張琪

美國紐約州立大學布法羅分校（State University of New York at Buffalo）博士後；

中國藥科大學藥理學博士。 ^[1] 

江蘇省高校醫藥教育研究會副理事長；

江蘇省藥理學會常務理事；

藥學核心期刊《中國臨牀藥理學與治療學》、《中華男科學雜誌》編委

江蘇省食品藥品監督管理局新藥審評與現場核查專家 ^[1] 

在基礎研究領域着重於各類新藥的臨牀前與臨牀的藥物動力學、藥效學篩選、藥理學機制靶點、藥效-藥動學模型研究，以及骨質疏鬆症、高脂血症等重大疾病的代謝組學研究。尤其是代謝組學方法學及其應用的研究成果處於國內外前列。 ^[1] 

近年來承擔國家自然科學基金面上項目5項（主持3項，聯合單位負責人2項）；國際合作項目2項（美國紐約州立大學、美國FDA-馬里蘭大學）；國家973預研項目1項；省基金1項（抗骨質疏鬆一類新藥的臨牀前研究）；省臨牀醫學專項1項（骨質疏鬆生物標記物研究）；參與國家973、省部科研項目8項。申請專利8項（2項授權）。發表學術文章約80篇（46篇被SCI收錄）；參與編寫英文論著1部，中文著作、化工辭典各1部。

主持建立了“南京工業大學藥動藥效研究與評價中心”，中心擁有藥物分析、藥效評價、分子生物學、細胞培養、動物實驗等技術平台，按照國家食品藥品監督管理局頒佈的“藥物臨牀試驗生物樣本分析實驗室管理指南”的要求進行建設、管理和運行。有資質從事新藥藥學、臨牀前藥物動力學、藥理學以及臨牀藥物動力學（生物等效性實驗）檢測部分的研究與新藥報批工作。 ^[1] 

江蘇省“333高層次人才培養工程”培養對象

江蘇省“六大人才高峯”培養對象

南京市“321”領軍型科技創業人才

南京工業大學首屆“工大才俊”高層次人才培養對象 ^[1] 

藥理學、藥物動力學（本科生課程）；現代藥理學（研究生課程） ^[1] 

英文論著：《Strontium: Chemical Properties, Applications and Health Effects》一書中的第一章節“The Effects of Strontium on Physiology, Pharmacology and Toxicity of the Human”出版社：NOVA Publishers出版日期：2013年ISBN：978-1-62257-631-9

中文論著：《10000個科學難題（醫學卷）》， “藥動學-藥效學結合模型—連接體內藥物濃度與藥效關係的橋樑”，科學出版社，2011年8月正式出版，P955-958。 “十一五”國家重點圖書出版規劃項目

辭典：《化工辭典（第五版）》，化學工業出版社，2014年5月 ^[1] 

1.Tumor-targeting,enzyme-activatednanoparticlesforsimultaneouscancerdiagnosisandphotodynamictherapy.JournalofMaterialsChemistryB, 2016,4 (1) :113-120

2.Diketopyrrolopyrrole Derivatives Grafting Hyaluronic Acid for Targeted Photodynamic Therapy, Chemistryselect, 2016, 1, 3071-3074

3.Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy, ACS Applied Materials & Interfaces, 2016, 8, 10737-10742

4.Associationbetweenthemetabolomeandbonemineraldensityinpre-andpost-menopausalChinesewomenusingGC-MS.MolecularBioSystems,2016，12（7）：2265-2275

5.Wnt/b-catenin signaling plays an important role in the protective effects of FDP-Sr against oxidative stress induced apoptosis in MC3T3-E1 cell. Bioorganic & Medicinal Chemistry Letters. 2016 (26): 4720-4723

6.Triptolidedisruptsfattyacidsandperoxisomeproliferator-activatedreceptor(PPAR)levelsinmalemicetestesfollowedbytesticularinjury:AGC-MSbasedmetabolomicsstudy.Toxicology,

2015；336:84-95.

7.Strontiumfructose 1,6-diphosphate-alleviatecyclophosphamide induced – oligozoospermia byimproving antioxidant and inhibiting androgone apoptosis via FSA/FASL pathway. Andrologia，2015 ,47（9: 995-1003）

8.PharmacokineticsandtissuedistributionofAucubin,AjugolandCatalpolinratsusingavalidatedsimultaneousLC-ESI-MS/MSassay.JournalofChromatographyB,2015,1002:245-253.

9.Apre-clinical pharmacokinetic study inratsofthreenaturally occurringiridoidglycosides, Picroside-I, IIandIII,using a validated simultaneous HPLC – MS/ MS assay, J.Chromatogr.B，2015, 993-994：47–59

10.Quantitative ananlysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: applicationtopharmacokineticandtissuedistributionstudy. Journal of Pharmaceutical and Biomedical Analysis, 88(2014): 191-200.

11.Simultaneous determinationofosthole,bergaptenandisopimpinellininratplasmaandtissuesbyliquidchromatography–tandemmassspectrometry；JournalofChromatographyB，970（2014）：77-85

12.Metabolomic analysis of simvastatin and fenofibrate in high - lipid diet - induced hyperlipidemia rats. Acta Pharmacologica Sinica, 2014, 33(4): 479-489 IF: 2.35

13.Comparativepharmacokineticswithsingle substances and Semen Cuscutae extract after oral administration and intravenous administration Semen Cuscutae and single hyperosede and astragalin to rats. Analytical Methods.2014,6,7250–7259.

14.Metabolomic Profiles Delineate Signature Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS. PLOS ONE, 2013,8(2):e54965.

15 Simultaneous determination of Eleutheroside B and Eleutheroside E in rat plasma by high performance liquid chromatography-electrospray ionization mass spectrometry and its application in a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci, 2013, 917-918 : 84-92.

16.Rapid analysis of tadalafil in human blood plasma and seminal plasma by liquid chromatography/tandem mass spectrometry. J Pharm Biomed Anal, 2013,77C :149-157.

17.Simultaneous determination of oridonin, ponicidin and rosmarinic acid from Herba Isodi Rubescentis extract by LC-MS-MS in rat plasma. Journal of chromatographic science, 2013, 51 (10): 910-8.

18.Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of raddeanin A in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci, 2013,912:16-23.

19.Expression and distribution of Attractin related changes in the different developmental stages of rats testis. InternationalJournalofMolecularMedicine, 2013 32(3): 599-606.

20.Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1, 6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS European Journal of Pharmacology, 718(2013)：524-532.

21. Strontium fructose 1, 6-fiphosphate (FDP-Sr) treatment prevents bone loss in a rat model of postmenopausal osteoporosis via OPG\RANKL\RANK pathway. Acta Pharmacologica Sinica, 2012, 33(4): 479-489

22.GC-TOF/MS-based metabolomic proiling of estrogen deiciency-induced obesity in ovariectomized rats. Acta Pharmacologica Sinica , 2011(32): 270-278

23. Synthesis and pharmacokinetics of strontium fructose 1,6-diphosphate (Sr-FDP) as a potential anti-osteoporosis agent in intact and ovariectomized rats. J Inorg Biochem, 2011,105(4):563-568.

24.Metabonomic profiling of diet-induced hyperlipidaemia in a rat model.Biomarkers 2010 May;15(3):205-16.

25.Strontium fructose 1,6- diphosphate alleviates early diabetic testopathy by suppressing abnormal testicular matrix metallop- roteinase system in streptozocin-treated rats [J]. J Pharmacy Pharmacology, 2009, 61: 229-236

26.(2-Pyridyl)acetone-Promoted Cu-Catalyzed O- Arylation of Phenols with Aryl Iodides, Bromides, and Chlorides. The Journal of Organic Chemistry, 2009, 74:7187–7190

27. Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats. Acta Pharmacologica Sinica, 2009, 30(12):1674-1687 ^[1]