複製鏈接
請複製以下鏈接發送給好友
https://baike.baidu.hk/item/徐峻/11012893
複製
複製成功

徐峻

（中山大學教授、博士導師）

鎖定
徐峻，男，博士，安徽合肥人，2009年3月歸國擔任中山大學教授、博士導師，藥物分子設計研究中心主任。兼任中科院上海有機所客座教授、中國醫學科學院藥用植物研究所客座研究員、暨南大學客座教授。
長期從事小分子新藥的設計與研發工作。主要研究方向為：中藥藥效組學、醫藥化學、藥物設計、化學信息學、多變量統計分析、化學結構圖論算法、化學結構專利文獻檢索引擎、蛋白質NMR結構解析和模擬。
中文名
徐峻
畢業院校
中國科技大學
學位/學歷
博士
職    務
中山大學藥物分子設計研究中心主任
職    稱
教授

目錄

  1. 1 人物經歷
  2. ▪ 教育經歷
  3. ▪ 工作經歷
  4. 2 教授課程
  1. 3 社會兼職
  2. 4 研究方向
  3. 5 學術成果
  4. ▪ 科研項目
  1. ▪ 發表論文
  2. 6 獲獎記錄
  3. 7 學術交流

徐峻人物經歷

徐峻教育經歷

1983.09 – 1988.09 中國科技大學近代大學化學系 碩士/博士研究生
1990.04 – 1992.10 澳大利亞國立大學高等化學研究院核磁共振中心 博士後
1991.10 – 1993.03 加拿大MicGill大學化學系 博士後 [1] 

徐峻工作經歷

1993.03 – 1995.08 美國TRIPOS公司 資深研究員
1995.08 – 1998.05 美國薩特勒波譜學實驗室 研發總監
1998.08 – 2002.02 德國Boehringer Ingelheim製藥北美研發中心 主管科學家
2002.02 – 2007.09 美國DPI製藥 藥物設計與信息學總監
2008.03 – 至今 中山大學藥學院 教授、博士導師，藥物分子設計研究中心主任 [1] 

徐峻教授課程

主講課程
藥物設計導論（研究生課程）
藥學前沿（大學生高年級課程）
參講課程
現代藥物發現中的關鍵技術 [1] 

徐峻社會兼職

英國皇家化學會會士(FRSC),匹茲堡大學兼職教授、墨爾本皇家理工大學兼職教授、中國化學會計算化學專業委員會委員、國家中醫藥管理局中藥專利資源重點研究室學術委員會副主任、廣東省超算學會常務理事、廣東省中西醫結合學會中藥專業委員會常務委員。 計算機與應用化學雜誌編委(2010)、Molecular Diversity雜誌編委(2000)、Current Medicinal Chemistry編委(Editorial Board Member, 2014)

徐峻研究方向

1、藥物設計方法學（化學信息學、生物信息學算法研究、生物雲計算、超算）
2、中藥現代化研究（活性成分發現與尋靶、先導化合物發現與優化）
3、藥物研發（抗病毒藥物、抗菌素、抗代謝類藥物、抗炎藥物、抗衰老藥物） [1] 

徐峻學術成果

徐峻科研項目

2009年以來主持的國家級科技項目：
1、國家重大新藥創制科技重大專項2010ZX09102-305，2010-2012，防治甲型H1N1流感的新藥臨牀前與臨牀研究
2、國家重大新藥創制科技重大專項“面向新藥創制的動態可及小分子虛擬與實體化合物資源庫”(課題編號2018ZX07935010)，2018.6-2021.12
3、國家自然科學基金(課題編號81173470)，2012-2015降血脂中藥複方的多靶標作用機制
4、國家自然科學基金(課題編號81473138), 2015-2018基於配體-靶標網絡的抗2型糖尿病藥物設計新方法研究
5、廣東省引進創新科研團隊專項計劃(編號2009010058)：重大人類致病病毒特異性藥物研發，2011.1-2015.12
6、廣州超級計算應用研發與扶持專項(2012Y2-00048)基於生物學網絡的藥物設計關鍵技術研究與應用， 2013.1-2015.12
7、廣東省前沿與關鍵技術創新(省重大科技)專項, 藥物創新大數據公共服務平台(課題編號2015B010109004), 2016-01-01 至 2018-12-31 [1] 

徐峻發表論文

Selected publications between2018 and 2010:
2018
  1. Yuying Fang†, Wenjuan Xia†, Bao Cheng, Pei Hua, Huihao Zhou, Qiong Gu*, Jun Xu*, Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer’s disease, European Journal of Medicinal Chemistry, 2018, 149, 129-138 (IF=4.519)
  2. Haobin Cai, Yunxia Luo, Xin Yan, Peng Ding, Yujie Huang, Shijie Zhang, Rong Zhang, Yunbo Chen, Zhouke Guo, Qi Wang*, Jiansong Fang* and Jun Xu*, The Mechanism of Actions for Bushen-yizhi Formula as a Therapeutic Agent against Alzheimer’s Disease, Scientific Reports, 2018, 8:3104-3117 (IF=5.228)
  3. Xiangkun Luo, Jie Cai, Zhiyong Yin, Pan Luo, Chanjuan Li, Hang Ma, Navindra Seeram, Qiong Gu*, Jun Xu, Fluvirosaones A and B, Two Indolizidine Alkaloids with a Pentacyclic Skeleton from Flueggea virosa, Organic Letters, 2018,20(4), 991-994 (IF=6.579)
  4. Zhihong Liu, Jiewen Du, Xin Yan, Jiali Zhong, Lu Cui, Jinyuan Lin，Lizhu Zeng, Peng Ding, Pin Chen, Xinxin Zhou, Huihao Zhou, Qiong Gu*, and Jun Xu*, TCMAnalyzer: a Chemo- and Bioinformatics Web Service for Analyzing Traditional Chinese Medicine, 2018, J. Chem. Inf. Model., 2018, 58, 550-555 (IF=4.068)
  5. Chanjuan Li, Bao Cheng, Sai Fang, Huihao Zhou, Qiong Gu*, Jun Xu*, Design, syntheses and lipid accumulation inhibitory activities of novel resveratrol mimics, European Journal of Medicinal Chemistry, 2018, 143, 114-122. (IF=4.519)
  6. Miao Yu, Qiong Gu, and Jun Xu*, Discovering new PI3Kα inhibitors with a strategy of combining ligand-based and structure-based virtual screening, Journal of Computer-Aided Molecular Design, 2018, 32:347-361(IF= 3.028)
  7. Jun Xu, Chemoinformatics of Chinese Herbal Medicines, Eds. Thomas Engel and Johann Gasteiger, Applied Chemoinformatics, Wiley-VCH, 2018, ISBN 978-3-527-34201-3, pp 237-244.
2017
  1. Peng Ding, Xin Yan, Zhihong Liu, Jiewen Du, Yuehua Xu, Huihao Zhou, Qiong Gu, Jun Xu*, PTS: A Pharmaceutical Target Seeker, Database: The Journal of Biological Databases and Curation, 2017, 2017: bax095. Published online 2017 Dec 28. doi: 10.1093/database/bax095. (IF=3.290)
  2. Shao-Nan Liu, Jiayuan Hu, Shen H. Tan, Qian Wang, Jun Xu, Yan Wang, Yan Yuan* and Qiong Gu*, ent-Rosane diterpenoids from Euphorbia milii showing an Epstein–Barr virus lytic replication assay, RSC Advances, 2017, 7, 46938-46947. (IF=3.108)
  3. Yingchen Ju, Zhihong Liu, Zizhen Zhang, Lijun Duan, Qi Liu, Qiong Gu, Cheng Zhang, Jun Xu*, and Huihao Zhou*, Membrane binding stabilizes the insertion sequence structure of Proteus vulgaris L-amino acid deaminase and increases its catalytic activity, Nature Scientific Reports, SREP-17-32768A, accepted on October 6, 2017. DOI: 10.1038/s41598-017-08848-4. (IF=5.228)
  4. Jiali Zhong，Zhihong Liu，Xinxin Zhou* and Jun Xu*， Synergic Anti-Pruritus Mechanisms of Action for the Radix Sophorae Flavescentis and Fructus Cnidii Herbal Pair， Molecules 2017, 22(9), 1465-1478; doi:10.3390/molecules22091465 (IF=2.861)
  5. He Peng, Zhihong Liu, Xin Yan, Jian Ren* and Jun Xu*, A de novo substructure generation algorithm for identifying the privileged chemical fragments of liver X, Nature Scientific Reports, 2017, 77: 11121-11138. SREP-16-44982B, accepted on July 21, 2017. DOI: 10.1038/s41598-017-08848-4. (IF=5.228)
  6. Jie Cai, Chanjuan Li, Zhihong Liu, Jiming Ye, Qiong Gu, and Jun Xu*, Predicting DPP-IV inhibitors with machine learning approaches, Journal of Computer-Aided Molecular Design, 2017, 31 (4) :1-10. (IF= 3.028)
2016
  1. Yongsheng Lin, Qian Wang, Qiong Gu,* Hongao Zhang, Cheng Jiang, Jiayuan Hu, Yan Wang, Yuan Yan,* and Jun Xu*, Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication, Journal of Natural Products, 2016, 1(17): 53-60. (IF=3.662)
  2. Xiangkun Luo, Chanjuan Li, Pan Luo, Xin Lin, Hang Ma, Navindra P. Seeram, Ching Song, Jun Xu*, and Qiong Gu*, Pterosin Sesquiterpenoids from Pteris cretica as Hypolipidemic Agents via Activating Liver X Receptors, Journal of Natural Products, 2016, 79 (12), 3014–3021. DOI: 10.1021/acs.jnatprod.6b00558. (IF=3.662);
  3. Jiewen Du, Xin Yan, Zhihong Liu, Lu Cui, Peng Ding, Xiaoqing Tan, Xiuming Li, Huihao Zhou, Qiong Gu* and Jun Xu*. cBinderDB: a covalent binding agent database, Bioinformatics, 2016, 33(8): 1258-1260. DOI 10.1093/bioinformatics/btw801. (IF=7.352)
  4. Zhihong Liu, Peng Ding, Xin Yan, Minghao Zheng, Huihao Zhou, Yuehua Xu, Yunfei Du, Qiong Gu, Jun Xu *. ASDB: a resource for probing protein functions with small molecules. Bioinformatics. 2016, 32(11): 1752-1754. (IF=7.352)
  5. Ling Wang, Ye Cheng Li, Meng Yan Xu, Xiao Qian Pang, Zhihong Liu, Wen Tan* and Jun Xu*, Chemical fragments-based CDK4/6 inhibitors prediction and web server, RSC Advances, 2016, 6(21):16972-16981. (IF=3.289)
  6. Ling Wang, Lei Chen, Miao Yu, Lihui Xu, Bao Cheng, Yongsheng Lin, Qiong Gu, Xianhui He*, Jun Xu*, Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays, Nature Scientific Reports, 2016, 6:18987-19000. DOI: 10.1038/srep18987. (IF=5.228), 2016, Published: 06 January
  7. Wenbin Zhong, Guoping Pan, Lin Wang, Shiqian Li, Jingsong Ou, Mengyang Xu, Jiwei Li, Biying Zhu, Xiuye Cao, Hongling Ma, Chaowen Li, Jun Xu, Vesa M Olkkonen, Bart Staels, Daoguang Yan, ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis. Circulation Research, 2016, 119(12): 1296-1312. DOI: 10.1161/CIRCRESAHA.116.309603. (IF=11.02). Published on December 9, 2016.
  8. Cheng Jiang, Pan Luo, Yu Zhao, Jialing Hong, Susan Morris-Natschke, Jun Xu, Chin-Ho Chen, Kuo-Hsiung Lee, Qiong Gu*, Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity, Journal of Natural Products, 2016, 79(3): 578-583. DOI: 10.1021/acs.jnatprod.5b01012. (IF=3.662)
2015
  1. WenJian Lan, ShengJiao Fu, MengYang Xu, WanLing Liang, Chi-Keung Lam, GuoHua Zhong, Jun Xu, DePo Yang and HouJin Li*, Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri, Marine Drugs, 2016, 14(1), DOI: 10.3390/md14010018. (IF=3.345).
  2. Hang Ma, Ling Wang, Daniel Niesen, Ang Cai, Bongsup Cho, Wen Tan*, Qiong Gu, Jun Xu* and Navindra P Seeram*, Structure Activity Related, Mechanistic, and Modeling Studies of Gallotannins containing a Glucitol-Core and α-Glucosidase, RSC Advances, 2015, 5(130):107904–107915. DOI: 10.1039/C5RA19014B, First published online 14 Dec 2015. (IF=3.289)
  3. Lin Zhou, Fangming Song, Qian Liu, Mingli Yang, Jinmin Zhao, Renxiang Tan, Jun Xu, Ge Zhang, Julian M. W. Quinn, Jennifer Tickner and Jiake Xu*, Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-kB and NFAT Pathways Int. J. Mol. Sci. 2015, 16(11): 27087–27096. DOI: 10.3390/ijms161125998. (IF=3.257)
  4. Long Li, Xiu Le, Ling Wang, Qiong Gu, Huihao Zhou and Jun Xu*, Discovering New DNA Gyrase Inhibitors Using Machine Learning Approaches, RSC Advances, 2015, 5(128): 105600 – 105608. DOI: 10.1039/C5RA22568J. (IF=3.840)
  5. Xin Yan, Chenzhong Liao, Zhihong Liu, Arnold T. Hagler, Qiong Gu*, Jun Xu*, Chemical Structure Similarity Search for Ligand-Based Virtual Screening: Methods and Computational Resources, Current Drug Targets, 2015, 17(14):1580-1585. DOI:10.2174/1389450116666151102095555. (IF=3.021)
  6. Lu Cui, Yu Wang, Zhihong Liu, Hongzhuan Chen, Hao Wang*, Xinxin Zhou*, Jun Xu*, Discovering New Acetylcholinesterase Inhibitors by Mining the Buzhongyiqi Decoction Recipe Data, J. Chem. Inf. Model., 2015, 55 (11), 2455–2463. DOI: dx.doi.org/10.1021/acs.jcim.5b00449. (IF=4.068)
  7. Qianzhi Ding, Chanjuan Li, Ling Wang, Yali Li, Huihao Zhou, Qiong Gu*, Jun Xu*, Identifying Farnesoid X Receptor Agonists with Naïve Bayesian and Recursive Partitioning Approaches, Medicinal Chemistry Communication, 2015, 6(7): 1393-1403. DOI: 10.1039/c5md00149h (IF=2.495)
  8. Le Xiu, Qiong Gu*, Jun Xu*, Identifying MurI Uncompetitive Inhibitors by Correlating Decomposed Binding Energies with Bioactivity, RSC Advances, 2015, 5(51): 40536 – 40545. DOI: 10.1039/C5RA03079J. (IF=3.840)
  9. Sai Fang, Lei Chen, Miao Yu, Bao Cheng, Yongsheng Lin, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Qiong Gu, Jun Xu*, Synthesis, Antitumor Activity, and Mechanism of Action of 6-Acrylic Phenethyl Ester-2-pyranone Derivatives, Organic & Biomolecular Chemistry , 2015, 13(16): 4714 - 4726. DOI: 10.1039/c5ob00007f. (IF3.487).
  10. Yali Li, Ling Wang, Zhihong Liu, Chanjuan Li, Xu Jiake, Qiong Gu*, Jun Xu*, Predicting Selective Liver X Receptor β Agonists Using Multiple Machine Learning Methods, Mol. BioSyst., 2015, 11(5): 1241-1250. DOI: 10.1039/C4MB00718B, Received 17 Dec 2014, Accepted 20 Feb 2015, First published online 20 Feb 2015 (IF=3.183).
  11. Yu Wang, Hu Ge, Yufang Xie, Yingyan He, Mengyan Xu, Qiong Gu*, Jun Xu*, Predicting dual-targeting anti-influenza agents using multi-models, Molecular Diversity, 2015, 19(1):123-134. DOI: 10.1007/s11030-014-9549-z. Online Oct 2, 2014. (IF=2.544)
  12. Xin Yan, Peng Ding, Zhihong Liu, Ling Wang, Chenzhong Liao, Qiong Gu, Jun Xu*. Big data in drug design( In Chinese). Chin Sci Bull, 2015, 60(5-6) : 558–565, doi: 10.1360/N972014-01144.
2014
  1. Zhihong Liu, Jingwei Zhou, Ruibo Wu*, Jun Xu*, The Mechanism of Assembling Isoprenoid Building Blocks 1. Elucidation of the Structural Motifs for Substrate Binding in Geranyl Pyrophosphate Synthase, J. Chem. Theory. Comput., 2014, 10 (11): 5057–5067 (IF=5.310). DOI: 10.1021/ct500607n.
  2. Chanjuan Li, Hu Ge, Lujia Cui, Yali Li, Bao Cheng, Guodong Zhang, Ziying Zhang, Hao Qi, Yan Ruan, Qiong Gu*, Jun Xu*, Molecular Mechanism of Action of K(D)PT as an IL-1RI Antagonist for the Treatment of Rhinitis, RSC Advances, 2014, 4 (89): 48741 – 48749. DOI: 10.1039/C4RA09046B. (IF=3.840)
  3. Zhihong Liu, Minghao Zheng, Xin Yan, Qiong Gu, Johann Gasteiger, Johan Tijhuis, Peter Maas, Li, J., Jun Xu*, ChemStable: a web server for rule-embedded naive Bayesian learning approach to predict compound stability, J Comput Aided Mol Des, 2014, 28(9): 941-950. DOI:10.1007/s10822-014-9778-3. (IF=2.782)
  4. Ling Wang, Xiu Le, Long Li, Yingchen Ju, Zhongxiang Lin, Qiong Gu*, Jun Xu*, Discovering New Agents Active against Methicillin-resistant Staphylococcus aureus with Ligand-based Approaches, J. Chem. Inf. Model., 2014, 54 (11): 3186–3197. DOI: 10.1021/ci500253q (IF=4.068)
  5. Lei Chen, Ling Wang, Qiong Gu* and Jun Xu*, An in silico protocol for identifying mTOR inhibitors from natural products , Molecular Diversity, 2014, 18(4), 841-852. DOI: 10.1007/s11030-014-9543-5. (IF=2.544)
  6. Minghao Zheng, Zhihong Liu, Xin Yan, Qianzhi Ding, Qiong Gu*, Jun Xu*, LBVS: An Online Platform for Ligand-based Virtual Screening Using Publicly Accessible Databases, Molecular Diversity, 2014, 18(4), 829-840. DOI: 10.1007/s11030-014-9545-3. (IF=2.544)
  7. Chutian Shu, Hu Ge, Michael Song, Jyun-hong Chen, Huimin Zhou, Qu Qi, Feng Wang, Xifeng Ma, Xiaolei Yang, Genyan Zhang, Yanwei Ding, Dapeng Zhou, Peng Peng, Cheng-kon Shih, Jun Xu, Frank Wu, Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes, ACS Medicinal Chemistry Letters, 2014, 5(8): 921-926. DOI: 10.1021/ml5001905, Publication Date (Web): June 16, 2014. (IF=3.073)
  8. Ling Wang, Lei Chen, Zhihong Liu, Minghao Zheng, Qiong Gu*, Jun Xu, *, Predicting mTOR Inhibitors with a Classifier Using Recursive Partitioning and Naïve Bayesian Approaches, PLOS ONE, 2015, 9(5): e95221.Published: May 12, 2014, DOI: 10.1371/journal.pone.0095221. (IF=3.534)
  9. Qian Liu, Huafei Wu, Shek Man Chim, Lin Zhou, Jinmin Zhao, Haotian Feng, Qingli Wei, Qing Wang, Ming H Zheng, Ren Xiang Tan, Qiong Gu, Jun Xu, Nathan Pavlos, Jennifer Tickner, Jiake Xu*, SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation, Biochemical pharmacology, 2013, 86(12):1775-1783. DOI: 10.1016/j.bcp.2013.09.017. (IF=5.091)
  10. Hu Ge, Jinggong Liu, Yu Wang, Wenxia Zhao, Qingqing He, Ruibo Wu, Ding Li*, Jun Xu*, Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols, Organic & Biomolecular Chemistry, 2014, 12(27), 4941-495. DOI: 10.1039/C4OB00589A , First published online 17 Apr 2014. (IF=3.487)
  11. Hu Ge, Yu Wang, Wenxia Zhao, Lin Wei, Xin Yan, Jun Xu*, Scaffold hopping of potential anti-tumor agents by WEGA: a shape-based approach, Med. Chem. Commun., 2014, 5 (6): 737 – 741. DOI:10.1039/C3MD00397C (IF=2.626)
  12. Xin Yan, Li, J.*, Qiong Gu, Jun Xu*, gWEGA: GPU-Accelerated WEGA for Molecular Superposition and Shape Comparison, Journal of Computational Chemistry, 2014, 35(15):1122-1130. DOI: 10.1002/jcc.23603. (IF=3.601)
  13. Hu Ge, Ge Liu, Yangfei Xiang, Yu Wang, Chaowan Guo, Nanhao Chen, Yingjun Zhang, Yifei Wang*, Kaio Kitazato*, Jun Xu*, The mechanism of poly-galloyl-glucoses preventing influenza A virus entry into host cells, PLOS ONE. 2014, 9(4):e94392. DOI: 10.1371/journal.pone.0094392. (IF=3.534)
  14. Bo Xu, Ling Wang, Lorenzo González-Molleda, Yan Wang, Jun Xu*, Yan Yuan*, Antiviral Activity of (+)-Rutamarin against KSHV by Inhibiting Catalytic Activity of Human Topoisomerase II, Antimicrob. Agents Chemother., 2014, 58(1):563-573. DOI: 10.1128/AAC.01259-13. (IF=4.451)
  15. Jinggong Liu, Lin Liu, Hu Ge, Jinbo Gao, Qingqing He, Lijuan Su, Jun Xu, Lianquan Gu, Zhishu Huang, Ding Li*, Syntheses and characterization of non-bisphosphonate quinoline derivatives as new FPPS inhibitors, Biochim. Biophys. Acta - General Subjects, 2014,1840(3):1051-1062. DOI: 10.1016/j.bbagen.2013.11.006. (IF=5.083)
  16. Nanhao Chen, Jingwei Zhou, Jiabo Li, Jun Xu, Ruibo Wu*, Concerted Cyclization of Lanosterol C-ring and D-ring Under Human Oxidosqualene Cyclase Catalysis: An ab initio QM/MM MD Study, J. Chem. Theory Comput., 2014, 10 (3): 1109–1120. DOI: 10.1021/ct400949b. (IF=5.310).
  17. Hui Cui, Bo Xu, Taizong Wu, Jun Xu, Yan Yuan*, Qiong Gu*, Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein−Barr Virus Lytic Replication. Journal of Natural Products, 2014, 77 (1): 100–110. DOI: 10.1021/np400757k. (IF=3.662).
  18. Taizong Wu, Hui Cui, Jun Xu, Qiong Gu*, Chemical constituents from the roots of Elephantopus scaber L. Biochemical Systematics and Ecology. 2014, 54 : 65–67. DOI: 10.1016/j.bse.2013.12.012. (IF=0.988).
  19. Yingying Cao, Ling Wang, Zhongxiang Lin, Fengyin Liang, Zhong Pei, Jun Xu, Qiong Gu*, Dehydroabietylamine derivatives as multifunctional agents for the treatment of Alzheimer's disease, Med. Chem. Commun., 2014,5(11): 1736-1743. DOI:10.1039/c4md00305e. (IF=2.319).
2013
  1. Ling Wang, Qiong Gu, Xuehua Zheng, Jiming Ye, Zhihong Liu, Xiaopeng Hu, Arnold T. Hagler, Jun Xu*, Discovery of New Selective Human Aldose Reductase Inhibitors through Virtual Screening Multiple Binding Pocket Conformations, J. Chem. Inf. Model., 2013, 53 (9): 2409–2422, Publication Date (Web): July 31, 2013 (Article), DOI: 10.1021/ci400322j . (IF=4.068).
  2. Hu Ge, Jinggong Liu, Yu Wang, Wenxia Zhao, Qingqing He, Shao, J., Ruibo Wu, Ding Li* and Jun Xu*, The tri-targeted inhibition mechanism of green tea polyphenols as cholesterol lowering agents, European Journal of Medicinal Chemistry, 2013, 12, 494-4951.
  3. Jun Xu*, Arnold T. Hagler, Chemistry for Life Sciences, Science China Chemistry, 2013, 56(10)： 1-2.
  4. Hu Ge, Yu Wang, Chanjuan Li, Nanhao Chen, Yufang Xie, Mengyan Xu, Yingyan He, Xinchun Gu，Ruibo Wu, Qiong Gu, Liang Zeng, Jun Xu*, Molecular dynamics-based virtual screening: Accelerating drug discovery process by high performance computing, J. Chem. Inf. Model., 2013, 53(10):2757–2764. DOI: 10.1021/ci400391s. (IF=4.068).
  5. Guodong Zhang, Hu Ge, Qiong Gu*, Jun Xu*, Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands, Science China Chemistry, 2013, 56(10):1402-1412. DOI:10.1007/s11426-013-4952-3. (IF=2.429).
  6. Xin Yan, Jiabo Li*, Zhihong Liu, Minghao Zheng, Hu Ge, Jun Xu*, Enhancing Molecular Shape Comparison by Weighted Gaussian Functions, J. Chem. Inf. Model., 2013, 53(8):1967–1978. DOI: 10.1021/ci300601q. (IF=4.068).
  7. Yingying Cao, Yu Wang, Hu Ge, Xilin Lu, Zhong Pei, Qiong Gu*, Jun Xu, Salvianolic Acid A, a Polyphenolic Aerivative from Salvia miltiorrhiza Bunge, as a Multifunctional Agent for the Treatment of Alzheimer's Disease, Molecular Diversity, 2013, 17(3), 515-524, DOI 10.1007/s11030-013-9452-z. (IF=2.08).
  8. Qiong Gu, Xin Yan, Jun Xu*, Drug Discovery Inspired by Mother Nature: Seeking Natural Biochemotypes and the Natural Assembly Rules of the Biochemome, Journal of Pharmacy & Pharmaceutical Sciences, 2013, 16(2): 331-341. (IF=2.33).
  9. Qiong Gu*, Yaoyao Chen, Hui Cui, Jun Xu, Chrysanolide A, an unprecedented sesquiterpenoid trimer from the flowers of Chrysanthemum indicum L. RSC Advances, 2013, 3(26): 10168–10172. DOI: 10.1039/c3ra23172k. (IF=3.289).
  10. Yining Dong, Ling Wang, Qiong Gu, Haiqin Chen, Xiaoming Liu, Yuanda Song, Wei Chen, Arnold T.Hagler, Hao Zhang, Jun Xu*, Optimizing Lactose Hydrolysis by Computer-guided Modification of the Catalytic Site of a Wild-type Enzyme, Molecular Diversity, 2013, 17(2): 371-382. DOI: 10.1007/s11030-013-9437-y.( IF=2.08).
  11. Jun Xu*, Qiong Gu, HaiBo Liu, JiaJu Zhou, XianZhang Bu, ZhiShu Huang, Gui Lu, Ding Li, DongQing Wei, Ling Wang, LianQuan Gu, Chemomics and drug innovation, FEATURE ARTICLE, SCIENCE CHINA Chemistry, 2013, 56(1): 71–85. DOI:10.1007/s11426-012-4761-0. (IF=2.429).
2012
  1. Xin Yan, Qiong Gu, Feng Lu, Jiabo Li *, Jun Xu*, GSA: A GPU-accelerated Structure Similarity Algorithm and Its Application in Progressive Virtual Screening, Molecular Diversity, 2012, 16(4): 759-769. DOI: 10.1007/s11030-012-9403-0. (IF=3.153).
  2. Xiaoyi Zeng, Xiu Zhou, Jun Xu, Stanley M. H. Chan, Charlie L. Xue, Juan C. Molero, Jiming Ye,*, Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds, Biochemical Pharmacology, 2012, 84(6), 830–837. (IF=5.091).
  3. Jiarong Xu, Jun Xu*, Hongzhuan Chen*, Interpreting the Structural Mechanism of Action for MT7 and Human Muscarinic Acetylcholine Receptor 1 Complex by Modeling Protein-protein Interaction, Journal of Biomolecular Structure and Dynamics, 2012, 30(1):30-44. DOI:10.1080/07391102.2012.674188. (IF=2.983).
  4. Dane Huang, Qiong Gu, Hu Ge, Jiming Ye, Noeris K Salam, Arnold T. Hagler, Hongzhuan Chen, Jun Xu*, On the Value of Homology Models for Virtual Screening: Discovering hCXCR3 Antagonists by Pharmacophore-Based and Structure-Based Approaches, J. Chem. Inf. Model., 2012, 52(5): 1356-1366. DOI: 10.1021/ci300067q. (IF=4.068).
  5. Feng Lu, Qiong Gu, Ruibo Wu, Jun Xu*, A Structure-Similarity-Based Software for the Cardiovascular Toxicity Prediction of Traditional Chinese Medicine, Bioinformation, 2012, 8(2): 110-113. (IF=5.323).
2011
  1. Jiansong Fang, Dane Huang, Wenxia Zhao, Hu Ge, Haibin Luo *, Jun Xu*, A new protocol for predicting novel GSK-3β ATP competitive inhibitors, J. Chem. Inf. Model. 2011, 51(6): 1431–1438. DOI: 10.1021/ci2001154 . (IF=4.068).
  2. Wenxia Zhao, Qiong Gu, Ling Wang, Hu Ge, Jiabo Li*, Jun Xu*, Three-Dimensional Pharmacophore Modeling of Liver-X Receptor Agonists, J. Chem. Inf. Model., 2011, 51(9): 2147-2155. DOI: 10.1021/ci100511v. (IF=4.068).
  3. Aixia Yan*, Liyu Wang, Shuyu Xu, Jun Xu*, Aurora-A Kinase Inhibitor Scaffolds and Binding Modes, Drug Discovery Today, 2011, 16(5/6): 260-269. DOI:10.1016/j.drudis.2010.12.003. (IF=5.625).
  4. Haibo Liu, Hu Ge, Yong Peng, Peigen Xiao, Jun Xu*, Molecular Mechanism of Action for Reversible P2Y12 Antagonists, Biophysical Chemistry, 2011, 155(2/3):74–81. DOI: 10.1016/j.bpc.2011.03.001. (IF=2.363).
2010
  1. Hu Ge, Yifei Wang*, Jun Xu*, Qiong Gu, Haibo Liu, Peigen Xiao, Jiaju Jia, Yanhuai Liu, Zirong Yang, Hua Su, Anti-flu Agents from Traditional Chinese Medicine, Nat. Prod. Rep., Royal Society of Chemistry, 2010, 27(12):1758-1780. DOI:10.1039/c0np00005a. (IF=10.986).
  2. Qiong Gu, Jun Xu*, Lianquan Gu*, Selecting Diversified Compounds to Build a Tangible Library for Biological and Biochemical Assays. Molecules 2010, 15(7): 5031-5044. DOI: 10.3390/molecules15075031. (IF=2.465).
  3. Haibo Liu, Wei Cui, Jun Xu*, Yong Peng*, Jiaju Zhou, Peigen Xiao, Molecular Simulations of the Inhibition of Active Components in Traditional Chinese Medicine on the Thromboxane A2 Receptor, Acta Phys. Chim. Sin., 2010, 26(9): 2549-2556. DOI: 10.3866/PKU.WHXB20100844. (IF=0.844).
  4. Haibo Liu, Jun Xu*, Yong Peng, Jiaju Zhou, Peigen Xiao,Targets of Danshen’s Active Components for Activating Blood Circulation Activities, Acta Phys. Chim. Sin., 2010, 26(1): 199-205. DOI: 10.3866/PKU.WHXB20091222. (IF=0.844).
  5. Xiaofan Ding, Lifang Jiang, Changwen Ke, Zhan Yang, Chunliang Lei, Kaiyuan Cao, Jun Xu, Lin Xu, Xingfen Yang, Yonghui Zhang, Ping Huang, Weijun Huang, Xun Zhu, Zhenjian He, Liping Liu, Jun Li, Jie Yuan, Jueheng Wu, Xiaoping Tang, Mengfeng Li*, Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates, Virus Genes, 2010, 41(3): 329–340. DOI: 10.1007/s11262-010-0526-z. (IF=1.285).
2008 and before
  1. Jun Xu, Haibo Liu, Jiaju Zhou, Molecular Biology Interpretation of the Traditional Chinese Medicine, Planta Medica, 2008, 74(9): 1144.
  2. Jun Xu*, Yizeng Liang, Progressive screening using scaffold-based classification approach( In Chinese), Computer & applied Chemistry, 2007, 24(1), 23-30.
  3. Xu, J., Sun, Y, Liu, Y., Liang, Y. ,Graphic Formal Language for Markush Structure Representation, 2007 Computer & applied Chemistry , 2007, 24(1): 31-37.
  4. Xian Chen, Yizeng Liang, Jun Xu*, Toward Automated Biochemotype Annotation for Commercial Available Compound Libraries, Molecular Diversity, 2006,10(3): 495-509. DOI:10.1007/s11030-006-9047-z.
  5. Jun Xu*, Qiang Zhang, and Chen-Kon Shih, V-Cluster Algorithm: A New Algorithm for Clustering Molecules Based upon Numeric Data, Molecular Diversity., 2006, 10(3): 463-478. DOI: 10.1007/s11030-006-9023-7.
  6. Jun Xu, 2D-Structure and Substructure Searching, Chemoinformatics - From Data to Knowledge, Ed. J. Gasteiger, 2003, Wiley-VCH.
  7. Jun Xu, A New Approach to Find Natural Chemical Structure Classes, J. Medicinal Chemistry, 2002, 45, 5311-5320.
  8. Jun Xu, Arnold T. Hagler, Chemoinformatics and Drug Discovery, Molecules, 2002, 7, 566-600.
  9. Jun Xu, J. Stevenson, Drug-Like Index: A New Approach to Measure Drug-Like Compounds and Their Diversity, J. Chem. Inf. Comput. Sci., 2000, 40(3): 1177-1187. DOI: 10.1021/ci000026+.
  10. Jun Xu, Chemical Diversity Exploration and Combinatorial Chemistry in Drug Discovery, Progress in Chemistry, 1999, 11(3): 286-299.
  11. Jun Xu, C-13 NMR Spectral Prediction by Means of Generalized Atom Center Fragment Method, Molecules, 1997, 2: 131-145.
  12. Jun Xu, GMA: A Generic Match Algorithm for structural Homorphism, Isomorphism, Maximal Common Substructure Match and Its Applications, J. Chem. Inf. Comput. Sci., 1996, 36: 25-34.
  13. Jun Xu, The Use of Fuzzy Graph in Chemical Structure Research, Fuzzy Logic in Chemistry, Academic Press., Ed. Dennis H. Rouvray, 1998, 249-281.
  14. Xu, J., Weber, P.L., Borer, P.N., Computer-assisted assignment of peptides with non-standard amino acids, Journal of Biomolecular NMR, 1995, 5: 183-192.
  15. Jun Xu, Fuzzy graph theory applications in structure determination and elucidation from multidimensional NMR, J. of Spectroscopy, 1995, 34(1): 1-9.
  16. Xu, J., Straus, S.K. and Sanctuary, B.C., Use of fuzzy mathematics for complete automated assignment of protein 1H 2D NMR spectra, J. Magn. Res., Series B., 1994, 103(1): 53-58. DOI:10.1006/jmrb.1994.1006.
  17. Xu, J and Borer, P.N., Rigorous deduction theory for assignment of multiple dimensional NMR using the independent spin coupling network (ISNet) approach, J. Chem. Inf. Comput. Sci., 1993, 34(2): 349-356. DOI: 10.1021/ci00018a020.
  18. Xu, J., Straus, S.K. and Sanctuary, B.C., Automation of protein 2D proton NMR assignment by means of fuzzy mathematics and graph theory, J. Chem. Inf. Comput. Sci., 1993, 33(5), 668-682.
  19. Xu, J. and Sanctuary, B.C., CPA: constrained partitioning algorithm for initial assignment of protein 1H resonance from DQF-COSY and TOCSY, J. Chem. Inf. Comput. Sci., 1993, 33(3): 490-500.
  20. Xu, J., Gray, B.N. and Sanctuary, B.C., Automated extraction of spin coupling topologies from 2D NMR correlation spectra for protein 1H resonance assignment, J. Chem. Inf. Comput. Sci., 1993, 33(3): 457-489. [1] 

徐峻獲獎記錄

2009年蘇州工業園第三屆科技領軍人才
2010年蘇州第一屆科教領軍人才 [1] 

徐峻學術交流

1 Charles Perkins Centre, The University of Sydney New method for anti-diabetes drug discovery Sydney, Australia January 19, 2015 Invited Speaker
2 Research School of Chemistry, Australian National University New methods to identify drug leads against systematic diseases Canberra, ACT 2601, Australia Tuesday, January 20, 2015 Invited Speaker
3 American Association Pharmaceutical Scientists Pharmacological Network Navigator San Diego, USA Nov 2-6, 2014 Speaker
4 2014 Innovative TCM & Botanic Drug International Summit Exploring TCM mechanism of action: case studies Nanchang, China Sept 18-19, 2014 Keynote Speaker and Session Chair
5 International Conference on Theoretical and High Performance Computational Chemistry 2014 New Methodology and HPC-Supported Algorithms for Drug Discovery Beijing, China Sept 14-18, 2014 Speaker
6 13th Meeting of the Consortium for Globalization of Chinese Medicine Chemomics-guided TCM Mechanism Elucidation Beijing, China Aug 27-29, 2014 Panelist
7 The 9th International Symposium for Chinese Medicinal Chemists Drug Design Methodology in Big Data Era Shengyang, China Aug 18, 2014 Session Chair and Speaker
8 Drug Discovery and Therapy World Congress 2014 Privileged Fragment Target Network for Anti T2D Drug Discovery Boston, USA June 16-19, 2014 Session Chair and Speaker
9 School of Department of Pharmacology The Mutual Inspirations of TCM and West Medicine New Haven, Connecticut 06520-8066 2014/4/1 Keynote
10 Taiwan Medicinal Chemistry Society 2014 Annual Conference The Mutual Inspirations of TCM and West Medicine Taipei 2014-1-21 2014-1-23 Keynote
11 China Medicinal Chemistry Society 2014 Annual Conference HPC and High Performance Drug Discovery Ji’nan Nov 18-20, 2014 Invited
12 2013 Innovative TCM and Botanic Medicine International Summit TCM and Medicinal Chemistry Nanchang Nov 6-7, 2013 Keynote
13 National Center for Biotechnology Information(NCBI) Biochemome-based Drug Discovery Bethesda, USA 2013.8.26 Invited
14 The 4th Australia-China Biomedical Research Conference Molecular glue: a new mechanism for anti virus drug discovery Hangzhou 2013.10.10-13 Invited
15 School of Medicine, University of Pennsylvania Chemoinformatics and Drug Discovery: Anti-Flu agents from Traditional Chinese Medicine Philadelphia, USA 2013.8.29 Invited
16 The 15th SAPA-NE Annual Conference Drug Innovation and World Traditional Medicine Patent Database Cambridge,USA 2013.5.25-26 Keynote
17 School of Pharmacy, University of Pittsburgh Chemomics& Drug Innovation Pittsburg, USA 2013.3.29 Invited
18 University of California San Diego Drug Discovery Inspired by Mother Nature San Diego USA 2012.10.1 Invited
19 Mechanism-based Natural Product Development Conference Seeking natural biochemotypes and the natural assembly rules ofthe Biochemome Vancouver, Canada 2012.9.21-22 Session Chair, Keynote
20 The 28th Chinese Chemical Society Annual Conference From Genomics to Chemomics Chengdu, China 2012.4.13-15 Invited [1] 
參考資料
  • 1.    徐峻  ．中山大學藥學院[引用日期2019-08-25]