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馬林

（中山大學教授）

鎖定
馬林，男，1959年11月出生，博士，中山大學化學學院教授。
中文名
馬林
出生日期
1959年11月
畢業院校
中山大學
學位/學歷
博士
專業方向
有機化學
任職院校
中山大學
職    稱
教授

目錄

  1. 1 人物經歷
  2. ▪ 教育經歷
  3. ▪ 工作經歷
  4. 2 講授課程
  1. 3 科研方向
  2. 4 學術成果
  3. ▪ 科研項目
  4. ▪ 論文
  1. ▪ 著作
  2. ▪ 專利
  3. 5 獲獎情況

馬林人物經歷

馬林教育經歷

1982年畢業於吉林大學化學系生物化學專業；
1985年畢業於中國科學院長春應化所功能高分子專業獲碩士學位；
1996年9月到中山大學應用化學與化學工程學院任教授，並獲有機化學專業博士學位。 [1] 

馬林工作經歷

1985年7月回吉林大學酶工程國家重點實驗室工作；
1990年12月任副教授；
1996年9月到中山大學應用化學與化學工程學院任教授；
2001年1月-2001年7月在瑞典隆德大學生物技術系做訪問學者；
2002年12月-2003年6月在香港中文大學生物化學系做高級訪問學者。 [1] 

馬林講授課程

《化學生物學導論》，化學院本科生基礎課，54學時；
《化學生物學綜合實驗》，化學院本科生專業實驗課，120學時；
《化學生物學》，化學院研究生專業課，80學時。 [1] 

馬林科研方向

化學生物學，酶學及其應用。目前主要從事酪氨酸酶、葡萄糖苷酶、乙酰膽鹼酯酶等酶抑制劑的設計合成及活性篩選，籌建化學生物學實驗室（化學微生物學實驗室、化學遺傳學實驗室和組合合成實驗室），進行化合物對細胞功能的調控研究。 [1] 

馬林學術成果

馬林科研項目

1. 生物合成和生物轉化研究，國家基金重點項目，25萬，2000.1-2004.12；
2. 從傳統中藥中篩選和開發用於老年痴呆症介入治療的先導藥物。廣州市重點項目, 25萬，2002.01-2004.12；
3. 西藏林芝產丹蔘的綜合性開發研究，廣州市重大項目，100萬，2002.01-2004.12；
4. 酶催化功能高分子化合物聚氨基醌的合成及性質研究，國家自然科學基金項目，17萬元2001.01-2003.12；
5. 二取代鄰苯醌的酶促合成及其藥理意義，高校骨幹教師資助項目，6萬元， 2000.01-2002.12。 [1] 

馬林論文

1. L. Ma, S.G.Cao, B.X.Yan, et al,. Induce Rebuliding of Conformetion of Aspartase, Ann. N. Y. Acad. Sci., 672, 62-67, 1992.
2. S.GCao , L.Ma, Feng Y, et al, Improvement of Enzymatic Properties by Hydrophobic Interaction.Bioche-mical Engineering. 100-102, 1992.
3. S.G Cao ,Y .Feng , L. Ma, et al,.A Study on Increasing Enzymatic Stability and Activity in Organic Solvents. Ann.N.Y. Acad.Sci. ,627:152,1992.
4. S.G Cao , Z.B. Liu , Y. Feng , L.Ma, et al,. Esterification and Transesterifacation With Immobilized Lipase in Organic Solvent. Applied Biochem and Biotech., 32:1-6,1992.
5. Y.G. Ma, J.G.Tang, L.Ma S.Y.Liu et al,. Photoluminescence and Electroluminescence of Poly p-Phenyl Phenol Prepared by Enzymitic Catalyzed Polymerization. Chin. Phys.Lett, 11(6), 387, 1994.
6. H.Yang, S.G.Cao, L.Ma et al,.A New Kind of Immobilized Lipase in Organic Solvent and Its Structure Model. Biochemical and Biophysical Communitions. 200(1):83, 1994.
7. L.Ma, Z.J.Li, Y.H.Cheng, J.C.Shen。Regulation of Lactate Dehydrogenase Activity by Synthetic Polycations.Ann. N. Y. Acad. Sci. ,750, 75, 1995.
8. L.Ma, B.X.Yan, H.T.Zou, et al,.Alteration of Specificity in L-Aspartase in the Presence of Alcohol.Ann. N. Y. Acad. Sci.1995. 750, 134.
9. W.Liu, L.Ma, J.D, Wang, et al,. Effect of Aggregation of p-Phenylphenol on Enzymatic Polymer Synthesis in Dioxane/Water Mixture J.Polymer Science: Part A: Polymer Chemistry.33, 2339-2345, 1995.
10. W. Liu , J.D.Wang, L. Ma, et al., Enzymatic Polymerization of p-Phenylphenol in Aqueous Micells .Ann.N.Y. Acad. Sci.750, 138,1995.
11. S.G.Cao, S.D. Liu, L. Ma , et al. Studies on a New Type of Immobilized Lipase Fitting in Organic Solvents. Ann.N.Y.Acad.Sci .750, 222, 1995.
12. L.Ma X.T.Wang, X.Tang et al,.《Immobilization of Prostaglandin Synthetase by Hydrophobic Adsorption》 56, 223,1996. Appied Biochem. Biotechnol.
13. W. Liu, L. Ma, X.D.Sun, et al.,《Fluorometric Assays for Horseradish Peroxidase in Non aqueous Media》56, 1996.Applied Biochem and Biotechol.
14. Y.X. Shi, Y.M. Jing, D.X.Sui, Y.L.Li, T.Chen, L.Ma, Z.T.Ding《Affinity Chromatography of Trypsin Using Chitosan as Ligand Support》J. Chro-matography A. 742, 107, 1996.
15. Cao-SG, Yang-H , Ma-L, Guo-SQ .《Enhancing Enzymatic-Properties by the Immobilization Method》Applied biochem.biotech 1996, Vol 59, Iss 1, 7-14。
16. Wang,S.G, Liu W, Ji X.S, Ma L, et al.《Stopped-flow pre-steady-state kinetic study of horeseradish prooxidase catalysis in nonaqueous media》Ann.N.Y.Acad.Sci 799,364,1996.
17. Gu L.Q, Wei H.F, Zhang X.C, Xu G, Ma L.《Bio reduction of quinone derivatives by immobilized Baker’s Yeast in hexane》Chinese J. Chemistry, 16(1-4)1998.
18. D.L.Liu, L.Ma.《Armillariella tabescen Enzymatic detoxification of Afatoxin B1 Part III: Immobilized enzymatic detoxifacation》Ann.N.Y.Acad.Sci 864, 592-599,1998.
19. D.L.Liu, D.S.Yao, L.Q.Gu, L.Ma,《Armillariella tabescen Enzymatic detoxification of Afatoxin B1 Part II》Ann.N.Y.Acad Sci, 864, 586-591,1998.
20. D.S.Yao, D.L.Liu,R.Liang,L.Q.Gu, L.Ma,《Screening of the Fungus whose Multienzyme system Has Detoxification Activity towards Aflatoxin B1》Ann.N.Y.Acad.Sci 864, 579-585,1998.
21. Liu D.L, Yao D.S, Liang R, Ma L,et al.《Detoxification of Aflatoxin B1 by Enzymes Isolated from Armillariella Tabescens》 Food and Chemical Toxicology xx: 1-12,1998.
22. Li M.S, Ma L,Zhang X.Z et al.《Synthesis of substituted 1,2-benzoquinones and substituted 3-hydroxy-4(1H)-pyridinones: application of oxidation-michael addition in organic synthesis》Chinese J.Chem,17(4):377-383,1999.
23. Li M.S, Gu L.Q,Huang Z.S. Ma L et al.《Synthesis of 6-substituted 3-hydroxy-4(1H)- pyridinones: oxidation-michael addition 3-hydroxy-4(1H)-pyridinones》Tetrahedron 55(8):2237-2244,1999.
24. Liu D.L,Yao D.S, Liang Y.Q, Zhou T. H, Song Y.P, Ma L. Production, purification, and characterization of an intracellular aflatoxin-detoxifizyme from Armillariella tabescens(E-20) Food Chem.Toxico. 39:461-466,2001.
25. Lin Ma et al *Water activity dependence of lipase catalysis in organic media explains successful transesterification reactions Enzyme and Microbial Technology 31:1024-1029, 2002.
26. An, Lin-Kun; Bu, Xian-Zhang; Wu, Hai-Qiang; Guo, Xin-Dong; Ma, Lin; Gu, Lian-Quan. The Reaction of Tanshinones with biogenic amine metabolites in vitro, Tetrahedron 2002, 42, 10315-10321.
27. Guo xin dong, Ma Lin, Gu Lianquan, 1,2-Diethyl-3-hydroxy-6-phenylthiopyridin- 4(1H)-one, Acta Cryst, 2002, E58,175-177.
28. Lin-Kun An,,Xian-Zhang Bu, Hai-Qiang Wu, Xin-Dong Guo, Lin Ma and Lian-Quan Gu, Reaction of tanshinones with biogenic amine metabolites in vitro Tetrahedron 48，(2003) 1–8.
29. Yufang Wang , Lin Ma, Zhong Li, Zhiyun Du, Zhong Liu, Jiangke Qin, Xiaodong Wang, Zhishu Huang, Lianquan Gu, Albert S.C. Chen Synergetic inhibition of metal ions and genistein on a-glucosidase FEBS Letters 576 (2004) 46–50.
30. Yufang Wang, Lin Ma, Chaole Pang,a Minju Huang, Zhishu Huang, and Lianquan Gu Synergetic inhibition of genistein and D-glucose on a-glucosidase Bioorganic & Medicinal Chemistry Letters14 (2004) 2947–2950.
31. Zhang, S.-L.; Huang, Z.-S.; An, L.-K.; Bu, X.-Z.; Ma, L.; Li, Y.-M.; Chan, A. S. C.;Gu,L.-Q.; Synthesis of Zwitterionic 4-Hydroxycoumarin Derivatives through a Unique Reaction of 4-Hydroxycoumarins with p-Benzoquinone and Pyridine Org. Lett.; 2004; 6(26); 4853-4855.
32. Zhou JL, Lu YJ, Ou TM, Zhou JM, Huang ZS, Zhu XF, Du CJ, Bu XZ, Ma L, Gu LQ, Li YM, Chan ASC Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase J.MED.CHEM. 48 (23): 7315-7321 ,2005.
33. Qin JK, Bu XZ, Wang YF, Du ZY, Wang XY, Huang ZS, Ma L, An LK, Gu LQ Synthesis of 2,2 '-(substituted arylmethylene) bis(1,6,6-trimethyl- 6,7,8,9-tetra- hydro-phenanthro[1,2-b]furan-10,11-dione) derivatives CHIN. CHEM. LETT. 16 (11): 1451-1454 ,2005.
34. Du ZY, Qin JK, Mao XP, Ma L, Gu LQ 1,2-Dihydro-1,6-dimethylphenanthro[1,2- b]furan-10,11-dione hemihydrate ACTA CRYST. E 61: O2937-O2938,2005.
35. Mao XP, Huang JF, Duan ZF, Du ZY, Huang ZS, Ma L, Gu LQ Synthesis and characterization of novel multifunctional acylthiourea polymers CHIN. CHEM. LETT. 16 (5): 609-612,2005
36. Zhang SL, An LK, Huang ZS, Ma L, Li YM, Chan ASC, Gu LQ An intriguing reaction of 4-hydroxycoumarins with 2,3-dichloro-5,6- dicyanobenzoquinone TETRAHEDRON 61 (12): 3087-3090,2005.
37. An LK, Bu XZ, Huang ZS, Ma L, Gu LQ, Chan ASC, Li YM Synthesis of new benzoimidazole derivatives CHIN. CHEM. LETT.16 (1): 7-10,2005.
38. Guo XD, Huang ZS, Bao YD, An LK, Ma L, Gu LQ Two new sequiterpenoids from Helicteres angustifolia CHIN.CHEM. LETT 16 (1): 49-52,2005.
39. Du ZY, Wang YF, Mao XP, Qin JK, Ma L, Gu LQ (2E,6E)-2,6-Bis(3,5-di- tert-butyl-4-hydroxybenzylidene)cyclohexanone acetic acid solvate ACTA CRYST E 61: O587-O588,2005.
40. Qiong Shen,Quan Peng, Jialiang Shao, Xufeng Liu ,Zhishu Huang ,Xianzhang Pu ,Lin Ma,et al. Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitorsEuropean Journal of Medicinal Chemistry 40 (2005) 1307–1315.
41. Huang, Shi-Liang; Luo, Yi; Huang, Zhi-Shu; Wang, Xing-Yuan; Bu, Xian-Zhang; Liu, Pei-Qing; Ma, Lin; Xie, Bing-Fen; Liu, Zong-Chao; Li, Yue-Ming; Chan, Albert S. C.; Gu, Lian-Quan. Synthesis and cytotoxicity of 9-substituted benzo[de]chromene-7,8 -dione and 5-benzyl-9-substituted benzo[de]chromene-7,8-dione. Synthetic Communications (2006), 36(18), 2667-2684.
42. Liu, Yan; Zou, Lan; Ma, Lin; Chen, Wen-Hua; Wang, Bo; Xu, Zun-Le. Synthesis and pharmacological activities of xanthone derivatives as  -glucosidase inhibitors. Bioorganic & Medicinal Chemistry (2006), 14(16), 5683-5690.
43. Huang, Shi Liang; Luo, Yi; Huang, Zhi Shu; Bu, Xian Zhang; Liu, Pei Qing; Ma, Lin; Li, Yue Ming; Chan, Albert S. C.; Gu, Lian Quan. The mechanism on cyclization, debenzylation and oxidation of 1-[1-(benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one. Chinese Chemical Letters (2006), 17(6), 769-772.
44. Shen, Qiong; Peng, Quan; Shao, Jialiang; Liu, Xufeng; Huang, Zhishu; Pu, Xianzhang; Ma, Lin; Li, Yue-Ming; Chan, Albert S. C.; Gu, Lianquan. Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry (2006), 41(6), 793.
45. Du, Zhi-Yun; Bao, Ya-Dan; Liu, Zhong; Qiao, Wei; Ma, Lin; Huang, Zhi-Shu; Gu, Lian-Quan; Chan, Albert S. C. Curcumin analogs as potent aldose reductase inhibitors. Archiv der Pharmazie (　Weinheim　, 　Germany　) (2006), 339(3), 123-128.
46. Du, Zhi-Yun; Liu, Rong-Rong; Shao, Wei-Yan; Mao, Xue-Pu; Ma, Lin; Gu, Lian-Quan; Huang, Zhi-Shu; Chan, Albert S. C. α-Glucosidase inhibition of natural curcuminoids and curcumin analogs.European Journal of Medicinal Chemistry (2006), 41(2), 213-218.
47. Mao, Xuepu; Guo, Gangjun; Huang, Jinfeng; Du, Zhiyun; Huang, Zhishu; Ma, Lin; Li, Pei; Gu, Lianquan. A novel method to prepare chitosan powder and its application in cellulase immobilization.Journal of Chemical Technology and Biotechnology (2006), 81(2), 189-195.
48. Qin, Jiang Ke; Bu, Xian Zhang; Wang, Yu Fang; Du, Zhi Yun; Wang, Xing Yuan; Huang, Zhi Shu;Ma, Lin; An, Lin Kun; Gu, Lian Quan. Synthesis of 2,2'-(substituted arylmethylene)bis(1,6,6- trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives. Chinese Chemical Letters(2005), 16(11), 1451-1454.
49. Wen H, Zhou YY, Lin CL, Ge H, Ma L, Wang ZH, Peng WL, Song HC. Methyl 2-(2-(4-formylphenoxy)- acetamido)-2substituted acetate derivatives: A new class of acetylcholinesterase inhibitors. Bioorg.med.chem. lett. 17 (8): 2123-2125 ,2007.
50. Liu Y, Ma L, Chen WH, Wang B, Xu ZL. Synthesis of xanthone derivatives with extended pi-systems as alpha-glucosidase inhibitors: Insight into the probable binding mode.Bioorg.med.chem.15 (8): 2810-2814,2007. [1] 

馬林著作

1. 《生物有機化學》古練權，馬林，高等教育出版社，施普林格出版社共同出版，1998年6月；
2. 《生物有機化學》古練權，馬林，科技圖書股份有限公司（台灣，繁體字版），2001；
3. 《化學生物學導論》馬林 古練權主編，化學工業出版社，2006年2月第一版。 [1] 

馬林專利

1. 用於治療高血氨症及肝性腦病的含二氫呋喃環結構的丹蔘酮類化合物 國際專利 國際申請號：PCT/CN01/00861，申請日期：2001年6月1日；
2. 芳香胺-鄰醌聚合物及其製備方法和用途 中國專利 申請號：01129947.9；
3. 芳香胺-2,3-吡啶二酮聚合物及其製備方法和用途 申請號：03113553.6；
4. 羥基蒽醌類衍生物及其在製備抗癌藥物中的應用 發明專利 申請號：200310112459.2。 [1] 

馬林獲獎情況

1994年獲全國第四屆青年科技獎。 [1] 
參考資料