任建東

科研項目

1. 國家自然科學基金面上項目：Kupffer細胞外泌體運載S100A9經NLRP3細胞焦亡途徑致急性胰腺炎肺損傷的機制研究

2. 國家自然科學基金面上項目：硫酸乙酰肝素激活NLRP3炎性小體介導細胞炎症反應：急性胰腺炎重症化的新機制

3. 國家自然科學基金青年基金：鉀離子通道MaxiK在HS/TLR4信號途徑參與急性胰腺炎重症化中的功能機制研究

4. 中國博士後科學基金特別資助1項：鉀離子通道MaxiK在TLR4介導的失血性休克再灌注肝損傷中的功能機制研究

5. 四川省自然科學基金面上項目1項：萘莫司他通過靶向NLRP3炎性小體的激活過程阻止急性胰腺炎重症化的功能機制研究

6. 四川省衞生廳課題2項：（1）低氧條件下痤瘡丙酸桿菌對皮脂腺細胞NLRP3炎症信號的激活作用研究；（2）RP105對HS/TLR4炎症信號的負向調節作用研究

7. 成都軍區十二五課題1項：鉀離子通道MaxiK抑制劑paxilline逆轉肝癌細胞化療耐藥作用的研究

發表文章

1. Luo ZL, Sun HY, Wu XB, Cheng L, Ren JD（通訊作者）. Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation. Food Funct. 2021 21;12(12):5658-5667.

2. Wu XB, Sun HY, Luo ZL, Cheng L, Duan XM, Ren JD（通訊作者）. Plasma-derived exosomes contribute to pancreatitis-associated lung injury by triggering NLRP3-dependent pyroptosis in alveolar macrophages. Biochim Biophys Acta Mol Basis Dis. 2020;1866(5):165685.

3. Yang Y, Ren JD（共一）, Huang Q, Wu J, Yuan X, Jiang W, Wen Y, Tang L, Sun H. CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p. Front Genet. 2020;11:206.

4. Ren JD, Wu XB, Jiang R, Hao DP, Liu Y. Molecular hydrogen inhibits LPS triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species. BBA-Mol Cell Res. 2016; 1863(1):50-55.

5. Ren JD, Ma J, Hou J, Xiao WJ, Jin WH, Wu J, Fan KH. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm. 2014; 2014: 930894

6. Ren JD, Xing YJ, Fan KH, Yu BT, Jin WH, Jiang Y, Jing L, Wu XC, Wang SH, Wu J, Chen H. Pharmacological blockade of the MaxiK channel attenuates experimental acute pancreatitis and associated lung injury in rats. Int Immunopharmacol. 2014; 21(1): 220-224.

7. Ren JD, Fan L, Tian FZ, Fan KH, Yu BT, Jin WH, Tan YH, Cheng L. Involvement of a membrane potassium channel in heparan sulphate-induced activation of macrophages. Immunology. 2014;141(3): 345-352.

8. Ren JD, Luo ZL, Tian FZ, Qian Wang, Kun Li, Chao Wang. Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg. 2012; 72（6）:1555-1561.

9. Ren JD, Gao HF, Tang M, Gu JS, Xia PY, Xiao GX. Lipopolysaccharide (LPS) detoxification of analogue peptides derived from limulus anti-LPS factor. Peptides.2010; 31（10）:1853-1859.

10. Ren JD, Gu JS, Gao HF, Xia PY, Xiao GX. A synthetic cyclic peptide derived from Limulus anti-lipopolysaccharide factor neutralizes endotoxin in vitro and in vivo. Int Immunopharmacol. 2008; 8: 775-781.

11. Luo ZL, Ren JD, Huang Z, et al. The Role of Exogenous Hydrogen Sulfide in Free Fatty Acids Induced Inflammation in Macrophages. Cell Physiol Biochem. 2017;42(4):1635-1644.(通訊作者)

12. Gong JQ, Ren JD, Tian FZ, et al. Management of patients with sphincter of Oddi dysfunction based on a new classification. World J Gastroenterol. 2011;17(3):385-390.

13. Zhang QX, Li SS, Ren JD, et al. ROS-triggered nanoinducer based on dermatan sulfate enhances immunogenic cell death in melanoma. J Control Release. 2022;348:22-33.

14. Luo ZL, Cheng L, Ren JD, et al. Hydrogen-rich saline protects against ischemia/reperfusion injury in grafts after pancreas transplantations by reducing oxidative stress in rats. Mediators Inflamm. 2015; 2015:281985.

15. Luo ZL, Cheng L, Ren JD, et al. Progressive balloon dilatation following hepaticojejunostomy improves outcome of bile duct stricture after iatrogenic biliary injury. BMC Gastroenterol. 2013;13:70.

16. Liu Y, Ni B, Ren JD, et al. Cyclic Limulus anti-lipopolysaccharide (LPS) factor-derived peptide CLP-19 antagonizes LPS function by blocking binding to LPS binding protein. Biol Pharm Bull. 2011;34(11):1678-83.

授權發明專利：

1. 任建東，田伏洲. 脒基胍基取代芳雜環類化合物的合成方法及其用途（授權專利號：ZL201110100517.4）

2. 任建東，田伏洲. 一種快速診斷胰腺創傷和急性胰腺炎的測試卡（授權專利號：ZL201210355770.9） ^[1] 

教育經歷

2002.9 -- 2005.6

第三軍醫大學 藥劑學 碩士研究生畢業 醫學碩士學位

1995.9 -- 1999.6

第二軍醫大學 藥學 大學本科畢業 理學學士學位

2005.9 -- 2008.12

第三軍醫大學 藥理學 博士研究生畢業 醫學博士學位

工作經歷

2017.7 --

電子科技大學醫學院 副教授

2012.9 -- 2017.6

成都軍區總醫院藥劑科 副主任藥師

2009.9 -- 2012.8

成都軍區總醫院全軍普外中心 博士後

1999.7 -- 2009.8

空軍武昌場站 藥師、主管藥師 ^[1] 

炎症進展機制和人工智能輔助藥物重定位研究 ^[1] 

四川省學術和技術帶頭人後備人選、軍隊醫療成果一等獎、軍事科學技術進步二等獎 ^[1]