複製鏈接
請複製以下鏈接發送給好友

陳飛

(復旦大學研究員)

鎖定
陳飛,中國,博士,復旦大學研究員。 [1] 
中文名
陳飛
國    籍
中國
學位/學歷
博士
主要成就
西北大學醫學院優秀畢業生 [1] 

陳飛工作經歷

研究員(青年傑出人才) 復旦大學生物醫學研究院/附屬腫瘤醫院(2021.12-至今)
青年研究員 復旦大學生物醫學研究院/附屬腫瘤醫院(2019.12-2021.11)
博士後 美國斯隆凱特琳癌症中心 (2018.3-2019.11) [1] 

陳飛教育經歷

博士 美國西北大學(2018)
碩士 復旦大學(2012)
學士 山東大學(2009) [1] 

陳飛研究方向

申請人的主要研究方向是基因轉錄和表觀遺傳調控的機制研究以及它們在癌症和發育中的功能研究。主要利用生物化學、基因組學、生物信息學、遺傳學和細胞分子生物學等前沿方法研究轉錄和表觀遺傳調控的分子機制及其在腫瘤發生發展、轉移,胚胎幹細胞的乾性維持和分化,與發育過程中的功能。在該研究方向,以通訊或第一作者在ScienceCell等雜誌發表10多篇文章。 [1] 

陳飛所獲人才項目

上海高校特聘教授(2019)

陳飛所獲獎項

西北大學醫學院優秀畢業生(Driskill Award)(2018)
教育部自然科學一等獎(第五完成人)(2016) [1] 

陳飛代表論文

Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H*, Chen FX*. R-loop dependent promoter-proximal termination maintains genome stability. Nature. (Accept in principle). (*: corresponding)
Hu S#, Song A#, Peng L#, Tang N, Qiao Z, Wang Z, Lan F, Chen FX*. H3K4me2/3 modulate the stability of RNA polymerase II pausing. Cell Research. 2023 May;33(5):403-406. (*: corresponding)
Hu S#, Peng L#, Song A#, Ji YX#, Cheng J, Wang M, Chen FX*. INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II. Molecular Cell. 2023 Apr 11:S1097-2765(23)00212-5. (*: corresponding)
Wang Z#, Song A#, Xu H#, Hu S, Tao B, Peng L, Wang J, Li J, Yu J, Wang L, Li Z, Chen X, Wang M, Chi Y, Wu J, Xu Y, Zheng H, Chen FX*. Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1. Science Advances. 2022 Apr;8(13):eabm5504. (*: corresponding)
Wang X, Qi Y, Wang Z, Wang L, Song A, Tao B, Li J, Zhao D, Zhang H, Jin Q, Jiang YZ, Chen FX*, Xu Y*, Chen X*. RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Cell Reports. 2022 Apr 26;39(4):110732. (*: corresponding)
Hu S#, Peng L#, Xu C#, Wang Z, Song A, and Chen FX*. SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape. Molecular Cell. 2021 Nov 4;81(21):4425-4439.e6. (*: corresponding)
Zheng H#, Qi Y#, Hu S#, Cao X#, Xu C#, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX*, Xu Y*. (2020) Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science. 2020 Nov 27;370(6520):eabb5872. (*: corresponding)
Chen FX, Smith ER, Shilatifard A. Born to run: Control of RNA polymerase II transcription elongation. Nature Reviews Molecular Cell Biology. 2018 May 8. doi:10.1038/s41580-018-0010-5.
Chen FX, Xie P, Collings CK, Cao K, Marshall SA, Rendleman EJ, Ugarenko M, Zhang A, Shiekhattar R, Smith ER, Shiekhattar R, Zhang MQ, Shilatifard A. PAF1 regulation of promoter-proximal pause release via enhancer activation. Science. 2017 Sep 22;357(6357):1294-1298.
Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A. PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II. Cell. 2015 Aug;162(5):1003-1015.
Chen F, Gao X, Shilatifard A. Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide. Genes & Development. 2015 Jan 1;29(1):39-47.
Chen F*, Yang H*, Dong Z*, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z#, Xu Y#. Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Research. 2013 Feb;23(2):306.
Fang R*, Chen F*, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y#, Shi YG#. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Molecular Cell. 2013 Feb 7;49(3):558-70.
Chen FX, Marshall SA, Deng Y, Tianjiao S. Measuring Nascent Transcripts by Nascent-seq. Methods in Molecular Biology. 2018;1712:19-26.
Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer.Cancer Discovery. 2019 Oct 3. pii: CD-19-0529. [1] 
參考資料