李愛華

1985年，江西農業大學獸醫系畢業，獲學士學位；1988年，江蘇農學院獸醫系畢業，獲碩士學位；1998年，中國科學院水生生物研究所，獲博士學位；1999-2000年，丹麥皇家農業與獸醫大學(KVL)訪問學者；2002-2004年，韓國國立健康研究院(Korean NIH)，博士後。 ^[1] 

魚類細菌性疾病病原生物學、致病機理及防治技術。 ^[1] 

主持或參與承擔了973項目、國家自然科學重點基金，國家自然科學基金面上項目，國家科技攻關項目，國家支撐計劃項目，中國科學院知識創新工程項目，教育部留學回國人員擇優基金，省院合作項目、省自然科學基金。 ^[1] 

在魚類藥理學，特別是漁藥藥代動力學、漁藥的臨牀治療試驗、病原細菌的耐藥性和耐藥質粒以及在環境脅迫對魚類非特異性免疫影響等方面做出了國內開拓性的研究工作。此外，研究了多種寄生蟲的超氧化物歧化酶（SOD）和半胱氨酸蛋白酶基因的分子結構，研究了魚類小瓜蟲的生物學以及成蟲蟲體勻漿液對虹鱒魚魚苗的免疫作用。在虹鱒魚、斑點叉尾鮰、黃顙魚和鱘魚上分離鑑定了多種新型致病細菌。研究重點是氣單胞菌屬細菌，特別是嗜水氣單胞菌的分子流行病學和致病機。

在國內或國際上首次報道了多種魚類細菌性疾病，包括：虹鱒魚的魏斯氏菌（Weissellasp）病，這是國際上該細菌作為病原菌的首次報道，並得到了國際同行後續的證實；報道鱘魚的分枝桿菌病，包括髮現了2種新的魚類致病性分枝桿菌- Mycobacterium porcinum和Mycobacterium arpuense；鱘魚的的停乳鏈球菌（Streptococcus dysgalactiae）病；黃顙魚的鯰愛德華氏菌（Edwardsiellaictaluri）病；烏鱧的舒伯特氣單胞菌（Aeromonas schubertii）病，圓口銅魚的殺鮭氣單胞菌（Aeromonas salmonicida）病。 ^[1] 

在漁藥毒理學、漁藥藥效學的臨牀評價、水產動物藥代動力學、魚類病原菌耐藥性及耐藥機理、環境脅迫對魚類非特異性免疫功能的影響等領域在國內做出了開創性的研究。 ^[1] 

發表論文74篇，其中SCI論文40多篇，獲發明專利2項，正在申請的發明專利1項，參編或主編著作11部。此外，多次赴國外參加相關的學術交流活動。 ^[1] 

1.Tongtong Li, Meng Long, Cheng Ji, Zhixin Shen, François-JoëlGatesoupe, Xujie Zhang, Qianqian Zhang, Lanli Zhang, Yuanli Zhao, Xinhua Liu, Aihua Li. Alterations of the gut microbiome of largemouth bronze gudgeon (Coreiusguichenoti) suffering from furunculosis. Scientific Reports, 2016,6:30606. doi: 10.1038/srep30606。（通訊作者）

2.Meng Long, Tue K. Nielsen, Jorgen J. Leisner, Lars H. Hansen, Zhi X. Shen,Qian Q. Zhang, Aihua Li. Aeromonas salmonicida subsp. salmonicida strains isolated from Chinese freshwater fish contain a novel genomic island and possible regional-specific mobile genetic elements profiles. FEMS Microbiology Letters 2016, 363 (17): fnw190.Doi: 10.1093/femsle/fnw190 （通訊作者）

3.Ji Y, Li J, Qin Z,Li A, Gu Z, Liu X, Lin L, Zhou Y*. Contribution of nuclease to the pathogenesis of Aeromonas hydrophila. Virulence, 2015,6(5):515-522, SCI IF: 4.2.

4.Wu N, Zhang XY, Huang B, Zhang N, Zhang XJ, Guo X, Chen XL, Zhang Y, Wu H, Li S, Li AH, Zhang YA*. Investigating the potential immune role of fish NCAMs: Molecular cloning and expression analysis in mandarin fish. Fish and Shellfish Immunology, 2015, 46(2): 765-777.

5.Xiaojuan Hu, Xiangping Hu, Baoqing Hu, Chungen Wen , YanhaiXie, Dan Wu, Zhiying Tao, Aihua Li, Qian Gao. Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristariaplicata. Fish & Shellfish Immunology, 2014, 40: 446-454.

6.Meng Long, Juan Zhao, Tongtong Li, Carolina Tafalla, Qianqian Zhang, Xiehao Wang, Xiaoning Gong, Zhixin Shen, Aihua Li. Transcriptomic and proteomic analysis of splenic immune mechanisms of rainbow trout (Oncorhynchus mykiss) infected by Aeromonas salmonicida subsp. salmonicida. Journal of Proteomics, 2015,122:41–54（通訊作者）

7.Xujie Zhang, Wuming Yang, Han Wu, Aihua Li. Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicaemia outbreaks in pond cultured cyprinid fish in an epidemic area, central China. Aquaculture, 2014, 32: 1-6.（通訊作者）。

8.Tongtong Li, MengLong ,François-JoëlGatesoupe,Qianqian Zhang, Aihua Li&Xiaoning Gong. Comparative analysis of the intestinal bacterial communities in different species of carp by pyrosequencing. Microbial Ecology, August 2014 DOI 10.1007/s00248-014-0480-8（通訊作者）

9.Zhang Defeng, Zhang Qianqian&Li Aihua. Development of a multiplex PCR assay for rapid and simultaneous detection of four genera of fish pathogenic bacteria. Letters in Applied Microbiology 2014，59: 471–478. doi:10.1111/lam.12303 （通訊作者）。

10.Defeng Zhang,Aihua Li, YujuanGuo, Qianqian Zhang, Xuenian Chen, Xiaoning Gong. Molecular characterization of Streptococcus agalactiaein diseased farmed tilapia in China. Aquaculture, 2013,412–413:64–69. （通訊作者）

11.Li Juan Zhao, Jin Fang Lu, P. Nie, Ai Hua Li, Bang Xi Xiong, Hai Xia Xie. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiellaictaluri. Veterinary Microbiology, 2013, 166 :233–241.

12.Bao-Qing Hu , Yi Liu , Chun-Gen Wen , Ai-Hua Li , Xiang-Ping Hu, Dan Wu, Xiao-Juan Hu, Zhi-Ying Tao. Cloning and expression of selenoprotein W from pearl musselsCristariaplicata. Comparative Biochemistry and Physiology Part B，2014，167：8-15（通訊作者）.

13.Xu-Jie Zhang, Wu-Ming Yang, De-Feng Zhang, Tong-Tong Li, Xiao-Ning Gong &Ai-Hua Li. Does the gastrointestinal tract serve as the infectious route of Aeromonas hydrophila in crucian carp (Carassiuscarassius)? Aquaculture Research, 2013, 1–14.（通訊作者）

14.Liu Jinyu&Li Aihua. First case of Aeromonas schubertii infection in the freshwater cultured snakehead fish, Ophiocephalusargus(Cantor), in China. Journal of Fish Diseases 2012, 35, 335–342. （通訊作者）

15.Cheng Ji, De Feng Zhang, Ai Hua Li, Xiao Ning Gong. Effect of berberinehydrochloride on grass carp Ctenopharyngodonidella serum bactericidal activity against Edwardsiellaictaluri. Fish & Shellfish Immunology, 2012,33 (1):143-145. （通訊作者）

16. Ji Cheng, Li Aihua, Xie Jun, Zhang Defeng& Liu Jinyu. Bactericidal activity of grass carp CtenopharyngodonidellaC9-deficient serum against Aeromonas hydrophila. Journal of Fish Biology (2011) 79, 2083–2086. （通訊作者）

17.JinYu Liu, Ai Hua Li, Dong Ren Zhou, Zhou RuiWen&XuePingYe. Isolation and characterization of Edwardsiellaictaluri strains as pathogens from diseased yellow catfish Pelteobagrusfulvidraco(Richardson) cultured in China. Aquaculture Research, 2010,41:1835-1844. （通訊作者）

18.Defeng Zhang, Aihua Li, Jun Xie & Cheng Ji. In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria. Aquaculture Research, 2010,41:1095-1100. （通訊作者）

19.Jinyu Liu, Wuming Yang, Cheng Ji, AihuaLi.. First description of a novel lactic acid bacterium Weissella sp. isolated from diseased rainbow trout Oncorhynchus mykiss (Walbaum) in China. Veterinary Microbiology , 2009,136: 314–320.（通訊作者）

20.Wuming Yang, Aihua Li. Isolation and characterization of Streptococcus dysgalactiae from diseased Acipenserschrenckii. Aquaculture, 2009.294:14-17. （通訊作者）

21.張倩倩，劉天強，李彤彤，徐靜，龍夢，王謝昊，李愛華*。玉屏風散對魚類非特異性免疫和免疫相關基因表達的影響。水生生物學報，2015，39（6）：1076~1084。 ^[1]