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陳吉龍

（福建農林大學動物科學學院（蜂學學院）院長）

鎖定
陳吉龍，男，漢族，1965年8月出生，福建福州人，美國僑眷，研究生學歷，博士學位，致公黨黨員。現任福建農林大學動物科學學院院長、教授、博士生導師。 [1] 
國家973計劃項目首席科學家，享受國務院特殊津貼專家 [45]  ，福建省“閩江學者”，福建省“百人計劃”入選者，中國科學院“百人計劃”入選者 [2]  。曾任中國科學院微生物研究所二級研究員，研究組長，博士生導師，中國科學院大學崗位教授 [2]  。擔任中國致公黨第十五屆中央委員會委員 [9]  ，福建省第十二屆政協委員 [2]  [10]  ，福建省科協第九屆委員會委員 [2]  [8]  [11]  ，第十屆、第十一屆福建省僑聯兼職副主席 [4]  [37]  ，教育部高等學校動物醫學類專業教學指導委員會委員 [2]  [6]  ，美國微生物學會和美國細胞生物學會會員，《微生物學報》編委 [29]  。
中文名
陳吉龍
性    別
男
籍    貫
福建長樂
學    歷
博士研究生
職    稱
教授
出生日期
1965年8月

目錄

  1. 1 人物經歷
  2. 2 專業學術團體
  3. 3 科研方向
  1. 4 承擔課題
  2. 5 學術成就
  3. 6 社會任職
  1. 7 所獲榮譽
  2. 8 學術論著

陳吉龍人物經歷

1982-1986年 福建農林大學(原福建農學院)　學士 [2] 
1986-1989年 中國農業大學(原北京農業大學)　碩士 [2] 
1989-1992年　北京大學　博士 [5] 
1992-1993年　中國科學院遺傳與發育生物學研究所（原中國科學院發育生物學研究所）　助理研究員
1993-1994年　中國科學院發育生物學研究所　副研究員(中國科學院破格提拔)
1994-1998年　美國愛荷華大學（University of Iowa）生物化學系　博士後
1998-2000年　中國科學院發育生物學研究所，副研究員、研究員、研究組負責人、青年科學家創新小組負責人
2000-2008年　美國愛荷華大學（University of Iowa）醫學院訪問學者 研究員
2008年-至今　中國科學院“百人計劃”。中國科學院微生物研究所研究員（2017年起為兼職）、研究組負責人、博士生導師 [3] 
2013年-至今 福建農林大學動物科學學院院長，教授，博士生導師，福建省“百人計劃”入選者 [2] 
2017年12月當選福建省僑聯第十屆委員會兼職副主席 [4] 
2023年8月當選福建省僑聯第十一屆兼職副主席 [37]  。

陳吉龍專業學術團體

擔任中國畜牧獸醫學會獸醫公共衞生學分會副理事長 [2]  [7]  ，中國免疫學會獸醫免疫分會副理事長 [31]  ，中國畜牧獸醫學會動物傳染病學分會副理事長 [38]  。

陳吉龍科研方向

主要從事動物病原微生物與免疫學、病毒致癌機理等領域研究。 [2]  包括以下幾個研究方向：
1、流感病毒致病機理研究；
2、宿主抗病毒免疫的調控機制研究；
3、長鏈非編碼RNA與病毒感染、腫瘤發生的關係；
4、病毒感染和癌基因誘發腫瘤發生的分子機理。 [12] 
陳吉龍 陳吉龍

陳吉龍承擔課題

正在主持及主持過國家自然科學基金重大研究計劃培育項目、重點項目、面上項目、國家“973”計劃課題、國家科技重大專項課題、國家科技支撐專項課題等20多個項目。 [2] 
正在主持的項目：
（1）項目名稱：非細胞因子依賴性的宿主早期抗病毒免疫應答機制；經費來源：國家自然科學重點項目（聯合基金項目） [39]  ；
（2）項目名稱：動物流感病毒與宿主RNA 互作機制研究（2021YFD1800205）；經費來源：國家重點研發計劃課題 [40]  ；
（3）項目名稱：新鑑定的lncRNAs在流感病毒與宿主互作過程中的作用及其機制；經費來源：國家自然科學基金重點項目； [2] 
（4）項目名稱：STATs蛋白在宿主抗流感病毒天然免疫中的功能研究；經費來源：國家自然科學基金聯合基金項目（促進海峽兩岸科技合作聯合基金）； [13] 

陳吉龍學術成就

在國際上最早篩選、鑑定並命名了重要的長鏈非編碼 RNA--lncRNA NRAV，發現NRAV在抗病毒天然免疫反應中具有重要調控功能 [14]  ；在國際上首次應用Knockout小鼠模型，揭示了PIM激酶家族在Abl癌基因誘發淋巴細胞癌/白血病中的關鍵性作用；應用Knockout小鼠模型，揭示了Abl癌蛋白持續激活JAK/STAT信號通路的分子機理；系統地研究了病原微生物入侵機體後，T細胞活化的信號轉導通路。揭示了Itk/SLP76/PLC1信號通路的活化機制；系統地研究了一些小分子GTPase、分子馬達蛋白在細胞內物質轉運及其與細胞轉化癌變關係的分子機理。揭示了Cdc42和dynein在細胞內物質轉運中的關鍵性作用；深入地研究了細胞因子信號通路的負調控機制。闡明瞭細胞因子信號的抑制因子(SOCS1)的功能，並在國際上首次鑑定了SOCS1的磷酸化位點。 [15] 
在國內外重要學術刊物上發表論文80餘篇，授權專利4項，主編專著一本（高等教育出版社，ISBN: 7-04-005107-9），其中SCI論文60餘篇，在國際核心學術刊物 Lancet、The Lancet Infectious Diseases、Cell Host & Microbe、Nucleic Acids Research、Blood、PLoS Pathogens、PNAS、Cancer Research、Oncogene、Journal of Cell Biology、Neoplasia、Journal of Virology、Journal of Biological Chemistry、Veterinary Research、Veterinary Microbiology、Molecular Cancer等雜誌上發表了高水平研究論文。先後十多次應邀參加國際學術會議，多次在大會或分組會上做學術報告或主持會議，發表了30餘篇國際學術會議論文摘要。 [2] 

陳吉龍社會任職

福建省僑聯第十一屆委員會兼職副主席 [37] 

陳吉龍所獲榮譽

福建省自然科學獎二等獎（主持人） [30] 
第七屆中國僑界貢獻獎二等獎 [2] 
大北農科技獎創新獎二等獎 [2] 
中國科學院朱李月華優秀教師獎 [16] 
中國科學院微生物研究所優秀教師獎教金 [17] 
北京大學光華獎
北京農業大學（現為中國農業大學）科技進步二等獎
國家教委科技進步三等獎
《發育生物學進展》獲國家教委第三屆優秀教材中青年獎(第一作者)
中國科學院發育生物學研究所先進工作者
美國心臟協會研究獎(Research award) [3] 

陳吉龍學術論著

1.ShashaLiu#, Siya Liu#, Ziding Yu#, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, JinxuanHong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang and Ji-Long Chen*. STAT3 regulates antiviral immunity by suppressingexcessive interferon signaling. Cell Reports. 2023;42(7):112806. [41]  (*為通訊作者，下同)
2. KulRaj Rai#, Yuan Liao#, Mengjuan Cai#, Haori Qiu, Faxin Wen, Min Peng, Song Wang,Shasha Liu, Guijie Guo, Xiaojuan Chi, Mohamed Maarouf, Yuhai Chen, Shile Huang and Ji-Long Chen*. MIR155HG plays abivalent role in regulating innate antiviral immunity by encoding longnoncoding RNA-155 and microRNA-155-5p. mBio. 2022, e0251022 [42]  .
3. Yun Ma#, Guijie Guo#, Tingting Li, Faxin Wen, Jianling Yang,Biao Chen, Xuefei Wang and Ji‑Long Chen*. A novel imatinib-upregulated long noncoding RNA plays acritical role in inhibition of tumor growth induced by Abl oncogenes. Molecular Cancer. 2022, 21(1):5. [43] 
4. Yingying Li, Shasha Liu, Yuhai Chen, Biao Chen, Meng Xiao, Bincai Yang, Kul Raj Rai,Mohamed Maarouf, Guijie Guo* and Ji-Long Chen*. Syk facilitates influenza A virus replication by restraining innate immunityat the late stage of viral infection. Journal of Virology. 2022; doi:10.1128/jvi.00200-22 [51]  . [44] 
5. Shasha Liu Yuan Liao, Biao Chen, Yuhai Chen, Ziding Yu, Haitao Wei, Lianfeng Zhang, Shile Huang, Paul B. Rothman, George Fu Gao and Ji-Long Chen*. Critical role of Syk-dependent STAT1 activation ininnate antiviral immunity. Cell Reports, 2021,34(3):108627. doi:10.1016/j.celrep.2020.108627. [32] 
6. Meng Xiao, Yuhai Chen, Song Wang, Shasha Liu,Kul Raj Rai, Biao Chen, Fang Li, Yingying Li, Mohamed Maarouf and Ji-Long Chen*. Long Noncoding RNAIFITM4P regulates host antiviral responses by acting as a ceRNA. Journal of Virology, 2021, doi: 10.1128/JVI.00277-21. [33] 
7. Qingsen Wang, Wenliang Pan, Song Wang, Chen Pan, Hongya Ning, Shile Huang, Shih-Hsin Chiu* and Ji-Long Chen*. Protein tyrosine phosphatase SHP2 suppresses host innate immunity againstinfluenza A virus through regulating EGFR-mediated signaling. Journal of Virology, 2021,95(6):e02001-20. [34] 
8. Biao Chen, Yuhai Chen, Kul Raj Rai, Xuefei Wang,Shasha Liu, Yingying Li, Meng Xiao, Yun Ma, Guoqing Wang, Guijie Guo, Shile Huang and Ji-Long Chen*. Deficiencyof eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity. Frontiers in Immunology. 2021;12:723885. doi: 10.3389/fimmu.2021.723885. [35] 
9. Kul Raj Rai, Biao Chen, Zhonghui Zhao, YuhaiChen, Jiayue Hu, Shasha Liu, Mohamed Maarouf, Yingying Li, Meng Xiao, Yuan Liao and Ji-Long Chen*. Robustexpression of p27Kip1 induced by viral infection is critical for antiviralinnate immunity. Cellular Microbiology. 2020, e13242. [36] 
10. Jiayue Hu, George Fu Gao and Ji-Long Chen*. Strengthening the role of ethnic minority women in science and medicineinChina. Lancet, 2019;393(10171):527-528 [18]  .
11. Ye Chen, Jin Tian and Ji-Long Chen*. Challenges to eliminaterabies virus infection inChina by 2020. The Lancet Infectious Diseases, 2017,17(2): 135-136.
12. Fang Li, Yuhai Chen, Zhaoyuan Zhang, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, Guijie Guo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research, 2015; 43(21):10321-37.
13. Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George Fu Gao, Guoshun Wang and Ji-Long Chen*. NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. Cell Host & Microbe, 2014; 16(5):616-626.
14. Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George Fu Gao and Ji-Long Chen*. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathogens, 2014; 10(1):e1003845. [19] 
15. Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang and Ji-Long Chen*. Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to the viral replication by suppressing IFITM3 protein expression. Journal of Virology, 2014; 88(15):8375-8385 [46]  .
16.Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes. Cancer Research, 2013; 73(15): 4898-4908. [15] 
17.Song Wang, Hua Li, Yuhai Chen, Haitao Wei, George F.Gao. , Hongqiang Liu, Shile Huang and Ji-Long Chen*. Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42. The Journal of Biological Chemistry, 2012, 287 (13): 9804-9816. [15] 
18. Guijie Guo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, Runsheng Chen,Shile Huang and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediatedcellular transformation by acting as a competitive endogenous RNA. Oncogene, 2015;34(14):1768-1779.
19.Ji-Long Chen, Andre Limnander and Paul B. Rothman. Pim-1 and Pim-2 kinases are required for Pre-B cell transformation by v-Abl oncogene. Blood, 2008,111(3):1677-1685. [15] 
20. Guijie Guo, Xiaoxue Qiu, Song Wang, Yuhai Chen, Paul B. Rothman, Zixu Wang, Yaoxing Chen, Guoshun Wang and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene, 29, 3845–3853, 2010. [15] 
21.Xuefei Wang, Shile Huang and Ji-Long Chen*. Understanding of leukemic stem cells and their clinical implications. Molecular Cancer, 2017; 16(1):2. [20] 
22. Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen*. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway. Molecular Cancer, 2019,18(1):84-95. [21] 
23. Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, Yanhui Xie, Sicheng Shu, Yuan Liao and Ji-Long Chen*. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Veterinary Research, 2018,49(1):98. [22] 
24. Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, Guijie Guo, Jing Zhang, Sheng-Ming Dai, Huji Xu and Ji-Long Chen*. Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23. Frontiers in Immunology. 2018 Nov 14;9:2641. doi: 10.3389/fimmu.2018.02641. eCollection 2018. [23] 
25. Riyue Feng, Xuefei Wang, Ke Chen, Guijie Guo, Yuan Liao, Liping Sun, Shile Huang and Ji-Long Chen*. Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis. Neoplasia, 2018,20(11):1095-1105. [24] 
26. Xiaoyong Chen, Shasha Liu, Mohamed Maarouf, Shile Huang and Ji-Long Chen*. Host immune response to influenza A virus infection. Frontiers in Immunology. 2018; 9:320. [25] 
27. Shi-long Chen, Guifeng Luo, Zhou Yang, Shuncheng Lin, Shaoying Chen, Song Wang, Mohsan Ulah Goraya, Xiaojuan Chi, Xiancheng Zeng and Ji-Long Chen*. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways. Veterinary Research, 2016; 47(1):74.
28. Jingyun Wei, Yanmei Ma, Long Wang, Xiaojuan Chi, Ruoxiang Yan, Song Wang, Xinxin Li, Xiaoyong Chen, Wenhan Shao and Ji-Long Chen*. Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection. Veterinary Microbiology. 2017; 203:234-244. [26] 
29. Binxiang Cai, Qingling Bai, Xiaojuan Chi, Mohsan Ullah Goraya, Long Wang, Song Wang, Biao Chen and Ji-Long Chen*. Infection with classical swine fever virus induces expression of type III interferons and activates innate immune signaling. Frontiers in Microbiology, 2017;8:2558. [27] 
30. Song Wang, Chao Chen, Zhou Yang, Xiaojuan Chi, Jing Zhang and Ji-Long Chen*. Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome. Scientific Reports, 2016；6:23746.
31. Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, Ziding Yu ,Binxiang Cai, Ji-Long Chen* and Hongwei Liu*. 3-anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein & cell, 2016; 7(11):839-843. [2] 
32. Zhilong Chen, Guifeng Luo, Quanxi Wang*, Song Wang*, Xiaojuan Chi, Yifan Huang, Haitao Wei, Baocheng Wu, Shile Huang and Ji-Long Chen*. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Veterinary Microbiology, 2015; 175(2-4):232-243.
33. Mohsan Ullah Goraya, Song Wang, Muhammad Munir and Ji-Long Chen*. Induction of innate immunity and its perturbation by influenza viruses. Protein & Cell, 2015;6(10):712-721. [28] 
34. Qinghuang Chen, Ke Chen, GuijieGuo, Fang Li, Chao Chen, Song Wang, Grzegorz Nalepa, Shile Huang and Ji-Long Chen*. A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis. PLoS One, 2014;9(10):e111611. [2] 
35. Guijie Guo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan and Ji-Long Chen*. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced byBcr-Abloncogene. FEBS Letters, 2014; 588(9):1780-1786. [2] 
36. Jing Ouyang, Jiayue Hu and Ji-long Chen*. lncRNAs regulate the innate immune response to viralinfection. Wiley Interdisciplinary Reviews-RNA, 2016, 7(1):129-143 [47]  .
37. Ji-Long Chen, Raymond V.Fucini, Lynne Lacomis, Hediye Erdjument-Bromage, Paul Tempst and Mark Stamnes*. Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. Journal of Cell Biology, 2005, 169(3):383-389 [50]  .
38. Ji-Long Chen, Kathryn L.Huisinga, Michaela M. Viering, Sharon A. Ou, C.-ting Wu and Pamela K. Geyer*. Enhancer action in trans is permitted throughout the Drosophila genome. Proceedings of The National Academy of Sciences of The United States of America, 2002, 99(6):3723-3728 [48]  .
39. Ji-Long Chen, Jatinder P.Ahluwalia and Mark Stamnes*. Selective effects of calcium chelators on anterogradeand retrograde protein transport in the cell. Journal of Biological Chemistry, 2002,277(38):35682-7 [49]  .
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