劉偉

2002年畢業於山東大學化學院，獲理學博士學位。2003-2009年在美國Louisiana State University；University of Texas Southwestern Medical Center做博士後研究員從事大環金屬配合物癌症靶向生物探針的設計、合成及生物活性的研究；2009年7月回國，在山東大學晶體所任教授，碩士生導師。

光動力治療（photodynamic therapy, PDT）是近幾十年來發展起來的一種癌症治療技術。該技術利用光激發癌細胞內部的光敏劑分子（photosensitizer ,PS）產生高細胞毒性的單線態氧從而在細胞內部殺死癌細胞，而使正常組免受傷害。它與手術、化療和放療等三大傳統的治療腫瘤手段相比，具有許多優點和特點。自上世紀70年代進入臨牀研究以來，PDT在惡性腫瘤的治療中取得了令人矚目的成就，已成為腫瘤防治研究中的一個十分活躍的領域。它不僅能有效地治療體表腫瘤，同樣亦可治療呼吸道、胃腸道、顱腦、眼、膀胱等部位的腫瘤。美國、日本、荷蘭和加拿大等國的衞生部門已相繼確認了這一腫瘤新療法的合法性。PDT在治療非腫瘤疾病方面也得到了廣泛的重視，在不久的將來可能成為治療皮膚病、老年黃斑病變和白血病等頑疾的有效手段。作為PDT的光敏劑，卟啉 （Porphyrin, Por）及其衍生物酞菁（Phthalocyanine, Pc）一直以來發揮着領銜的作用。迄今，美國食品和醫藥管理局（Food and Drug Administration, FDA）唯一批准臨牀應用於腫瘤治療的PDT光敏劑，Photofrin,就是一種血卟啉衍生物（HpD）的提純物，在美國用來治療食道癌和肺癌。在世界範圍內，Photofrin已經廣泛應用於治療各種惡性腫瘤並取得了很大成功。本課題旨在設計併合成出成分單一，高單線態氧產率、高選擇性的酞菁類光敏劑並進行相應的生物功能測試，為光動力治療開發新型、高效的癌症治療及顯影藥物。

在信息技術領域，半導體器件佔着舉足輕重的作用。作為典型的盤狀有機半導體分子，金屬酞菁因其具有的高遷移率、高穩定性、高有序的超薄膜生長特性，是當今有機半導體領域的研究熱點之一。酞菁作為少數幾種有實際應用價值的分子材料之一，已經在人類生活的多個方面得到應用：如（1）光導材料，已經應用到複印機和激光打印機中。（2）電致變色材料，應用到氣體傳感器中。（3）光記錄材料，應用到商用和家用的CD-R光碟中；（4）光動力治療藥物，應用到癌症的治療中，正在進行後期測試；（5）非線性光學材料，可以保護精密儀器和人眼免受激光的傷害；（6）酞菁類液晶材料， 等等。 項目的工作旨在於解決酞菁類分子半導體研究中的侷限問題，基於酞菁分子結構多樣性特點，設計合成出溶解度高、穩定性好、親水性好的取代酞菁。從而研發出性能優良的酞菁分子半導體以及酞菁/無機複合半導體材料和器件。

所獲獎勵：

2002山東省高校優秀科研成果獎（自然科學類）一等獎

2003國家教育部推薦國家科學技術進步獎（自然科學類）二等獎

2003山東省科學技術獎 （自然科學類）二等獎

2008 Conference Award from University of Texas Southwestern MedicalCenter USA ^[1] 

近期代表性論文

1. Dongmei Xu, Nannan Wu, Kai Le, Fenglong Wang, Zhou Wang, Lili Wu, Wei Liu,* Ancheng Ouyang and JiurongLiu, Bimetal oxide-derived flower-like heterogeneous Co/MnO@C composites withsynergistic magnetic–dielectric attenuation for electromagnetic waveabsorption. J. Mater. Chem. C, 2020, 8, 2451--2459

2. Jiabao Pan, Ancheng Ouyang, Wenjuan Fang, Guanghui Cheng, Wei Liu, *Fang Wang, Dongmu Zhao, KaiLe and Jianzhuang Jiang, cis-Silicon phthalocyanine conformation endowsJ-aggregated nanosphere with unique near-infrared absorbance and fluorescenceenhancement: a tumor sensitive phototheranostic agent with deep tissuepenetrating ability. J. Mater. Chem. B, 2020, 8, 2895--2908

3. Kai Le, Mengjiao Gao, Dongmei Xu, Zhou Wang, Guanwen Wang, Guixia Lu,

Wei Liu, * Fenglong Wang * and Jiurong Liu *, In situtransformation of ZIF-67 into hollow Co2V2O7 nanocages on graphene as ahighperformance cathode for aqueous asymmetric supercapacitors. Inorg. Chem.Front., 2020, 7, 3646–3656.

4. Kai Le, Mengjiao Gao, Dongmei Xu, Zhou Wang, Guanwen Wang,Wei Liu,* Fenglong Wang *, and Jiurong Liu *, Polypyrrole-coatedFe2O3 nanotubes constructed from nanoneedles as high-performance anodes foraqueous asymmetric supercapacitors. Dalton Trans., 2020, 49, 9701–9709

5. NannanWu, Dongmei Xu b, ZhouWang , Fenglong Wang , Jiurong Liu a, *Wei Liu, Qian Shao, Hu Liu, Qiang Gao,Zhanhu Guo Achieving superior electromagnetic wave absorbers through the novelmetal-organic frameworks derived magnetic porous carbon nanorods, Carbon 2019,433-444

6. Kai Le, Mengjiao Gao, Wei Liu, *Jiurong Liu* , Zhou Wang , FenglongWang, Vignesh Murugadoss，Shide Wu, Tao Ding* , Zhanhu Guo*，MOF-derived hierarchical core-shell hollow iron-cobalt sulfides nanoarrayson Ni foam with enhanced electrochemical properties for high energy densityasymmetric supercapacitors，Electrochimica Acta 2019, 323，134826

7. Dongmei Xu, Jing Qiao,‡ Nannan Wu, WeiLiu,*, Fenglong Wang, Longfei Lv, Jiabao Pan,Yazhuo Dong,§ and JiurongLiu*, Facile Synthesis of Three-Dimensional Porous Co/MnOCompositesDerived from Bimetal Oxides for Highly Efficient ElectromagneticWaveAbsorption ACS Sustainable Chem. Eng. 2019, 7,8687−8695

8. Kai Le, Zhou Wang, Fenglong Wang, Qi Wang, Qian Shao,VigneshMurugadoss,Shide Wu,Wei Liu,*aJiurong Liu, * Qiang Gao* and Zhanhu Guo * Sandwich-like NiCo layered doublehydroxide reduced graphene oxide nanocomposite cathodes for high energy densityasymmetric supercapacitors Dalton Trans., 2019, 48,5193

9. Jiabao Pan, YangYang, Wenjuan Fang, Wei Liu*,Kai Le, Dongmei Xu, and Xiangzhi Li* Fluorescentphthalocyanine−graphene conjugate with enhanced NIR absorbance for imaging andmulti-modality therapy ACS Appl. Nano Mater. 2018,1, 2785−2795

10. Yuxing Ni , Kai Le,Wenjing Du, Wenjuan Fang, Xi Chen, WeiLiu,∗ Yana Wang, Jiurong Liu.High response to nitrogen dioxide derived from antimonyperoxide modified tin oxide porous nanocomposites serving as gas sensingmaterial Sensorsand Actuators B: Chemical 2017, 247, 216–223

11. Wenjing Du, NannanWu, Zhou Wang, Jiurong Liu,∗ Dongmei Xu, Wei Liu High response and selectivity of platinum modified tin oxideporous spheres for nitrogen dioxide gas sensing at low temperature. Sensorsand Actuators B, 2018 257, 427–435

12. Song Qiu, HailongLyu, Jiurong Liu*, Yuzhen Liu, Nannan Wu, and Wei Liu. Facile Synthesis of Porous Nickel/Carbon CompositeMicrospheres with Enhanced Electromagnetic Wave Absorption by Magnetic andDielectric Losses. ACS Appl. Mater. Interfaces2016, 8, 20258−20266

13. Liqiang Luan, WenjuanFang, Wei Liu,* MinggangTian, Yuxing Ni, Xi Chen and Xiaoqiang Yu. Phthalocyanine-cRGD conjugate: synthesis, photophysical properties and invitro biological activity for targeting photodynamic therapy. Org. Biomol. Chem., 2016, 14, 2985–2992

14. Yuxiang Chen, WenjuanFang, Kang Wang*, Wei Liu,and Jianzhuang Jiang,* Nonperipheral Tetrakis(dibutylamino)phthalocyanines.New Types of 1,8,15,22-Tetrakis(substituted)phthalocyanine Isomers, Inorg. Chem. 2016, 55, 9289−9296.

15. Huili Cao, XinzhenWang, Hongbo Gu, Jiurong Liu,* Liqiang Luan, Wei Liu,* Yiran Wang and Zhanhu Guo* Carbon coated manganese monoxide octahedronnegative-electrode for lithium-ion batteries with enhanced performance. RSCAdv., 2015, 5, 34566

16. Shimei Guo, ShenyuWang, Nannan Wu, Jiurong Liu,* Yuxing Ni and Wei Liu* Facile synthesis of porous Fe2TiO5 microparticulatesserving as anode material with enhanced electrochemical performances. RSCAdv., 2015, 5, 103767.

17. Liqiang Luan, WenjuanFang, Wei Liu*, nggang Tian,Yuxing Ni, Xi Chen, Xiaoqiang Yu, JingHe, Yang Yang and Xiangzhi Li. 4-tert-Butylphenoxy substituted phthalocyaninewith RGD motif as highly selective one-photon and two-photon imaging probe formitochondria and cancer cell, Journal of Porphyrinsand Phthalocyanines, 2016, 20: 397–406.

18. Shimei Guo, JiurongLiu,* Song Qiu, Wei Liu,*Yiran Wang, Nannan Wu, Jiang Guo and Zhanhu Guo. Porous ternary TiO2/MnTiO3@C hybridmicrospheres as anode materials with enhanced electrochemical performances.J.Mater. Chem. A, 2015,3, 23895

19. Jiawei Shi,Liqiang Luan, Wenjuan Fang, Tianyu Zhao, Wei Liu*, Deliang Cui.High-sensitive low-temperature NO₂ sensor based on Zn(II)phthalocyanine with liquid crystalline properties. Sensors and Actuators B 2014,204, 218–223.

20. Liqiang Luan,Lanlan Ding, Jiawei Shi, Wenjuan Fang, Yuxing Ni, Wei Liu* Effectof Axial Ligands on the Molecular Configurations, Stability, Reactivity andPhotodynamic Activities of Silicon Phthalocyanines. Chem. Asian J. 2014, 9，3491-3497.

21. Xinzhen Wang, Song Qiu, Guixia Lu, Cuizhu He,Jiurong Liu,* Liqiang Luan and Wei Liu* Fabrication of porous MnOmicrospheres with carbon coating for lithium ion battery application. CrystEngComm,2014, 16, 1802–1809

22. Liqiang Luan,Lanlan Ding, Weijia Zhang, Jiawei Shi, Xiaoqiang Yu, Wei Liu*. ANaphthalocyanine Based Near-Infrared Photosensitizer: Synthesis and In VitroPhotodynamic Activities. Bioorg.& Med. Chem. Lett. 2013, 23， 3775-3779.

23. Xinzhen Wang, Wei Liu , Jiurong Liu*, Fenglong Wang, Jing Kong, Song Qiu, Cuizhu He,and Liqiang Luan.Synthesis of Nestlike ZnO Hierarchically Porous Structures and Analysis ofTheir Gas Sensing Properties. ACS Appl. Mater. Interfaces, 2012, 4(2), 817–825

24. Cuizhu He, Song Qiu,Xinzhen Wang, Jiurong Liu,* Liqiang Luan, WeiLiu*, Masahiro Itoh and Ken-ichi Machida. Facile synthesis of hollow porous cobaltspheres and their enhanced electromagnetic properties. J. Mater. Chem., 2012, 22, 22160

25. Ajay N. Singh, WeiLiu, Guiyang Hao, Amit Kumar, Anjali Gupta, Orhan K. Oz, Jer-TsongHsieh, and Xiankai Sun. Multivalent Bifunctional ChelatorScaffolds for Gallium-68 Based Positron Emission Tomography Imaging ProbeDesign: Signal Amplification via Multivalency. Bioconjugate Chem., 2011, 22 (8), 1650–1662

26. Liu, Wei; Hao, Guiyang; Long,Michael A.; Anthony, Tiffani; Hsieh, Jer-Tsong; Sun, Xiankai*. Imparting Multivalency to a BifunctionalChelator: A Scaffold Design for Targeted PET Imaging Probes. AngewandteChemie, International Edition, 2009, 48, 7346-7349