李大偉

1981.9-1985.7 河南農業大學植保專業 本科生

1985.7-1988.8 河南農業大學植保系 助教

1988.9-1991.7 瀋陽農業大學植物病理學專業 碩士研究生

1991.9-1995.3 北京農業大學植物病理學專業 博士研究生

1995.12-1997.11 中國科學院遺傳所 博士後

1997.12-2002.12 中國農業大學農業生物技術國家重點實驗室 副教授

1999.11-2002.8 美國 University of Colorado Health Sciences Center 生化與分子遺傳學系 博士後

2002.12-今 中國農業大學生物學院微生物學與免疫學系及農業生物技術國家重點實驗室 教授、博士生導師

2007.3-2007.9 美國Oregon State University的James Carrington教授實驗室高級研究學者

2014-2022 中國植物病理學會 理事

《植物病理學報》、《生物工程學報》 編委 ^[1] 

主要從事分子植物病毒學的基礎理論及應用基礎研究。近年來以大麥條紋花葉病毒 (Barley stripe mosaic virus，BSMV) 為研究重點, (1) 分析BSMV編碼蛋白之間的相互作用、表達調控及其在病毒複製、移動和致病性中的作用； (2)BSMV編碼蛋白的翻譯後修飾及其功能分析；(3)BSMV與寄主植物的相互作用的分子機制, 包括關鍵致病因子及其氨基酸的鑑定、病毒蛋白-寄主蛋白互作的生物學功能分析等。 ^[1] 

本科生《病毒學》

研究生《生命科學文獻研讀（微生物專業）》

研究生《科技論文寫作》（主持） ^[1] 

Gerda Szakonyi, Joel M Guthridge, Dawei Li, Young Kendra, Michael V Holers, Xiaojiang S Chen, 2001, Structure of complement receptor 2 in complex with its C3d ligand, Science, 292: 1725-1728.

Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang, DeCaprio James, Ellen Fanning, Gerda Szakonyi, Xiaojiang S Chen, 2003, Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen, Nature, 423: 512-518.

Dahai Gai, Dawei Li, Carla V Finkielstein, Robert D Ott, Poonam Taneja, Ellen Fanning, Xiaojiang S Chen, 2004, Insights into the oligomeric states, conformational changes and helicase activities of SV40 large tumor antigen, Journal of Biological Chemistry, 279: 38952-38959.

Dahai Gai, Rui Zhao, Dawei Li, Carla V Finkielstein, Xiaojiang S Chen, 2004, Mechanisms of conformational change for a replicative hexameric helicase of SV40 large T antigen, Cell, 119: 47-60.

Lihua Guo, Yunhe Cao, Dawei Li, Shengniao Niu, Zhunan Cai, Chenggui Han, Yafeng Zhai, Jialin Yu, 2005, Analysis of nucleotide sequences and multimeric forms of a novel satellite RNA associated with Beet black scorch virus, Journal of Virology, 79: 3664-3674.

Yunhe Cao, Xuefeng Yuan, Xiaoxing Wang, Lihua Guo, Zhunan Cai, Chenggui Han, Dawei Li*, Jialin Yu, 2006, Effect on viral pathogenicity of Beet black scorch virus coat protein, Progress in Biochemistry and Biophysics, 33: 127-134.

Zhaohui Wang, Shuoguo Fang, Zhiyan Zhang, Chenggui Han, Dawei Li*, Jialin Yu, 2006, Development of an ID-ELISA for the detection of Rice black-streaked dwarf virus in plants, Journal of Virological Methods, 134: 61-65.

Xuefeng Yuan, Yunhe Cao, Dehui Xi, Lihua Guo, Chenggui Han, Dawei Li*, Yafeng Zhai, Jialin Yu, 2006, Analysis of the subgenomic RNAs and the small ORFs of Beet black scorch virus by in vitro transcripts, Journal of General Virology, 78: 3077-3086.

Dehui Xi, Jiang Li, Chenggui Han, Dawei Li*, Jialin Yu, Xueping Zhou, 2008, Complete nucleotide sequence of a new strain of Tobacco necrosis virus A infecting soybean in China and infectivity of its full-length cDNA clone, Virus Genes, 36: 259-266.

Montgomery T A, Howell M, Cuperus J T, Dawei Li, Alexander A, Chapman E J, Fahlgren N, Allen E, and James C Carrington, 2008, Specificity of ARGONAUTE7-miR390 interaction and dual functionality of ARGONAUTE7-miR390 complexes in TAS3 trans-acting siRNA formation, Cell, 133: 128-141.

Yongliang Zhang, Jiang Li, Heng Pu, Jin Jin, Xiaofeng Zhang, Mingkuan Chen, Bin Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2010, Development of Tobacco necrosis virus A as a vector for efficient and stable expression of FMDV VP1 peptides, Plant Biotechnology Journal, 8(4): 506-523.

Bo Zhou, Yongliang Zhang, Xianbing Wang, Jiangli Dong, Bin Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2010, Oral administration of plant-based rotavirus VP6 induces antigen-specific IgAs, IgGs and passive protection in mice, Vaccine, 28(37): 6021-6027.

Yanhong Han, Haiying Xiang, Qian Wang, Yuanyuan Li, Wenqi Wu, Chenggui Han, Dawei Li, Jialin Yu, 2010, Ring structure amino acids affect the suppressor activity of Melon aphid-borne yellows virus P0 protein. Virology, 406(1): 21-27.

Yanjing Zhang, Xiaofeng Zhang, Shaofang Niu, Chenggui Han, Jialin Yu, Dawei Li*, 2011, Nuclear localization of Beet black scorch virus capsid protein and its interaction with importin a, Virus Research, 155(1): 307-315.

Cheng Yuan Cui Li, Lijie Yan, Andrew O Jackson, Zhiyong Liu, Chenggui Han, Jialin Yu, Dawei Li*, 2011, A high throughput Barley stripe mosaic virus vector for virus induced gene silencing in monocots and dicots, PLoS ONE, 6: e26468.

Yu Cui, Mi Yeon Lee, Naxin Huo, Jennifer Bragg, Lijie Yan, Cheng Yuan, Cui Li, Sara J. Holditch, Jingzhong Xie, Ming-Cheng Luo, Dawei Li, Jialin Yu, Joel Martin, Wendy Schackwitz, Yong-Qiang Gu, John P. Vogel, Andrew O. Jackson, Zhiyong Liu, David F. Garvin, 2012, Fine mapping of the Barley stripe mosaic virus resistance gene Bsr1 in the model grass Brachypodium distachyon, PLoS ONE, 7(6): e38333.

Xiuchun Zhang, Xiaofeng Zhang, Jasleen Singh, Dawei Li, and Feng Qu, 2012, Temperature-dependent survival of Turnip crinkle virus -infected Arabidopsis plants relies on an RNA silencing-based defense that requires DCL2, AGO2, and HEN1, Journal of Virology, 86: 6847-6854.

Xiaohui Wang, Yanjing Zhang, Jin Xu, Lindan Shi, Huiyan Fan, Dawei Li, Chenggui Han, Jialin Yu, 2012, The R-rich motif of Beet black scorch virus P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity, Virus Research, 167(2): 207-218.

Jin Xu, Xianbing Wang, Lindan Shi, Yuan Zhou, Dawei Li, Chenggui Han, Ziding Zhang, Jialin Yu, 2012, Two distinct sites are essential for virulent infection and support of variant satellite RNA replication in spontaneous Beet black scorch virus variants. Journal of General Virology, 93(12): 2718-2728.

Mi Yeon Lee，Lijie Yan，Florien A. Gorter, Brian Y.T. Kim, Yu Cui, Yue Hu, Cheng Yuan, Jessica Grindheim, Uma Ganesan, Zhiyong Liu, Chenggui Han, Jialin Yu, Dawei Li*, Andrew O. Jackson*, 2012, Brachypodium distachyon Bd3-1 resistance is elicited by the Barley stripe mosaic virus Triple Gene Block 1 movement protein. Journal of General Virology, 93(12): 2729-2739. (Cover story)

Xiuling Cao, Yingui Lu, Dianping Di, Zhiyan Zhang, He Liu, Lanzhi Tian, Aihong Zhang, Yanjing Zhang, Lindan Shi, Bihong Guo, Jin Xu, Xifei Duan, Xianbing Wang, Chenggui Han, Hongqin Miao*, Jialin Yu*, Dawei Li*, 2013, Enhanced virus resistance in transgenic maize expressing a dsRNA-specific endoribonuclease gene from E. coli. PLoS ONE, 8(4): e60829.

Xiaofeng Zhang, Xiaofei Zhao, Yanjing Zhang, Shaofang Niu, Feng Qu, Yongliang Zhang, Chenggui Han, Jialin Yu, Dawei Li*, 2013, N-terminal basic amino acid residues of Beet black scorch virus capsid protein play a critical role in virion assembly and systemic movement, Virology Journal, 10(1): 200.

Kun Zhang, Shaofang Niu, Dianping Di, Lindan Shi, Deshui Liu, Xiuling Cao, Hongqin Miao, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li, Yongliang Zhang, 2013, Selection of reference genes for gene expression studies in virus-infected monocots using quantitative real-time PCR. Journal of Biotechnology, 168(1): 7-14.

Tao Zhuo, Yuanyuan Li, Haiying Xiang, Zhanyu Wu, Xianbin Wang, Ying Wang, Yongliang Zhang, Dawei Li, Jialin Yu, Chenggui Han, 2014. Amino acid sequence motifs essential for P0-mediated suppression of RNA silencing in an isolate of Potato leafroll virus from Inner Mongolia. Molecular Plant-Microbe Interactions, 27(6): 515-527.

Xiuling Cao, Xuejiao Jin, Xiaofeng Zhang, Ying Li, Chunyan Wang, Xianbing Wang, Jian Hong, Xiaofeng Wang, Dawei Li, Yongliang Zhang*, 2015. Morphogenesis of endoplasmic reticulum membrane-invaginated vesicles during Beet black scorch virus infection: role of auxiliary replication protein and new implications of three-dimensional architecture. Journal of Virology, 89(12): 6184-6195.

Xiaofei Zhao, Xiaoling Wang, Kai Dong, Yongliang Zhang, Yue Hu, Xin Zhang, Yanmei Chen, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2015, Phosphorylation of Beet black scorch virus coat protein by PKA is required for the assembly and stability of virus particles. Scientific Reports, 5: 11585.

Yue Hu，Zhenggang Li, Cheng Yuan, Xuejiao Jin, Lijie Yan, Xiaofei Zhao, Yongliang Zhang, Andrew O. Jackson, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2015, Phosphorylation of TGB1 by protein kinase CK2 promotes Barley stripe mosaic virusmovement in monocots and dicots, Journal of Experimental Botany, 66 (15): 4733-4747.

Kai Dong, Ying Wang, Zhen Zhang, Long-Xiang Chai, Xin Tong, Jin Xu, Dawei Li, Xian-Bing Wang, 2016, Two amino acids near the N terminus of Cucumber mosaic virus 2b play critical roles in the suppression of RNA silencing and viral infectivity, Molecular Plant Pathology, 17(2): 173–183.

Jin Xu, Deshui Liu, Yongliang Zhang, Ying Wang, Chenggui Han, Dawei Li, Jialin Yu, Xian-Bing Wang, 2016, Improved pathogenicity of a Beet black scorch virus variant by low temperature and co-infection with its satellite RNA. Frontiers in Microbiology, 7: 1771.

Guoxin Wang, Ling Wang, Yu Cui, Meihua Yu, Chen Dang, Hao Wang, Xuejiao Jin, Lijie Yan, Qiuhong Wu, Dawei Li, Zhiyong Liu, 2017, RNA-seq analysis of Brachypodium distachyon responses to Barley stripe mosaic virus infection, The Crop Journal, 5(1): 1-10.

Xiao-Feng Zhang, Rong Sun, Qin Guo, Shaoyan Zhang, Tea Meulia, Randal Halfmann, Dawei Li, Feng Qu*, 2017, A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus, PLoS Pathogens, 13(3): e1006253.

Kun Zhang, Yongliang Zhang，Meng Yang, Songyu Liu, Zhenggang Li, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2017, The Barley stripe mosaic virus γb protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes, PLoS Pathogens, 13(4): e1006319.

Michael J. Adams, Scott Adkins, Claude Bragard, David Gilmer, Dawei Li, Stuart A. MacFarlane, Sek-Man Wong, Ulrich Melcher, Claudio Ratti, Ki Hyun Ryu, ICTV Report Consortium, 2017, ICTV virus taxonomy profile: Virgaviridae.Journal of General Virology, 98(8): 1999-2000.

Zhihao Jiang, Zhaolei Li, Ning Yue, Kun Zhang, Dawei Li, Yongliang Zhang*, 2018, Construction of infectious clones of lychnis ringspot virus and evaluation of its relationship with barley stripe mosaic virus by reassortment of genomic RNA segments, Virus Research,243: 106-109.

Xuejiao Jin, Zhihao Jiang, Kun Zhang, Pengfei Wang, Xiuling Cao, Ning Yue, Xueting Wang, Xuan Zhang, Yunqin Li, Dawei Li, Byung-Ho Kang, Yongliang Zhang*, 2018, Three-dimensional analysis of chloroplast structures associated with virus infection, Plant Physiology, 176(1): 284-294.

Xiaoling Wang，Xiuling Cao，Min Liu, Ruiqi Zhang, Xin Zhang, Zongyu Gao, Xiaofei Zhao, Kai Xu, Dawei Li, Yongliang Zhang*, 2018, Hsc70-2 is required for Beet black scorch virus infection through interaction with replication and capsid proteins, Scientific Reports, 8: 4526.

Meng Yang, Zhenggang Li, Kun Zhang, Xuan Zhang, Yongliang Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Kai Xu*, Dawei Li*, 2018, Barley stripe mosaic virusγb interacts with glycolate oxidase and inhibits peroxisomal ROS production to facilitate virus infection, Molecular Plant, 11(2): 338-341.

Zhenggang Li, Yongliang Zhang, Zhihao Jiang, Xuejiao Jin, Kun Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2018, Hijacking of the nucleolar protein fibrillarin by TGB1 is required for cell-to-cell movement of Barley stripe mosaic virus, Molecular Plant Pathology, 19(5): 1222-1237.

Xuan Zhang, Kai Dong, Kai Xu, Kun Zhang, Xuejiao Jin, Meng Yang, Yongliang Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2018, Barley stripe mosaic virus infection requires PKA-mediated phosphorylation of γb for suppression of both RNA silencing and host cell death response, New Phytologist, 218(4): 1570-1585.

Meng Yang, Yongliang Zhang, Xialin Xie, Ning Yue, Xianbing Wang, Chenggui Han, Jialin Yu, Yule Liu*, Dawei Li*, 2018, Barley stripe mosaic virus γb subverts autophagy to promote viral infection by disrupting the ATG7-ATG8 interaction, Plant Cell, 30（7）1582-1585 ^[1] 

甜菜黑色焦枯病毒作為外源基因的表達載體（ZL02155378.5） ^[1] 

獲國家教委科技進步一等獎（1997）

北京市科學技術二等獎（2002）

教育部二等獎（自然科學類）（2003）

2003年度國家傑出青年科學基金獲得者。

河南省科學技術進步二等獎（2008） ^[1]