李曉濤

1989 重慶醫科大學, M.D

1989-1992 重慶醫科大學附屬第一醫院，住院醫師，主治醫師。

1992-1995 美國德克薩斯大學生物醫學研究院 Research Fellowship

1995-2001 美國UT M.D. Anderson癌症中心Graduate Research Assistant。

2001 美國德克薩斯大學生物醫學研究院, M.D. Anderson癌症中心Ph.D.

2001-2005 美國Baylor醫學院, Postdoctoral Associate。

2005-2006 美國Baylor醫學院, Instructor.

2006-2007．8月 美國Baylor醫學院, Assistant Professor.

2007．8月 至今 華東師範大學，教授(當時已全職回華東師範大學工作)

我們後來在REGγ（一種蛋白酶體激活因子）介導的非泛素依賴的蛋白酶體（proteasome）降解通路的研究中首次發現並證實了REGγ蛋白複合體的第一個生物學靶位點。該發現突破了REGγ僅具有降解短肽鏈模型底物的禁區，並提出了REGγ可以直接降解細胞內完整生物蛋白的新理論（Cell Jan., 2006）。我們的最新研究（Mol.Cell June, 2007）進一步發現了REGγ-蛋白酶體的多種靶蛋白，而這些蛋白質對細胞週期/腫瘤發生發展的調控起着重要的作用。這些研究結果都進一步揭示了REGγ（一種蛋白酶體激活因子）介導的降解通路的生物學意義。

我們今後的重點研究方向包括：REGγ與蛋白質降解原理及調控的基礎理論研究;REGγ與惡性腫瘤發生發展機制的研究;REGγ的病理生理學;REGγ相關的抗癌藥物探索;脊椎動物中REGγ的生物學作用。

科研項目：

主持並參與了多項美國NIH研究項目。

目前參與上海市科委"細胞信號轉導網絡研究技術"研發公共服務平台。

當時主持的科研項目受教育部“985”人才基金的資助。

科研成果：

1. Li X, Larbi Amazit, Weiweng Long, David M. Lonard, John J. Monaco and

O’Malley B.W. Proteolytic turnover of p21 by the REGgamma-proteasome pathway. (2007) (Mol. Cell, 26, 831-842)

2. Li X., Lonard D., Jung S.Y., Malovannaya A., Feng Q., Qin J., Tsai S. Y., Tsai M-J., and O’Malley B.W. The SRC-3/AIB1 coactivator is degraded in an ubiquitin- and ATP-independent manner by the REGg-proteasome (2006) Cell. 124, 381-392.

3. Verma S., Ismail A., Gao X., Fu G., Li X., O’Malley B. W., Nawaz Z. Ubiquitin-conjugating enzyme, UBCH7 act as a coactivator for steroid hormone receptors. (2004) Mol. Cell. Biol. 24, 8716-26.

4. Li X. Lonard D. M. and O’Malley B. W. A Contemporary Understanding of Progesterone Receptor Function (Review). (2004) Mechanisms of Aging and Development. 125, 669-78.

5. Auboeuf D., Dowhan D.H., Li X., Larkin K., Ko L., Berget S.M., O''''Malley B.W. CoAA, a Nuclear Receptor Coactivator Protein at the Interface of Transcriptional Coactivation and RNA Splicing. (2004). Mol. Cell. Biol. 24, 442-53.

6. Li X. and O''''Malley B.W. Unfolding the action of progesterone receptors (minireview). (2003). J. Biol. Chem. 10, 39261-4.

7. Li X., Wong J., Tsai S.Y., Tsai M.J., and O''''Malley B.W. (2003). Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol. Cell. Biol. 23, 3763-73.

8. Li X., Bhattacharya C., Maity S., Dayal S, and Klein W.H. (2002). Ectoderm Gene Activation in Sea Urchin Embryos Mediated by CCAAT Binding Factor CBF. Differentiation. 70, 109-19

9. Angerer L.M., Oleksyn D. W., Levine A.M., Li X., Klein W.H. and Angerer R. (2001). Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Development. 128, 4393-404

10. Yuh C., *Li X., Davidson E.H., and Klein W.H. (2001). Correct Expression of Spec2a in the Sea Urchin Embryo Requires Both Otx and Other cis-Regulatory Elements. Dev. Biol. 232, 424-438

11. Huang L., *Li X., El-Hodiri H.M., Dayal S., Athula H.W., and Klein W.H. (2000). Involvement of Tcf/Lef in Establishing Cell Types along the Animal-Vegetal Axis of Sea Urchins. Dev. Genes Evol. 210, 73-81.

12. Li X., Athula HW and Klein WH. (1999). Requirement of SpOtx in Cell Fate Decisions in the Sea Urchin Embryo and Possible Roles as a Mediator of b-Catenin Signaling. Dev. Biol. 212, 425-439

13. Klein W.H. and Li X. (1998). Function and Evolution of Otx Proteins. Biochem. Biophys. Res. Commun. 258, 22-34

14. Li X., Chuang C.K., Mao C.A., Angerer L.M., and Klein WH. (1997). Two Otx proteins generated from alternative splicing of multiple transcripts of a single gene in Strongylocentrotus purppuratus. Dev. Biol. 187, 253-266

15. Chuang C.K., Athula H.W., Mao C.A., Li X. and Klein W.H. (1996). Transient Appearance of S. purpuratus Otx in Micromere Nuclei: Cytoplasmic Retention of SpOtx Mediated Through an a-Actinin SH3 Domain. Dev. Genetics 19, 231-239

16. Li X., Weinstock G.M. and Murray B.E. (1995). Generation of Auxotrophic mutants of Enterococcus faecalis. J. Bacteriol. 177, 6866-6873

1.Research Achievement Award, Genes and Development Program， UT M.D. Anderson Cancer Center, 2001.

2.Ruth L.Kirschstein National Research Service Award, NIH 2003

3.Award for Scientific Presentations in the Society of Chinese Bioscientists in North America-Texas Annual Symposium, 2003-2005

4.The Endocrine Society Award, 87th Annual Meeting of the Endocrine Society, San Diego, 2005