陳華青

1994/7 - 1997/11，倫敦大學King's College London，免疫學，博士

1986/9 - 1989/8，上海第二醫科大學，免疫學，碩士

1982/9 - 1986/8，復旦大學，微生物學，學士 ^[1] 

2007 - 至今 華東師範大學，生命科學學院生命醫學研究所，高級工程師

1998 - 2006 上海實業科華生物技術有限公司研發部主任，高級工程師

1994 - 1997GlaxoWellcome英國研究中心（葛蘭素），細胞生物學，訪問學者

1993 - 1994 英國Wellcome Research Laboratories,訪問學者

1989 - 1992 衞生部上海生物製品研究所免疫學研究室，助理研究員 ^[1] 

中國細胞生物學會會員‚ 中國免疫學會會員‚ 中國生化和分子生物學會會員，上海市生物工程學會終生會員

《現代免疫學》, Diabetes Obes Metab, Sci Rep等雜誌的特約審稿人 ^[1] 

免疫、炎症與代謝，以及相關的疾病模型 ^[1] 

本科生《生物專業英語》

研究生《分子免疫學》 ^[1] 

近年來主要從事免疫學、代謝和疾病模型等方面研究，發表文章三十多篇，申請專利兩項，參編著作五部。 ^[1] 

1.Therapeutic potentiation of the immune system by costimulatory Schiff base-forming drugs. Nature 1995,377:71-75

2.Schiff base forming drugs: mechanisms of immune potentiation and therapeutic potential‚ Journal of Molecular Medicine 1996, 74:497-504

3.Convergence of Schiff base costimulatory signalling and T-cell receptor signalling at the level of MAP kinase ERK2‚ Journal of Immunology‚ 1997‚ 159(5) : 2274-81

4.Potentiation of the immune system by Schiff base-forming drugs: Mechanism of action and therapeutic potential‚ BioDrugs‚ 1997,7(3):217-231

5.席夫鹼和免疫增強劑：作用機理及應用潛力：上海免疫學雜誌，中青年學者論壇，1998‚18(3):132-134

6.離子轉運抑制劑對席夫鹼增強免疫效應的影響：上海免疫學雜誌，2000‚20(3):145-147

7.抗HBeAg不同位點的單克隆抗體雜交瘤細胞株的製備及其應用:檢驗醫學，2006‚21(4):369-372

8.G蛋白偶聯受體及其信號傳導在免疫與炎症中的作用，現代免疫學，2009‚29(6): 441.

9.Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways. PLoS ONE 2011‚ 6(10): e27006.10.丁酸鈉及其G蛋白偶聯受體對T淋巴細胞的調節作用，現代免疫學，2012,32(5):362

11.A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-cells in Type 2 Diabetic Mice. PLoS ONE, 2015 Jul 24;10(7):e0134051. doi: 10.1371/journal.pone.0134051.

12.PubAngioGen: a database and knowledge for angiogenesis and related diseases. Nucleic Acids Research, 2015; 43(Database issue):D963-7

13.Lage genomic fragment deletion and functional cassette knock in via Cas9 protein mediated genome editing in one cell embryos. Sci Rep; 2015; 5:17517

14.LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat. Med. 2016, 22(5):539

15.Effects of Melanocortin 3 and 4 receptor deficiency on energy homostasis in rats. Sci Rep; 2016; 6:34938

16.A Betulinic acid derivative SH479 inhibits collagen-induced arthritis by modulating T cell differentiaion and cytokine balance. Biochem Rharmacol. 2017; 126:69-78

17.SH479, a betulinic acid derivative, ameliorates experimental autoimmune encephalomyelitis by regulating the Th17/Treg balance, Molecular Pharmacology. 2017; 91:1-12

18.Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress. Int J Cancer. 2017, 140(12):2734-2747.

19.Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. Atherosclerosis 2018, 271:26-35

20.Kisspeptin receptor GPR54 promotes adipocyte diffferentiation and fat accumulation in mice. Frontiers in Physiology,2018, 9:209

21.GPR54 Deficiency Reduces the Treg Population and Aggravates Experimental Autoimmune Encephalomyelitis in Mice, SCIENCE CHINA Life Sciences 2018, 61(6), 675–687

22.Novel Rat Models for Atherosclerosis, J Cardiol and Cardiovasc Sciences, 2018, 2(2): 29-33 ^[1] 

芳香雜環類小分子有機化合物及衍生物、製備方法及醫藥用，ZL2013 1 0429958.8

白樺脂酸衍生物在製備抑制T細胞分化的藥物中的應用，201310320606.9 ^[1] 

1. 參編Vaccines: New Advances in Technologies and Applications‚ Aug.1996‚ Edited by Ostriker‚ R.‚ Savage‚ L. M.‚ IBC publications‚Maryland.

2. 參編Vaccines II: New Advances in Technologies and Applications‚ 1997‚ Edited by Thibeault‚ C.A.‚ Davage‚L.M.‚ IBC publications‚ Maryland.

3. 《助你慧眼識免疫》編委：章谷生主編，上海市免疫學會組編，北京，科學出版社，2008年8月

4. 參編普通高等教育“十一五”國家級規劃教材《免疫學原理和技術》，錢旻主編，北京，高等教育出版社，2011年5月

5. 參編普通高等教育教材《分子細胞生物學》第三版，陳曄光主編，北京，高等教育出版社，2019年8月 ^[1]