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吝易
鎖定
吝易人物經歷
2014-2020年 西南醫學中心,博士後
吝易研究方向
人口老齡化的加劇使神經退行性疾病逐漸成為世界性健康難題。此類疾病的共同特徵是特定蛋白質在腦部形成異常凝集。影響上述凝集過程的核心機制是蛋白質及其他生物大分子的相變:生理狀態下,這些蛋白通過液液相變形成無膜細胞器,從而對細胞內空間進行分隔,精確協調各種生化反應;病理狀態下,異常相變造成蛋白質不溶性聚集,進而導致神經元死亡。我們希望系統性地研究生物大分子相變的分子機制及其對神經系統功能的影響,最終達到通過人工干預調控病理狀態下的相變,從而治療神經退行性疾病的目的。
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吝易主要成就
代表性論文
• Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P. Tu, and Steven L. McKnight, Redox-mediated Regulation of an Evolutionarily Conserved Cross-β Structure Formed by the TDP43 LC Domain. (2020) PNAS. Nov 17;117(46):28727-28734
• Yi Lin#, Eiichiro Mori#, Masato Kato#, Siheng Xiang#, Leeju Wu, Ilmin Kwon and Steven L. McKnight, Toxic PR Poly- Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. (2016) Cell. Oct 20; 167(3):789-802; #co-first authors
• Dylan T. Murray#, Masato Kato#, Yi Lin, Kent R. Thurber, Ivan Hung, Steven L. McKnight, and Robert Tycko, Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains. (2017) Cell. Oct 19; 171(3):615–627; #co-first authors
• Masato Kato, Yi Lin, Steven L. McKnight, Cross-β Polymerization and Hydrogel Formation by Low-Complexity Sequence Proteins. (2017) Methods. Aug 15; 126:3–11
• Siheng Xiang, Masato Kato, Leeju C. Wu, Yi Lin, Ming Ding, Yajie Zhang, Yonghao Yu, Steven L. McKnight, The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei. (2015) Cell. Nov 5;163(4):829-39
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吝易所獲榮譽
Oliver Smith Academic Achievement Award (2013)
Marquette University Fellowship (2012-2014)
吝易科普活動
- 參考資料
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- 1. 吝 易-清華大學生命科學學院 .清華大學生命科學學院[引用日期2022-12-24]
- 2. 兩個年輕人的叛逆與冒險 .高山科學經典.2022-12-21[引用日期2022-12-24]