童光志

1982年畢業於華中農學院獸醫系, 獲農學學士學位，

1985年畢業於中國農業科學院研究生院,獲農學碩士學位，

1990年畢業於中國人民解放軍獸醫大學，獲農學博士學位。

1982-1986在中國農業科學院哈爾濱獸醫研究所從事馬傳染性貧血病病毒的分子生物學研究

1986-1988在美國華盛頓州立大學從事牛I型和IV型皰疹病毒的分子克隆,物理圖譜及重複序列研究

1989-1993在哈爾濱獸醫研究所獸醫生物技術國家重點實驗室從事牛皰疹病毒及馬傳染性貧血病毒等的分子生物學研究

1993-1996.1在美國華盛頓州立大學美國農業部動物疾病研究中心作為訪問教授從事牛惡性卡他熱病毒(牛III型皰疹病毒)變異的分子基礎研究

1996.1-2007在哈爾濱獸醫研究所獸醫生物技術國家重點實驗室從事馬傳貧強弱毒比較及弱毒減毒分子基礎；雞、牛和豬皰疹病毒基因工程疫苗及其強弱毒分子鑑別診斷方法的研究；豬生殖-呼吸綜合徵病毒致病及免疫機理的研究。

2007.10任中國農業科學院上海獸醫研究所所長，從事豬繁殖與呼吸綜合徵的治病與免疫機制，以及豬流感病毒分子流行病學以及豬在流感病毒跨種間的感染過程的作用，以及偽狂犬病毒及雞痘病毒載體多價工程疫苗的研究、以及哺乳動物疫苗的研究。

曾任獸醫生物技術國家重點實驗室主任， 博士生導師；華中農業大學中國農業大學、華南農業大學和揚州大學等8所大學客座教授，黑龍江省政協委員，中國畜牧獸醫學會獸醫生物技術分會理事長。國務院政府特殊津貼獲得者，首批入選“百千萬人才工程”和農業部“神農計劃”提名人，中國農業科學院跨世紀學科帶頭人，農業部有突出貢獻中青年專家。863計劃生物與現代農業領域基因操作主題專家組成員。

現任中國畜牧獸醫學會動物傳染病學分會、禽病學分會、畜牧獸醫生物技術分會副理事長，中國微生物學會獸醫微生物分會副主任委員，獸醫生物技術國家重點實驗室、家畜疫病病原生物學國家重點實驗室和農業微生物國家重點實驗室學術委員會委員，國家農業轉基因生物安全委員會委員。 ^[2] 

多年來一直從事動物傳染病病原流行病學及新型基因工程疫苗的研究，目前主要研究方向為豬繁殖障礙相關疫病（豬藍耳病、豬流感、豬偽狂犬病、豬乙型腦炎等）的預防（動物用基因工程疫苗）與控制技術的應用與基礎研究。 ^[2] 

1、國家重點研發計劃

2、中國農業科學院創新工程

3、國家生豬現代產業技術體系科研專項 ^[2] 

研究成果獲國家科技進步二等獎2項，省部級自然科學獎、技術發明獎、科技進步獎14項；兩項疫苗產品獲得新獸藥證書，8種基因工程疫苗獲得轉基因安全證書，獲得國家發明專利23項；在國內外專業期刊上發表學術論文600餘篇，其中在國際雜誌發表190餘篇，主編/參編著作11部；培養博士後16名、博士研究生63名、碩士研究生86名。

國務院政府津貼獲得者，國家“百千萬人才”入選人，六部委共同頒發的留學人員成就獎，全國優秀科技工作者，全國優秀博士學位論文指導教師，首屆全國優秀農業科技工作者，農業部有突出貢獻中青年專家，第九屆黑龍江省勞動模範，第十二屆上海市科技精英，哈爾濱市勞動模範，第四屆中華農業英才獎。 ^[3] 

上海領軍人才（2008）、上海市十大科技精英（2011）。 ^[2] 

（1）Xuchen Zheng#, Hao Zheng#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, Yafeng Qiu, Zhiyong Ma, Guangzhi Tong*. Acid/base character of the Japanese Encephalitis Virus E protein residue 138 alters neurovirulence in mice. Journal of Virology, 2018, 92（22）:e00108-18.

（2）Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Kuan Zhao, Yujiao Zhang, Lin Li, Tongling Shan, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.

（3）Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu，Kuan Zhao, Guangzhi Tong*. Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly- pathogenic PRRSV and CSFV. Vaccine, 2018, 36:3269-3277.

（4）Kuan Zhao^§, Li-Wei Li^§, Yu-Jiao Zhang, Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Yan-Jun Zhou, Guang-Zhi Tong^*. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163.

（5）Zhi-qing Yu, Wu Tong, Hao Zheng, Li-wei Li, Guo-xin Li, Fei Gao, Tao Wang, Chao Liang, Chao Ye, Ji-qiang Wu, Qinfeng Huang*, Guang-zhi Tong*. Variations in glycoprotein B contribute to immunogenic difference between PRV Variant JS-2012 and Bartha-K61. Veterinary Microbiology, 2017, 208:97-105.

（6）Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Tongling Shan, Guoxin Li, Guangzhi Tong*. A Simple method for developing an infectious cDNA clone of Japanese encephalitis virus. Virus Genes, 2017, 53:4-14.

（7）Shen Yang, Yuan Zhan, Yanjun Zhou, Yifeng Jiang, Xuchen Zheng, Lingxue Yu, Wu Tong , Fei Gao, Zhiyong Ma, Guangzhi Tong*. Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity. Scientific Reports, 2016, 6:29665.

（8）Wu Tong, Guoxin Li, Chao Liang, Fei Liu, Qin Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated Pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016, 130:110-117.

（9）Wu Tong, Fei Liu, Hao Zheng, Chao Liang, Yan-jun Zhou, Yi-feng Jiang, Tong-ling Shan, Fei Gao, Guo-xin Li*, Guang-zhi Tong*. Emergence of a Pseudorabies virus variant with increased virulence to piglets. Veterinary Microbiology, 2015, 181:236-240.

（10）Liwei Li, Fei Gao, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Shen Yang, Tianqi Xia, Zehui Qu, Guangzhi Tong*. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Scientific Reports, 2015, 5:17010.

（11）Yi-feng Jiang^#，Tian-qi Xia^#，Yan-jun Zhou，Ling-xue Yu， Shen Yang， Qin-feng Huang, Li-wei Li，Fei Gao，Ze-hui Qu，Wu Tong，Guang-zhi Tong*. Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain. Veterinary Microbiology, 2015, 179:242-249.

（12）Chao Ye^†, Qing-Zhan Zhang^†, Zhi-Jun Tian^†, Hao Zheng, Kuan Zhao, Fei Liu, Jin-Chao Guo, Wu Tong, Cheng-Gang Jiang, Shu-Jie Wang, Mang Shi, Xiao-Bo Chang, Yi-Feng Jiang, Jin-Mei Peng, Yan-Jun Zhou, Yan-Dong Tang, Ming-Xia Sun, Xue-Hui Cai, Tong-Qing An*, Guang-Zhi Tong*. Genomic characterization of emerged pseudorabies virus in China reveals marked sequence divergence: evidence for existence of two major genotypes. Virology, 2015, 483:32-43.

（13）Liwei Li, Zuzhang Wei, Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu, Hao Zheng, Wu Tong, Shen Yang, Haihong Zheng, Tongling Shan, Fei Liu, Tianqi Xia, Guangzhi Tong*. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Research, 2015, 195:86-94.

（14）Tong-Qing An¹, Jin-Mei Peng¹, Zhi-Jun Tian¹, Hong-Yuan Zhao, Na Li, Yi-Min Liu, Jia-Zeng Chen, Chao-Liang Leng, Yan Sun, Dan Chang, Guang-Zhi Tong*. Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012. Emerging Infectious Diseases, 2013, 19(11):1749- 1755.

（15）Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Chunyan Chen, Guangzhi Tong*, Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication in vivo. Journal of Virology, 2012, 86（18）：9941-9951.

（16）Xuchen Zheng#, Hao Zheng#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, Yafeng Qiu, Zhiyong Ma, Guangzhi Tong*. Acid/base character of the Japanese Encephalitis Virus E protein residue 138 alters neurovirulence in mice. Journal of Virology, 2018, 92（22）:e00108-18.

（17）Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Kuan Zhao, Yujiao Zhang, Lin Li, Tongling Shan, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.

（18）Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu，Kuan Zhao, Guangzhi Tong*. Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly- pathogenic PRRSV and CSFV. Vaccine, 2018, 36:3269-3277.

（19）Kuan Zhao§, Li-Wei Li§, Yu-Jiao Zhang, Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Yan-Jun Zhou, Guang-Zhi Tong*. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163.

（20）Zhi-qing Yu, Wu Tong, Hao Zheng, Li-wei Li, Guo-xin Li, Fei Gao, Tao Wang, Chao Liang, Chao Ye, Ji-qiang Wu, Qinfeng Huang*, Guang-zhi Tong*. Variations in glycoprotein B contribute to immunogenic difference between PRV Variant JS-2012 and Bartha-K61. Veterinary Microbiology, 2017, 208:97-105.

（21）Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Tongling Shan, Guoxin Li, Guangzhi Tong*. A Simple method for developing an infectious cDNA clone of Japanese encephalitis virus. Virus Genes, 2017, 53:4-14.

（22）Shen Yang, Yuan Zhan, Yanjun Zhou, Yifeng Jiang, Xuchen Zheng, Lingxue Yu, Wu Tong , Fei Gao, Zhiyong Ma, Guangzhi Tong*. Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity. Scientific Reports, 2016, 6:29665.

（23）Wu Tong, Guoxin Li, Chao Liang, Fei Liu, Qin Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated Pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016, 130:110-117.

（24）Wu Tong, Fei Liu, Hao Zheng, Chao Liang, Yan-jun Zhou, Yi-feng Jiang, Tong-ling Shan, Fei Gao, Guo-xin Li*, Guang-zhi Tong*. Emergence of a Pseudorabies virus variant with increased virulence to piglets. Veterinary Microbiology, 2015, 181:236-240.

（25）Liwei Li, Fei Gao, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Shen Yang, Tianqi Xia, Zehui Qu, Guangzhi Tong*. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Scientific Reports, 2015, 5:17010.

（26）Yi-feng Jiang#，Tian-qi Xia#，Yan-jun Zhou，Ling-xue Yu， Shen Yang， Qin-feng Huang, Li-wei Li，Fei Gao，Ze-hui Qu，Wu Tong，Guang-zhi Tong*. Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain. Veterinary Microbiology, 2015, 179:242-249.

（27）Chao Ye†, Qing-Zhan Zhang†, Zhi-Jun Tian†, Hao Zheng, Kuan Zhao, Fei Liu, Jin-Chao Guo, Wu Tong, Cheng-Gang Jiang, Shu-Jie Wang, Mang Shi, Xiao-Bo Chang, Yi-Feng Jiang, Jin-Mei Peng, Yan-Jun Zhou, Yan-Dong Tang, Ming-Xia Sun, Xue-Hui Cai, Tong-Qing An*, Guang-Zhi Tong*. Genomic characterization of emerged pseudorabies virus in China reveals marked sequence divergence: evidence for existence of two major genotypes. Virology, 2015, 483:32-43.

（28）Liwei Li, Zuzhang Wei, Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu, Hao Zheng, Wu Tong, Shen Yang, Haihong Zheng, Tongling Shan, Fei Liu, Tianqi Xia, Guangzhi Tong*. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Research, 2015, 195:86-94.

（29）Tong-Qing An1, Jin-Mei Peng1, Zhi-Jun Tian1, Hong-Yuan Zhao, Na Li, Yi-Min Liu, Jia-Zeng Chen, Chao-Liang Leng, Yan Sun, Dan Chang, Guang-Zhi Tong*. Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012. Emerging Infectious Diseases, 2013, 19(11):1749- 1755.

（30）Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Chunyan Chen, Guangzhi Tong*, Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication in vivo. Journal of Virology, 2012, 86（18）：9941-9951.

獲得部級科技成果獎4項。

1、《肉食獸細小病毒通用核酸探針的製備及應用研究》獲1992年總後勤部科技進步二等獎。

2、《犬腺病毒通用和特異DNA探針的製備及應用研究》獲1992年總後勤部科技進步三等獎。

3、《雞傳染性喉氣管炎病毒三個基因的克隆鑑定及研究》獲1997年哈爾濱市科委科技進步二等獎。

4、《豬呼吸及生殖障礙綜合徵病原的分離鑑定》獲1997年農業部科技進步三等獎。