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朱偉明

(中國海洋大學教授)

鎖定
朱偉明,男,1965年2月生,現任中國海洋大學醫藥學院教授、博士生導師,海洋藥物教育部重點實驗室副主任。第九屆“中國藥學會-施維雅青年藥物化學獎”獲得者。兼任《中國海洋藥物》雜誌編委,中國藥學會海洋藥物專業委員會委員、中國微生物學會海洋微生物專業委員會委員,中國海洋生物化學與分子生物學分會理事。 [1] 
近10年承擔973、863、NSFC、國家重大新藥創制專項等國家級研究課題15項,發現新化合物400餘個,在《Journal of American Chemical Society》、《Organic Letters》、《Journal of Natural Products》、《Tetrahedron》等知名學術期刊上發表SCI收錄的研究論文130篇,1篇學術論文被評為Marine Drugs“2015最佳論文獎(Best Paper Award 2015)”。 [1] 
中文名
朱偉明
國    籍
中國
畢業院校
武漢大學
職    稱
教授

朱偉明研究領域

1、從海洋等來源的特境微生物“talented strains”資源中發掘創新藥物先導化合物
利用生物學與化學相結合的集成篩選方法,從海洋等特殊環境微生物中篩選並發現具有重要生物活性的藥物先導化合物及藥源微生物“talented strains”新資源。
2、非“talented strains”向“talented strains”的轉化研究:
利用化學誘導和共培養技術,激活微生物中表達次生代謝產物的沉默基因,轉化“非天才菌株”為“天才菌株”。
3、天然藥物的優化:
對具有重要生物活性的微生物天然產物進行結構修飾,探討構效關係,獲得臨牀候選藥物。 [1] 

朱偉明在研課題

滸苔共附生微生物及其含氮、滷代等克生活性產物研究”(No. 41376148, 2014–2017,國家自然科學基金
環境脅迫增加海洋真菌的化學多樣性研究”(No. 21172204, 2012–2015,國家自然科學基金)
深海微生物活性物質的發現及其生物合成技術(No. 2012AA092104-1, 2012–2015,863子課題)
海洋微生物次生代謝產物的生理活性及其機制”(No. 2010CB833804, 2010–2014, 973子課題)
“逆轉多藥耐藥抗乳腺癌化合物HDZ-137成藥性評價”(No. 2011AA09070106, 2011–2014,863課題)。 [1] 

朱偉明教育背景

1981–1985年:武漢大學化學系,畢業並獲得理學學士學位
1985–1988年:武漢大學化學系,畢業並獲得理學碩士學位,發表論文1篇(現為SCI期刊)。
1997–2001年:中科院昆明植物研究所,畢業並獲得理學博士學位,發表SCI論文14篇(第一作者SCI論文8篇)。 [1] 

朱偉明個人經歷

1988–2003年:雲南師範大學化學系,從事有機化學科研與教學工作,任講師、副教授、教授;承擔國家、省級課題各1項,發表論文15篇,主編教參1部。
2001–2003年:中國科學院上海有機化學研究所博士後,從事活性產物噴腦皂甙元及其衍生物合成研究,申請中國發明專利3項(授權2項)。
2003–今:中國海洋大學醫藥學院,從事海洋天然產物化學的科研與教學工作,任教授、碩導、博導。承擔973、863、NSFC等國家級課題15項,發表SCI論文115篇,申請中國發明專利25項(授權12項)。 [1-2] 
2017年12月8日中國海洋大學朱偉明教授應邀作客“未央導師論壇”,做了題為《特境微生物來源的活性產物研究》的報告。 [2] 

朱偉明代表性論文

2015
1.Fandong Kong,et al,Weiming Zhu. New a-glucosidase inhibitors from a marinesponge-derived fungus,Aspergillussp. OUCMDZ-1583.RSC Adv.2015, 5(84), 68852–68863.(影響因子3.84
2.Liping Wang,et al,Weiming Zhu.Biomimetic semi-synthesis of fradcarbazole A and its analogues.Tetrahedron2015, online, DOI: 10.1016/j.tet.2015.08.06
3.CuitingLv, et al, Kui Hong,Weiming Zhu,Ruohua Chen,Caiguo Huang,Ophiobolin O isolated fromAspergillusustusinduces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/Cyclin D1 signaling.Mar Drugs2015, 13(1): 431–443.
2014
1.Peng Fu, et al,Weiming Zhu.Acyclic Congeners fromActinoalloteichuscyanogriseusProvide Insights into Cyclic Bipyridine Glycoside Formation.Org Lett2014, 16(16): 4264–4267.(影響因子6.32
2.Peng Fu,et al,Weiming Zhu.Cyanogramide with a NewSpiro[indolinonepyrroloimidazole]Skeleton fromActinoalloteichuscyanogriseus.Org Lett2014,16(14): 3708–3711.
3.Fandong Kong,et al,Weiming Zhu*.Thiodiketopiperazines from the marine-derived fungusPhomasp. OUCMDZ-1847.J NatProd2014, 77 (1): 132–137.
4.Kunlai Sun,et al,Weiming Zhu*. Indolediterpenoids and isocoumarin from the fungus,Aspergillusflavus, isolated from the prawn,Penaeusvannamei.Mar Drugs2014, 12(7): 3970–3981.
5.Yi Wang,et al,Weiming Zhu*. Phenolic Polyketides from the Co-Cultivation of Marine-DerivedPenicilliumsp. WC-29-5 andStreptomycesfradiae007.Mar Drugs2014, 12(4): 2079–2088.
6.Pei Wang,et al,Weiming Zhu*.Alkaloids from the mangrove-derived actinomyceteJishengellaendophytica161111.Mar Drugs2014, 12(1):477–490.
7.Tonghan Zhu,et al,Weiming Zhu*. New rubrolides from the marine-derived fungusAspergillusterreusOUCMDZ-1925.J Antibiot(Tokyo).2014, 67(4): 315–318.
8.王立平,莊以彬,孫坤來,朱偉明. PKC-412滷代衍生物的合成及細胞毒活性研究.有機化學,2014, 34(8): 1603–1608.
2013
1.Yiguang Zhu, et al,Weiming Zhu, and Changsheng Zhang, Insights into caerulomycin A biosynthesis: atwo-component monooxygenase CrmH-catalyzed oxime formation.J. Am. Chem. Soc.,2013, 135(50): 18750–18753(影響因子10.68
2.Yaqin Fan, et al,Weiming Zhu,Indole-diterpenoids with anti-H1N1 activity from the aciduric fungusPenicillium camembertiOUCMDZ-1492.J Nat Prod2013, 76(7): 1328–1336.(影響因子3.17
3.Wenxia Sun, et al,Weiming Zhu,and Caiguo Huang, Ophiobolin-O reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human breast carcinoma (MCF-7/ADR) cells.Mar Drugs2013, 11(11): 4570–4584.
4.Pei Wang, et al,Weiming Zhu,Diketopiperazine derivatives from the marine-derived actinomyceteStreptomycessp. FXJ7.328.Mar Drugs2013, 11(4): 1035–1049.(影響因子3.98
5.Liping Wang,Weiming Zhu, Versicolactones A and B: total synthesis and structure revision.Tetrahedron Lett2013, 54(49): 6729–6731(影響因子2.68
6.Peng Fu, et al,Weiming Zhu, α-Pyrones from the marine-derived actinomyceteNocardiopsisdassonvillei subsp.dassonvilleiXG-8-1.RSC Adv2013, 3(43): 20726–20731.(影響因子2.56
7.Jinkai Zheng, et al,Weiming Zhu, Antimicrobial ergosteroids and pyrrole derivatives from halotolerantAspergillus flocculosusPT05-1 cultured in a hypersaline medium.Extremophiles2013, 17(6): 963-971.(影響因子2.20
8.Yi Wang, et al,Weiming Zhu, Developments around the bioactive diketopiperazines: a patent review.Expert OpinTher Pat.2013, 23(11): 1415–1433.(影響因子3.52
9.趙成英,朱統漢,朱偉明. 2010—2013之海洋微生物新天然產物.有機化學,2013,33(6): 1195–1234.
2012
1.Peng Fu, et al,Weiming Zhu, New indolocarbazoles from a mutant strain of the marine-derived actinomyceteStreptomyces fradiae007M135.OrgLett2012, 14(24): 6194–6197.(影響因子6.14
2.Peng Fu, et al,Weiming Zhu,Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strainStreptomycessp. FMA.OrgLett2012, 14(9): 2422–2425.
3.Yiguang Zhu,et al,Weiming Zhu,Changsheng Zhang, Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase.Org. Lett.2012, 14(11):2666–2669.
4.Junfeng Wang, et al,Weiming Zhu, Cytotoxic Polyphenols from the FungusPenicillium expansum091006 endogenous with Mangrove PlantExcoecaria agallocha.Planta Med2012,78(17): 1861–1866.(影響因子2.15
2011
1.Peng Fu,et al,Weiming Zhu,Cyclic bipyridine glycosides from the marine-derived actinomyceteActinoalloteichuscyanogriseusWH1-2216-6,OrgLett2011, 13(22): 5948–5951.
2.Yibin Zhuang, et al,Weiming Zhu. New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus,Aspergillus versicolorLCJ-5-4,OrgLett2011, 13 (5): 1130–1133.
3.Peng Fu, et al,Weiming Zhu,α-Pyrones and diketopiperazine derivatives from the marine-derived actinomyceteNocardiopsis dassonvilleiHR10-5,JNatProd2011, 74(10):2219–2223.
4.Hui Wang,et al,Weiming Zhu, Anti-influenza virus polyketides from the acid-tolerant fungusPenicillium purpurogenumJS03-21,JNatProd2011, 74(9):2014–2018.
5.Peng Fu, et al,Weiming Zhu, Cytotoxic bipyridines from the marine-derived actinomyceteActinoalloteichus cyanogriseusWH1-2216-6,JNatProd2011, 74(8): 1751–1756.
6.Yibin Zhuang, et al,Weiming Zhu, Cyclopeptides and polyketides from coral-associated fungus,Aspergillus versicolorLCJ-5-4,Tetrahedron, 2011, 67(37): 7085–7089.
7.Zhihong Xu, et al,Weiming Zhu.Antifungal quinazolinones from marine-derivedBacillus cereusand their preparation,BioorgMedChemLett2011, 21(13): 4005–4007.
8.朱偉明,王俊鋒,海洋真菌生物活性物質研究之管見,菌物學報2011, 30(2): 218–228.
2010
9.Jinkai Zheng, et al,Weiming Zhu,Cyclic tripeptides from the halotolerant fungusAspergillus sclerotiorumPT06-1,JNatProd2010, 73(6): 1133–1137.
10.Zhenyu Lu,et al,Kui Hong,Weiming Zhu.Cytotoxic polyphenols from the marine-derived fungusPenicillium expansum,J NatProd2010, 73(5): 911–914.
2009
1.Jinkai Zheng,et al,Weiming Zhu, Novel cyclic hexapeptides from marine-derived fungus,Aspergillus sclerotiorumPT06-1,Org Lett2009, 11(22): 5262–5265.
2.Zhenyu Lu, et al,Weiming Zhu, Sesquiterpenoids and benzofuranoids from the marine-derived fungusAspergillus ustus094102,JNatProd2009, 72(10): 1761–1767.
3.Lin Duan, et al,Weiming Zhu. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant,Myristica fragrans,Planta Med2009, 75(11): 1241–1245.
2008
1.Hongwen Tao, et al,Weiming Zhu, Resin glycoside constituents ofIpomoea pes-caprae(beach morning glory),JNatProd2008, 71(12): 1998–2003.
2.Min Zhang, et al,Weiming Zhu, Cytotoxic alkaloids and antibiotic nor-dammarane triterpenoids from marine-derived fungusAspergillus sydowi.JNatProd2008, 71 (6): 985–989.
3.Zhenyu Lu, et al,Weiming Zhu, Citrinin dimers from the halotolerant fungusPenicillium citrinumB-57,JNatProd2008,71 (4): 543–546.
4.Zhenjian Lin, et al,Weiming Zhu, Polyketides fromPenicilliumsp.JP-1, anendophytic fungus associated withthe mangrove plantAegiceras corniculatum,Phytochemistry2008, 69(5): 1273–1278.(影響因子3.35
5.Fazuo Wang, et al,Weiming Zhu, Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungusAspergillus fumigatus,Tetrahedron2008, 64(34): 7986–7991.(影響因子3.02
6.Fazuo Wang, et al,Weiming Zhu, Six new ergosterols from the marine-derived fungusRhizopussp.Steroids2008,73(1): 19–26.(影響因子2.83
7.Yapeng Zhang, et al,Weiming Zhu,Isolation, structure elucidation, and antimycobacterial properties of dimeric naphtho-gamma-pyrones from the marine-derived fungusAspergillus carbonarius,Chem Biodiversity2008, 5(1):93–100. [1] 
參考資料