馬傑

2000.09-2005.06,吉林大學,博士研究生（碩博）

1995.09-2000.07, 白求恩醫科大學，醫學本科生 ^[1] 

2020.12-至今，院長，吉林大學藥學院

2019.10-至今，主任，吉林省基因與細胞治療產品工程研究中心

2015.09-至今，教授，吉林大學藥學院

2014.10-至今，博士研究生導師，吉林大學藥學院2012.12-2020.12，副院長，吉林大學藥學院

2010.09-2015.08，副教授/碩士生導師，吉林大學藥學院

2008.04-2012.03,博士後,Rearch Associate,布朗大學醫學院

2005.06-2010.09,講師, 吉林大學藥學院 ^[1] 

重組蛋白質、基因與細胞藥物研究 ^[1] 

1. Yuanhua Lu, Jianan Zhao, Yafei Tian, Dan Shao, Zhiqi Zhang, Siqi Li, Jialin Li, Hugang Zhang, Wei Wang, Ping Jiao* and Jie Ma*. Dichotomous roles of Men1 in macrophages and fibroblasts in bleomycin-induced pulmonary fibrosis. Int. J. Mol. Sci. 2022, 23, 5385.

2. Shuo Wu, Zongliang Wang, Yu Wang, Min Guo, Mengyang Zhou, Liqiang Wang, Jie Ma* and Peibiao Zhang*. Peptide-grafted Microspheres for Mesenchymal Stem Cell Sorting and Expansion by Selective Adhesion. Frontiers in Bioengineering and Biotechnology. 2022; 10: 873125.

3. Mengyang Zhou, Min Guo, Xincui Shi, Jie Ma, Shutao Wang, Shuo Wu, Weiqun Yan*, Feng Wu* and Peibiao Zhang*. Synergistically Promoting Bone Regeneration by Icariin-Incorporated Porous Microcarriers and Decellularized Extracellular Matrix Derived From Bone Marrow Mesenchymal Stem Cells. Frontiers in Bioengineering and Biotechnology. 2022; 10: 824025.

4. Yuanhua Lu, Jie Ma*, Jian Lin, Yafei Tian, Yongjun Ma, Wei Wang, Jialin Li, Hugang Zhang, Ping Jiao*. Cell membrane breakage and triggering T cell infiltration are involved in human telomerase reverse transcriptase (hTERT) promoter-driven novel peptide KK-64 for liver cancer gene therapy. Bioengineered. 2021;12:2, 12708-21.

5. L.X Chen, J. Qian, Z. Wang, X.L. Cong and J.Ma*. Integrated proteomics and transcriptomics identified novel potential prognostic biomarkers in ovarian cancer. J Biol Regul Homeost Agents. Nov-Dec 2021;35(6). Doi: 10.23812/21-322-A. Ahead of Print.

6. Lixin Chen, Ji Qian, Qinghua You*, Jie Ma*. LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway. Bioengineered. 2021;12(2):10089-100.

7. Jian Lin, Yuanhua Lu, Bizhou Wang, Ping Jiao* and Jie Ma*.Analysis of immune cell components and immune-related gene expression profiles in peripheral blood of patients with type 1 diabetes mellitus. J Transl Med (2021) 19:319.

8. Chao Zhou, Jie Ma*, Yuanhua Lu, Wan Zhao, Bingxue Xu, Jian Lin, Wenjun Ma, Yafei Tian, Qi Zhang, Wei Wang, Weiqun Yan, Ping Jiao*. TERT promoter regulating melittin expression induces apoptosis and G0/G1 cell cycle arrest in esophageal carcinoma cells. Oncology Letters, 2021 Jan;21(1):16..

9. Tongjian Zhao, Jie Ma, Lulu Li, Wenjing Teng, Yafei Tian, Yongjun Ma, Wei Wang, Weiqun Yan*, Ping Jiao*. MKP-5 Relieves Lipotoxicity-Induced Isletβ-Cell Dysfunction and Apoptosis via Regulation of Autophagy. Int J Mol Sci. 2020 Sep 28;21(19):E7161. doi: 10.3390/ijms21197161.

10. Xue-Kun Liu, Yan-Qiu Wang, Tong-Jian Zhao, Yuan-Hua Lu, Jia-Nan Zhao, Xiao-Yu Geng, Jie Ma* Design and Synthesis of 7-Azaindole Derivatives and Their Antitumor and Analgesic Activities. J.Chem.Soc.Pak., 2020, 42(03), 460-468.

11. Yuanhua Lu, Jie Ma*, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Chao Zhou, Xiu Liu, Wenjing Teng, Wei Wang,Weiqun Yan, Ping Jiao*. The role of MKP-5 in adipocyte-macrophage interactions during obesity. Obesity Facts, 2020（13）：1，86-101.

12. Song Z, Ma J, Lu Y, Zhou C, Zhao T, Ai X, Wei X, Lin J, Wang W, Yan W, Jiao P. The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced isletβ-cell dysfunction and apoptosis. Exp Cell Res. 2019(382):1,111467. 2019 Sep 1. pii: S0014-4827(19)30307-6. doi: 10.1016/j.yexcr.2019.06.012.

13. Zhan JY, Ma J*, Zheng QC*. Molecular dynamics investigation on the Asciminib resistance mechanism of I502L and V468F mutations in BCR-ABL. J Mol Graph Model. 2019 Jun;89:242-249.

14. Yuze Yuan, Nan Ran, Lingxin Xiong, Guoqiang Wang, Xuewa Guan, Ziyan Wang, Yingqiao Guo, Zhiqiang Pang, Keyong Fang, Junying Lu, Chao Zhang, Ruipeng Zheng, Jingtong Zheng, Jie Ma*, Fang Wang*. Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies. J Immunol Res. 2018; 2018: 1943497. Published online 2018 Jun 28.

15. Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng, Ping Jiao. Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells. Cancer Cell Int. 2018; 18: 53. Published online 2018 Apr 4.

16. Shao D, Ma J, Zhou C, Zhao JN, Li LL, Zhao TJ, Ai XL, Jiao P. STAT3 down-regulation induces mitochondria-dependent G2/M cell cycle arrest and apoptosis in esophageal carcinoma cells. Clin Exp Pharmacol Physiol. 2017, 44(3):413-420.

17. Li X, Shen J, Tan L, Zhang Z, Gao D, Luo J, Cheng H, Zhou X, Ma J, Ding K, Lu X. Design and synthesis of N-(4-aminopyridin-2-yl)amides as B-Raf(V600E) inhibitors. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2760-2763.

18. Jiang S, Wang Y, Ren D, Li J, Yuan G, An L, Du P, Ma J*.Antidiabetic mechanism of Coptis chinensis polysaccharide through its antioxidant property involving the JNK pathway. Pharm Biol. 2015 Jul;53(7):1022-1029. (通訊作者)

19. Dejun Sun,*, Miaonan Sun, Wenhe Zhu,, Zhiding Wang, Yuefei Li, Jie Ma,*The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM. Toxins 2015, 7(2), 423-438.

20. Rieder F, Nonevski I, Ma J, Ouyang Z, West G, Protheroe C, Depetris G, Schirbel A, Lapinski J, Goldblum J, Bonfield T, Lopez R, Harnett K, Lee J, Hirano I, Falk G, Biancani P, Fiocchi C.T-Helper 2 Cytokines, Transforming Growth Factorβ1, and Eosinophil Products Induce Fibrogenesis and Alter Muscle Motility in Patients With Eosinophilic Esophagitis. Gastroenterology. 2014 May;146(5):1266-1277.

21. Haotian Wang, Xinmin Zhang, Ning Kong, Anhui Wei, Yanhong Zhang, Jie Ma*, Yulai Zhou, Weiqun Yan. Expression, purification and characterization of a recombinant Tat47-57-Oct4 fusion protein in Pichia pastoris. Molecular Medicine Reports. 2014, 92(2): 471-475.

22. Jie Ma, Annamaria Altomare, Michele Guarino, Michele Cicala, Florian Rieder, Claudio Fiocchi, Dan Li, Weibiao Cao, Jose Behar, Piero Biancani, Karen M. Harnett. HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. American Journal of Physiology- Gastrointestinal and Liver Physiology. 2012, 303(5): G635-G645.

23. Annamaria Altomare, Jie Ma#, Michele Pier Luca Guarino, Ling Cheng, Florian Rieder, M. Ribolsi, Claudio Fiocchi, Piero Biancani, Karen M. Harnett, Michele Cicala. Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. Neurogastroenterology and Motility. 2012, 24(10): 943-e463.( #共同第一作者)

24. Ping Jiao, Bin Feng, Jie Ma, Yaohui Nie, Erin Paul, Yujie Li, Haiyan Xu. Constitutive activation of IKKβin adipose tissue prevents diet-induced obesity in mice. Endocrinology, 2012, 153(1): 154-165.

25. Jie Ma, Annamaria Altomare, Florian Rieder, Jose Behar, Piero Biancani, Karen M. Harnett. ATP: a mediator for HCl-Induced TRPV1 activation in esophageal mucosa. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2011, 301(6):G1075-G1082.

26. Ping Jiao, Jie Ma, Bin Feng, Hao Zhang, J. Alan-Diehl, Y. Eugene-Chin, Weiqun Yan, Haiyan Xu. FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβpathways. Obesity, 2011, 19(3): 483-491.

27. Roy C. Orlando, William G. Paterson, Karen M. Harnett, Jie Ma, Jose Behar, Piero Biancani, Michele Pier Luca Guarino, Annamaria Altomare, Michele Cicala, Weibiao Cao. Esophageal disease: updated information on inflammation. Annals of the New York Academy of Sciences. 2011, 1232: 369-375.

28. Jie Ma, Annamaria Altomare, Suzanne de la Monte, Ming Tong, Florian Rieder, Claudio Fiocchi, Jose Behar, Hideo Shindou, Piero Biancani, Karen M. Harnett. HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2010, 299(3): G791-G798.

29. Michele Pier Luca Guarino, Ling Cheng, Jie Ma, Karen M. Harnett, Piero Biancani, Annamaria Altomare, F. Panzera, Jose Behar, Michele Cicala. Increased TRPV1 gene expression in esophageal mucosa of patients with non-erosive and erosive reflux disease. Neurogastroenterology and Motility. 2010, 22(7): 746-751

30. Jie Ma, Karen M Harnett, Jose Behar, Piero Biancani, Weibiao Cao. Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. American Journal of Physiology- Gastrointestinal and Liver Physiology. 2010, 298(2): G233-G240. ^[1] 

1． 馬傑等，TAT-EGF融合蛋白的製備及其在隱形面膜中的應用。(ZL 201711470311.4)

2． 馬傑等，抗腫瘤多肽及其在抗腫瘤領域的應用。（ZL 201910609086.0）

3． 馬傑等，一種腫瘤靶向性載體pcTERT及其構建方法及其應用。（ZL 201810543497.X） ^[1]