張文

2008年至2011年，任華東師範大學化學系黨總支書記。 ^[1] 

生物電分析化學

熒光分析

化學修飾電極 ^[3] 

國家自然科學基金項目：納米過氧化物電極及其對水體中細菌的快速計數和作用機理的電化學分析研究，上海市科委納米專項基金：納米過氧化物高效催化電極材料及其應用於水體中大腸桿菌的快速計數研究 , 與美國EXTECH INSTRUMRNT 公司合作項目：水體中細菌電化學傳感器的研究，承擔上海市“曙光計劃”（人才計劃項目）

基於納米氧化物催化材料的可控合成、功能化及分子識別

神經退行性疾病分析新方法的研究

新型COD分析方法、理論的研究及其儀器的開發

用納米科技建立電分析化學的新原理、新方法研究

神經系統損傷病理和藥理的電分析方法研究

超微傳感器在心肌細胞損傷和修復中的應用研究

化學修飾電極電色效應和電色材料及其在分析儀器中的應用研究

納米氧化物紫外屏蔽性能的評價方法及其分析

儀的研究與開發

納米氧化物材料性能評估儀器的研究

國家“九五”科技攻關項目：

國產電化學儀器的改進及新電極、傳感器的研製

國家“十五”重點科技攻關項目：

納米COD傳感器及其快速在線COD

電化學檢測儀的研製與開發

水質自動檢測系統及關鍵技術及集成設備研製 ^[3] 

1. Yi Lai, Yingying Zhu, Zhiai Xu*, Xianli Hu, Madiha Saeed, Haijun Yu, Xingxing Chen, Jun Liu, Wen Zhang*, Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid β. Adv. Funct. Mater.2020, 30, 1908473.

2. Li Lei, Min Li, Sufen Wu, Zhiai Xu*, Ping Geng, Yang Tian, Ying Fu, and Wen Zhang*, Non-invasive In-situ Ratiometric Imaging of Biometals Based on Self-Assembling Peptide Nanoribbon. Anal. Chem. 2020, 92(8), 5838-5845.

3. Yijing Dang, Fengyang Wang, Lingling Li, Yi Lai, Zhiai Xu*, Zhi Xiong, Ao Zhang, Yang Tian, Chunyong Ding, and Wen Zhang* Activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice. Chem. Commun. 2020, 56, 707-710

4. Yi Lai, Zhiai Xu, Xianli Hu, Li Lei, Lingling Li, Liang Dong, Haijun Yu, Wen Zhang*. Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor. Small2019, 15, 1904397.

5. Chunyong Ding, Fengyang Wang, Yijing Dang, Zhiai Xu, Lingling Li, Haijun Yu, Yi Luo, Ruimin Huang, Ao Zhang, and Wen Zhang, Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity. Anal. Chem. 2019, 91, 24, 15577-15584.

6. Li Lei, Rui Geng, Zhiai Xu*, Yijing Dang, Xianli Hu, Lingling Li, Ping Geng, Yang Tian, Wen Zhang*. Glycopeptide Nanofiber Platform for Ab-Sialic Acid Interaction Analysis and Highly Sensitive Detection of Ab. Anal. Chem. 2019, 91, 8129-8136.

7. Rui Geng, Danqin Lu, Yi Lai, Sufen Wu, Zhiai Xu* and Wen Zhang*, Peptide nanotube for carbon dioxide chemisorption with regeneration properties and water compatibility. Chem. Commun. 2019, 55, 26, 3797-3800.

8. Li Lei, Zhiai Xu*, Xianli Hu, Yi Lai, Jie Xu, Bo Hou, Ya Wang, Haijun Yu, Yang Tian, Wen Zhang*. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma. Small 2019, 15(22), 1900157

9. Liang Dong, Zhiai Xu,Shangjie An, Xiaodan Jia, Wen Zhang and Xiue Jiang. A glutathione-depleted prodrug platform of MnO2-coated hollow polydopamine nanospheres for effective cancer diagnosis and therapy. New Journal of Chemistry, 2020, 44, 7838--7848.

10. Liang Dong, Chao Wang, Wenyao Zhen, Xiaodan Jia, Shangjie An, Zhiai Xu, Wen Zhang and Xiue Jiang. Biodegradable iron-coordinated hollow polydopamine nanospheres for dihydroartemisinin delivery and selectively enhanced therapy in tumor cells. J. Mater. Chem. B, 2019, 7, 6172-6180.

11. F. Wang, Y. Zhu, J. Xu, Z. Xu*, G. Cheng, W. Zhang*. Highly selective and ratiometric fluorescent nanoprobe for the detection of cysteine and its application in test strips. Analytical and Bioanalytical Chemistry, 2018, 410, 4875-4884.

12. Y. Wang, J. Xu, L. Lei, F. Wang, Z. Xu*, G. Cheng, W. Zhang*. Multi-functional carbon dots-based nanoprobe for ratiometric enzyme reaction monitoring and biothiol analysis. Sensors and Actuators B-Chemical, 2018, 264, 296-303.

13. F. Wang, C. Feng, Z. Xu*, W. Zhang*. A ratiometric fluorescent probe for rapid and sensitive detection of biothiols in fetal bovine serum, Talanta, 2017, 169, 149-155.

14. Q. Huang, Y. Wang, L. Lei, Z. Xu*, W. Zhang*, Photoelectrochemical biosensor for acetylcholinesterase activity study based on metal oxide semiconductor nanocomposites, J. Electroanal. Chem. 2016, 781, 377-382.

15. F. Wang, Q. Sun, B. Feng, Z. Xu*, J. Zhang, J. Xu, L. Lu, H. Yu, M. Wang, Y. Li and W. Zhang*, Polydopamine-functionalized graphene oxide loaded with gold nanostars and doxorubicin for combined photothermal and chemotherapy of metastatic breast cancer, Adv. Healthc. Mater. 2016, 5, 2227–2236.

16. J. Zhang, J. Liu, Y. Zhu, Z. Xu*, J. Xu, T. Wang, H. Yu and W. Zhang*, Photodynamic micelles for amyloid β degradation and aggregation inhibition, Chem. Commun. 2016, 52, 12044-12047.

17. Y. Wang, L. Lu, H. Peng, J. Xu, F. Wang, R. Qi, Z. Xu* and W. Zhang*, Multi-doped carbon dots with ratiometric pH sensing properties for monitoring enzyme catalytic reactions. Chem. Commun., 2016, 52, 9247-9250.

18. P. Geng, C. Feng, L. Zhu, J. Zhang, F. Wang, K. Liu, Z. Xu, and W. Zhang*, Evaluation of sialic acid expression on cancer cells via an electrochemical assay based on biocompatible Au@BSA Architecture and lectin-modified Nanoprobes, Electroanalysis 2016, 28, 1331 – 1339.

19. L. Zhu, J. Zhang, F. Wang, Y. Wang, L. Lu, C. Feng, Z. Xu*, W. Zhang*. Selective amyloid β oligomer assay based on abasic site-containing molecular beacon and enzyme-free amplification, Biosens. Bioelectron., 2016, 78, 206-212. ^[3]