莫德林

1、動物肌肉發育差異的遺傳與分子調控機制

2、脂肪時空分佈以及肌內脂肪含量差異的遺傳與分子調控機制

1、1996.09-2000.06，華中農業大學，本科/學士，動物科學

2、2001.09-2006.06，華中農業大學，研究生/博士，動物遺傳育種與繁殖

3、2014.02-2015.02，Cornell University/美國，訪問學者，動物科學

4、2006.09-2009.06，中山大學，博士後

5、2009.06-2010.12，中山大學，講師

6､2011.01-2019.12， 中山大學，副教授 ^[1] 

7、2020.01-至今， 中山大學，教授 ^[1] 

本科生必修課《普通生物學》（課程負責人）、《細胞生物學》（生物醫學工程學院） ^[1] 

1、劉小紅、陳瑤生、李加琪、王希斌、張哲、陳贊謀、袁金鋒、莫德林、張從林、宋德清、陳清森、唐凡、曾檢華、謝水華、羅豔鳳, 2016，數字化種豬育種關鍵技術研發與產業化應用，廣東省科技進步獎二等獎

2、王翀、莫德林、張豪、陳瑤生、李加琪、楊慧榮、吳珍芳、張哲、邱志鵬、覃立立、李莉、餘麗明、鄧振強、張育喬、李巖、吳同山、潘炎均、鄧春武、鞏振華，現代豬分子育種技術的應用與推廣，2013，廣東省農業技術推廣一等獎，廣東省農業廳。

3、陳瑤生、李加琪、張勤、劉小紅、王翀、劉海良、王志剛、張豪、吳秋豪、薛明、莫德林、丁向東、羅旭芳、餘麗明、鄭華，國家和區域性種豬遺傳評估系統關鍵技術研發與應用，2011年，廣東省科學技術進步一等獎，廣東省科技廳。

4、莫德林，中山大學-廣東温氏食品集團有限公司獎勵基金温氏傑出產業服務獎教金，2015，中山大學-温氏食品集團有限公司基金管理委員會

5、莫德林，李寶健遺傳學研究基金，2017年，中山大學

6、莫德林，校級優秀本科畢業論文指導老師，中山大學

首次提出胚胎早期myoD的起始表達時間差異及其所導致的初級肌纖維形成時間是影響動物產肉量的關鍵因素。

1、國家自然科學基金面上項目，myoD表達時間對肌纖維數量的影響及其在豬品種間表達時間差異的分子機制，31772565，莫德林（主持人），2018.1-2021.12；

2、國家自然科學基金面上項目，初級肌纖維形成時間對豬瘦肉量的影響及其調控機制，31272417，莫德林（主持人），2013.1-2016.12

3、國家自然科學基金青年項目，豬caveolin基因家族相互作用蛋白鑑定以及對脂肪與肌細胞膽固醇轉運機理的研究，30700568，莫德林（主持人），2008.1-2010.12

4、國家重點研發計劃課題，不同區域地方豬雜交利用關鍵技術研究與示範，2018YFD0501206，莫德林（主持人），2018.1-2020.12

5､ 國家自然科學基金委（NSFC）-廣東聯合基金項目，藍塘豬背最長肌脂肪含量與脂肪酸組成形成的分子機制，U1201213，陳瑤生（主持人）、莫德林（第三），2013.01-2016.12

6、國家自然科學基金委（NSFC）-廣東聯合基金項目，不同豬種肌肉生長髮育差異的分子機制與調控研究，U0731003，陳瑤生（主持人）、莫德林（第三），2013.01-2016.12

2019年

41. Yaping Nie#, Shufang Cai#, Renqiang Yuan, Suying Ding, Xumeng Zhang, Luxi Chen, Yaosheng Chen,Delin Mo*.Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.Cell Death & Differentiation, 2019. (IF：8.09,中科院一區) ^[1] 

40. Xumeng Zhang#,Yaping Nie#, Shufang Cai#, Suying Ding, Bingqiang Fu, Hong Wei, Luxi Chen, Xiaohong Liu, Minggui Liu, Renqiang Yuan, Boqing Qiu, Zuyong He, Peiqing Cong, Yaosheng Chen,Delin Mo*. Earlier demethylation of myogenic genes contributes to embryonic precocious terminal differentiation of myoblast in miniature pigs.The FASEB Journal, 2019, 33 (8) :9638-9655. IF=5.595. Q1 ^[1] 

39. Shufang Cai. Qi Zhu, Cilin Guo, Renqiang Yuan, Xumeng Zhang, Yaping Nie, Luxi Chen, Ying Fang, Keren Chen, Junyan Zhang,Delin Mo*, Yaosheng Chen*. MLL1 promotes myogenesis by epigenetically regulating Myf5,Cell Proliferation, 2019;00:e12744.(IF：5.05)Q1 ^[1] 

38.SuyingDing, YapingNie, XumengZhang, XiaohongLiu, ChenWang, RenqiangYuan, KerenChen, QiZhu, ShufangCai, YingFang, YaoshengChen,Delin Mo*. The SNPs in myoD gene from normal muscle developing individuals have no effect on muscle mass.BMC Genetics, (2019) 20:72 (IF:2.55) ^[1] 

37. Xumeng Zhang,Shufang Cai, Luxi Chen, Renqiang Yuan, Yaping Nie, Suying Ding, Ying Fang, Qi Zhu, Keren Chen, Hong Wei, Yaosheng Chen,Delin Mo*. Integrated miRNA-mRNA transcriptomic analysis reveals epigenetic mediated embryonic muscle growth differences between Wuzhishan and Landrace pigs.Journal of Animal Science，2019，97:1967–1978. (IF:1.714) Q1 ^[1] 

36. Luxi Chen, Yue Zhang, Hu Chen, Xumeng Zhang, Xiaohong Liu, Zuyong He, Peiqing Cong, Yaosheng Chen, andDelin Mo*. Comparative transcriptome analysis reveals more complicated adipogenic process in intramuscular stem cells than that of subcutaneous vascular stem cells.Journal of Agricultural and Food Chemistry, 2019，67, 16, 4700-4708. （IF=3.412.中科院一區）Q1 ^[1] 

2018年

35. RenqiangYuan, Xumeng Zhang, Ying Fang, Yaping Nie, Shufang Cai, Yaosheng Chen,Delin Mo*. Mir-127-3p inhibits the proliferation of myocytes by targeting KMT5a.Biochem Biophys Res Commun. 2018, 503(2):970-976. Q3 ^[1] 

2017年

34. Zhuning Yuan, Yaosheng Chen, Xumeng Zhang, Xingyu Zhou, Mingsen Li, Hu Chen, Ming Wu, Ying Zhang,Delin Mo*. Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast.Biochemical and Biophysical Research Communications, 2017, 484: 592-597 Q3 ^[1] 

33.Delin Mo#, Kaifan Yu#, Hu Chen, Luxi Chen, Xiaohong Liu, Zuyong He, Peiqing Cong, Yaosheng Chen *. Transcriptome Landscape of Porcine Intramuscular Adipocytes during Differentiation.J Agric Food Chem.2017, 65(30):6317-6328（3.15，中科院一區）Q1 ^[1] 

32.Shuihua Xie,Luxi Chen,Xumeng Zhang,Xiaohong Liu,Yaosheng Chen,Delin Mo*. An integrated analysis revealed different microRNA-mRNA profiles during skeletal muscle development between Landrace and Lantang pigs.Sci Rep.2017, 7(1):2516 Q1 ^[1] 

31.Yaping Nie, Hu Chen, Cilin Guo, Zhuning Yuan, Xingyu Zhou, Ying Zhang, Xumeng Zhang,Delin Mo* & Yaosheng Chen*. Palmdelphin promotes myoblast differentiation and muscle regeneration.Sci Rep.2017, 7:41608. Q1 ^[1] 

2016年

30. Xingyu Zhou#, Mingsen Li#, Huaxing Huang, Keren Chen, Zhuning Yuan, Ying Zhang, Yaping Nie, Hu Chen, Xumeng Zhang, Luxi Chen, Yaosheng Chen*, andDelin Mo*. HMGB2 regulates satellite cell-mediated skeletal muscle regeneration via IGF2BP2.Journal of Cell Science,2016, 129(22):4305-4316. (IF: 5.5) Q2 ^[1] 

29. Hu Chen, Renqiang Yuan, Ying Zhang, Xumeng Zhang, Luxi Chen, Xingyu Zhou, Zhuning Yuan, Yaping Nie, Ming Li,Delin Mo*, Yaosheng Chen*. ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation.Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016, 1859(11):1459-1469. (IF: 5.55) Q1 ^[1] 

28. Xumeng Zhang, Yaosheng Chen, Jinchun Pan, Xiaohong Liu, Hu Chen, Xingyu Zhou, Zhuning Yuan, Xilong Wang andDelin Mo*. iTRAQ-based quantitative proteomicanalysis reveals the distinct early embryomyofiber type characteristics involved in Landrace and miniature pig.BMC Genomics, 2016, 17:137 Q1 ^[1] 

27. Ming Li,Hu Chen,Luxi Chen,Yaosheng Chen,Xiaohong Liu,Delin Mo*. miR-709 modulates LPS-induced inflammatory response through targeting GSK-3β.International Immunopharmacology, 2016, 36: 333–338 (IF: 2.65) ^[1] 

2015年

26. Mingsen Li#, Xingyu Zhou#, Yaosheng Chen, YapingNie, Huaxing Huang, Hu Chen andDelin Mo*. Not all the number of skeletal muscle fibers is determined prenatally.BMC Developmental Biology, 2015, 15:42(IF: 2.45) ^[1] 

25.Ming Wu, Gongshe Yang, Yaosheng Chen, Xingyu Zhou, Hu Chen, Mingsen Li, Kaifan Yu, Xumeng Zhang, ShuihuaXie, Ying Zhang, Guiyan Chu,Delin Mo*. Cep2 attenuates myoblast differentiation but does not affect proliferation.International journal of biological sciences,2015, 11(1): 99-108. (IF: 4.37) Q2 ^[1] 

2014年

24. Hu Chen,Delin Mo, Ming Li, Yun Zhang, Luxi Chen, Xumeng Zhang, Mingsen Li, Xingyu Zhou, Yaosheng Chen.miR-709 inhibits 3T3-L1 cell differentiation by targeting GSK3βof Wnt/β-catenin signaling.Cellular Signaling. 2014, 26(11): 2583-2589. (IF: 4.47) ^[1] 

23. Kaifan Yu#,Delin Mo#（並列第一作者）, Ming Wu, Hu Chen, Luxi Chen, Mingsen Li, Yaosheng Chen. Activating transcription factor 4 regulates adipocyte differentiation via altering the coordinate expression of CCATT/enhancer binding protein β and peroxisome proliferator-activated receptorγ.FEBS Journal. 2014, 281(10):2399-2409.(IF:3.99) ^[1] 

22. Hu Chen,Siqi Wang,Luxi Chen,Yaosheng Chen,Ming Wu,Yun Zhang,Kaifan Yu,Zheng Huang,Lijun Qin,Delin Mo*. MicroRNA-344 inhibits 3T3-L1 cell differentiation via targeting GSK3β.FEBS Letter.2014, 588(3):429-435.(IF:3.54) ^[1] 

2013年

21. Lijun Qin,Yaosheng Chen,Xiaohong Liu,Sanxing Ye,KaifanYu,Zheng Huang,Jingwei Yu,Xingyu Zhou,Hu Chen,Delin Mo*. Integrative Analysis of Porcine microRNAome during Skeletal Muscle Development.PLoS ONE, 2013, 8(9): e72418.(IF: 3.73) ^[1] 

20.Xiao Zhao,Zheng Huang,Xiaohong Liu,Yaosheng Chen,Wen Gong,Kaifan Yu,LijunQin,HuChen,Delin Mo*. The switch role of the Tmod4 in the regulation of balanced development between myogenesis and adipogenesis.Gene.2013,532(2):263-71.(IF: 2.2) ^[1] 

19.Anning Li#,Delin Mo#（並列第一作者）,Xiao Zhao,Wei Jiang,Peiqing Cong,ZuyongHe,Shuqi Xiao,Xiaohong Liu,Yaosheng Chen. Comparison of the longissimus muscle proteome between obese and lean pigs at 180 days.Mamm Genome.2013, 24(1-2):72-9 (IF: 2.5) ^[1] 

2012年

18. Yunxue Guo,Yaosheng Chen,Yun Zhang,Yue Zhang,Luxi Chen,Delin Mo. Up-regulated miR-145 Expression Inhibits Porcine Preadipocytes Differentiation by Targeting IRS1.Int J Biol Sci.2012;8(10):1408-17. (IF: 3.17) ^[1] 

17. Yunxue Guo#,Delin Mo#（並列第一作者）, Yue Zhang, Yun Zhang, Peiqing Cong, Shuqi Xiao, Zuyong He, Xiaohong Liu, Yaosheng Chen*. MicroRNAome Comparison between Intramuscular and Subcutaneous Vascular Stem Cell Adipogenesis.PLoS ONE. 2012,7(9): e45410.(IF: 3.73) ^[1] 

16. Qin LL, Li XK, Xu J,Mo DL, Tong X, Pan ZC, Li JQ, Chen YS, Zhang Z, Wang C, Long QM. Mechano growth factor (MGF) promotes proliferation and inhibits differentiation of porcine satellite cells (PSCs) by down-regulation of key myogenic transcriptional factors.Mol Cell Biochem. 2012, 370(1-2):221-30. ^[1] 

2011年

15.Xiao Zhao#,Delin Mo#（並列第一作者）, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin, YunaNiu, YunxueGuo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen*. Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness.PLoS ONE,2011, 6(5): e19774.（IF: 4.35，被Nature genetics等他引84次） ^[1] 

14. Yuna Niu,Delin Mo, Limei Qin, Chong Wang, Chunyan Zhou, Anning Li, Xiao Zhao, Shuqi Xiao, Qiwei Wang, Ying Xie, Jing Li, Zuyong He, Peiqing Cong, Yaosheng Chen. LPS-induced miR-1224 negatively regulates tumor necrosis factor-alpha gene expression by modulating Sp1.Immunology, 2011,133(1):8-20.（IF:3.7） ^[1] 

13. Weiquan Chen, Yaosheng Chen, Limei Qin, Anning Li, Xiao Zhao, Xiaoying Wang, ShuqiXiao,Delin Mo*. Transcription Factor Sp1 is Essential for the Regulation of the Porcine Caveolin-1 Gene.DNA and Cell Biology,2011, 30(7):491-7,（IF: 2.28） ^[1] 

2010年

12. LimeiQin, YaoshengChen, YunaNiu, WeiquanChen, QiweiWang, ShuqiXiao, AnningLi, YingXie, JingLi, XiaoZhao, ZuyongHeandDelinMo*. A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway.BMC Genomics. 2010, 11:320.（被Genome biology等他引139次，IF: 4.2） ^[1] 

11. Anning Li, Yaosheng Chen, Xiao Zhao, Yuna Niu, Peiqing Cong, Zongwu Zhang, Weiquan Chen, Wei Jiang,Delin Mo*. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene.Mol Genet Genomics. 2010. 284(3):185-95.（IF: 2.84） ^[1] 

10.ShuqiXiao, JianyuJia,DelinMo, QiweiWang, LimeiQin,ZuyongHe,XiaoZhao, YukaiHuang, AnningLi, JingweiYu, YunaNiu, XiaohongLiu, YaoshengChen.Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing.PLoS One.2010,29;5(6):e11377. ^[1] 

9. Shuqi Xiao,Delin Mo, Qiwei Wang, JianyuJia, Limei Qin, Xiangchun Yu, YunaNiu, Xiao Zhao, Xiaohong Liu, Yaosheng Chen. Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling.BMC Genomics, 2010, 11:544.（IF:4.2） ^[1] 

8.ZongwuZhang#,DelinMo#,FeiLing, ChongWang, AnningLi, XiaoZhao, YanfangLi, YaoshengChen.Characterization and promoter activity analysis of a new porcine gene: NICE-3.DNA Cell Biol.2010,29(3):141-7.（IF:2.0） ^[1] 

7.ZhishengZhang#,DelinMo#, PeiqingCong, ZuyongHe, FeiLing, AnningLi, YunaNiu, XiaoZhao, ChunyanZhou, YaoshengChen.Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene.Mol Biol Rep.2010,37(3):1611-8. ^[1] 

2009年

6. Xiao S, Li S, Zhang J, Zhang S, Dai L, Bao Y, Jiang N, Gao Y, Zhao Z,Mo D, Chen Y, Zhao Z. Cloning and characterization of class 1 and class 2 insulin-like growth factor-I mRNA in Songliao black pig.Mol Biol Rep. 2009, 36(2):415-21. ^[1] 

2008年

5.Delin Mo, Zhengmao Zhu, Marinus F W te Pas, Xinyun Li, Shulin Yang, Heng Wang, Huanling Wang and Kui Li. Characterization, expression profiles, intracellular distribution and association analysis of porcine PNAS-4 gene with production traits.BMC Genetics, 2008, 9:40.（IF: 2.35） ^[1] 

2007年

4. Li X, Zhu Z,Mo D, Wang H, Yang S, Zhao S, Li K. Comparative molecular characterization of ADSS1 and ADSS2 genes in pig (Sus scrofa).Comp Biochem Physiol B Biochem Mol Biol. 2007, 147(2):271-7. ^[1] 

2006年

3. Zhu Z, Li Y,Mo D, Li K, Zhao S. Molecular characterization and expression analysis of the porcine caveolin-3 gene.Biochem Biophys Res Commun. 2006, 346(1):7-13. ^[1] 

2. Wang H, Zhu Z, Wang H, Yang S,Mo D, Li K. Characterization of different expression patterns of calsarcin-1 and calsarcin-2 in porcine muscle.Gene. 2006, 374:104-11 ^[1] 

2003年

1.Mo DL, Liu B, Wang ZG, Zhao SH, Yu M, Fan B, Li MH, Yang SL, Zhang GX, Xiong TA and Li K. Genetic variation and relationship of seventeen Chinese indigenous pig breeds using ten serum protein loci.Asian-Australasian Journal of Animal Sciences. 2003, 16(7): 939-944. ^[1] 

1、一種用於豬背膘厚標記輔助選擇的分子標記的方法（ZL2011110448950.7）發明專利，莫德林，陳瑤生，朱曉萍，王翀，李加琪，李華周，專利權人：中山大學

2、一種評價豬的脂肪沉積性能的方法（ZL2011110451463.6），發明專利，陳瑤生，莫德林，朱曉萍，王翀，李加琪，姜增固。專利權人：中山大學

3、抗菌肽Protegrin-1在防治豬藍耳病中的應用（ZL201310469273.6），劉小紅、郭春和、莫德林、陳瑤生、高進濤，專利權人：中山大學

4、氯化血紅素在製備抗豬繁殖與呼吸綜合徵病毒藥物上的應用（ZL201310196386.3），劉小紅、汪亮亮、高進濤、莫德林、陳瑤生，專利權人：中山大學