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殷戰

鎖定
殷戰，1965年8月生，研究員，主要研究方向為發育生物學。1999年於新加坡國立大學生物系獲哲學博士學位 [1]  ，1999年-2003年在美國Case Western Reserve University醫學院藥學系做博士後研究；2003年-2005年在美國University of Pennsylvania醫學院醫學系分子心臟病學研究中心做博士後研究，2005年受聘為中科院水生生物研究所研究員、2018年4月至2020年7月任副所長（主持工作），2020年7月起任水生所所長。入選中國科學院“百人計劃”，2006年獲百人計劃擇優資助，2009年獲得國家傑出青年科學基金資助、2016年入選第二批國家“萬人計劃”領軍人才。 [2-3] 
殷戰自2005年5月回到水生所組建學科組以來，以斑馬魚為主要研究模式，並結合鯽、鯉等養殖魚類，針對魚類生長代謝、肌肉生長、性別發育等方面的內分泌調控開展研究；並曾利用斑馬魚為模式，探索環境內分泌干擾物的生物學效應的體內評價研究。 [2] 
中文名
殷戰
國    籍
中國
出生日期
1965年8月
畢業院校
武漢大學
畢業院校
中國科學院水生生物研究所 [2] 
新加坡國立大學
主要成就
2009年獲得國家傑出青年科學基金資助
2016年入選第二批國家“萬人計劃”領軍人才 [2] 

目錄

  1. 1 人物經歷
  2. 2 研究方向
  3. 3 課題研究
  4. 4 專家類別
  5. 5 代表論著

殷戰人物經歷

1999年於新加坡國立大學生物系獲哲學博士學位 [1]  ，1999年-2003年在美國Case Western Reserve University醫學院藥學系做博士後研究；2003年-2005年在美國University of Pennsylvania醫學院醫學系分子心臟病學研究中心做博士後研究，2005年受聘為中科院水生生物研究所研究員、2018年4月至2020年7月任副所長（主持工作），2020年7月至2023年9月任中國科學院水生生物研究所所長。 [4] 

殷戰研究方向

魚類分子病理學

殷戰課題研究

2005年5月中國科學院水生生物研究所組建學科組，開展了魚類內分泌對生長、肌肉發育等方面調控機制的研究工作。主要以斑馬魚為主要研究模式，並結合鯽魚為養殖模式，集中關注魚類的內分泌生長調控軸、在魚類營養、代謝、生長、繁殖等方面的內分泌調控研究方面，開展了較為系統地研究工作。並在採用基因編輯技術和遺傳標記輔助育種方面，針對模式魚類和養殖魚類的代謝調控、肌肉生長、可控性魚類性腺發育技術研究等方面也正在取得許多深具潛力的研究進展。對利用斑馬魚為模式生物系統的環境內分泌干擾物評價體內模式也曾進行了一系列有益的探索。 [1] 

殷戰專家類別

百人;傑青

殷戰代表論著

1. Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z.* . 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25 (OH) 2 D3. Cell Reports. 19:1444-1455.
2. Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z*. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics (In press)
3. Dai, X., Shu, Y., Lou, Q., Tian, Q., Zhai, G., Song, J., Lu, S., Yu, H., He, J., Yin, Z. * 2017. Tdrd12 Is Essential for Germ Cell Development Maintenance in Zebrafish. International Journal of Molecular Sciences. 18(6), 1127;
4. Yang, J., Li Z., Gan, X., Zhai, G., Gao, J., Xiong, C., Qiu, X., Wang, X., Yin, Z.*, Zheng, F.* 2016. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences. 17(11), 1746.
5. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q and Yin Z* 2016. Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh. Frontier in Endocrinology. 7:88.
6. Zhai, G., Shu, T., Xia, Y., Jin, X., He, J., Yin Z. * 2016. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A. Science Bulletin. 62 (3), 197-203.
7. Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W.*, Yin, Z*. 2016. The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models Scientific Reports. 6, Articlenumber:18597
8. Dai X, Jin X, Chen X, He J, Yin Z*. 2015. Sufficient numbers of early germ cells are essential for female sex development in zebrafish. PLoS One. 2015 Feb 13;10(2):e0117824.
9. Dai X, Zhang W, Zhuo Z, He J, Yin Z*. 2015. Neuroendocrine regulation of somatic growth in fishes (Review). Science in China Life Science. 58(2):137-47. Review.
10. Cheng,X., Chen,X., Li, D., Jin, X., He, J., Yin Z*. 2015. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. General and Comparative Endocrinology. 214：87-94.
11. Cheng, X., Chen, X., Jin, X., He, J., Yin, Z*. 2014. Generation and Characterization of Gsuα:EGFP Transgenic Zebrafish for Evaluating Endocrine-Disrupting Effects. Toxicology and Applied Pharmacology. 278(1): 78-84.
12. He, W., Dai, X., Chen, X., He, J., Yin, Z*. 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221(3):429-440.
13. Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155 (6)：2199-2212.
14. Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E.*, Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.
15. Mei Y, Yin N, Jin X, He J, Yin Z* 2013. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9.
16. Chen D, Li L, Tu X, Yin Z*, Wang Q*. 2013. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human Molecular Genetics. 22(5):963-76.
17. Cui X, Zhang, J., Du, R., Wang, L., Archacki, S., Zhang, Y., Yuan, M., Ke, T., Li, H., Li, D., Li, C., Li, DW., Tang, Z., Yin, Z*., Liu, M*. HSF4 is involved in DNA damage repair through regulation of Rad51. Biochimica et Biophysica Acta-Molecular Basis of Diseases. 1822(8):1308-15.
18. Ji C., Jin X., He J.,Yin, Z*. 2012. Use of TSHbeta:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 262(2):149-155
19. Jiang N., Jin X., He J., Yin Z*. 2012 The Roles of follistatin 1 in Regulation of Zebrafish Fecundity and Sexual Differentiation. Biology of Reproduction. 87 (3) 54, 1-8.
20. Chen X., Lou Q., He J. & Yin Z*. 2012. Role of Zebrafish Lbx2 in Embryonic Lateral Line Development. PLoS ONE 6(12): e29515.
21. Lou Q., He J., Hu L., Yin Z*. 2012. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et Biophysica Acta - Molecular Cell Research. 823(5):1024-32.
22. Li X., He J., Hu W & Yin Z * 2009. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6):2767-74.
23. Ma L., Li D., Wang J., He J & Yin Z * 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus). Aquatic Toxicology. 91 (1): 19-25.
24. Trivedi CM*, Luo Y*, Yin Z*, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. 2007. HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3？. Nature Medicine. 13(3): 324-331. (*Equal first author).
25. Yin, Z.*, Gonzales, L*., Kolla, V., Rath, N., Zhang, Y., Lu, MM., Kimura, S., Ballard, PL., Beers, MF., Epstein, JA. & Morrisey, EE. 2006. Hop functions downstream of Nkx2.1 and Gata6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. American Journal of Physiology, Lung Cellular and Molecular Physiology. 291：L191-199. (*Equal first author)
26. Yin, Z., Jeni Haynie, Bryan R. Williams and Yu-Chung Yang. 2003. C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. Journal of Biological Chemistry. 278, 22838-22845.
27. Yin, Z. Haynie, J., Yang, X.,. Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. 2002. The essential role of Cited2, a negative regulator hif-1 in heart development and neurulation.Proceedings of National Academy of Sciences of the United States of America. 99, 10488-10493. [1] 
參考資料