李程

2000-2004 東北師範大學生命科學學院 本科

2004-2007 廈門大學生命科學學院 細胞生物學碩士

2007-2010 廈門大學生命科學學院 細胞生物學博士 ^[1] 

2011.02-2014.07 廈門大學醫學院 助理教授

2015.09-2015.12 肯塔基大學藥學院 訪問學者

2015.12-2016.09 辛辛那提大學醫學院 訪問學者

2014.08-2021.07 廈門大學醫學院 副教授

2021.08~至今 廈門大學醫學院 教授 ^[1] 

角膜和眼表疾病，包括眼部幹細胞的基礎研究，角膜組織工程，環境污染物損傷眼表機制研究。

中國生物醫學工程學會組織工程與再生醫學分會委員

中國醫藥教育協會醫療器械管理眼科分會委員

中國中藥協會眼保健中醫藥技術專業委員會青年委員

海峽兩岸醫藥衞生交流協會眼科學專委會眼表與淚液學組青年委員

廈門市醫學會轉化醫學分會委員

廈門市醫學會眼科學分會青年副主任委員分會委員 ^[1] 

1. 國家自然科學基金面上項目，82070931，m6A甲基轉移酶Mettl3在角膜鱗狀上皮化生中的作用及機制研究，2021.1-2024.12，55萬。

2. 國家自然科學基金面上項目，81100639，自噬在角膜內皮損傷中的作用及機制研究，2018/01-2021/12，56萬。

3. 國家自然科學基金面上項目，81470601，Brd4調控角膜上皮幹細胞的機理研究，2015/1-2018/12，73萬。

4. 國家自然科學基金青年項目，81770891，Hif-1α在眼表鱗狀上皮化生中的功能研究，2012/1-2014/12，23萬。

5. 華夏轉化醫學青年基金項目，2017-A-001，植物源性組織工程角膜上皮載體的開發與應用，2017/07-2020/06，30萬。

6. 廈門市重要重大疾病聯合攻關項目，3502Z20159017，眼化學傷的早期精準診斷與快速重建的臨牀研究，2016/1-2018/12，20萬。

7. 廈門大學“生命科學與人類健康學科羣”學科發展項目，PKHD1基因在虹膜-角膜內皮綜合徵發生中的作用及機制研究，2019/1-2020/12，40萬，主持

8. 廈門大學校長基金項目，Brd4在眼表LSCD發生中功能研究，2015/1-2016/12，50萬，主持

9. 福建省自然科學基金面上項目，2016J01416，溴基結構域蛋白4調控角膜緣幹細胞的機理研究，2015/4-2018/4，4萬。 ^[1] 

1. Zhong Y#, Fang X#, Wang X, Lin Y, Wu H*, Li C*. Effects of Sodium Hyaluronate Eye Drops With or Without Preservatives on Ocular Surface Bacterial Microbiota. Front Med. 2022 Feb 14;9:793565.

2. Wang X, Zhong Y, Liang M, Lin Z, Wu H*, Li C*. Crosslinking-Induced Corneal Endothelium Dysfunction and Its Protection by Topical Ripasudil Treatment. Dis Markers. 2022 Jan 13;2022:5179247.

3. Li W, Li X, Cui F, Xu Z, Dong N*, Li C*. The Ocular Surface Characteristics in Prostate Cancer Patients Treated with Androgen Deprivation Therapy. Dis Markers. 2021 Nov 9;2021:5390195.

4. Zong R, Zhu F, Han W, Wang Y, Wang G, Wang Y, Mao Y, Guan T, Liu Z, Xue Y*, Li C*. Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure. J Proteomics. 2021 Aug 16:104351.

5. Wang G，An X，Jin M, Wang X, Zong R, Liu Z, Liu Z, Xue Y*, Li C*. Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses. Exp Eye Res. 2021, 108706.

6. Li Z, Liu M, Ke J, Wang J, Wu C, Li C*, Li Z*, Wu Y*. Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years. Nanoscale Adv. 2021, 3 (18) , 5240-5254

7. Han Y#, Jiang L#, Shi H#, Xu C, Liu M, Li Q, Zheng L, Chi H, Wang Y, Liu Z, You M, Loh X, Wu Y*, Li Z*, Li C*. Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye. Bioact Mater. 2021 Jul 28;9:77-91.

8. Jin M, Wang Y, An X, Kang H, Wang Y, Wang G, Gao Y, Wu S, Reinach P, Liu Z, Xue Y, Li C*. Phenotypic and transcriptomic changes in the corneal epithelium following exposure to cigarette smoke. Environmental Pollution. 2021, 117540,

9. An X, Wang G, Jin M, ZhouX, Gao S, Chen J, Reinach P, Liu Z, Xue Y*, Li C*. Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo. Front Cell Dev Biol. 2021 Jun 30; 9:675998.

10. Han Y#, Xu C#, Shi H#, Yu F, Zhong Y, Liu Z, Loh X, Wu Y*, Li Z*, Li C*. Engineered bio-adhesive polyhedral oligomeric silsesquioxane hybrid nanoformulation of amphotericin B for prolonged therapy of fungal keratitis. Chemical Engineering Journal. 2021, 421, 129734

11. Dong N#*, Cai Q#, Li Z, Xu L, Wu H, Lin Z, Qiu B, Li C*, Lin Z*. Convenient hyaluronidase biosensors based on the target-trigger enhancing of the permeability of a membrane using an electronic balance as a readout. Analyst. 2021 May 17;146(10):3299-3304.

12. Tao Y, Luo F, Lin Y, Dong N*, Li C*, Lin Z*. Quantitative gold nanorods based photothermal biosensor for glucose using a thermometer as readout. Talanta. 2021, 230, 122364

13. Li X#, Wang X#, Wang Y, Wu H*, Li C*. Effect of Proparacaine Hydrochloride Eye Drops on the Ocular Surface. International Journal of Ophthalmology & Visual Science. 2021; 6(1): 46-53

14. Ma W, Wang G, Li X, Wu H, Liu Z, Dong N*, Li C*. Study of Factors Influencing Dry Eye in Rheumatoid Arthritis. J Ophthalmol. 2020 Aug 8;2020:5768679.

15. Wang G, Chen P, Wang Y, Wang Y, Reinach PS, Xue Y, Liu Z*, Li C*. Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery. Adv Healthc Mater. 2020 Jul;9(14):e2000469.

16. Jin M, Wang Y, Wang Y, Li Y, Wang G, Liu X, Xue Y*, Liu Z, Li C*. Protective effects on corneal endothelium during intracameral irrigation using N-(2)-L-alanyl-L-glutamine. Front Pharmacol. 2020，11: 369.

17. Wang Y, Zhang Y, Lin Z, Wu H*, Li C*. Case Studies of Mycobacterium abscess Infection after Laser in Situ Keratomileusis. Case Reports in Clinical Medicine, 2019 Dec；8(12): 307-314

18. Han Y#, Li C#*, Cai Q, Bao X, Tang L, Ao H, Liu J, Jin M, Zhou Y, Wan Y, Liu Z*. Studies on bacterial cellulose/poly vinyl alcohol (BC/PVA) hydrogel composites as tissue-engineered corneal stroma. Biomed Mater. 2019 Nov 12. doi: 10.1088/1748-605X/ab56ca .

19. Wang G, Xue Y, Wang Y, Dong F, Shen M, Zong R, Liu Z*, Li C*. The role of autophagy in the pathogenesis of exposure keratitis. J Cell Mol Med. 2019， 23(6):4217-4228.

20. Yang Q, Tang L, Shen M, Wang Y, Wei Y, Jeyalatha V, Chen P, Dong F, Wang G, Wu S, Liu Z*, Li C*. Effects of diesel exhaust particles on the condition of mouse ocular surface. Ecotoxicol Environ Saf. 2018, 163(11):585-593.

21. Wang G, Dong N, Wang Y, Li J, Dong F, Jeyalatha V, Wu J, Shen M, Yang Q, Chen P, Xue Y, Liu Z, Li C*. Epithelial dysplasia in pterygium postoperative granuloma. Exp Eye Res. 2018, 175(8):199-206.

22. Li J#, Li C#, Wang G, Liu Z, Chen P, Yang Q, Dong N, Wu H, Liu Z*, Li W*. APR-246/PRIMA-1Met Inhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium. Invest Ophthalmol Vis Sci. 2016, 57(2):444-52.

23. Li C, Dong N, Wu H, Dong F, Xu Y, Du H, He H, Liu Z*, Li W*. A novel method for preservation of human corneal limbal tissue. Invest Ophthalmol Vis Sci. 2013, 54(6), 4041-4047.

24. Li C, Dong F, Jia Y, Du H, Dong N, Xu Y, Wang S, Wu H, Liu Z*, Li W*. Notch signal regulates corneal endothelial-to-mesenchymal transition. Am J Pathol. 2013, 183(3), 786-795.

25. Li C, Yin T, Dong N, Dong F, Fang X, Qu YL, Tan Y, Wu H, Liu Z*, Li W*. Oxygen tension affects terminal differentiation of corneal limbal epithelial cells. J Cell Physiol. 2011, 226(9), 2429-2437.

26. Dong N, Qin W, Xue Y, Li C*, Liu Z*. Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell. In Vitro Cell Dev Biol Anim. 2013, 49(7), 508-514.

27. Dong N#, Li C#, Chen W, Qin W, Xue Y, Wu H, Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue, Int J Ophthalmol, 2014, 7(1), 62-65. ^[2]