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陳娟

（重慶醫科大學教授）

鎖定
陳娟，香港中文大學博士，研究員，博士生導師，重慶醫科大學檢驗醫學院副院長，感染性疾病分子生物學教育部重點實驗室副主任 [34]  ；中國青年女科學家獎獲得者 [32]  ，教育部青年長江學者 [1]  ，國家優秀青年基金獲得者 [2]  ，重慶市三八紅旗手 [33]  ，重慶英才·創新領軍人才(教育領域) [3]  ，重慶市高校創新羣體負責人 [2]  ，重慶市高等學校巴渝學者特聘教授 [4]  ; 中華醫學會微生物與免疫學會青年委員會副主任委員，中華醫學會肝病分會青年委員，重慶市免疫學會代謝免疫專業委員會副秘書長，重慶市生物化學與分子生物學會理事、重慶市科學技術協會第六屆委員會副主席。 [45]  主要致力於乙肝病毒基礎與臨牀研究，突破乙肝病毒研究領域的多項技術瓶頸，從乙肝病毒複製關鍵因子的發現、cccDNA表觀調控機制、乙肝病毒致癌機制到抗病毒藥物新靶點開發，並取得了一系列成果。 [5] 
中文名
陳娟 [5] 
國    籍
中國 [5] 
民    族
漢 [5] 
畢業院校
香港中文大學 [5] 
學位/學歷
博士 [5] 
職    業
教師
職    務
研究員 [5] 

目錄

  1. 1 個人簡介
  2. 2 代表性成果
  3. ▪ 通訊作者論文
  4. ▪ 第一作者論文
  5. 3 獲獎情況

陳娟個人簡介

陳娟，重慶醫科大學教授 [6]  ，博士生導師，教育部青年長江學者 [1]  ，國家優秀青年基金獲得者 [2]  ，重慶英才·創新領軍人才(教育領域) [3]  ，重慶市高校創新羣體負責人 [2]  ，重慶市高等學校巴渝學者特聘教授 [4]  。近年來在Hepatology、Oncogene、Clinical Cancer Research、Journal of Virology等國際期刊正式發表發表SCI收錄論文30餘篇(具體參見代表性成果部分)，單篇最高IF 14.07 分 [2]  。申請人先後主持國家自然科學基金6 項（國際合作項目1項） [2]  、重慶市自然科學基金計劃項目3 項、獲第五批重慶市高校支持計劃資助 [7]  、帶領的團隊獲得重慶市“高校創新研究羣體” [8]  ；作為研究骨幹參加國家科技部傳染病“十二五”、“十三五”重大專項 [6]  。Frontiers in Pharmacology 期刊編委，Journal of Virology、Frontiers in Pharmacology 等多個SCI 雜誌審稿人。

陳娟代表性成果

陳娟通訊作者論文

[1] Long QX, Liu BZ, Deng HJ, Wu GC, Deng K,Chen YK, Liao P, Qiu JF, Lin Y, Cai XF, Wang DQ, Hu Y, Ren JH, Tang N, Xu YY,Yu LH, Mo Z, Gong F, Zhang XL, Tian WG, Hu L, Zhang XX, Xiang JL, Du HX, Liu HW,Lang CH, Luo XH, Wu SB, Cui XP, Zhou Z, Zhu MM, Wang J, Xue CJ, Li XF, Wang L,Li ZJ, Wang K, Niu CC, Yang QJ, Tang XJ, Zhang Y, Liu XM, Li JJ, Zhang DC,Zhang F, Liu P, Yuan J, Li Q, Hu JL*, Chen J*,Huang AL*.Antibody responses toSARS-CoV-2 in patients with COVID-19. Nat Med. 2020 Jun;26(6):845-848. [35] 
[2] Long QX, Tang XJ, Shi QL, LiQ, Deng HJ, Yuan J, Hu JL, Xu W, Zhang Y, Lv FJ, Su K, Zhang F, Gong J, Wu B,Liu XM, Li JJ, Qiu JF, Chen J*, Huang AL*.Clinical and immunologicalassessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020Aug;26(8):1200-1204. [36] 
[3] Cheng ST, Hu JL, Ren JH, Yu HB, Zhong S, Wai Wong VK, Kwan Law BY, Chen WX, Xu HM,Zhang ZZ, Cai XF, Hu Y, Zhang WL, Long QX, Ren F, Zhou HZ, Huang AL*, Chen J*.Dicoumarol, an NQO1inhibitor, blocks cccDNA transcription by promoting degradation of HBx.J Hepatol. 2021 Mar;74(3):522-534. [37] 
[4] Zhou HZ, Li F, Cheng ST, Xu Y, Deng HJ, Gu DY, Wang J, Chen WX,Zhou YJ, Yang ML, Ren JH, Zheng L*, Huang AL*, Chen J*. DDX17-regulated alternativesplicing that produced an oncogenic isoform of PXN-AS1 to promote HCCmetastasis.Hepatology. 2022Apr;75(4):847-865. [40] 
[5]L Zhou, JH Ren, ST Cheng, HM Xu, WX Chen, DP Chen, VKW Wong, BYK Law, Y Liu, XF Cai, H Tang, HB Yu, JL Hu, Y Hu, HZ Zhou, F Ren, L He, ZW Hu, H Jiang, HY Xu, AL Huang*, J Chen*. A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein. Hepatology 2019 May;69(5):1885-1902. [9] 
[6] Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, Yang YF, Huang Y, Liu Y, Chen WX, Cai XF, Tang H, Hu Y, Zhang WL, Liu X, Long QX, Zhou L, Tao NN, Zhou HZ, Yang QX, Ren F, He L, Gong R, Huang AL, Chen J. SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases. Hepatology 2018 Oct;68(4):1260-1276. [10] 
[7] Long QX, Jia YJ, WangX, Deng HJ, Cao XX, Yuan J, Fang L, Cheng XR, Luo C, He AR, Tang XJ, Hu JL, HuY, Tang N, Cai XF, Wang DQ, Hu J, Qiu JF, Liu BZ, Chen J*, Huang AL*. Immune memory inconvalescent patients with asymptomatic or mild COVID-19. Cell Discov. 2021 Mar 25;7(1):18. [38] 
[8] LK Ran, Y Chen, ZZ Zhang, NN Tao, JH Ren, L Zhou, H Tang, X Chen, K Chen, WY Li, ALHuang，J Chen.SIRT6 overexpression potentiates apoptosis evasion in hepatocellular carcinomavia BCL2-associated X protein-dependent apoptotic pathway.Clinical Cancer Research 2016 ;22(13):3372-3382. [11] 
[9] CL Song, H Tang, LK Ran, BC Ko, ZZ Zhang, X Chen, JH Ren, NN Tao, WY Li, AL Huang ,J Chen.Sirtuin 3 inhibits hepatocellular carcinoma growth throughthe glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway.Oncogene 2016 ;35(5):631-641. [12] 
[10] JH Ren, Y Tao, ZZ Zhang, WX Chen, K Chen, CL Song, LK Ran, WY Li, AL Huang,J Chen.Sirtuin1 (SIRT1) regulates HBV transcription and replication by targeting transcription factor AP-1.Journal of Virolgoy2014; 88(5):2442-2451. [13] 
[11] Yu,Hai-Bo#; Cheng, Sheng-Tao#; Ren, Fang#; Chen, Yong; Shi, Xiao-Feng; Wong,Vincent Kam Wai; Law, Betty Yuen Kwan; Ren, Ji-Hua; Zhong, Shan; Chen,Wei-Xian;Xu, Hong-Mei; Zhang, Zhen-Zhen; Hu, Jie-Li; Cai, Xue-Fei; Hu, Yuan;Zhang, Wen-Lu; Long, Quan-Xin; He, Lin; Hu, Zhong-Wen; Jiang, Hui; Zhou,Hong-Zhong; Huang, Ai-Long*; Chen, Juan*; SIRT7 restricts HBV transcription andreplication through catalyzing desuccinylation of histone H3 associated withcccDNA minichromosome, Clinical Science, 2021, 135(12): 1505-1522 [39] 
[12] CL Song, JH Ren, LK Ran, YG Li , XS Li ,X Chen, WY Li , AL Huang,J Chen. Cyclin D2 plays a regulatory role in HBV replication.Virology2014, 462-463: 149–157. [14] 
[13] YW Wang, XF Shan, Z Liang,YL Shan, W Huang, D Zhang, AZ Zen, X Zhou,Y Zhao, XY Gong,G Xu,X Zhang, J Chen, AL Huang. Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy.PLoS ONE2015;10(6):e0131337. [15] 
[14] ST Cheng, H Tang, JH Ren, X Chen, AL Huang,J Chen. Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo.PLoS One2017;12(6):e0179605. [16] 
[15] JH Ren, X Chen, L Zhou, NN Tao, HZ Zhou, B Liu, WY Li, AL Huang,J Chen. Protective Role of Sirtuin3 (SIRT3) in Oxidative Stress Mediated by Hepatitis B Virus X Protein Expression.PLoS ONE2016 ;11(3):e0150961. [17] 
[16] Q He, WY Li, JH Ren, Y Huang, Q Hu,J Chen, WX Chen. ZEB2 inhibits HBV transcription and replication by targeting its core promoter.Oncotarget2016,7(13):16003-16011. [18] 
[17] NN Tao, JH Ren, H Tang, LK Ran, HZ Zhou, B Liu, AL Huang,J Chen. Deacetylation ofKu70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.Biochem BiophysRes Commun2017;485(4):713-719. [19] 
[18] ST Cheng, H Ren, XF Cai,H Jiang,J Chen. HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis.Biochem Biophys Res Commun2018 Jan 22 [Epub ahead of print]. [20] 
[19] ST Cheng, D Yuan, Y Liu, Y Huang, X Chen, HB Yu, L He, H Jiang, JH Ren,J Chen. Interleukin-35 Level Is Reduced in Patients with Chronic Hepatitis B Virus Infection.International Journal of Medical Sciences2018; 15(2): 188-194. [21] 
[20] WY Li, JH Ren, NN Tao, LK Ran, X Chen, HZ Zhou, B Liu, XS Li, AL Huang,J Chen.The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.ArchivesVirology2016 ;161(3):621-630. [22] 
[21] L Xu, Z Tu, G Xu, Y Wang, WL Pan, X Zhan, Q Luo, Y Huang,J Chen, AL Huang. Epirubicin directly promotes hepatitis B virus (HBV)replication in stable HBV-expressing cell lines:a novelmechanism of HBV reactivation following anticancer chemotherapy.Molecular Medicine Reports2014 ;9(4):1345-1350. [23] 

陳娟第一作者論文

[1]J Chen, AW Chan,KF To, W Chen, Z Zhang, JH Ren,CL Song, YS Cheung, PB Lai, SH Cheng, MH Ng, AL Huang, BCKo. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by Protein Kinase B/Glycogen Synthase Kinase-3β/β-Catenin Signaling.Hepatology2013 ;57(6):2287-2298. [24] 
[2] J Chen, B Zhang, N Wong, WI Lo, KF To, WH Chan, HL Ng, YS Ho, SH Cheng, BS Lai, J Yu, HK Ng, MT Ling, AL Huang, XF Cai, and BC Ko. Sirtuin 1 (SIRT1) is upregulated in a subset of hepatocellular carcinoma and is essential for tumor cell growth. Cancer Research 2011,71(12),4138-4149. [25] 
[3] L Wang, J Chen, Y Zeng, JWei, JJ Jing, G Li, L Su, XJ Tang, TC Wu, L Zhou. Functional Variant in the SLC22A3-LPAL2-LPA Geneluster Contributes to the Severity of Coronary Artery Disease. Arteriosclerosis Thrombosis and Vascular Biology 2016 ;36(9):1989-1996. [26] 
[4] C Zou,J Chen,K Chen, S Wang, YY Cao, J Zhang, Y Sheng, AL Huang, H Tang. Functional analysis of miR-181a and Fas involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.Experimental Cell Research2015 ;331(2):352-361. [27] 
[5] Q Fu, X Tang, J Chen, L Su, MZhang, L Wang, J Jing, L Zhou. Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.PLoS ONE2015;10(9):e0138652. [28] 
[6] ZZhang,J Chen,YHe,XZhan,RZhao,YHuang,HXu,ZZhu,QLiu. miR-125b inhibits hepatitis B virus expression in vitro throughtargeting of the SCNN1A gene. Archives of Virology 2014;159(12):3335-3343. [29] 

陳娟獲獎情況

[1] 研究論文入選重慶市科協首屆自然科學優秀學術論文,2016（見公示附件） [30] 
[2] 研究論文入選重慶市科協自然科學優秀學術論文,2017（見公示附件） [31] 
[3] 2021年3月4日，重慶市人力資源和社會保障局、市婦女聯合會決定，授予陳娟“重慶市三八紅旗手”榮譽稱號。 [33] 
[4] 2022年7月，榮獲第十七屆“中國青年女科學家獎”。 [32]  [41-42] 
[5]2022年，榮獲第十七屆中國青年科技獎。 [43] 
[6]2023年，被授予2022年度全國三八紅旗手稱號。 [44] 
[7]2023年12月，獲得吳孟超醫學青年基金獎。 [46] 
參考資料
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