高國全

1965年7月出生

2005年1月加入中國共產黨，博士學位，教授職稱

1986年畢業於蚌埠醫學院，獲醫學學士學位

1997年畢業於中山醫科大學，獲醫學生物化學博士學位

2004年晉升為教授

1999年1月至2002年6月，分別在美國佐治亞州醫學院生化系和南卡醫科大學眼科研究所進行博士後研究工作

2002年6月回國工作，擔任生化教研室主任

2013年12月，任中山大學中山醫學院副院長。 ^[2] 

代謝性疾病與內源性調控分子

腫瘤病理性血管新生抑制與代謝調控 ^[1] 

2020-2022 調控脂肪細胞ATGL降解和脂解活性的關鍵分子及其在肥胖中的作用（2019B1515120077），廣東省區域聯合基金重點項目，100萬元，第一申請人

2020-2022 二甲雙胍選擇性治療KRAS突變型結直腸癌的作用及其機制研究（202002020022），廣州市基礎研究計劃民生科技專題，100萬元，第一申請人

2020.1-2020.12 中山大學科技成果轉化類項目,新型基因工程候選藥物K5-M5治療血管新生性疾病的臨牀前研究，30萬，第一申請人

2019-2022 調控組織穩態和代謝平衡關鍵分泌因子的鑑定和機制研究（2018YFA0800400），科技部國家重點研發計劃，課題骨幹，分配經費70萬

2019-2022 PEDF抑制乳腺癌異質血管生成的作用及機制（81872165），國家自然科學基金，直接經費57萬元，第一申請人

2018 中山大學2018年國際科研合作研究重點項目立項， KBP調控巨噬細胞極化和成纖維細胞活化促進糖尿病足發生的關鍵作用及其抑制劑的研發，10萬元，第一申請人

2018 中山大學2018年度科研平台運行資助專項，廣東省基因操作和生物大分子產物工程技術研究中心，10萬元，第一申請人

2017-2018 Milstein Medical Asian American Partnership Foundation Research Project Award in Translational Medicine

Project Title: The preclinical research of monoclonal antibody drug treatment for diabetic foot targeting the blood vessels.

Grant Duration: One year with non-cost extension of an additional year allowable.

Grant Amount: Total amount: $60,000; $50,000 to Zhongshan School of Medicine, Sun Yat-sen University and $10,000 to University of Oklahoma Health Sciences Center.

2017-2018 糖尿病微血管併發症的關鍵致病分子及機制研究，中山大學“國家重點研發計劃前瞻培育項目”，50萬元，第一申請人

2014-2017 PEDF在糖尿病創傷癒合中的關鍵作用及機制（2015A030311043），廣東省自然科學基金重點項目，30萬元，第一申請人

2015-2017 以血管生成為靶點治療糖尿病足的單克隆抗體候選藥物（201508020033），廣州市科技計劃產學研協同創新重大專項（民生科技研究），100萬元，第一申請人

2015-2018 PEDF調節內皮祖細胞抑制糖尿病創傷癒合的作用及機制（81471033），國家自然科學基金，75萬元，第一申請人

2013-2015 以血管生成為靶點治療肝癌的新型基因工程候選藥物臨牀前研究（2013ZX09102-053），科技部新藥創制十二五重大專項滾動項目，391萬元，第一申請人

2013-2016 PEDF調節鼻咽癌細胞EMT抑制鼻咽癌轉移的作用及機制（81272338），國家自然科學基金，65萬元，第一申請人

2012-2015 PEDF在糖尿病外周微血管損傷修復中的作用及機制，廣東省高等學校高層次人才項目，50萬元，第一申請人

2012-2015 PEDF34抑制前列腺癌血管新生和誘導腫瘤細胞凋亡的雙重作用及機制（81172163），國家自然科學基金，60萬元，第一申請人

2011-2013 以血管生成為靶點治療肝癌的新型基因工程候選藥物（2011Y1-00017-8），廣州市科技攻關新藥專項，40萬元，第一申請人

2010-2012 人纖溶酶原K5環狀結構域抗血管新生活性的機制及結構特徵（10251008901000009），廣東省自然科學基金重點項目，20萬元，第一申請人

2009-2011 2型糖尿病干預和緩解的代謝記憶機制研究（教育部“長江學者和創新團隊發展計劃”創新團隊）100萬元，核心成員（3/10），Changjiang Scholars and Innovative Research Team in University.（985 project PCSIRT 0947）。

2010-2012 青蒿素類抑制角膜血管新生的作用及分子機制（30971208），國家自然科學基金，32萬元，第一申請人

2009-2010 以血管生成為靶點治療肝癌的新型基因工程候選藥物（科技部新藥創制重大專項：候選藥物研究，2009ZX09103-642），150萬元，第一申請人

2009-2011 激肽釋放酶結合蛋白KBP抑制胃癌淋巴管新生的作用及機制（30872980），國家自然科學基金，31萬元，第一申請人 ^[1] 

1. Jinye Xie#, Liangping Xia#, Wei Xiang, Wenzhuo He, Haofan Yin, Fang Wang, TianxiaoGao,Weiwei Qi, Zhonghan Yang, Xia Yang*, Ti Zhou*, Guoquan Gao*. Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1. PNAS June 9, 2020 117 (23) 13012-13022. (Impact factor 9.412)

2. Di Che#, Zhenzhen Fang#, Li Yan, Jieping Du, Fangping Li, JinyeXie, Juan Feng, Ping Yin, Weiwei Qi, Zhonghan Yang, Jianxing Ma, Xia Yang*, Guoquan Gao*, Ti Zhou*. Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex. Diabetologia. 2020 May 6. doi: 10.1007/s00125-020-05147-y. Online ahead of print. (Impact factor 7.518)

3. Ping Jiang#, Mao Huang#, Weiwei Qi#, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao*, Xia Yang*. FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma. Journal of Experimental & Clinical Cancer Research. 2019 Sep 11; 38(1):400. doi: 10.1186/s13046-019-1414-6. (Impact factor 7.068)

4. Cen Li#, Zhijian Huang#, LiuqingZhu#, Xianhuan Yu, Tianxiao Gao, Juan Feng, Honghai Hong, Haofan Yin, Ti Zhou, Weiwei Qi, Zhonghan Yang, Chao Liu*, Xia Yang*, Guoquan Gao*. The contrary intracellular and extracellular functions of PEDF in HCC development. Cell Death & Disease. 2019 Oct 3;10(10):742. doi: 10.1038/s41419-019-1976-4. (Impact factor 6.304)

5. Yuling Mao#, Liuqing Zhu#, Zhijian Huang#, Chuanghua Luo, Ti Zhou, Lei Li, Guannan Wang, Zhonghan Yang, Weiwei Qi*, Xia Yang*,Guoquan Gao*. Stem-like tumor cells involved in heterogeneous vasculogenesis in breast cancer. Endocr Relat Cancer. 2020 Jan. pii: ERC-19-0054.R1. doi: 10.1530/ERC-19-0054. (Impact factor 4.8)

6.Jing Deng, Ping Jiang, Tianyou Yang, Mao Huang, JinyeXie, Chuanghua Luo, WeiweiQi, Ti Zhou, ZhonghanYang, Yan Zou, GuoquanGao*, XiaYang*. β2-adrenergic receptor signaling promotes neuroblastoma cell proliferation via activating autophagy. Oncology Reports. 2019 Aug 6. doi: 10.3892/or.2019.7266. (Impact factor 3.417)

7.Jing Deng, Ping Jiang, Tianyou Yang, Mao Huang, WeiweiQi, Ti Zhou, ZhonghanYang, Yan Zou, GuoquanGao*, XiaYang*.Targeting β3-adrenergic receptor signaling inhibits neuroblastoma cell growth via suppressing the mTOR pathway. Biochemical and Biophysical Research Communications. 2019 Jun 18;514(1):295-300. doi: 10.1016/j.bbrc.2019.04.099. (Impact factor 2.985)

8. Feng J#, Dong C#, Long Y, Mai L, Ren M, Li L, Zhou T, Yang Z, Ma J, Yan L*, Yang X*, Gao G*, Qi W*. Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization. Cell Commun Signal. 2019 Jun 10; 17(1):60. doi: 10.1186/s12964-019-0376-9. (Impact factor 5.1)

9. Ma L, Luo S, Zhou L, Zhao Z, Li Q, Xu L, Gong B, Qi W, Zhou T, Yang X, Gao G*, Mei W*, Yang Z*. TanshinoneⅡAphenanthroimidazole derivative polarizes macrophage to improve metabolic homeostasis. Biochemical and Biophysical Research Communications. 2019 Jun 30;514(3):861-867. doi:10.1016/j.bbrc.2019.05.056. Epub 2019 May 10. (Impact factor: 2.985)

10.Ma C, Xie J, Luo C, Yin H, Li R, Wang X, Xiong W, Zhang T, Jiang P, Qi W, Zhou T, Yang Z, Wang W, Ma J, Gao G*, Yang X*. OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF‑C expression and secretion. Int J Oncol. 2019 Feb;54(2):572-584. doi: 10.3892/ijo.2018.4648. Epub 2018 Nov 26 (Impact factor: 3.33)

11. Mao Huang, Weiwei Qi, Shuhuan Fang, Ping Jiang, Cong Yang, Yousheng Mo, Chang Dong, Yan Li, Jun Zhong, Weibin Cai, Zhonghan Yang, Ti Zhou, Qi Wang*, Xia Yang*, Guoquan Gao*. Pigment epithelium-derived factor plays a crucial role in the Alzheimer's disease by negative regulation of Aβ42. Neurotherapeutics, 2018 Jul;15(3):728-741. doi: 10.1007/s13311-018-0628-1. (Impact factor: 5.72)

12. Liuqing Zhu, JinyeXie, Zhenyin Liu, Zhijian Huang, Mao Huang, Haofan Yin, Weiwei Qi, Zhonghan Yang, Ti Zhou, Guoquan Gao*, Jing Zhang*, Xia Yang*. PEDF/VEGF ratio plays a crucial role in the spontaneous regression of infant hemangioma and the therapeutic effect of propranolol. Cancer Science, 2018. DOI:10.1111/cas.13611 (Impact factor: 3.9)

13. Ma C, Luo C, Yin H, Zhang Y, Xiong W, Zhang T, Gao T, Wang X, Che D, Fang Z, Li L, Xie J, Huang M, Zhu L, Jiang P, Qi W, Zhou T, Yang Z, Wang W, Ma J, Gao G*, Yang X*. Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion. Gastric Cancer. 2017 Dec 14. doi: 10.1007/s10120-017-0787-5. (Impact factor 5.45)

14. Fang S, Hong H, Li L, He D, Xu Z, Zuo S, Han J, Wu Q, Dai Z, Cai W, Ma J, Shao C, Gao G*, Yang X*. Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78. Cell Death Dis.2017 Oct 26;8(10):e3144. doi: 10.1038/cddis.2017.528. (Impact factor 5.9)

15. Zhang T, Yin P, Zhang Z, Xu B, Che D, Dai Z, Dong C, Jiang P, Hong H, Yang Z, Zhou T, Shao J, Xu Z, Yang X*, Gao G*. Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial-mesenchymal transition and metastasis. Cell Death Dis. 2017 Jun 1;8(6):e2838. doi:10.1038/cddis.2017.114.Erratum in: Cell Death Dis. 2018 Jul 16;9(8):784. PubMed PMID: 28569772; PubMed Central PMCID: PMC5520876. (Impact factor 5.9)

16. Ma C, Yin H, Zhong J, Zhang Y, Luo C, Che D, Fang Z, Li L, Qin S, Liang J, Qi W, Yang Z, Zhou T, Ma J, Yang X*, Gao G*. Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation. Int J Oncol. 2017 Apr 20. doi: 10.3892/ijo.2017.3972. [Epub ahead of print] PubMed PMID: 28440474. (Impact factor 3.333)

17. Feng J, Li L, Ou Z, Li Q, Gong B, Zhao Z, Qi W, Zhou T, Zhong J, Cai W, Yang X, Zhao A, Gao G*, Yang Z*. IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. Cell Mol Immunol. 2018 May;15(5):493-505. doi: 10.1038/cmi.2016.71. Epub 2017 Feb 13. PubMed PMID: 28194019. (Impact factor 7.551)

18. Zhou T, Che D, Lan Y, Fang Z, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, Ma C, Yang Z, Cai W, Zhong J, Ma J, Yang X*, Gao G*. Mesenchymal marker expression is elevated in Müller cells exposed to high glucose and in animal models of diabetic retinopathy. Oncotarget. 2017 Jan 17;8(3):4582-4594. doi:10.18632/oncotarget.13945. PubMed PMID: 27999189. (Impact factor 5.168)

19. Che D, Zhou T, Lan Y, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, Ma C, Wu Q, Yang X*, Gao G*. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016 Dec;38(6):1815-1822. doi: 10.3892/ijmm.2016.2768. PubMed PMID: 27748912. (Impact factor 2.341)

20. Li S, Mao Y, Zhou T, Luo C, Xie J, Qi W, Yang Z, Ma J, Gao G*, Yang X*. Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma. Oncotarget. 2016 May 31;7(22):32408-20. doi:10.18632/oncotarget.8717. PubMed PMID: 27083052; PubMed Central PMCID:PMC5078022. (Impact factor 5.168)

21. Liang ZW, Wang Z, Chen H, Li C, Zhou T, Yang Z, Yang X, Yang Y, Gao G*, Cai W*. Nestin-mediated cytoskeletal remodeling in endothelial cells: novel mechanistic insight into VEGF-induced cell migration in angiogenesis. Am J Physiol Cell Physiol.2015 Mar 1;308(5):C349-58. doi: 10.1152/ajpcell.00121.2014. PubMed PMID:25500739. (Impact factor 3.395)

22. Qi W, Yang C, Dai Z, Che D, Feng J, Mao Y, Cheng R, Wang Z, He X, Zhou T, Gu X, Yan L*, Yang X*, Ma JX*, Gao G*. High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppression of Wnt Signaling. Diabetes. 2014 Nov 3. pii: DB_141111. (Impact factor 8.5)

23. Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Yang ZH, Yang X*, Gao GQ*. Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J Biol Chem. 2014 Oct 8. pii: jbc.M114.567792. (Impact factor 4.6)

24. Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Yang Z, Cai W, Yang X*, Gao G*. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014 Nov; 148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5. (Impact factor 4.2)

25. Huang L, Zhang T, Li S, Duan J, Ye F, Li H, She Z, Gao G*, Yang X*. Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway. PLoS One. 2014 Sep 30; 9(9):e108286. doi: 10.1371/journal.pone.0108286. eCollection 2014. (Impact factor 3.6)

26. Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, Yang X, Gao G*, Yang Z*. Proapoptotic PEDF functional peptides inhibit prostate tumor growth-A mechanistic study. BiochemPharmacol. 2014 Sep 28. pii: S0006-2952(14)00556-5. doi: 10.1016/j.bcp.2014.09.012. [Epub ahead of print] (Impact factor 4.7)

27. Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, Hong HH, Qi WW, Zhou T, Li CY, Yang X*, Gao GQ*. Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation. J Biol Chem. 2014 Oct 31; 289(44):30785-99. doi: 10.1074/jbc.M114.590000. Epub 2014 Sep 15. (Impact factor 4.6)

28. Xia Y*, Lin LY, Liu ML, Wang Z, Hong HH, Guo XG, Gao GQ. Selective inhibition of CDK7 ameliorates experimental arthritis in mice. Clin Exp Med. 2014 Aug 23. (Impact factor 2.3)

29. Zhiyu Dai, Tizhou, Cen Li, Weiwei Qi, Yuling Mao, Juling Lu, Yachao Yao, Lei Li, Ting Zhang, Honghai Hong, Shuai Li, Weibin Cai, Zhonghan Yang, Jianxing Ma, Xia Yang* and Guoquan Gao*. Intracellular Pigment Epithelium-Derived Factor Contributes to Triglyceride Degradation. Int J Biochem Cell Biol. 2013 Sep; 45(9):2076-86. doi: 10.1016/j.biocel.2013.07.008. Epub 2013 Jul 22. (Impact factor 4.2)

30. Zhiyu Dai, Weiwei Qi, Cen Li, Juling Lu, Yuling Mao,Yachao Yao, Lei Li, Ting Zhang, Honghai Hong, Shuai Li, Ti Zhou, Zhonghan Yang, Xia Yang, Guoquan Gao*, Weibin Cai*. Dual Regulation of Adipose Triglyceride Lipase by Pigment Epithelium-Derived Factor: A Novel Mechanistic Insight into Progressive Obesity. Mol Cell Endocrinol. 2013 Sep 5; 377(1-2):123-34. doi: 10.1016/j.mce.2013.07.001. Epub 2013 Jul 10. (Impact factor 4.1)

31. Yachao Yao, Lei Li, Xuan Huang, Xiaoqiong Gu, Zumin Xu, Yang Zhang, Lijun Huang, Shuai Li, Zhiyu Dai, Cen Li, Ti Zhou, Weibin Cai, ZhonghanYang, Guoquan Gao*, Xia Yang*. SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway. FEBS J. 2013 Jul; 280(14):3244-55. doi: 10.1111/febs.12303. (Impact factor 4.25)

32. Rui Cheng, Cen Li, Chaoyang Li, Ling Wei, Lei Li, Yang Zhang, Yachao Yao, Xiaoqiong Gu, Weibin Cai, Zhonghan Yang, Xia Yang*, Guoquan Gao*. Artemisinin derivative inhibits corneal neovascularization via inducing ROS-dependent endothelial cell apoptosis. Invest Ophthalmol Vis Sci. 2013 May 15;54(5):3400-9. doi: 10.1167/iovs.12-11068. (Impact factor 3.5)

33. Weibin Cai, Yang Zhang, Rui Cheng, Zheng Wang, Shuhuan Fang, Zumin Xu, Xia Yang, Zhonghan Yang, Jian-xin Ma, Chunkui Shao*, Guoquan Gao* . Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1a Pathway. PLoS ONE, December 2012；7(12): e53152. doi:10.1371/journal.pone.0053152. (Impact factor 4.1)

34. Zhiyu Dai, Lei Lu, ZhonghanYang, Yuling Mao, Juling Lu, Cen Li, Weiwei Qi, Yifei Chen, Yachao Yao, Lei Li, Shaobo Chen, Yang Zhang, Weibin Cai, Xia Yang*, Guoquan Gao* . Kallikrein-binding Protein Inhibits LPS-induced TNF-α by Upregulating SOCS3 Expression. J Cell Biochem. 2013 May;114(5):1020-8. (Impact factor 2.87)

35. Cen Li, Lei Li, Rui Cheng, Zhiyu Dai, Chaoyang Li, Yachao Yao, Ti Zhou, Zhonghan Yang, Guoquan Gao*, Xia Yang*. Acidic/neutral amino acid residues substitution in NH2 terminal of Plasminogen kringle5 exerts enhanced effects on corneal neovascularization. Cornea, 2013 May;32(5):680-8. (Impact factor 1.73)

36. Zhiyu Dai, Yifei Chen, Weiwei Qi, Lijun Huang, Yang Zhang, Ti Zhou, Xia Yang*, Guoquan Gao*. Codon optimization increases human Kallistatin expression in Escherichia coli. Preparative Biochemistry & Biotechnology, 2013; 43(1):123-36. (Impact factor 0.5)

37. Li L, Yang J, Wang WW, Yao YC, Fang SH, Dai ZY, Hong HH, Yang X, Shuai XT*, Gao GQ* . Pigment epithelium-derived factor gene loaded in cRGD-PEG-PEI suppresses colorectal cancer growth by targeting endothelial cells. Int J Pharmaceut. 2012 Sep; 438:1-10. (Impact factor 3.5)

38. Jianfang Ma, Chaoyang Li, Chunkui Shao, Guoquan Gao, Xia Yang*. Decreased K5 receptor expression in the retina, a potential pathogenic mechanism for diabetic retinopathy. Molecular Vision 2012; 18:330-336. (Impact factor 2.511)

39. Zhou T, He X, Cheng R, Zhang B, Zhang RR, Chen Y, Takahashi Y, Murray AR, Lee K, Gao G, Ma JX*. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2012 Jan; 55(1):255-66. （IF:6.9）

40. Zumin Xu, Shuhuan Fang, YufangZuo, Yang Zhang, Rui Cheng, Qingsong Wang, Zhonghan Yang, Weibin Cai, Jianxing Ma, Xia Yang*, Guoquan Gao* . Combination of PEDF with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by down-regulating VEGF expression and angiogenesis. Cancer Sci, 2011 Oct; 102(10):1789-98. Epub 2011 Jul 29.. (Impact factor 3.8)

41.Xiaoqiong Gu，Yachao Yao，Rui Cheng, Yang Zhang, Zhiyu Dai, Genping Wan, ZhonghanYang，Weibin Cai，Guoquan Gao* , Xia Yang*. Plasminogen K5 activates mitochondrial apoptosis pathway of endothelial cells by regulating Bak and Bcl-xL subcellular distribution. Apoptosis, 2011, 16(8):846-55. (Impact factor 4.5)

42.Yang Zhang, Jiande Han, Xia Yang, Qingsong Wang, Chunkui Shao, Dingbo Shi, Weibin Cai, Zhonghan Yang, Guoquan Gao . Pigment epithelial derived factor inhibits angiogenesis and growth of gastric carcinoma by down-regulation of VEGF. Oncol Rep, 26:681-686, 2011. (Impact factor 1.7)

43.Wu X, Hong H, Yue J, Wu Y, Li X, Jiang L, Li L, Li Q, Gao G* , Yang X*. Inhibitory Effect of Small Interfering RNA on Dengue Virus Replication in Mosquito Cells. Virol J, 7:270-277, 2010. (Impact factor 2.44)

44.Weidong Zheng, Yanhui Liu, Huifang Liu, Zhihong Chen, Yan Wang ,Liyan Zhang, Guoquan Gao*, Zhibin Yao*. Molecular characterization of Tyr530Ser and IVS16-1GT mutations causing severe factor V deficiency. ThrombHaemost. 2010 Sep 1; 104(3):536-43. (Impact factor 4.7)

45.Qing Gong, Xia Yang, Weibin Cai, Guoquan Gao*, Zhonghan Yang*. Expression and Identification for Functional Epitope of Pigment Epithelium-derived Factor with Anti-angiogenic Activity. Protein J. 2010 Apr; 29(3):167-73. (Impact factor 1.02)

46.Jun Yang, Shuqin Chen, Xuan Huang, Jiande Han, Qingsong Wang, Dingbo Shi, Rui Cheng, Guoquan Gao*, Xia Yang*. Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis. Cancer Biol Ther. 2010 Jun 15; 9(12):967-74. (Impact factor 2.8, cover story with commentary)

47.Yang X, Cai W, Xu Z, Chen J, Li C, Liu S, Yang Z, Pan Q, Li M, Ma J, Gao G. High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5. J Cell Mol Med. 14(10):2519-2530, 2010 Oct (Impact factor 5.2)

48.Zhou T, Hu Y, Chen Y, Zhou K, Zhang B, Gao G*, Ma JX*. The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4371-9. (Impact factor 3.6)

49.Huasheng Yang, Rui Cheng, Guoying Liu, Qinghua Zhong, Chaoyang Li, Weibin Cai, ZhonghanYang, Jianxing Ma, Xia Yang, Guoquan Gao. PEDF inhibits growth of retinoblastoma by anti-angiogenic activity. Cancer Science. 100(12):2419-2425, 2009 Dec. (Impact factor 3.5)

50.Yang Z, Mo X, Gong Q, Pan Q, Yang X, Cai W, Li C, Ma JX, He Y, Gao G. Critical effect of VEGF in the processof endothelial cell apoptosis induced by high glucose. Apoptosis. 13(11):1331-43, 2008 Nov. (Impact factor 4.1)

51.Baohe Zhu, Lei Lu, Weibin Cai, Xia Yang, Chaoyang Li, Zhonghan Yang, Wenhua Zhan, Jian-xing Ma, Guoquan Gao. Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing VEGF production and angiogenesis. Molecular Cancer Therapeutics, 6(12): 3297-3306, 2007. (Impact factor 5.2, highlight paper)

52.Lei Lu, Zhonghan Yang, Baohe Zhu, Shuhuan Fang, Xia Yang, Weibin Cai, Chaoyang Li, Jian-xing Ma, Guoquan Gao. Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity. Cancer Letter, 257(1):97-106, Nov 2007. (Impact factor 3.3)

53.Xia Yang, Rui Cheng, Chaoyang Li,Weibin Cai, Jian-xing Ma, Qianping Liu, Zhonghan Yang, Zhihong Song, Zuguo Liu, Guoquan Gao. Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity. Cancer Biology & Therapy, 5(4):399-405, 2006. (Impact factor 3.3)

54.Qingsong Wang, Xia Yang, Zhonghan Yang, Guoquan Gao. A novel method for expression and purificationof human Pigment Epithelium-derived Factor with biological activities in Escherichia coli. Preparative Biochemistry & Biotechnology, 36(2):127-138, 2006. (Impact factor 0.8)

55.Weibin Cai, Jianfang Ma, Chaoyang Li, Zhonghan Yang, Xia Yang, Wei Liu, Zuguo Liu, Mintao Li, Guoquan Gao. Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization. J Cell Biochem, 96(6):1254-1261, 2005. (Impact factor 3.6)

56.Gao G, Shao C., Zhang S.X., Dudley A., Fant J, and Ma J-x. Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage. Diabetologia, 46,689-698, 2003. (Impact factor 5.7)

57.Gao G, Li Y, Fant J, Becerra SP, Crosson C and Ma J-x. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and spraguedawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes, 51(4), 1218-1225, 2002. (Impact factor 9.1)

58.Gao G, Li Y, Gee S, Dudley A, Fant J, Crosson C and Ma J-x. Down-regulation of endogenous VEGF and up-regulation of PEDF: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. J Biol Chem, 277(11), 9492-9497, 2002. (Impact factor 7.7)

59.Gao G and Ma J-x. Tipping the balance for angiogenic disorders. Drug Discovery Today, 7(3), 171-172, 2002. (Impact factor 6.6)

60.Gao G, Li Y, Zhang D, Gee S, Crosson CE and Ma J-x. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett, 489,270-276, 2001. (Impact factor 3.7) ^[1] 

廣東省基因操作和生物大分子產物工程技術研究中心主任

海洋微生物功能分子廣東省高校重點實驗室主任

廣東省生物化學學會理事長

中國生物化學與分子生物學學會理事（2010-2018）

中國生物化學與分子生物學學會醫學分會理事（第四屆）

中國生物化學與分子生物學學會醫學分會常務理事（第五屆、第六屆2015）

中國生物化學與分子生物學學會教學委員會委員、副秘書長（2014-2018）

中國生物化學與分子生物學學會教學委員會委員、副主任委員（2018-）

中國生物化學與分子生物學會脂質與脂蛋白專業委員會委員（2012- ）

中國生物化學與分子生物學會代謝專業委員會委員（2016- ）

中國微生物學會海洋微生物學專業委員會委員（2012- ）

中華醫學會糖尿病學分會糖尿病基礎研究與轉化醫學學組成員（2012-）

廣東省本科高校臨牀醫學專業教學指導委員會委員（2016.5-）

國家醫學考試中心生物化學組成員（2011-）

全國繼續醫學教育委員會基礎（機能）組成員

中山大學學報（醫科版）編委

癌症雜誌責任編委

中華腫瘤防治雜誌編委

中國生物化學與分子生物學報編委

醫學分子生物學雜誌編委

世界華人消化雜誌編委 ^[1]