劉海燕

曾於1993-1995年作為聯合培養研究生在瑞士蘇黎世高等理工學院物理化學實驗室學習；

1996年畢業於中國科學技術大學生物系，獲博士學位；

曾1993-1995年作為聯合培養研究生在瑞士蘇黎世高等理工學院物理化學實驗室學習；

1998-2000年在杜克大學和北卡羅來納大學作博士後研究； ^[1] 

現任中國科學技術大學教授、博士生導師。

2023年12月，人工智能生物技術與合成生物學安徽省基礎學科研究中心主任。 ^[4] 

1、計算生物學/生物信息學/結構生物學 ^[1] 

中國科學技術大學劉海燕教授、陳泉副教授團隊採用數據驅動策略，開闢出一條全新的蛋白質從頭設計路線，在蛋白質設計這一前沿科技領域實現了關鍵核心技術的原始創新，為工業酶、生物材料、生物醫藥蛋白等功能蛋白的設計奠定了堅實基礎。 ^[3] 

1. Jianbin He，Zhiyong Zhang， Yunyu Shi*， Haiyan Liu*； Efficiently explore the energy landscape of proteins in molecular dynamics simulations by amplifying collective motions， J.Chem.Phys. 2003, in press.

2. Jiang Zhu, Qianqian Zhu, Yunyu Shi* and Haiyan Liu*; How Good can We Predict Native Contacts in Proteins Based on Decoy Structures and Their Energies? Proteins, 2003，in press.

3. G.. A. Cisnero, H. Liu, Y. Zhang and W. Yang*; Ab initio QM/MM study shows there is no general acid in the reaction catalyzed by 4-oxalocrotonate tautomerase, J. Am. Chem. Soc., 2003, in press.

4. Zhiyong Zhang, Yunyu Shi*, and Haiyan Liu*, Molecular dynamics simulations of peptides and proteins with amplified collective motions. Biophys. J., 2003,84,3583-3593.

5. J-Y Hasegawa*, M. Ishida, H. Nakatsuji*, Zhengyu Lu, Haiyan Liu, Weitao Yang, Energetics of the electron transfer from bacteriopheophytin to ubiquinone in the photosynthetic reaction center of Rhodopseudomonas Viridis: theoretical study, J. Phys. Chem. B 2003,107, 838-847.

6. Jiang Zhu, Yunyu Shi*, and Haiyan Liu*; Parametrization of a Generalized Born/Solvent-Accessible Surface Area Model and Applications to the Simulation of Protein Dynamics; J. Phys. Chem. B 2002, 106, 4844-4853.

7. Li Xie, Haiyan Liu*; The Treatment of Solvation by a Generalized Born Model and a Self-Consistent Charge-Density Functional Theory-Based Tight-Binding Method; J. Comput. Chem. 2002, 23,1404-1415.

8. Wei Gu, Jiang Zhu and Haiyan Liu*, DIFFERENT PROTONATION STATES OF THE BACILLUS CEREUS BINUCLEAR ZINC METALLO--LACTAMASE ACTIVE SITE STUDIED BY COMBINED QUANTUM MECHANICAL AND MOLECULAR MECHANICAL SIMULATIONS, J. Theore. Comput. Chem., 2002, 1, 69-80.

9. Yingkai Zhang, Haiyan Liu and Weitao Yang*; Ab initio QM/MM and free energy calculations of enzyme reactions, in Computational Methods for Macromolecules: Challenges,Methods, Ideas - Proceedings of the 3rd International workshop on Algorithms for Macromolecullar Modelling, New York, October 13-15, 2000. Eds. Schlick, T. and Gan, H.H. Lecture Notes in Computational Science and Engineering , Springer Verlag, 2002.

10. Zhengyu Lu, Haiyan Liu, Marcus Elstner, and Weitao Yang*, Parameterization of COSMO Solvent Model for Self-Consistent charge Density-Functional Based Tight-Binding Calculations；in REVIEWS OF MODERN QUANTUM CHEMISTRY A Celebration of the Contributions of Robert G Parr, K.D. Sen Ed, World Scientific, Singapore, 2002.

11. Haiyan Liu, Marcus Elstner, Efthimios Kaxiras, Thomas Frauenheim, Jan Hermans* and Weitao Yang*; Quantum Mechanics Simulation of Protein Dynamics on Long Time Scale; Proteins, 2001, 44，484-489.

12. Jiang Zhu, Hao Fan, Haiyan Liu & Yunyu Shi*; Structure-based ligand design for flexible proteins: Application of new F-DycoBlock; J.Comput.Aid.Mol.Des.;2001，15，979-996.

13. Jiang Zhu, Haibo Yu, Hao Fan, Haiyan Liu and Yunyu Shi*, Design of new selective inhibitors of cyclooxygenase-2 by dynamic assembly of molecular building blocks; J.Comput.Aid.Mol.Des. 2001，15，447-463.

14. Liu, Haiyan; Zhang, Yingkai; Yang Weitao*; How is the active site of enolase organized to catalyze two different reaction steps? J. Am. Chem. Soc., 2000, 6560.

15. Zhang, Yingkai, Liu, Haiyan; Yang, Weitao*; Free energy calculation on enzyme reactions with an efficient iterative procedure to determine mininmum energy paths on a combined abinitio QM/MM poteintial energy surface, J. Chem. Phys., 2000, 112, 3483-3492.

16. Liu, Haiyan*, Luo, Qiming; Duan, Zhihong; Shi, Yunyu; Structure-based Ligand Design by Dynamically Assembling Molecular BuildingBlocks at Active Site, Proteins, 1999, 36, 462-470.

17. Gou, Qingxiang*; Liu, Haiyan; Ruan, X.Q.; Zheng, X. Q.; Shi, Y. Y.; Liu, Y.C.; Experimental and theoretical studies on the inclusion complexation of beta-cyclodextrin with phenothiazine derivatives; J. Incl.Phenom. Macro.; 1999,35,487-496. ^[2] 

18.在J. Am.. Chem. Soc.、J. Mol. Biol.、J. Chem. Phys.等雜誌發表研究論文三十餘篇。

2000年入選中國科學院“引進國外傑出人才”項目。2001年獲“國家傑出青年基金”資助。