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黃震

（四川大學教授）

鎖定
黃震，男，瑞士蘇黎世聯邦理工大學博士，四川大學教授，博士生導師。
中文名
黃震
國    籍
中國
民    族
漢
畢業院校
瑞士蘇黎世聯邦理工大學
學位/學歷
博士
職    務
四川大學博士生導師
職    稱
教授

目錄

  1. 1 工作經歷
  2. 2 學術兼職
  3. 3 研究方向
  1. 4 獲獎情況
  2. 5 教學經驗
  3. 6 發明專利
  1. 7 論文代表

黃震工作經歷

1980-1984年，獲得四川大學學士學位，分析化學專業
1984-1987年，獲得北京大學碩士學位，生物有機化學專業
1988-1994年，獲得瑞士蘇黎世聯邦理工大學（ETH, Zurich）博士學位，化學生物學專業。
1994-1998年，哈佛大學醫學院遺傳系博士後,從師於2009年諾貝爾醫學獎得主邵斯達克教授(Professor Jack Szostak)
1998年, 被聘入紐約城市大學布魯克倫學院為助理教授
2004年, 升為副教授，並被聘入喬治亞州立大學化學系
2009年, 升為喬治亞州立大學終身正教授,獲大學傑出教授獎，併為美國佐治亞州癌症研究傑出研究員
2014–今，四川大學生命科學學院正教授 [1] 

黃震學術兼職

2007 – 2010 中美化學及化學生物學教授協會（CAPA）第一任主席
2007 –今 美國癌症研究協會成員
2006 –今 美國晶體學協會成員
2002-2004 美國青年化學家協會（YACS）主席
1997-1998 美國華人生物化學家協會（ABC）主席
1994-今 美國化學學會成員 [1] 

黃震研究方向

他的主要研究興趣包括:硒核酸以及碲核酸創新性研究,包括生物化學合成,核糖核酸衍生化和核酸及核酸-蛋白複合物晶體結構及功能研究，以核酸和核酸-蛋白複合物結構測定為基礎的新藥研發，核酸適配體和核酶的篩選及功能研究，疾病的核酸檢測診斷，核酸基因測序，高保真鹼基識別與RNA芯片，核酸抗腫瘤藥物研究。 [1] 

黃震獲獎情況

2010 –今 中國科學化學編委會成員
2008-2013喬治亞州癌症研究傑出科學家獎（GCC）
2008喬治亞州立大學傑出教授獎
2008喬治亞州立大學教授成就獎
2008 CAPA傑出教授獎 [1] 

黃震教學經驗

1.核酸的化學和生物合成，抗癌藥物的發現，核酸-蛋白大分子結構，機理研究和核酸檢測
2.化學和藥物治療
3.高級化學生物學和生物有機化學
4.高級有機合成和機理 [1] 

黃震發明專利

1. Zhen Huang, Title: “RNA MICROCHIP DETECTION USING NANOPARTICLE-ASSISTED SIGNAL AMPLIFICATION”, 2014, PCT, filed.
2. Zhen Huang, Title: “METHODS AND COMPOSITIONS FOR INTERFERENCE WITH DNA POLYMERASE AND DNA SYNTHESIS”, 2013, US provisional application, filed.
3. Zhen Huang, Title: “NANOPARTICLE-ASSISTED RAPID RNA DETECTION ON RNA MICROARRAY”, 2013, US provisional application, filed.
4. Zhen Huang, Title: “Facile SELENIUM CONTAINING NUCLEOSIDES AS NUTRITIONAL SUPPLEMENTS”, 2013, PCT, filed.
5. Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2013, Chinese Patent pending.
6. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2013, US Patent, 8,354,524.
7. Zhen Huang, Title: “RNA Selective Detection and Quantitation Using Chip and Plate”, 2012, European Patent 1668158.
8. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2011, US Patent 12/562,960.
9. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2011, US Patent Application (divisional), 13/172,559.
10. Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2010, U.S. Provisional Application No.: 61/375,992.
11. Zhen Huang and Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2010, U.S. Patent Application No. 12/933,619 (National Phase Filing of PCT/US09/37823).
12. Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2010, US provisional patent, 61/375,560.
13. Zhen Huang, Title: “RNA Detection and Quantitation”, 2010, Oct. 20, European Patent, WO 2005/019469.
14. Zhen Huang, Title: “Ultraviolet and High-Performance Liquid Chromatography Methods for the Evaluation of Sunscreen Efficacy”, 2010, US provisional patent, 61/382,154.
15. Zhen Huang, Jia Sheng, Title: “Novel Compounds and Synthesis of Tellurium-derivatized Oligonucleotides for Structural and Functional Studies”, 2010, PCT/US10/36639.
16. Zhen Huang, Abdalla Hassan, Jia Sheng and Wen Zhang, Title: “Novel Compound and Derivatizaton of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics”, 2010, PCT/US10/35631.
17. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2010, US Patent, US7,982,030.
18. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2009, US Patent, US 7,592,446.
19. . Zhen Huang, Abdalla Hassan and Wen Zhang, Title: “Derivatization of DNAs and RNAs at 5-positions of pyrimidines for function, structure, and therapeutics”, 2009, US Provisional Patent Application, 60/180,028.
20. Zhen Huang, Jia Sheng and Abdalla Hassan, Title: “Novel Compounds and Derivatization of DNAs and RNAs at the 2' and 5-positions of pyrimidines with tellurium functionalities for function, structure, imaging, diagnosis, and therapeutics”, 2009, US Provisional Patent Application, 61/182,580.
21. Zhen Huang and Sarah Spencer, Title: “RNA Microchip for Rapid, Direct and Specific Detection of RNAs”, 2009, US Provisional Patent Application, 61/252,940
22. Zhen Huang and Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2009, PCT Patent Application, International application No. PCT/US2009/037823.
23. Zhen Huang, Title: “Se-containing nucleosides, synthesis methods, and anti-cancer activity”, 2008, US Provisional Patent Application, 61/083,815. [1] 

黃震論文代表

24. Hehua Liu, Xiang Yu, Yiqing Chen, Jing Zhang, Baixing Wu , Lina Zheng, Phensinee Haruehanroengra, Rui Wang, Suhua Li, Jinzhong Lin, Jixi Li, Jia Sheng, Zhen Huang*, Jinbiao Ma *& Jianhua Gan*,“Crystal structure of an RNA-cleaving DNAzyme”, NATURE COMMUNICATIONS, 2018, in press(IF: 12.1).
25. Yiqing Yiqing Chen, Jing Zhang, Hehua Liu, Yanqing Gao, Xuhang Li, Lina Zheng, Ruixue Cui, Qingqing Yao, Liang Rong, Jixi Li, Zhen Huang*, Jinbiao Ma* and Jianhua Gan*, “Unique 50-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X”, PLoS Biology, 2017, 15, e1002599 (IF: 9.797).
26. Zhang, Liu, et al., Zhen Huang*, Jinbiao Ma*, Jianhua Gan*, “Structural basis for single-stranded RNA recognition and cleavage by C3PO”, Nucleic Acids Research, 2016, 44, 9494–9504（IF:10.1）.
27. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M. Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L. Gerloff, Zhen Huang, Weihong Tanand Steven A. Benner, “Evolution of Functional Six-Nucleotide DNA”，Journal of American Chemical Society, 2015, 137（21）, 6734−6737 (IF:13.8).
28. Rob Abdur, Oksana O. Gerlits, Jianhua Gan, Jiansheng Jiang, Jozef Salon, Andrey Y. Kovalevsky, Alexander Chumanevich, Irene T. Weber, Zhen Huang*, “Novel Complex MAD Phasing and RNase H Structural Insights by Selenium Oligonucleotides”, Acta Crystallographica Section D, 2014, D70, 354-361.
29. Jia Sheng, Jianhua Gan, Alexie Soars, Jozef Salon and Zhen Huang*, “Structural Insights of Non-canonical U·U Pair and Hoogsteen Interaction Probed with Se Atom”, 2013, Nucleic Acids Research（IF:10.1）, 41(22), 10476-10487.
30. Jia Sheng, Jianhua Gan and Zhen Huang*, “Structure-Based DNA-Targeting Strategies with Small Molecule Ligands for Drug Discovery”, Medicinal Research Reviews, 2013, 33(5), 1119-1173.
31. Huiyan Sun, Sibo Jiang, Julianne Caton-Williams, Hehua Liu, and Zhen Huang*, “2-Selenouridine Triphosphate Synthesis and Se-RNA Transcription”, RNA, 2013, 19(9), 1309-1314.
32. Jia Sheng, Wen Zhang, Abdalla E. A. Hassan, Jianhua Gan, Alexei Soares, Song Geng, Yi Ren, Zhen Huang*, "Hydrogen Bond Formation between the Naturally Modified Nucleobase and Phosphate Backbone", Nucleic Acids Research（IF:10.1）, 2012,40(16), 8111-8118.
33. Huiyan Sun, Jia Sheng, Abdalla E. A. Hassan, Sibo Jiang, Jianhua Gan and Zhen Huang*, “Novel RNA Base Pair with Higher Specificity using Single Selenium Atom”, Nucleic Acids Res., 2012,40(11), 5171-5179.
34. Wen Zhang, Jia Sheng, Abdalla E. Hassan, and Zhen Huang*, "Synthesis of Novel 2’-Deoxy-5-(Methylselenyl)Cytidine and Se-DNAs for Structure and Function Studies", Chemistry-An Asian Journal, 2012,7(3), 476-479.
35. Jia Sheng, Abdalla E. A. Hassan, Wen Zhang, Jianfeng Zhou, Bingqian Xu, Alexei S. Soares and Zhen Huang*, "Synthesis, Structure and Imaging of Oligodeoxyribonucleotides with Tellurium-nucleobase Derivatization", Nucleic Acids Research, 2011, 39(9), 3962-3971.
36. Wen Zhang and Zhen Huang*, "Synthesis of the 5’-Se-Thymidine Phosphoramidite and Convenient Labeling of DNA Oligonucleotide", Organic Letter, 2011, 13(8), 2000-2003.
37. Julianne Caton-Williams, Lina Lin,Mathew Smith, and Zhen Huang*, "Convenient Synthesis of Nucleoside 5’-Triphosphates for RNA Transcription", Chemical Communications, 2011, 47, 8142-8144.
38. Lina Lin, Julianne Caton-Williams, Manindar Kaur, Andres M. Patino, Jia Sheng, Jaya Punetha, and Zhen Huang*, "Facile Synthesis of Nucleoside 5’-(alpha-P-seleno)-triphosphates and Phosphoroselenoate RNA Transcription", RNA, 2011, 17(10),1932-1938.
39. Lina Lin, Jia Sheng, and Zhen Huang*, "Nucleic Acid X-ray Crystallography via Direct Selenium Derivatization", Chemical Society Reviews (invited and peer reviewed), 2011, 40, 4591-4602.
40. Khin Lay Maw, Julianne Caton-Williams, Jozef Salon, Zhen Huang*, "Simple UV and HPLC Methods for the Evaluation of Sunscreen Efficacy", Journal of the American Academy of Dermatology, 2011, 65, 328-335.
41. Abdalla E. A. Hassan, Jia Sheng, Wen Zhang, and Zhen Huang*, "High Fidelity of Base Paring by 2-Selenothymidine in DNA", Journal of American Chemical Society, 2010, 132, 2120-2121. ##
42. Jia Sheng, Abdalla Hassan, Zhen Huang*, "Synthesis of the First Tellurium-Derivatized Oligonucleotides for Structural and Functional Studies", Chemistry - A European Journal, 2009, 15, 10210-10216.
43. Julianne Caton-Williams and Zhen Huang*, "Synthesis of Colored 4-Selenothymidine Triphosphate and its DNA Polymerase Incorporation into DNAs for Visualization, Structure and Function Studies", Angew. Chem. Int. Ed., 2008, 47, 1723-1725.
44. Jozef Salon, Jiansheng Jiang, Jia Sheng, Oksana O. Gerlits, Zhen Huang*, "Derivatization of DNAs with Selenium at 6-Position of Guanine for Function and Crystal Structure Studies", Nucleic Acids Research, 2008, 36, 7009-7018.
45. Jozef Salon, Jia Sheng, Jiansheng Jiang, Guexiong Chen, Julianne Caton-Williams, Zhen Huang*, “Oxygen Replacement with Selenium at the Thymidine 4-position for the Se-Base-Paring and Crystal Structure Studies”, Journal of American Chemical Society, 2007, 129, 4862-4863.
46. Jiansheng Jiang, Jia Sheng, Nicolas Carrasco, and Zhen Huang*, “Selenium Derivatization of Nucleic Acids for Crystallography”, Nucleic Acids Research, 2007, 35, 477-485.
47. Jozef Salon, Guexiong Chen, Yoani Portilla, Markus W. Germann, and Zhen Huang*, “Synthesis of a Novel 2’-Se-uridine Phosphoramidite and Its Incorporation into Oligonucleotides for Structure Study”, Organic Letters, 2005, 7, 5645-5648.
48. Nicolas Carrasco and Zhen Huang*, “Enzymatic Synthesis of Phosphoroselenoate DNA using Thymidine 5’-(a-P-Seleno)-triphosphate and DNA Polymerase for X-ray Crystallography using MAD”, Journal of American Chemical Society, 2004, 126, 448-449.
49. Nicolas Carrasco, Yuri Buzin, Elizabeth Tyson, Elizer Halpert, and Zhen Huang*, “Selenium Derivatization and Crystallization of DNA and RNA Oligonucleotides for X-ray Crystallography Using Multiple Anomalous Dispersion”, Nucleic Acids Research, 2004, 32, 1638-1646.
50. Zhen Huang* and Jack W. Szostak, “Evolution of Aptamers with a New Specificity and New Secondary Structures from an ATP Aptamer”, RNA, 2003, 9, 1456-1463.
51. Quan Du, Nicolas Carrasco, Marianna Teplova, Christopher J. Wilds, Martin Egli, and Zhen Huang*, “Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD”, Journal of American Chemical Society, 2002, 124, 24-25. [1] 
參考資料
  • 1.    黃　震  ．四川大學生命科學學院[引用日期2019-08-20]