-
文學軍
鎖定
- 中文名
- 文學軍
- 籍 貫
- 河南林州
- 出生日期
- 1971年5月24日
- 畢業院校
- 美國猶他大學
- 教學職稱
- 教授
- 性 別
- 男
文學軍教育經歷
1997年畢業於浙江大學材料科學與工程學院，獲碩士學位。
1998年5月至1999年8月就讀於美國辛辛那提大學材料科學與工程學專業，獲碩士學位。
1999年9月至2003年6月就讀於美國猶他大學生物醫學工程專業，獲博士學位。
文學軍工作經歷
2012年1月，創建蘇州睿研納米醫學科技有限公司，擔任董事長。
2013年6月，創立杭州睿凱生物科技有限公司，擔任董事長和首席科學家。
文學軍主要成就
率先研發了天然改性抗細菌生物膜材料——塑化蛋白抑菌納米塗層技術併產業化
[8]
，開發了高活性超短繞圈狀（looped）全合成多肽
[9]
用於幹細胞培養，來替代細胞外基質的大分子蛋白質和生長因子
[9]
。和張寧教授
[10-11]
一起發明了用於腦損傷和中風修復的可注射型水凝膠，可在無外源性幹細胞移植的條件下，利用內源性幹細胞實現受損區域的網絡化血管重建和神經再生，使失去知覺的鼠模型恢復到正常水平
[12]
。該成果於2009年9月份受到BBC
[13]
, Discovery
[14]
等媒體的關注報道。發明了用於急性脊髓損傷的再生材料
[15]
，在大鼠動物模型上實現了受損脊椎神經的再生和修復，修復後的動物運動能力恢復BBB評分超過10
[15]
。利用計算機輔助和三維打印技術製造出與原生椎間盤最近似的椎間盤替代產品——高仿生椎間盤
[16]
，2011年3月被美國麻省理工學院（MIT）TechnologyReview進行了專題介紹
[17]
。首次採用非細胞移植的方法，利用自體內源性幹細胞在兔動物模型上實現了功能性透明軟骨的再生，再生的軟骨高度表達透明軟骨特異的II型膠原蛋白
[18]
。
持有89項世界領先的核心技術，在2007-2014年間主持和參與30多個科研項目，總經費超過3000萬美元。
2008年榮獲美國國家科學基金青年科學家成就獎
[19-20]
。2012年當選世界生物工程領域聲譽最高的學術組織美國醫學與生物工程院（American Institute for Medical and BiologicalEngineering）院士（Fellow）
[1]
。獲得Sigma XI傑出青年科學家年度獎（2008）
[21]
，克萊門森大學校董事會獎（2008、2009、2010、2011、2012）
[22]
，克萊門森大學McQueen-Quattlebaum成就獎（2010），Michael J. Fox基金會應用人幹細胞治療帕金森病獎（2005）
[23-24]
，Coulter基金會生物工程技術臨牀轉化獎（2006），蘇州工業園區科技領軍人才（2011）
[25]
和蘇州市姑蘇領軍人才計劃（2013）
[26]
。
截止2014年10月，在《Progress in Polymer Science》
[27-28]
、《FASEB Journal》
[29]
、《Advanced Functional Materials》
[30]
、《Advanced healthcare Materials》
[31]
、《Journal of Neuroscience》
[32]
、《Biomaterials》
[33-35]
等學術期刊上發表論文100多篇。
2015年2月，在Elsevier發佈的2014年中國高被引學者（Most Cited Chinese Researchers）榜單中，位居生物醫學工程領域第一名
[36]
。
2009年，在文學軍院士主導下，美國弗吉尼亞聯邦大學再生醫學實驗室、生物製造實驗室共建併成立“NOVIS生物科技聯合實驗室”
[38]
，開展NAD+抗衰老研發與轉化課題項目。文學軍團隊利用再生醫學和生物工程將諾貝爾NAD+逆轉衰老科研成果成功實現產品化，並將其命名為諾維斯(NOVIS)。央視《影響力時代》欄目特邀文學軍教授做客欄目，與知名主持人水均益一起暢享生命科學未來。該成果受到美通社、華爾街、美國先驅日報、美國晨報等國際媒體關注。2019年8月31日，未來健康前沿學術高峯論壇——暨諾維斯“未來生命標準”新聞發佈會在國家會議中心隆重召開。
[39]
文學軍核心技術
3. Fabrication Of Nanofiber Reinforced Structures For Tissue Engineering; WO/2010/096795
5. Fabrication of three dimensional aligned nanofiber array; USPTO Issue # US 8580181 B1
6. Novel Material and Method for the Programmed Treatment of Diabetic Ulcers or Periodontal Diseases; ID: 12/856299
7. Injectable hydrogels prepared via synergic covalent and ionic crosslinking.
9. Delivery Devices And Methods For Long-Term Delivery Into Ear And Eye
10. Devices And Methods For Improved Viability Of Transplanted Cells
等80多項技術。
文學軍主要論文
1. Beachley, V. and X. Wen, Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions. Progress in Polymer Science, 2010. 35(7): p. 868-892.
[27]
2. Li, X., E. Katsanevakis, X. Liu, N. Zhang, and X. Wen, Engineering neural stem cell fates with hydrogel design for central nervous system regeneration. Progress in Polymer Science, 2012. 37(8): p. 1105-1129.
[28]
3. Beachley, V., E. Katsanevakis, N. Zhang, and X. Wen, A Novel Method to Precisely Assemble Loose Nanofiber Structures for Regenerative Medicine Applications. Advanced Healthcare Materials, 2013. 2(2): p. 343-351.
[31]
4. Deng, L.-X., P. Deng, Y. Ruan, Z.C. Xu, N.-K. Liu, X. Wen, G.M. Smith, and X.-M. Xu, A Novel Growth-Promoting Pathway Formed by GDNF-Overexpressing Schwann Cells Promotes Propriospinal Axonal Regeneration, Synapse Formation, and Partial Recovery of Function after Spinal Cord Injury. Journal of Neuroscience, 2013. 33(13): p. 5655-5667.
[32]
5. Li, X., X. Liu, L. Cui, C. Brunson, W. Zhao, N.R. Bhat, N. Zhang, and X. Wen, Engineering an in situ crosslinkable hydrogel for enhanced remyelination. Faseb Journal, 2013. 27(3): p. 1127-1136.
[29]
6. Li, X., X. Liu, B. Josey, C.J. Chou, Y. Tan, N. Zhang, and X. Wen, Short Laminin Peptide for Improved Neural Stem Cell Growth. Stem Cells Translational Medicine, 2014. 3(5): p. 662-670.
[44]
7. Wen, X.J. and P.A. Tresco, Fabrication and characterization of permeable degradable poly(DL-lactide-co-glycolide) (PLGA) hollow fiber phase inversion membranes for use as nerve tract guidance channels. Biomaterials, 2006. 27(20): p. 3800-3809.
[33]
8. Wen, X.J. and P.A. Tresco, Effect of filament diameter and extracellular matrix molecule precoating on neurite outgrowth and Schwann cell behavior on multifilament entubulation bridging device in vitro. Journal of Biomedical Materials Research Part A, 2006. 76A(3): p. 626-637.
9. Whatley, B.R., J. Kuo, C. Shuai, B.J. Damon, and X. Wen, Fabrication of a biomimetic elastic intervertebral disk scaffold using additive manufacturing. Biofabrication, 2011. 3(1).
[16]
10. Whatley, B.R., X. Li, N. Zhang, and X. Wen, Magnetic-directed patterning of cell spheroids. Journal of Biomedical Materials Research Part A, 2014. 102(5): p. 1537-1547.
[45]
11. Zdyrko, B., V. Klep, X. Li, Q. Kang, S. Minko, X. Wen, and I. Luzinov, Polymer brushes as active nanolayers for tunable bacteria adhesion. Materials Science & Engineering C, 2009. 29(3): p. 680-684.
[46]
12. Zhang, C., X. Wen, N.R. Vyavahare, and T. Boland, Synthesis and characterization of biodegradable elastomeric polyurethane scaffolds fabricated by the inkjet technique. Biomaterials, 2008. 29(28): p. 3781-3791.
[35]
13. Zhang, N., H.H. Yan, and X.J. Wen, Tissue-engineering approaches for axonal guidance. Brain Research Reviews, 2005. 49(1): p. 48-64.
[47]
14. Zhao, J., N. Zhang, G.D. Prestwich, and X. Wen, Recruitment of endogenous stem cells for tissue repair. Macromolecular Bioscience, 2008. 8(9): p. 836-842.
[48]
15. Zhao, W., X. Li, X. Liu, N. Zhang, and X. Wen, Effects of substrate stiffness on adipogenic and osteogenic differentiation of human mesenchymal stem cells. Materials Science & Engineering C, 2014. 40: p. 316-323.
[49]
等100多篇論文。
文學軍學術兼職
文學軍特邀評審專家
中國 國家自然科學基金(重點、面上、青年)等
美國 NIH, NSF, NASA, DOD, Veterans Affairs, Empire State Stem Cell Program (NYSTEM), American Chemical Society (ACS) Research Fund, American Heart Association (AHA), U.S. Civilian Research & Development Foundation (CRDF), Alzheimer’s Disease Association, North Carolina Biotechnology Center (Science & Technology Development Program), Alzheimer‘s & Related Diseases Research Award Fund (ARDRAF)等
加拿大 Canada Leader Opportunity Funds, Network of Centres of Excellence ofCanada
歐盟 Human Frontier Science Program
荷蘭 Technology Foundation STW (Netherlands),
瑞典 AO Foundation
俄羅斯 Skolkovo Institute of Science and Technology (SkTech) andMIT(SkTech/MIT Initiative),
拉脱維亞 education and science ministry
瑞士 Swiss National Science Foundation
意大利 Italian Ministry of Health
西班牙 Spain National Science Foundation
法國 Leducq Foundation
馬來西亞 Ministry of Science, Technology and Innovation Grant，
香港 Research Grants Council
文學軍特邀審稿人
Nature, Bone, Journal of Biomedical Materials Research, ASAIO Journal,Artificial Organ, Journal of Orthopedic Research, Langmuir, Journals of Materials Science, Advanced Materials, Biomaterials, Macromolecules, Biomacromolecules, Journal of Nanomaterials, Journal of Nanoscience and Nanotechnology, Nanomedicine, Journals of Materials Science: Materials in Medicine, Acta Biomaterialia, Journal of Neuroscience Methods, Journal of Biomaterial Applications, The Open Biomedical Engineering Journal, International Journal of Optomechatronics, Composites Science and Technology, Macromolecular Bioscience, Materials Science and Engineering, Tissue Engineering, Biofabrication, Journal of the Royal Society Interface, Proteomics, Applied Biochemistry and Biotechnology, PLoS One等
- 參考資料
-
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- 2. 學術報告---從生物材料，幹細胞工程到再生醫學（文學軍博士） ．浙江大學材料與工程學院．2013-6-24[引用日期2014-11-04]
- 3. 導師信息-文學軍教授 ．同濟大學醫學院[引用日期2015-02-09]
- 4. 美國醫學與生物工程院院士文學軍受聘魯東大學特聘教授 ．魯東大學．2018年7月13日[引用日期2018-07-13]
- 5. Meet Xuejun Wen, M.D., Ph.D ．Virginia Commonwealth University[引用日期2014-11-04]
- 6. Xuejun Wen, M.D., Ph.D. ．Clemson University[引用日期2014-10-22]
- 7. Department of Regenerative Medicine and Cell biology ．Medical University of South Corelina[引用日期2014-10-23]
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- 19. CLEMSON BIOENGINEER RECEIVES NATIONAL SCIENCE FOUNDATION CAREER AWARD FOR STEM CELL-VIABILITY RESEARCH ．Highbeam[引用日期2014-10-22]
- 20. Award Abstract #0748129 ．Nationnal Science Foundation[引用日期2014-10-22]
- 21. Xuejun Wen named Sigma Xi Researcher of the Year ．Clemson University[引用日期2014-10-23]
- 22. Clemson University： Board of Trustees Faculty and Staff Awards ．Clemson University[引用日期2014-10-23]
- 23. Michael J. Fox基金會應用人幹細胞治療帕金森病獎 ．Michael J. Fox基金會官方網頁[引用日期2014-10-23]
- 24. Michael J. Fox Foundation extends funding ．Clemson University[引用日期2014-10-23]
- 25. 關於表彰蘇州工業園區第二屆金雞湖雙百人才的決定 ．蘇州工業園區網[引用日期2014-10-23]
- 26. 市政府關於確定2013年第一批姑蘇創新創業領軍人才的通知 ．蘇州市政府信息公開網[引用日期2014-10-23]
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- 28. Engineering neural stem cell fates with hydrogel design for central nervous system regeneration ．Progress in Polymer Science[引用日期2014-10-23]
- 29. Engineering an in situ crosslinkable hydrogel for enhanced remyelination ．FASEB[引用日期2014-10-23]
- 30. The Implications of Polymer Selection in Regenerative Medicine: A Comparison of Amorphous and Semi-Crystalline Polymer for Tissue Regeneration ．Advanced Functional Materials[引用日期2014-10-23]
- 31. A Novel Method to Precisely Assemble Loose Nanofiber Structures for Regenerative Medicine Applications ．Advanced Healthcare Materials[引用日期2014-10-23]
- 32. A Novel Growth-Promoting Pathway Formed by GDNF-Overexpressing Schwann Cells Promotes Propriospinal Axonal Regeneration, Synapse Formation, and Partial Recovery of Function after Spinal Cord Injury ． Journal of Neuroscience[引用日期2014-10-23]
- 33. Fabrication and characterization of permeable degradable poly(dl-lactide-co-glycolide) (PLGA) hollow fiber phase inversion membranes for use as nerve tract guidance channels ．Biomaterials[引用日期2014-10-23]
- 34. Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro ．Biomaterials[引用日期2014-10-23]
- 35. Synthesis and characterization of biodegradable elastomeric polyurethane scaffolds fabricated by the inkjet technique ．Biomaterials[引用日期2014-10-23]
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- 42. Synthetic vascular tissue and method of forming same ．United States Patent and Trademark Office[引用日期2014-10-30]
- 43. Methods for promoting the revascularization and reenervation of CNS lesions ．United States Patent and Trademark Office[引用日期2014-10-30]
- 44. Short Laminin Peptide for Improved Neural Stem Cell Growth ．Stem Cells Trans Med[引用日期2014-10-23]
- 45. Magnetic-directed patterning of cell spheroids ．Journal of Biomedical Materials Research Part A[引用日期2014-10-23]
- 46. Polymer brushes as active nanolayers for tunable bacteria adhesion ．Materials Science and Engineering: C[引用日期2014-10-23]
- 47. Tissue-engineering approaches for axonal guidance ．Brain Research Reviews[引用日期2014-10-23]
- 48. Recruitment of Endogenous Stem Cells for Tissue Repair ．Macromolecular Bioscience[引用日期2014-10-23]
- 49. Effects of substrate stiffness on adipogenic and osteogenic differentiation of human mesenchymal stem cells ．Materials Science and Engineering: C[引用日期2014-10-23]
- 收起
