劉健

劉健 ^[1]  男

學歷學位 博士

職稱 博士生導師，教授

所屬學院 生物與食品工程學院

1）肥大細胞在肥胖和相關代謝疾病中作用機理研究；

2）組織蛋白酶在肥胖和血管疾病中作用機理的研究；

3）抗肥胖食品、藥物因子體外檢測平台的研究。

劉健,博士，合肥工業大學 “黃山學者”特聘教授，生物與食品工程學院肥胖和代謝疾病研究所所長，博士生導師。

1991-1995年，安徽大學生物化學專業，學士

1995-2001年，安徽省立醫院藥劑科，主管藥師

2001-2006，中國科學技術大學生命科學院細胞分子生物學專業碩-博連讀，博士

2006-2009年，分別在美國哈佛大學醫學院Brigham & Women’s Hosiptal，Beth Israel Deaconess Medical Center作博士後。

2009年11月-，合肥工業大學教授

基因組學

發表的相關論文：（影響因子參照JCR2009版，引用次數依據Web of Science2011年2月18日檢索結果）

1) Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Doria A, Libby P, Blumberg RS, Kahn BB, Shi GP. Genetic Deficiency and pharmacological stabilization of mast cells reduces diet-induced obesity and diabetes in mice. Nat Med. 2009; 15(8):940-947. (SCI 27.136) (被引用次數：29)

2) Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004; 24(8):1359-1366. (SCI, 7.235) (被引用次數：116)

3) Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis. 2006;184(2):302-311. (SCI, 4.552) (被引用次數：53)

4) Liu J, Ma L, Yang J, Ren A, Sun Z, Yan G, Sun J, Fu H, Xu W, Hu C, Shi GP. Increased serum cathepsin S in patients with atherosclerosis and diabetes. Atherosclerosis. 2006;186(2):411-419. (SCI, 4.552) (被引用次數：18)

5) Liu J, Shi GP, Zhang WQ, Zhang GR, Xu WH. Cathepsin L function in insect moulting: molecular cloning and functional analysis in cotton bollworm, Helicoverpa armigera. Insect Mol Biol. 2006; 15(6):823-834. (SCI, 2.568) (被引用次數：18)

6) Zimonjic DB, Liu J, Xu WH, Zhou X, Popescu NC, Shi GP. Assignment of murine placental cathepsin R to mouse chromosome bands 13B2-B3 by fluorescence in situ hybridization. Cytogenet Genome Res. 2005; 111(1):96. (SCI, 1.729)

7) Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007; 117(11):3359-3368. (SCI, 15.387)

8) Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007; 9(8):970-977.(SCI, 19.527)

9) Tang B, Chen X, Liu Y, Tian H, Liu J, Hu J, Xu W, Zhang W. Characterization and expression patterns of a membrane-bound trehalase from Spodoptera exigua. BMC Mol Biol. 2008; 20(9):51. (SCI, 2.848)

10) Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi MA, Darakhshan F, Guerre-Millo M, Clement K, Gelb BD, Dolgnov G, Shi GP. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol. 2008;28(12):2202- 2208. (SCI, 7.235)

11) Wei ZJ, Liao AM, Zhang HX, Liu J, Jiang ST. Optimization of supercritical carbon dioxide extraction of silkworm pupal oil applying the response surface methodology. Bioresour Technol. 2009;100(18):4214-4219. (SCI, 4.253)

12) Sun J, Zhang J, Lindholdt JS, Sukhova GK, Liu J, Pejler G, Gurish MF, Stevens RL, Libby P,Thompson RW, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009;120:973-982 (SCI, 14.816)

13) Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP.Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice. PLoS One. 2010; 5(11):e13973(SCI, 4.351)