王玲

學科方向：藥物化學、化學生物學

招生方向：生物材料、化學生物學

教師簡介 ^[1] 

1995～1999年南京理工大學化學化工學院高分子材料系學士學位。1999～2002年南京大學化學化工學院高分子系碩士學位，2002.9～2007.6香港科技大學博士學位。主要從事基於二磷酸鹽的生物材料和納米材料研究工作，其後繼續留在該實驗室做研究助理直至2007年11月。2008年2月開始在斯坦福大學病原體及微生物系做訪問學者，在Bogyo教授實驗室從事化學生物學方面的研究，主要是設計與合成酶的抑制劑。2008年底作為引進人才，回國南開大學工作。主要從事生物材料和藥物化學方面的工作。

代表性作品

1. Wang, J. Y.; Wang, Z. H.; Wang, L.;* Yang, Z. Y.; Kong, D. L.;* and Yang, Z. M.* "Incorporation of Supramolecular Hydrogels into Agarose Hydrogels Affords Novel Materials as Potential Drug Delivery Carriers" J. Mater. Chem., 2009, In Press.

2. Gao J., Wang H.M., Wang L.*, Wang J.Y., Kong D.L.*, Yang, Z. M.* " Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule " J. Am. Chem. Soc. 2009, 131, 11286-11287.

3. Wang, L., Yang, Z. M., Gao, J. H., Xu, K. M., Gu, H. W., Zhang, B., Zhang, X. X., Xu, B.* "A Biocompatible Method of Decorporation: Bisphosphonate Modified Magnetite Nanoparticles to Remove Uranyl Ions from Blood" J. Am. Chem. Soc. 2006, 128, .

4. Wang, L., Zhang, M., Yang, Z. M., Xu, B.* “The First Pamidronate Containing Polymer and Copolymer” (Highlighted by Chemical & Engineering News) Chem. Commun. 2006, 2795-2797.

5. Liang, G. L.; Wang, L.; Yang, Z. M.; Koon, H.; Mak, N. K.; Chang, C. K.*; Xu, B.* "Using enzymatic reaction to enhance photodynamic therapy effect of porphyrin dityrosine phosphates" Chem. Commun. 2006, 5021-5023.

6. Xu, K. M.; Ge, W. W.; Liang, G. L.; Wang, L.; Yang, Z. M.; Wang, Q. G.; Hsing, I.-M.; Xu, B.* "Bisphosphonate-containing supramolecular hydrogels for topical decorporation of uranium-contaminated wounds in mice" Intl. J. Radn. Biol., 2008, 84, 353-362.

7. Liang, G. L.; Xu, K. M.; Li, L. H.; Wang, L.; Kuang, Y.; Yang, Z. M.; Xu, B.* "Using Congo red to report intracellular hydrogelation resulted from self-assembly of small molecules" Chem. Commun. 2007, 4096-4098.

8. Gilbert, Y.; Deghorain, M.; Wang, L.; Xu, B.; Pollheimer, P. D.; Gruber, H. J.; Errington, J.; Hallet, B.; Haulot, X.; Verbelen, C,; Hols, P.; Dufrene, Y. F.* "Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction" Nano Letters 2007, 7(3), 796-801.

9. Wang, Q. G.; Yang, Z. M.; Wang, L.; Ma, M. L.; Xu, B.* "Molecular Hydrogel-Immobilized Enzymes Exhibit Superactivity and High Stability in Organic Solvents" Chem. Commun. 2007, 1032-1034.

10. Yang, Z. M., Liang, G. L., Wang, L., Xu, B.* “Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in vivo” J. Am. Chem. Soc. 2006, 128, 3038-3043.

11. Yang, Z. M., Xu, K. M., Wang, L., Gu, H. W., Wei, H., Zhang, M. J., Xu, B.* "Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds" Chem. Commun. 2005, 4414-4416.

12. Yang, Z. M.; Gu, H. W.; Zhang, Y.; Wang, L.; Xu, B.* “Small Molecule Hydrogels Based on a Class of Antiinflammatory Agents” Chem. Commun, 2004, 208-209.

13. Gu, H. W.; Ho, P. L.; Tsang, K. W. T.; Wang, L.; Xu, B.* “Using Biofunctional Magnetic Nanoparticles to Capture Vancomycin Resistant Enterococci and Other Gram-Positive Bacteria at Ultralow Concentration” J. Am. Chem. Soc. 2003, 125.

14. Gu, H. W.; Ho, P. L.; Tong, E.; Wang, L.; Xu, B.* “Presenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities” Nano Letters 2003, 3, 1261-1263.

15. Yang, Z. M., Wang, L., Yuan, J., Shen, J., Lin, S. C.*. “Synthetic Studies on Nonthrombogenic Biomaterials 14: Synthesis and Characterization of Poly(ether-urethane) Bearing Zwitterionic Structure of Phosphorylcholine on Surface” J Biomater. Sci. Polym. Edn. 2003, 707-718.

16. Chen, L., Wang, L., Yang, Z. M., Shen, J., Lin, S. C.*. “Synthetic Studies on Blood Compatible Biomaterials 13: A Novel Segmented Polyurethane Containing Phosphorylcholine Structure: Synthesis, Characterization and Blood Compatibility Evaluation” Chinese J Polym. Sci. 2003, 45-50.

17. Wang, L., Yang, Z. M., Chen, L., Shen, J., Lin, S. C.*. “Syntheses and characterization of a novel series of phosphorylcholines containing hydroxyl group” Chem. J of Chinese Univ. 2003, 24, 1034-1036.