劉宏生

2009.12-2010.12 美國哈佛大學醫學院，國家留學基金委訪問學者

2008.10-2008.12 香港大學李嘉誠醫學院，鄭裕彤基金院長訪問學者

2007.10-2008.9 武漢大學生命科學院，教育部高級訪問學者

2000.2-2004.2 日本岐阜大學醫學院微生物學與生物信息學專業，醫學博士

1988.10-1991.7 中國農業大學生物學院微生物專業，理學碩士

1981.10-1985.7 遼寧大學生物系微生物學專業 理學學士 ^[1] 

1985.7-2013.5 遼寧大學生物系和生命科學院任助教、講師、副教授、教授（博導）、院長

2013.5-2016.4 遼寧大學科技處 處長

2016.4.- 遼寧大學科學技術研究院 常務副院長 ^[1] 

遼寧省第十三屆政協委員。 ^[2] 

遼寧省“百千萬人才工程”百人層次專家

遼寧省普通高等學校教學名師

遼寧省第七屆優秀科技工作者

1、2016.1-2017.12 H5N1禽流感病毒NS1蛋白與人NOLC1蛋白的相互作用在CK2相關信號通路及感染機制中的作用研究（國家自然科學基金，項目編號：31570160）主持人。

2、2007年-2009年 人源化高致病性禽流感病毒cDNA 預測探針庫的研究（國家自然科學基金，項目編號：30671852）主持人。

3、2017.8- 納豆激酶專利技術轉化（瀋陽市科技局科技成果轉化推進計劃項目，項目編號：17-65-7-00）主持人。

4、2017.6-2019.12 1.1類抗腫瘤分子靶向新藥環苯替尼技術轉化（瀋陽市雙百工程—重大科技成果轉化項目，項目編號：250078）主持人。

5、2017.3.28 遼陽市生態保護紅線劃定（遼陽市環境保護局，財務編號：20017 00 2002）

6、2016.9-2017.9 提升高校歸國人員科研能力的研究（遼寧省教育科學“十三五”規劃2016年高校統戰理論研究專項課題，課題批准號：JG16ZXTZB021）主持人。

7、2016.1-2019.12遼寧省藥物分子模擬與設計工程實驗室建設(瀋陽市新興產業創新平台項目)主持人。

8、2015.6-2018.12 生物大分子的計算模擬及其功能與應用研究（遼寧省教育廳高等學校創新團隊，項目編號：LT2015011），主持人。

9、2015.6-2015.10瀋陽市留學歸國人才現狀調查及培養對策研究（瀋陽市人才工作辦公室），主持人。

10、2015.2-2017.12 水產品病原微生物及違禁藥物快速檢測方法研究（瀋陽市科技局大型儀器設備共享服務項目，項目編號：F15-165-4-00）主持人。

11、2014.6-2015.12 海蔘綠色生態規模化健康養殖技術研究與示範（遼寧省科技廳計劃項目，項目編號：K701401001）主持人。

12、2013.1-2016.12 納豆激酶創新藥物研發（瀋陽市科技局科技攻關專項，項目編號：F14-154-9-00）,主要執行人。

13、2013-2016年 納豆和納豆漿及相關產品研發 （瀋陽儲陽生物開發有限公司）主持人。

14、2013.1-2016.12 納豆激酶新藥前期的研究（遼寧省科學技術廳 科學技術計劃項目，項目編號：2013225086）主持人。 ^[1] 

1、Chunyu Zhu, Fangliang Zheng, Junfeng Zhu, Meichen Liu, Na Liu, Xue Li, Li Zhang1, Zaidong Deng, Qi Zhao and Hongsheng Liu(通訊作者). 2017. The interaction between NOLC1 and IAV NS1 protein promotes host cell apoptosis and reduces virus replication. Oncotarget. 10:1937-1945. (SCI二區，IF 5.998 TOP期刊)

2、Liang Xu, Yan Xi Hu, Yan Cheng Li, Yu Feng Liu, Li Zhang, Hai Xin Ai and Hong Sheng Liu(通訊作者). 2017. Study on the interaction of paeoniforin with human serum albumin (HSA) by spectroscopic and molecular docking techniques. Chemistry Central Journal (2017) 11:116. DOI 10.1186/s13065-017-0348-3. (SCI三區，IF 2.442)

3、Hongsheng Liu(通訊作者), Guofei Ren, Huan Hu, Li Zhang, Haixin Ai, Wen Zhang and Qi Zhao. 2017. LPI-NRLMF: lncRNA-protein interaction prediction by neighborhoodregularized logistic matrix factorization. Oncotarget. 8(61):103975-103984 (SCI二區，IF 5.998 TOP期刊)

4、Li Zhang, Hai-Xin Ai1, Shi-Meng Li, Meng-Yuan Qi, Jian Zhao, Qi Zhao and Hong-Sheng Liu(通訊作者). 2017. Virtual screening approach to identifying influenza virusneuraminidase inhibitors using molecular docking combinedwith machine-learning-based scoring function. Oncotarget. DOI：10.18632/oncotarget.20915. (SCI二區，IF 5.998 TOP期刊)

5、Huan Hu, Chunyu Zhu, Haixin Ai, Li Zhang, Jian Zhao, Qi Zhao and Hongsheng Liu(通訊作者). 2017. LPI-ETSLPL: lncRNA–protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction. Molecular BioSystems. 13:1781-1787.(SCI三區，IF 3.074)

6、Fangliang Zheng, Wenwen Zheng, Limei Li, Siming Pan, Meichen Liu, Weiwei Zhang, Hongsheng Liu(通訊作者), Chunyu Zhu(通訊作者). 2017. Chitosan Controls Postharvest Decay and Elicits Defense Response in Kiwifruit. Food and Bioprocess Technology. (2017) 10:1937–1945. (SCI 2.574, 一區 Top期刊)

7、Liang Xu, Yan-Xi Hu, Jin Li, Yu-Feng Liu, Li Zhang, Hai-Xin Ai, Hong-Sheng Liu(通訊作者). 2017. Probing the binding reaction of cytarabine to human serum albumin usingmultispectroscopic techniques with the aid of molecular docking. Journal of Photochemistry & Photobiology, B: Biology 173:187–195. (SCI索引 生物3區 IF 3.035, 2015)

8、Liang Xu, Yan-Xi Hu, Yan-Cheng Li, Li Zhang, Hai-Xin Ai, Yu-Feng Liu, Hong-Sheng Liu(通訊作者). 2017. In vitro DNA binding studies of lenalidomide using spectroscopic in combination with molecular docking techniques. Journal of Molecular Structure 1154 (2018) 9-18. (SCI 4區，IF 1.780, 2015)

9、Liang Xu, Yan-Xi Hu, Yan-Cheng Li, Li Zhang, Hai-Xin Ai, Hong-Sheng Liu, Yu-Feng Liu, Yu-Li Sang. 2017. Study on the interaction of tussilagone with human serum albumin (HSA) by spectroscopic and molecular docking techniques. Journal of Molecular Structure 1149 (2017) 645-654. (SCI 4區，IF 1.780, 2015)

10、Haixin Ai, Runlin Wu, Li Zhang, Xuewei Wu, Junchao Ma, Huan Hu, Liangchao Huang, Wen Chen, Jian Zhao, Hongsheng Liu(通訊作者). 2017. pSuc-PseRat: Predicting Lysine Succinylation in Proteins by Exploiting the Ratios of Sequence-Coupling and Properties. Journal Computational Biology. DOI: 10.1089/cmb.2016.0206. （SCI索引 生物4區 IF 1.537, 2015）

11、Haixin Ai, Li Zhang, Jikuan Zhang, Qi Zhao, Alan K Chang, Hongsheng Liu(通訊作者). 2017. Discrimination of thermophilic and mesophilic proteins using support vector machine and decision tree. Current Proteomics. Accepted. （SCI索引 工程技術4區 IF 0.590, 2015）

12、AI Hai-xin, ZHANG Li, ZHANG Xin-gang, CHEN Si-yao, HU Huan, WEI Hong-yun, MENG Xin-rui, WANG Tian-qi, ZHAO Jian, LIU Hong-sheng(通訊作者). 2017. Prokaryotic expression, purification and characterization of nattokinase. JOURNAL OF MICROBIOLOGY（微生物學雜誌）. 37(1): 20-27.

13、Li Zhang, Haixin Ai, Wen Chen, Zimo Yin, Huan Hu, Junfeng Zhu, Jian Zhao, Qi Zhao, Hongsheng Liu(通訊作者). 2017. CarcinoPred-EL: Novel models for predicting the carcinogenicity of chemicals using molecular fingerprints and ensemble learning methods. Scientific Reports. 7(1), 2118.（SCI索引 綜合2區 IF 5.228, 2015）

14、Li Zhang, Haixin Ai, Qi Zhao, Junfeng Zhu, Wen Chen, Xuewei Wu, Liangchao Huang, Zimo Yin, Jian Zhao, Hongsheng Liu(通訊作者). 2017. Computational Prediction of Influenza Neuraminidase Inhibitors Using Machine Learning Algorithms and Recursive Feature Elimination Method. Bioinformatics Research and Applications. Lecture Notes in Computer Science. 10330: 344-349. （EI）

15、Junfeng Zhu, Ying Xu, Chunyu Zhu, Jian Zhao, Xinrui Meng, Siyao Chen, Tianqi Wang, Xue Li, Li Zhang, Changlong Lu, Hongsheng Liu, Xun Sun. 2017. IL-33 induces both regulatory B cells and regulatory T cells in dextran sulfate sodium-induced colitis. International Immunopharmacology. 46: 38-47.（SCI索引 醫學3區 IF 2.551, 2015）

16、Yongjie Wang, Jinghong Rong, Jiaozhen Zhang, Yu Liu, Xuelian Meng, Hejian Guo, Hongsheng Liu & Lijiang Chen. 2017. Morphology, in vivo distribution and antitumor activity of bexarotene nanocrystals in lung cancer. Drug Development and Industrial Pharmacy. 43(1): 132-141.（SCI索引 醫學3區 IF 2.429, 2015）

17、Xiaoping Quan, Xiuqiang Chen, Deliang Sun, Bo Xu, Linlin Zhao, Xiaoqian Shi Hongsheng Liu, Bing Gao, Xiuli Lu. 2016. The mechanism of the effect of U18666a on blocking the activity of 3β-hydroxysterol Δ-24-reductase (DHCR24): molecular dynamics simulation study and free energy analysis. Journal of Molecular Modeling. 22: 46. （SCI索引 醫學3區 IF 1.438, 2015）

18、Xiuli Lu, Deliang Sun, Bo Xu, Jichuan Pan, Yanhong Wei, Xu Mao, Daojun Yu, Hongsheng Liu, Bing Gao. 2017. In Silico Screening and Molecular Dynamic Study of Nonsynonymous Single Nucleotide Polymorphisms Associated with Kidney Stones in the SLC26A6 Gene. The Journal of urology. 196(1): 118-123.（SCI索引 醫學2區 IF 4.700 , 2015）

19、Jianli LIU, Weiyu WANG, Hui YU, Xiangyu CAO, Ying WANG, Meijia LIU, Xiao YAN, Hongsheng Liu. 2016. ANTIOXIDANT ACTIVITY OF POLYSACCHARIDES EXTRACTED FROM Lentinus edodes MYCELIA AND THEIR PROTECTIVE EFFECTS ON INS-1 CELLS. Bioscience Journal, 32(6): 1679-1688.（SCI索引 生物4區 IF 0.218, 2015）

20、Qi Zhao, Hongsheng Liu, Chenggui Yao, Jianwei Shuai, Xiaoqiang Sun. 2016. Effect of Dynamic Interaction between microRNA and Transcription Factor on Gene Expression. BioMed Research International. 2676282.（SCI索引 生物3區 IF 2.134, 2015）

21、Yu Liu, Jia Yang, Xin Wang, Ju Liu, Zhaobo Wang, Hongsheng Liu, Lijiang Chen. 2016. In vitro and in vivo evaluation of redox-responsive sorafenib carrier nanomicelles synthesized from poly (acryic acid) -cystamine hydrochloride-D-α-tocopherol succinate. Journal of Biomaterials Science, Polymer Edition. 27(17): 1729-1747.（SCI索引 生物3區 IF 1.733, 2015）

22、Lijiang Chen, Yang Liu, Dechao Jia, Jia Yang, Jinhua Zhao, Changlan Chen, Hongsheng Liu, Xiao Liang. 2016. Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts. Journal of agricultural and food chemistry. 64(17): 3445-3455.（SCI索引 農林科學1區 IF 2.857, 2015）

23、Hai-Xin Ai, Yu-Chen Che, Li Wang, Li Zhang, Ying Gu, Yan-Ni Tan, Alan K. Chang and Hong-Sheng Liu(通訊作者). Paenibacillus liaoningensis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology (2016), 66, 3150–3156. （SCI索引 生物3區 IF 2.474, 2014）

24、Chunyu Zhu，Fangliang Zheng，Xiaoshuang She，Dan Zhao，Ying Gu，Yanting Duan，Alan K Chang，Hongsheng Liu(通訊作者). 2015. Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein，Virus Genes. 50:238-244. （SCI索引 醫學4區 IF 1.837, 2013）

25、Haixin Ai, Fangliang Zheng, Fangbo Deng, Chunyu Zhu, Ying Gu, Li Zhang, Xuejiao Li, Alan K. Chang, Jian Zhao, Junfeng Zhu, Hongsheng Liu(通訊作者). 2015. Structure-Based Virtual Screening for Potential Inhibitors of Influenza A Virus RNA Polymerase PA Subunit. Int J Pept Res Ther. 21 (1), 149-156. DOI 10.1007/s10989-014-9442-8. (International Journal of Peptide Research and Therapeutics SCI索引 生物4區 IF 1.100, 2013)

26、Haixin Ai, Li Zhang, Alan K. Chang, Hongyun Wei, Yuchen Che, Hongsheng Liu(通訊作者). 2014. Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza Avirus. J Mol. Model. 20:2142. DOI 10.1007/s00894-014-2142-7. （Journal Molecular Modeling，SCI索引 計算機3區 IF 1.884 ,2013）

27、Chunyu Zhu, Sugai Yin, Hongsheng Liu, Yan Liu, Maosheng Zhang, Shuqin Xiong, Fangliang Zheng. 2014. Heliocoverpa armigera single nucleocapsid nucleopolyhedrovirusORF52 is a ChaB homologous gene involved in per os infection. Genes Genom. DOI 10.1007/s13258-014-0222-9. （SCI索引 生物4區 IF 0.501 ,2013）

28、Jieliang Ma, Li Zhang, Aaron R. Tipton, Jiaping Wu, Angela F. Messmer-Blust, Melissa J. Philbrick, Yajuan Qi, Song-Tao Liu, Hongsheng Liu, Jian Li, and Shaodong Guo. (2014). Structural and functional analysis of the related transcriptional enhancer factor-1 and NF-κB interaction. Am J Physiol Heart Circ Physiol 306: 233–242. （SCI索引 醫學2區 TOP期刊 IF 3.783 ,2013）

29、Wenjing Zhang, Junyan Tao, Xiaoping Yang, Zhuliang Yang, Li Zhang, Hongsheng Liu, Kailang Wu, Jianguo Wu. Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection. 2014. Biochemical and Biophysical Research Communications 449(3):307-312. （SCI索引 生物3區 IF 2.390 ,2013）

30、Wang S, Liu X, Liu H, Zhang L, Guo Y, Yu S, Wozniak DJ, Ma LZ. (2015). The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa. Environ Microbiol Rep. 2014 7(2):330-340. （SCI索引 環境科學2區 IF 3.068 ,2013）

31、Shiwei Wang, Shan Yu, Zhenyin Zhang, Qing Wei, Lu Yan, Guomin Ai, Hongsheng Liu, Luyan Z. Ma.(2014). Coordination of Swarming Motility, Biosurfactant Synthesis, and Biofilm Matrix Exopolysaccharide Production in Pseudomonas aeruginosa. Applied and Environmental Microbiology 80(21):6724-6732. （SCI索引 生物3區 IF 3.820, 2013）

32、Fangliang Zheng, Nan Liu, Yuchen Che, Li Zhang, Lijie Shao, Junfeng Zhu, Jian Zhao, Haixin Ai, Alan K Chang, Hongsheng Liu(通訊作者). 2013. Cloning, expression and characterization of squalene synthase from Inonotus obliquus. Genes & Genomics. 35(5):631-639. （SCI索引 生物4區 IF 0.565 ,2013）

33、Chunyu Zhu, Fangliang Zheng, Tingting Sun, Yanting Duan, Jingzhen Cao, Huawei Feng, Lingling Shang, Ying Zhu and Hongsheng Liu(通訊作者). 2013. Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1. Virus Genes. 46(2): 287–292.（SCI索引 生物4區 IF 2.169 ,2013）

34、Xiuli Lu, Yong Zhang, Shuchao Chen, Yang Li, Dan Jia, Weiqi Wang, Bing Gao and Hongsheng Liu. 2013. Molecular Dynamics Simulation Study on the Mechanism of the Inhibition of ATP Hydrolysis with Inhibitors in Human Papillomavirus Type 18 E1 Helicase. Advances in Intelligent Systems Research，2013,May 23；45-47. (EI) ^[1]