Ginsenoside Rk1 ameliorates acetaminophen-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis. J Ginseng Res, 2017.
  4. Hou Jin-gang, Xue Jian-jie, Zhao Xing-hua, Wang Zi, Li Wei*, Li Xin-dian, Zheng Yi-nan. Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: synthesis and evaluation on murine H22 cells in vitroand in vivo, Chem Biol Drug Des, 2018.91(4):951-956
  5. Ma Zhi-na, Zhi Liu, Wang Zi, Ren Shen, Tang Shan, Wang Ying-ping, Xiao Sheng-yuan, Chen Chen, and Li Wei*. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways,Food Chemical Toxicology, 2017.110, 62-73.
  6. Wang Zi, Hu Jun-nan, Yan Meng-han, Xing Jing-jing, Liu Wen-cong, Li Wei*. Caspase-mediated anti-apoptotic effect of Ginsenoside Rg5, a main rare ginsenoside, on Acetaminophen-induced Hepatotoxicity in Mice. J Agric Food Chem.2017,65(42):9226-9236.
  7. Ma Zhi-na, Li Yan-zi, Li Wei*, Yan Xiao-tong, Yang Ge, Zhang Jing, Zhao Li-chun, Yang Li-min. Nephroprotective effects of Saponins from leaves of Panax quinquefoliusagainst cisplatin-induced acute kidney injury. Int. J. Mol. Sci. 2017, 18(7), 1407.
  8. Qi Zhen-lan, Wang Zi,Li Wei*, Hou Jin-gang, Liu Ying, Li Xin-dian, Li Hui-ping, Wang Ying-Ping. Nephroprotective effects of Anthocyanins from the fruits of Panax ginseng(GFA) on cisplatin-induced acute kidney injury in mice. Phytotherapy Research. 2017,31: 1400-1409
  9. Xu Xing-yue, Hu Jun-nan, Liu Zhi, Zhang Rui, He Yu-fang, Hou Wei, Wang Zhi-qing, Yang Ge, Li Wei*. Saponins (ginsenosides) from the Leaves of Panax QuinquefoliusAmeliorated Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem.2017, 65(18):3684-3692.
  10. Hu Jun-Nan, Liu Zhi, Wang Zi, Li Xin-Dian, Zhang Lian-Xue, Li Wei*, Wang Ying-Ping. Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury. Molecules, 2017, 22(4), 664.
  11. Liu Zhi, Wang Chong-Zhi, Zhu Xing-You, Wan Jin-Yi, Zhang Jing, Li Wei*, Ruan Chang-Chun (*), Yuan Chun-Su. Dynamic Changes in Neutral and Acidic Ginsenosides with Different Cultivation Ages and Harvest Seasons: Identification of Chemical Characteristics for Panax ginsengQuality Control,Molecules, 2017, 22(5), 734.
  12. Han Xin-yue, Hu Jun-nan, Wang Zi, Wei Sheng-nan, Zheng Si-wen, Wang Ying-ping, Li Wei *. 5-HMF Attenuates Liver Fibrosis in CCl4-Plus-Alcohol-Induced Mice by Suppression of Oxidative Stress. Journal of Nutritional Science and Vitaminology, 2017, 63(1):135-143. [3] 
  13. Li Wei, Qu Xin-Nan, Han Ye, Zheng Si-Wen, Wang Jia, and Wang Ying-Ping. Ameliorative Effect of 5-hydroxymethyl-2-furfural (5-HMF) on Acute Alcoholic Liver Oxidative Injury in Mice.Int. J. Mol. Sci. 2015, 16(2): 2446-2457.
  14. Li Wei, Yan Meng-Han, Liu Ying, Liu Zhi, Wang Zi, Chen Chen, Zhang Jing, Sun Yin-Shi. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients, 2016, 8(9), 566.
  15. Li Wei, Tian Yu-Hong, Liu Ying, Wang Zi, Tang Shan, Zhang Jing, Wang Ying-Ping. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. The Journal of Toxicological Sciences, 2016, 41(3):417-428.
  16. Li Wei, Su Xiao-min, Han Ye, Xu Qi, Zhang Jing, Wang Zi, Wang Ying-ping. Maltol, a Maillard reaction product, exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis, RSC Adv., 2015, 5(123), 101850-101859.
  17. Li Wei, Xu Qi, He Yu-Fang, Liu Ying, Yang Shu-Bao, Wang Zi, Zhang Jing, Zhao Li-Chun. Anti-Tumor Effect of Steamed Codonopsis lanceolata in H22 Tumor-Bearing Mice and Its Possible Mechanism. Nutrients, 2015, 7(10):8294-8307.
  18. Li Wei, Liu Ying, Wang Zi, Han Ye, Tian Yu-hong, Zhang Gui-shan, Sun Yin-shi, Wang Ying-ping. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice,Food & Function, 2015, 6(5): 1418-1427.
  19. Li Wei; Zhao Li-Chun, Sun Yin-Shi, Lei Feng-Jie, Wang Zi, Gui Xiong-Bin, Wang Hui. Optimization of Pressurized Liquid Extraction of Three Major Acetophenones from Cynanchum bungei using a Box-Behnken Design. Int. J. Mol. Sci. 2012, 13(11), 14533-14544.
  20. Li Wei, Zhang Ming, Gu Jian, Meng Zhao-jie, Wang Ying-ping, Chen Li, Zheng Yi-nan. Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 Diabetes mice induced by High-Fat Diet combining with Streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia. 2012, 83(1):192-198.
  21. Li Wei, Zhao Li-chun, Wang Zi, Zheng Yi-nan, Jian Liang, Wang Hui. Response Surface Methodology to Optimize Enzymatic Preparation of Deapio-platycodin D and Platycodin D from Radix Platycodi. Int. J. Mol. Sci. 2012, 13(4):4089-4100.
  22. Li Wei, Wang Zi, Wang Ying-ping, Jiang Chao, Liu Qun, Sun Yin-shi, Zheng Yi-nan.Pressurized liquid extraction combining LC-DAD-ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulata ‘Chachi’ (Guangchenpi), Food Chemistry. 2012, 130(4):1044-1049.
  23. Li Wei, Sun Yin-shi, Wang Zi, Zheng Yi-nan. Isolation and purification of saponins from Platycodon grandiflorum by semi-preparative high performance liquid chromatography and LC/ESI-MS. Journal of Liquid Chromatography & Related Technologies. 2012, 35(4):547-557.
  24. Li Wei, Zhang Ming, Wang Zi, Zheng Yi-nan, Wang Ying-ping, Zhang Jing. Simultaneous RP-HPLC Determination of Six Platycosides: Application to an Enzymatic Preparation Study. Chromatographia. 2011, 74(11-12):777-782.
  25. Li Wei, Zhang Ming, Zheng Yi-nan, Li Jing, Wang Ying-ping, Wang Yun-jing, Gu Jian, Jin Ying, Wang Hui, Chen Li. Snailase Preparation of Ginsenoside M1 from Protopanaxadiol-Type Ginsenoside and Their Protective Effects Against CCl4-Induced Chronic Hepatotoxicity in Mice. Molecules. 2011, 16(12):10093-10103.
  26. Li Wei, Wang Zi, Sun Yin-shi, Chen Li, Han Li-kun, Zheng Yi-nan. Application of response surface methodology to optimize ultrasonic-assisted extraction of four chromones in Radix Saposhnikoviae, Phytochemical Analysis, 2011, 22(4):313-321.
  27. Li Wei, Zhang Wei, Xiang Lan, Wang Zi, Zheng Yi-nan, Wang Ying-ping, Zhang Jing, Chen Li. Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum. Molecules. 2010, 15(12):8702-8708.
  28. Li Wei, Liu Zheng-bo, Wang Zi, Chen Li, Sun Yin-shi, Hou Jin-gang, Zheng Yi-nan. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J Sep Sci. 2010, 33(12):1870-1876.
  29. Li Wei,Wang Zi, Chen Li, Zhang Jing, Han Li-kun, Hou Jin-gang, Zheng Yi-nan.Pressurized liquid extraction followed by LC-ESI/MS for analysis of four chromones in Radix Saposhnikoviae. J.Sep. Sci. 2010, 33(17-18):2881-2887.
  30. Li Wei, Xiang Lan, Zhang Jing, Zheng Yi-nan, Han Li-kun, Saitoc Masato. A New triterpenoid saponin from the roots of Platycodon grandiflorum. Chin Chem Lett, 2007, 18(3):306-308.
  31. Li Wei, Shi lei-ling, Han li-qin, Zhang Jing. Development and validation of a RP-HPLC method for simultaneous determination of salicin and eight flavonoids in leaves of Salix matsudanaKoidz. Acta Chromatographica. 2013, 25(4):735-743.
  32. Han Ye, Xu Qi, Hu Jiang-ning, Han Xin-yue,Li Wei(*), Zhao Li-Chun. Maltol, a Food Flavoring Agent, Attenuates Acute Alcohol-induced Oxidative Damage in Mice. Nutrients, 2015, 7(1): 682-696.
  33. He YF, Nan ML, Sun JM, Meng ZJ, Li Wei (*), Zhang M. Design, Synthesis and Cytotoxicity of Cell Death Mechanism of Rotundic Acid Derivatives, Bioorganic & Medicinal Chemistry Letters, 2013, 23(9):2543–2547.
  34. Gu Jian, Li Wei (Co-first author), Xiao Dong, Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2.Fitoterapia. 2013, 83(1):192-198.
  35. Guan Feng Ying, Gu Jian, Li Wei, Zhang Ming, Ji Yingshi, Li Jing, Chen Li, M. Hatch Grant. Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells. Life Sciences, 2014 27(1-2):42-49 [2]  [4] 
主要著作
  1. 主編，金銀花標準化生產及加工利用，化學工業出版社，2013年12月， 19萬字，ISBN：9787122192332。
  2. 副主編，林下參栽培技術，吉林科學技術出版社/吉林出版集團，2013年6月，ISBN 978-7-5384-6914-1
  3. 參編，中國藥用植物誌，姜科等，2012年，北京大學出版社。 [2] 

李偉榮譽成就

申請發明專利46項，授權22項，轉讓實施7項。指導碩士研究生35人，博士2人，畢業30人。承擔本科生和研究生《中藥鑑定學》和《中藥加工與炮製》等課程，吉林省優秀課《中藥鑑定學》帶頭人。先後主持國家自然科學基金、博士後面上基金和吉林省科技發展計劃等10項國家和省部級科研課題。主持獲得吉林省專利金獎和吉林省自然科學二等獎各1項，參與獲得吉林省科技進步二等獎和三等獎各1項（第三和第二完成人），吉林省自然科學學術成果一等獎1項（第一完成人），二等獎3項（第一完成人），市科技進步一等獎和三等獎各1項。主/參編《金銀花標準化加工與利用》、《中國藥用植物誌》等多部著作及教材。
[1]. 人蔘/西洋參非藥用部位物質基礎解析與糖脂代謝調控機制，吉林省自然科學二等獎，第1完成人，2020年
[2]. 人蔘皂苷Rg5在製備預防急性腎損傷藥物中的用途，吉林省專利金獎，2019年，第1完成人。
[3]. 人蔘高效製備技術及作用機理研究在產品開發中的應用，遼寧省技術發明二等獎，2019年，第4完成人。
[4]. 紅參標誌性成分精氨酸糖苷的開發及其產業化，吉林省科技進步二等獎，第3完成人，2018年。
[5]. 中藥有效成分快速提取，吉林省自然科學學術成果獎，一等獎，第2完成人，2012年。
[6]. 桔梗中皂苷類成分的分離、製備、測定及生物轉化，吉林省自然科學學術成果獎，二等獎，第2完成人。
[7]. 救必應酸的製備及其衍生物的設計、合成及抗腫瘤活性的系列研究，吉林省自然科學學術成果獎，二等獎，第1完成人，2014年
[8]. 響應曲面法優化酶轉化製備白藜蘆醇的工藝優化，吉林省自然科學學術成果獎，三等獎，第三完成人，2014年，NO.20143121
[9]. 抗腫瘤人蔘皂苷M1衍生物的合成及結構優化, NO. 20120F-1-06-09，大連市科技進步一等獎，第9名，2012年。
[10]. 桔梗種質資源評價、品種選育及高效利用，長春市科技進步三等獎，第二名，2014年，NO.21014030402 [2] 
參考資料