項榮

主要從事人類疾病致病或易感基因的鑑定及其相關細胞和基因功能研究。

項榮主持和參與包括國家自然科學基金面上項目、國家科技重大專項子課題、863子課題、軍口項目子課題、省自然科學基金等在內的各級科研項目20餘項；在Circulation、J Neurosci、Eur Heart J、Apoptosis等雜誌上發表論文30餘篇；參與申請發明專利10餘項，已授權4項。主編教材1部，參編國家級規劃教材2部；參與教改課題4項；指導國家級、省級大學生創新課題3項，指導大學生國家級競賽一等獎2項、三等獎2項、省級競賽一等獎、二等獎等；連續獲校教學質量優秀獎3次、校級教學成果一等獎1次、教學“三十佳”1次等，被評為中南大學學科競賽優秀指導教師、創客空間優秀指導老師，湖南省“挑戰杯”優秀指導老師、長沙市大學生科創大賽優秀指導教師等 ^[1]  。

主要開展兩個方面的研究：

（1）運用新一代測序、色譜、細胞免疫等技術，從基因、分子、細胞、模式動物及人體水平探討動脈粥樣硬化、高血脂、心肌病等心血管相關疾病的發病機理，並結合臨牀篩選相關疾病的早期檢測診斷分子和預後標誌物；

（2）研究病原微生物感染、腫瘤、原發性多囊腎等疾病發生過程中相關細胞器、細胞信號轉導、細胞物質運輸、細胞代謝等細胞結構和功能的異常。 ^[3] 

湖南師範大學 | 生物科學 | 學士學位 | 大學本科畢業

武漢大學 | 微生物學 | 博士學位 | 博士研究生畢業

2007.5-2009.9 細胞生物學系 | 中南大學生命科學學院 講師

2009.9-2014.9 細胞生物學系 | 中南大學生命科學學院 | 副教授

2014.9-至今 細胞生物學系 | 中南大學生命科學學院 | 教授

湖南省遺傳學會青年委員 ^[1] 

[1] Xiang R, Fan L L, Huang H, et al. Increased RTN3 Leads to Obesity and Hypertriglyceridemia by Interacting with HSPA5[J]. Circulation, 2018.

[2] Guo S, Fan X F, Jin J Y, et al. A novel proximal 3q29 chromosome microdeletion in a Chinese patient with Chiari malformation type II and Sprengel’s deformity[J]. Molecular Cytogenetics, 2018, 11(1):8.

[3] Ding D B, Fan L L, Xiao Z, et al. A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation[J]. QJM: An International Journal of Medicine, 2018.

[4] Huang H, Ding D B, Fan L L, et al. Whole-exome sequencing identifies a Novel SCN5Amutation (C335R) in a Chinese family with arrhythmia[J]. Cardiology in the Young, 2018, 28(5):1-4.

[5] Li J J, Chen Y, Fan L L, et al. Microduplication of 10q26. 3 in a Chinese hypertriglyceridemia patient[J]. Molecular and cellular probes, 2018, 37: 28-31.

[6] Fan L L, Huang H, Jin J Y, et al. Whole exome sequencing identifies a novel mutation (c. 333+ 2T＞C) ofTNNI3Kin a Chinese family with dilated cardiomyopathy and cardiac conduction disease[J]. Gene, 2018, 648: 63-67.

[7] Huang H, Chen Y Q, Fan L L, et al. Whole-exome sequencing identifies a novel mutation of GPD1L(R189X) associated with familial conduction disease and sudden death[J]. Journal of cellular and molecular medicine, 2018, 22(2): 1350-1354.

[8] Xiang R, Du R, Guo S, et al. Microduplications of 10q24 Detected in Two Chinese Patients with Split-hand/foot Malformation Type 3[J]. Annals of Clinical & Laboratory Science, 2017, 47(6): 754-757.

[9] Xiang R, Fan L L, Lin M J, et al. The genetic spectrum of familial hypercholesterolemia in the central south region of China[J]. Atherosclerosis, 2017, 258: 84-88.

[10] Liu J S, Fan L L, Li J J, et al. Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy[J]. American Journal of Cardiology, 2017, 119(9): 1485-1489.

[11] Liu J S, Fan L L, Zhang H, et al. Whole-exome sequencing identifies two novel TTNmutations in Chinese families with dilated cardiomyopathy[J]. Cardiology, 2017, 136(1): 10-14.

[12] Xiang R, Fan L L, Huang H, et al. Whole-exome sequencing identifies a novel mutation of DSG2(Y198C) in a Chinese arrhythmogenic right ventricular cardiomyopathy patient[J]. International journal of cardiology, 2016, 214: 1-3.

[13] Wu P F, Guo S, Fan X F, et al. A novel ZRSmutation in a Chinese patient with preaxial polydactyly and triphalangeal thumb[J]. Cytogenetic and genome research, 2016, 149(3): 171-175.

[14] Du R F, Huang H, Fan L L, et al. A Novel Mutation of FOXC1(R127L) in an Axenfeld–Rieger Syndrome Family with Glaucoma and Multiple Congenital Heart Diseases[J]. Ophthalmic genetics, 2016, 37(1): 111-115.

[15] Chen Y, Wu Z, Zhao S, et al. Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity[J]. Scientific reports, 2016, 6: 27486.

[16] Fan L, Lin M, Chen Y, et al. Novel mutations of low-density lipoprotein receptor gene in China patients with familial hypercholesterolemia[J]. Applied biochemistry and biotechnology, 2015, 176(1): 101-109.

[17] Xiang R, Fan L L, Huang H, et al. A novel mutation of GATA4(K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis[J]. Gene, 2014, 534(2): 320-323.

[18] Yu B, Xiang R, Hu D, et al. A novel MYH7 mutation in a family with cardiomyopathy presenting with restrictive physiology and varying degrees of left ventricle hypertrophy[J]. European heart journal, 2014, 36(3): 178-178.

[19] Shi Q, Ge Y, Sharoar M G, et al. Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition[J]. Journal of Neuroscience, 2014, 34(42): 13954-13962.

[20] 項榮, 丁棟博, 範亮亮, 等. 稀土氧化鋅晶須抗菌效能及安全性研究[J]. 功能材料, 2013, 44: 186-191+ 197.

[21] 杜然, 範亮亮, 黃皓, 等. 原發性厚皮性骨膜病的遺傳學研究進展[J]. 中華醫學遺傳學雜誌, 2016 (2016 年 01): 105-107.

[22] 陳雨, 周帥鋒, 孫倩萊, 等. 2012-2014 年湖南省感染性腹瀉哨點醫院兒童諾如病毒感染及基因型別分析[J]. 實用預防醫學, 2016, 23(7): 773-776.

[23] 範亮亮, 馬立寧, 彭元亮, 等. PI3K/AKT 信號通路與心力衰竭[J]. 生命科學研究, 2015, 19(1): 85-90.

[24] 黃皓, 範亮亮, 項榮. HIV-1 輔助蛋白負性調節因子下調細胞膜表面分子的研究進展[J]. 細胞與分子免疫學雜誌, 2015 (6): 848-852.

[25] 項榮, 丁棟博, 範亮亮, 等. 氧化鋅的抗菌機制及其安全性研究進展[J]. 中國組織工程研究, 2014, 18(3): 470-475.

[26] 項榮, 嚴經緯, 範亮亮, 等. 動脈粥樣硬化中炎性反應與內質網應激的相互作用[J]. 基礎醫學與臨牀, 2014, 34(2): 253-256.

[27] 曹貝貝, 範亮亮, 項榮. 動脈粥樣硬化中自噬與凋亡在內質網的交叉對話[J]. 生物物理學報, 2013 (12): 911-918.

[28] 項榮, 胡豔, 曹貝貝. β-Arrestins 參與 GPCRs 信號通路的分子機制[J]. 中國生物化學與分子生物學報, 2013, 29(2): 122-127. ^[4]