鄧磊

2011年11月至2015年12月，比利時根特大學-弗拉芒生物技術研究所（VIB），生物化學與生物技術專業博士研究生。

2008年9月至2011年7月，華東理工大學-生物反應器工程國家重點實驗室，微生物學專業碩士研究生；

2002年9月至 2006年7月，武漢工程大學，生物工程專業本科生； ^[1] 

2018年12月至今，湖南大學生物學院，教授、嶽麓學者、博士生導師。

2016年5月至2018年12月，佐治亞州立大學生物醫學研究所，博士後研究員、助理研究員；

2016年2月至2016年5月，埃默裏大學醫學院，博士後研究員； ^[1] 

2007年2月至2008年7月，湖北省宜昌人福藥業有限責任公司，QA崗位；

Belgian Virology Association (BELVIR) 比利時病毒學學會會員

American Society for Microbiology (ASM) 美國微生物學會會員

International Society of Vaccines (ISV)國際疫苗學會會員 ^[1] 

長期從事廣譜抗流感疫苗研發工作。利用多學科交叉手段設計並研製口服、注射、滴鼻或皮膚免疫型蛋白亞單位或納米顆粒廣譜抗流感疫苗。主要突破性學術成果是成功研製了微針皮膚免疫肽段納米顆粒廣譜抗流感疫苗、雙層蛋白質納米顆粒廣譜抗流感疫苗和口服腸道菌載體廣譜抗流感疫苗，並深入研究了疫苗保護作用機制和長效免疫應答機制。

未來主要研究興趣為 1，研製新型廣譜抗甲、乙型流感疫苗 2，研製抗血凝素柄部的抗體治療劑 3，研製口服廣譜抗甲型流感疫苗 4，研發個性化治療癌症的多肽納米顆粒疫苗。 ^[1] 

主持國家自然科學基金青年項目，基於甲型流感血凝素柄部的廣譜疫苗研製與初步保護機制研究（202001-202212）

主持國家自然科學基金面上項目，抵抗甲型和乙型流感病毒感染的新型蛋白納米團簇廣譜疫苗的研究（202001-202312） ^[1] 

Lei Deng, Teena Mohan, Timothy Z. Chang, Gilbert X. Gonzalez, Ye Wang, Young-Man Kwon, Sang-Moo Kang, Richard W. Compans, Julie A. Champion, Bao-Zhong Wang*. Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses. Nature Communications. Jan 2018, 9:359. doi:10.1038/s41467-017-02725-4. Impact factor: 12.12 （ESI 高被引論文）

Lei Deng, Ki joon Cho, Walter Fiers and Xavier Saelens*. M2e-Based Universal Influenza A Vaccines. Vaccines, 2015, 3(1): 105-136. Impact factor: 4.76 （ESI 高被引論文）

Lei Deng, Timothy Z. Chang, Ye Wang, Song Li, Shelly Wang, Shingo Matsuyama, Richard W. Compans, Jian-Dong Li, Mark R. Prausnitz, Julie A. Champion, Bao-Zhong Wang*. Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice. Proceedings of the National Academy of Sciences of US. July 2018, https://doi.org/10.1073/pnas.1805713115. Impact factor: 9.661

Lei Deng, Kenny Roose, Emma R. Job, Riet De Rycke, Evelien Van Hamme, Amanda Goncalves, Eef Parthoens, Laetitia Cicchelero, Niek Sanders, Walter Fiers, Xavier Saelens*. Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus. Journal of Controlled Release, 2017, Oct 28;264:55-65. Impact factor: 7.79

Lei Deng and Bao-Zhong Wang*. A perspective of nanoparticle universal influenza vaccines. ACS Infectious Diseases, November 2018, DOI: 10.1021/acsinfecdis.8b00206. Impact factor: 4.325

Lei Deng, Jong R. Kim, Timothy Z. Chang, Han Zhang, Teena Mohan, Julie A. Champion, Bao-Zhong Wang*. Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge. Virology, February 2017, 509:82-89. Impact factor: 3.35

Lei Deng, Lorena Itatí Iba?ez, Veronique Van den Bossche, Kenny Roose, Walter Fiers, Xavier Saelens*. Protection against influenza A virus challenge with M2e-displaying filamentous E. coli phages. PLoS ONE, 2015, 10(5):e0126650. Impact factor: 2.806

Lei Deng, Bingyang Shi, Yingping Zhuang, Ju Chu, Xiaolin Shi and Siliang Zhang, Meijin Guo*. Performance and mechanism of neuroleukin in the growth and survival of sertoli cell-induced neurons in a coculture system. Cell Transplantation, 2014, 23(3): 381-394. Impact factor: 4.42

Lei Deng, Florencia Linero and Xavier Saelens*. Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes. Protocol, Vaccine Design, Volume 1404 of the series Methods in Molecular Biology pp 483-495. Springer Press. 14, April, 2016. (Linkage: http://link.springer.com/protocol/10.1007%2F978-1-4939-3389-1_31)

Dubravka Grdic Eliasson, Ajibola Omokanye, Karin Sch?n, Alexander Wenzel, Valentina Bernasconi, Mats Bemark, Karim El Bakkouri, Tine Ysenbaert, Lei Deng, Walter Fiers, Xavier Saelens and Nils Lycke*. M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection. Mucosal Immunology, March 2017, doi: 10.1038/mi.2017.14. Impact factor: 7.48 （ESI 高被引論文）

Ye Wang, Lei Deng, Sang-Moo Kang, Bao-Zhong Wang. Universal influenza vaccines: From viruses to nanoparticles. Expert review of vaccines, November 2018. 17(11): 967-976. Impact factor: 4.222

Timothy Z. Chang, Lei Deng, Bao-Zhong Wang, Julie A. Champion*. H7 Hemagglutinin nanoparticles retain immunogenicity after ＞3 months of 25°C storage. PLoS ONE. Aug 2018. 13(8): e0202300. Impact factor: 2.806

Yuan Luo, Teena Mohan, Wandi Zhu, Chao Wang, Lei Deng, and Bao-Zhong Wang*. Sequential Immunizations with heterosubtypic virus-like particles elicit cross protection against divergent influenza A viruses in mice. Scientific reports. March 2018. 8(1): 4577. Impact factor: 4.26

Teena Mohan, Lei Deng, Bao-Zhong Wang*. CCL28 chemokine: An anchoring point bridging innate and adaptive immunity. Int Immunopharmacol. August 2017, 24(51):165-170. Impact factor: 2.96

Silvie Van den Hoecke, Katrin Ehrhardt, Annasaheb Kolpe, Karim El Bakkouri, Lei Deng, Hendrik Grootaert, Steve Schoonooghe, Anouk Smet, Mostafa Bentahir, Kenny Roose, Michael Schotsaert, Bert Schepens, Nico Callewaert, Falk Nimmerjahn, Peter Staeheli, Hartmut Hengel and Xavier Saelens*. Hierarchical and redundant roles of activating FcγRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies. Journal of Virology, February, 2017, 91(3). Impact factor: 4.61

Ki Joon Cho, Bert Schepens, Kristof Moonens, Lei Deng, Walter Fiers, Han Remaut and Xavier Saelens*. Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody. Journal of Virology, January, 2016, 90(1): 611-615. (Epitopes described in ‘Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody’. Reference ID: 1029532; Linkage: www.iedb.org/assayld/2520406). Impact factor: 4.61

Bingyang Shi, Lei Deng, Xiaolin Shi, Sheng Dai, Hu Zhang, Yonghong Wang, Jingxiu Bi* and Meijin Guo*. The enhancement of neural stem cell survival and growth by coculturing with expanded Sertoli cells in vitro. Biotechnology Progress, 2012, 28(1): 196-205. Impact factor: 1.85

Suwen Hu, Lei Deng, Huamao Wang, Yingping Zhuang*, Ju Chu, Siliang Zhang, Zhonghai Li and Meijin Guo*. Bioprocess Development for the Production of Mouse-human Chimeric Anti-Epidermal growth factor receptor vIII Antibody C12 by Suspension Culture of Recombinant Chinese Hamster Ovary Cells. Cytotechnology, 2011, 63(3): 247-258. Impact factor: 1.21 ^[1] 

Baozhong Wang, Lei Deng. Headless Hemagglutin influenza vaccine. [Patent] (Provisional Patent Applicant, Georgia State University; Application No. 62567936) Filed Date: 2017, Oct.

Meijin Guo, Lei Deng, Siliang Zhang, Ju Chu and Yingping Zhuang. A Neuroleukin Obtaining Method. [Patent] (Patent Applicant, East China University of Science and Technology; Publication No., CN103088092A) 2013, May. [State Intellectual Property Office of the P.R.C] ^[1]