王永紅

王永紅，女，教授，生物化工專業博士生導師。

1984.9-1988.7華東理工大學，生物化學工程系，工學學士

1988.9-1991.7華東理工大學，生物化工專業，工學碩士

1996.9-2000.12華東理工大學，生物化工專業，工學博士

2001.10-2002.9 耐高温酵母的分子生物學 （日本大阪大學、京都大學）

1991.9-華東理工大學生工學院、國家生化工程技術研究中心（上海）

1．微生物過程工程：主要研究興趣集中在從代謝流的角度研究生物反應器生物培養/轉化過程的多水平調節問題和過程優化，尤其是組學研究（基因組、轉錄組、蛋白質組、代謝物組）應用於生物反應器微生物過程細胞代謝流控制與優化的研究。也包含微生物應用分子生物學和微生物代謝及其機理等方向。歡迎有較強的生物化學、分子生物學或數學背景，對代謝機理、代謝途徑、代謝網絡和生物信息學有興趣的同學報考。

2．生物反應器工程：主要研究興趣集中在受生物反應器結構及其操作影響的生物反應器流體動力學環境與微生物細胞/細胞羣體生長、代謝的相互影響和相互關係。歡迎有較強的化學工程、化工機械或數學背景，對生物反應器工程或微生物過程放大有興趣的同學報考。

在研的國家項目有：“蛋白質組學應用於生物反應器微生物過程優化的基礎研究”(國家自然科學基金項目)；“基因工程微生物表達系統發酵過程優化平台技術研究”(十五 “863”)和 “微生物表達蛋白藥物規模化製備平台技術”(十五科技重大專項)。

2002年在日本京都大學農學部應用分子生物學實驗室進行耐高温酵母的分子生物學研究。

參加過多項國家級科研項目的研究工作。如“在線計算機輔助的青黴素絲狀菌發酵工藝優化研究”和“青黴素遺傳育種及發酵工藝研究和新型攪拌槳研製” （“七五”“八五”國家攻關項目）；“光生物反應器研製及其在藻類大規模培養中的應用研究”（“九五”國家攻關）；“轉基因微藻高密度高表達培養技術研究”（九五海洋“863”）；“轉基因藍藻高密度高表達混合/異氧培養技術的基礎研究”（國家自然科學基金29876010）；“轉小鼠金屬硫蛋白基因集胞藻6803高密度高表達混合營養培養研究”（華東理工大學生物反應器工程國家重點實驗室開放課題）。

1. Wang, Y.H., Li, Y.G., Shi, D.J., Shen, G.M., Ru, B.G., Zhang, S.L.. Characteristics of mixotrophic growth of Synechocystis Sp. in an enclosed photobioreactor. Biotech. Lett., 24:1593-1597(2002)

2. 王永紅，葉濟宇，米華玲，李元廣，張嗣良。集胞藻Synechocystis sp. PCC6803利用葡萄糖生長與光和能量轉化的關係。植物學報，42:1122-1125(2000)

3. 王永紅，李元廣，施定基，沈國敏，茹炳根，張嗣良。集胞藻6803在封閉式光生物反應器中的混合營養培養。高技術通訊，11(5): 28-30(2001)

4. 王永紅，李元廣，施定基，沈國敏，茹炳根，張嗣良。封閉式光生物反應器集胞藻6803光自養和混合營養培養比較。華東理工大學學報，27:247-250(2001)

5. 王永紅，李元廣，施定基，沈國敏，茹炳根，袁航，張嗣良。集胞藻6803的混合營養培養-光照和葡萄糖的影響。生物工程學報，16:193-197(2000)

6.莊英萍,康源,王永紅。一種添加金屬離子提高必特螺旋黴素產量的發酵工藝，國家發明專利。 正陽縣呂河鄉黨委書記

1. Chen Y, Sun Y, Liu ZhH, Dong FQ, Li YY, Wang YH. Genome-scale modeling for Bacillus coagulans to understand the metabolic characteristics. Biotechnology and Bioengineering, 117(11): 3545-3558 （2020）.

2. Zhu XD, Sh X, Wang SW, Chu J, Zhu WH, Ye BC, Zuo P, Wang YH.High-throughput screening of high lactic acid-producing Bacillus coagulans by droplet microfluidic based flow cytometry with fluorescence activated cell sorting. Rsc Advances, 9(8): 4507-4513 （2019）.

3. Gao XW, Wang YH, Chu J. A preliminary study on the impact of exogenous A-Factor analogue 1,4-butyrolactone on stimulating bitespiramycin biosynthesis. Bioprocess and Biosystems Engineering, 42(12):1903-1913 (2019).

4. Song XQ, Zhang Y, Xue JY, Li Ch, Wang ZJ, Wang YH.Enhancing nemadectin production by Streptomyces cyaneogriseus ssp. noncyanogenus through quantitative evaluation and optimization of dissolved oxygen and shear force. Bioresource Technology, 255: 180-188 （2018）.

5. Zhu XD, Chu J, Wang YH. Advances in Microfluidics Applied to Single Cell Operation. Biotechnology Journal, 13(2): 1700416-1700424 （2018）.

6. Chen Y, Wang YH, Nielsen J. Systematic inference of functional phosphorylation events in yeast metabolism. Bioinformatics, 33(13):1995-2001 (2017).

7. Shen SH, Gu Y, Chai CS, Jiang WH, Zhuang YP, Wang YH. Enhanced alcohol titre and ratio in carbon monoxide-rich off-gas fermentation of Clostridium carboxidivorans through combination of trace metals optimization with variable-temperature cultivation. Bioresource Technology, 239: 236-243 (2017).

8. Tian XW, Wang YH, Chu J* Zhuang YP, Zhang SL. Enhanced L-lactic acid production in Lactobacillus paracasei by exogenous proline addition based on comparative metabolite profiling analysis. Applied Microbiology & Biotechnology, 100(5):2301-2310 (2016).

9. Chen Y, Dong FQ, Wang YH. Systematic development and optimization of chemically defined medium supporting high cell density growth of Bacillus coagulans. Applied Microbiology and Biotechnology, 100(18):8121-8134 (2016).

10. Ping KK, Wang ZJ, Lu F, Zhao W, Chu J, Zhuang YP, Wang YH. Effect of oxygen supply on the intracellular flux distribution and a two-stage OUR control strategy for enhancing the yield of sodium gluconate production by Aspergillus niger. Journal of Chemical Technology & Biotechnology, 91(5):1443-1451 (2016).

11. Lv XY, Guo YX, Zhuang YP, Wang YH.Optimization and validation of an extraction method and HPAEC-PAD for determination of residual sugar composition in L-lactic acid industrial fermentation broth with a high salt content. Analytical Methods, 7(21):9076-9083 (2015).

12. Tian X, Zhang N, Yang Y, Wang Y, Chu J, Zhuang Y, Zhang S. The effect of redox environment on l-lactic acid production by Lactobacillus paracasei—A proof by genetically encoded in vivo NADH biosensor. Process Biochemistry, 50(12):2029-2034 (2015).

13. Tian XW, Wang YH, Chu J, Zhuang YP, Zhang SL. L-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination. Bioprocess and Biosystems Engineering, 37(9):1917-1923 (2014).

14. Tian XW, Wang YH, Chu J, Zhuang YP, Zhang SL. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on L-lactic acid production efficiency by Lactobacillus paracasei. Process Biochemistry, 49(12):2049-2054 (2014).

15. Yin P, Li YY, Zhou J, Wang YH, Zhang SL, Ye BC, Ge WF, Xia YL. Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. Journal of Proteomics, 79:1-12 (2013)

16. Li C, Xia JY, Chu J, Wang YH, Zhuang YP, Zhang SL. CFD analysis of the turbulent flow in baffled shake flasks. Biochemical Engineering Journal, 70:140-150 (2013)

17. Li X, Shi H, Wang YH, Zhang SL, Chu J, Zhang M, Huang MZ, Zhuang YP. Effects of vitamins (nicotinic acid, vitamin B(1) and biotin) on phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5. International Journal of Hydrogen Energy, 36(16):9620-9625(2011)

18. Li X, Dai ZZ, Wang YH, Zhang SL. Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using fed-batch operation based on ORP level. International Journal of Hydrogen Energy, 36(20):12794-802(2011)

19. Li X, Wang YH, Zhang SL, Chu J, Zhang M, Huang MZ, Zhuang YP. Effects of light/dark cycle, mixing pattern and partial pressure of H2 on biohydrogen production by Rhodobacter sphaeroides ZX-5. Bioresource Technology, 102:1142-1148 (2011)

20. Qian JC, Qin XL, Yin Q, Chu J, Wang YH. Cloning and characterization of Kluyveromyces marxianus Hog1 gene. Biotechnology Letters 33:571-575 (2011)

21. Wang YH, Wu CH, Chu J, Hao YY, Zhuang YP, Zhang SL. Regulation of branched-chain amino acid catabolism: glucose limitation enhances the component of isovalerylspiramycin for the bitespiramycin production. Bioprocess and Biosystems Engineering, 33: 257-265 (2010)

22. Lu YF, Wang YH, Xu GQ, Chu J, Zhuang YP, Zhang SL. Influence of high solid concentration on enzymatic hydrolysis and fermentation of steam-exploded corn stover biomass. Applied Biochemistry and Biotechnology, 160: 360-369 (2010)

23. Li X, Wang YH, Zhang SL, Chu J, Zhang M, Huang MZ, Zhuang YP. Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using a novel strategy - shaking and extra-light supplementation approach. International Journal of Hydrogen Energy, 34: 9677-9685 (2009)

24. Li ZL, Wang YH, Chu J, Zhuang YP, Zhang SL. Leucine improves the component of isovalerylspiramycins for the production of bitespiramycin. Bioprocess and Biosystems Engineering, 32: 641-647 (2009)

25. Wang YH, Zhou J, Chu J, Qian JC, Zhang SL, Zhuang YP. Production and distribution of beta-glucosidase in a mutant strain Trichoderma viride T 100-14. New Biotechnology, 26: 150-156 (2009)

26. Xia JY, Wang YH, Zhang SL, Chen N, Yin P, Zhuang YP, Chu J. Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment. Biochemical Engineering Journal, 43: 252–260 (2009)

27. Zhou J, Wang YH, Chu J, Luo LZ, Zhuang YP, Zhang SL. Optimization of cellulase mixture for efficient hydrolysis of steam-exploded corn stover by statistically designed experiments. Bioresource Technology,100: 819-825 (2009)

28. Wang YH, Xi BX, Hao YY, Huang MZ, Zhang SL. A combined strategy to simultaneously improve the component of isovalerylspiramycin in a bitespiramycin (4”-O-acylspiramycins) complex and its biological titre. Process Biochemistry, 43:1013–1017 (2008)

29. Yin P, Wang YH, Zhang SL, Chu J, Zhuang YP, Wang ML, Zhou J. Isolation of soluble proteins from an industrial strain Streptomyces avermitilis in complex culture medium for two-dimensional gel electrophoresis, Journal of Microbiological Methods, 73: 105-110 (2008)

30. Yin P, Wang YH, Zhang SL, Chu J, Zhuang YP, Chen N, Li XF, Wu YB. Effect of hyphal morphology on bioreactor performance and avermectin production of Streptomyces avermitilis in submerged cultivations. Journal of the Chinese Institute of Chemical Engineers, 39: 609–615 (2008)

31. Zhou J, Wang YH, Chu J, Zhuang YP, Zhang SL, Yin P. Identification and purification of the main components of cellulases from a mutant strain of Trichoderma viride T 100-14. Bioresource Technology, 99: 6826-6833 (2008)

32. Zhao J, Wang YH, Chu J, Zhang SL, Zhuang YP, Yuan ZY. Statistical optimization of medium for the production of pyruvate oxidase by the recombinant E.coli. Journal of Industrial Microbiology and Biotechnology, 35: 257-262 (2008)

33. Hong J, Wang YH, Kumagai H, Tamaki H. Construction of thermotolerant yeast expressing thermostable cellulase genes. Journal of Biotechnology, 130: 114–123 (2007) ^[1]