張璨

2012年畢業於湖南師範大學生命科學與技術人才培養基地班，獲得生物科學學士學位；

2012年保送至浙江大學基礎醫學院直接攻博，2017年獲得幹細胞和再生醫學專業博士學位 ^[1] 

2017年7月進入湖南大學生物學院生物納米與組織工程學研究所任助理教授 ^[1] 

國際組織工程與再生醫學學會（Tissue Engineering and Regenerative Medicine International Society，TERMIS）會員，國際幹細胞學會（International Society for Stem Cell Research）會員，中國生物醫學工程學會會員。 ^[1] 

主要從事肌腱組織損傷再生修復及肌腱病治療的基礎研究，研究方向為肌腱組織工程；表觀遺傳與幹細胞定向分化；細胞與細胞外基質相互作用。研究興趣主要包括：1. 具有生物活性的肌腱組織工程支架開發；2. 肌腱表型維持和分化的小分子篩選和功能驗證；3. 大數據時代的肌腱組織發育和肌腱病發生的分析。 ^[1] 

[1] 湖南省自然科學基金青年項目（2019JJ50060），項目負責人

[2] 中央高校基本科研啓動項目 （022800531107051107），項目負責人

[3] 國家自然科學基金面上項目（31570987），項目主要參與人

[4] 國家自然科學基金面上項目（81572115），項目主要參與人 ^[1] 

目前在Advanced Drug Delivery Reviews, Biomaterials, Acta Biomaterialia, Stem Cells, Biomacromolecules等雜誌發表近10篇SCI論文，參與多項國家自然科學基金面上項目。

1. Can Zhang, Bei Xie, Yujian Zou, Dan Zhu, Lei Lei*, Dapeng Zhao*, Hemin Nie*, Zero-dimensional, one-dimensional, two-dimensional and three-dimensional biomaterials for cell fate regulation, Advanced Drug Delivery Reviews, 2018, 132: 33-56 (IF=15.519)

2. Can Zhang, Erchen Zhang, Long Yang, Wenjing Tu, Junxin Lin, Chunhui Yuan, Varisara Bunpetch, Xiao Chen*, Hongwei Ouyang*. Histone Deacetylase Inhibitor Treated Cell Sheet from Mouse Tendon Stem/Progenitor Cells Promotes Tendon Repair. Biomaterials, 172, 66-82. 2018(IF=10.273)

3. Can Zhang, Xianliu Wang, Erchen Zhang, Long Yang, Huihua Yuan, Wenjing Tu, Huilan Zhang, Zi Yin, Weiliang Shen, Xiao Chen*, Yanzhong Zhang*, Hongwei Ouyang*. An Epigenetic Bioactive Composite Scaffold with Well-aligned Nano?bers for Functional Tendon Tissue Engineering. Acta Biomaterialia 66, 141-156. 2018(IF=6.638) ^[1] 

4. Can Zhang, Huihua Yuan, Liu Huanhuan, Chen Xiao, Lu Ping, Zhu Ting, Yang Long, Yin Zi, Boon Chin Heng, Zhang Yanzhong*, Ouyang HongWei*. Well-aligned Chitosan-based Ultrafine Fibers Committed Teno-lineage Differentiation of Human Induced Pluripotent Stem Cells for Achilles Tendon Regeneration. Biomaterials 53, 716-730. 2015(IF=10.273)

5. Huanhuan Liu, Can Zhang, Shouan Zhu, Ping Lu, Ting Zhu, Xiaolan Gong, Ziwang Zhang, Jiajie Hu, Zi Yin, Boon Chin Heng, Xiao Chen*, Hongwei Ouyang*. Mohawk Promotes The Tenogenesis of Mesenchymal Stem Cells Through Activation of The TGFβ Signaling Pathway, Stem Cells 33, 443-455. 2015(IF=5.614)

6. Mingying Yang#*, Yajun Shuai#, Can Zhang#, Yuyin Chen, Liangjun Zhu, Chuanbin Mao*, Hongwei Ouyang. Biomimetic Nucleation of Hydroxyapatite Crystals Mediated by Antheraea pernyi Silk Sericin Promotes Osteogenic Di?erentiation of Human Bone Marrow Derived Mesenchymal Stem Cells. Biomacromolecules 15, 1185-1193. 2014(IF=5.667)

7. Huanhuan Liu, Shouan Zhu, Can Zhang, Ping Lu, Jiajie Hu, Yue Ma, Xiao Chen, Hongwei Ouyang*. Crucial Transcription Factors in Tendon Development and Differentiation: Their Potential for Tendon Regeneration. Cell Tissue Research 356, 287-298. 2014(IF=3.36)

8. Huanhuan Liu, Hongju Peng, Yan Wu, Can Zhang, Youzhi Cai, Guowei Xu, Qin Li, Xiao Chen, Junfeng Ji, Yanzhong Zhang*, Hongwei Ouyang*. The Promotion of Bone Regeneration by Nanofibrous Hydroxyapatite/Chitosan Scaffolds by Effects on Integrin-BMP/Smad Signaling Pathway in BMSCs. Biomaterials 34, 4404-4417. 2013 (IF=10.273)

9. Yin Zi, Hu JiaJie, Yang Long, Zheng Zefeng, An Chengrui, Wu Binbin, Zhang Can, Shen Weiliang, Liu Huanhuan, Chen Jialin, Heng Boonchin, Guo Guoji, Chen Xiao*, Ouyang Hongwei*. Single cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality. Science Advance. 2016 Nov 18;2(11):e1600874. doi: 10.1126/sciadv.1600874. (IF=12.804) ^[1] 

獲得第十七屆國際肌腱韌帶會議最佳研究者獎 ^[1]