楊曉明

教育及工作經歷

2010-至今西南大學藥學院

2007-2009四川大學-美國普渡大學生物化學系 理學博士

2004-2007四川大學化學學院 碩博連讀

2000-2004四川大學化學學院 理學學士

研究方向

(1)藥物分析方法學研究：熒光納米材料合成方法的探索，材料的表徵及其在藥物分析、疾病標誌物檢測中的應用。

(2)免疫分析方法學研究：結合新型熒光標記材料，構建免疫分析方法及其在藥物分析、食品安全、環境衞生中小分子檢測中的應用。

(3)探究潛在腫瘤標誌物Plk1及相關蛋白激酶在癌細胞信號通路中功能的研究：細胞增殖與調控，細胞信號轉導。 ^[1] 

1. Dan Zhong, Hong Miao, Kuncheng Yang,Xiaoming Yang*. Carbon dots originated from carnation for fluorescent and colorimetric pH sensing. Materials Letters, 2016, 166:89-92. (SCI, IF=2.489)

2. Lan Wang, Hong Miao, Dan Zhong and Xiaoming Yang*. Synthesis of dopamine-mediated Cu nanoclusters for sensing and fluorescent coding. Analytical Methods, 2016, 8:40-44. (SCI, IF=1.821)

3. Hong Miao, Dan Zhong, Zinan Zhou, Xiaoming Yang*. Papain-templated Cu nanoclusters: assaying and exhibiting dramatic antibacterial activity cooperating with H₂O₂. Nanoscale, 2015, 7:19066-19072. (SCI, IF=7.394)

4. Shanshan Zhu, Yan Zhuo, Hong Miao, Dan Zhong, Xiaoming Yang*. Detection of mercury(II) by DNA templated gold nanoclusters based on forming thymidine-Hg-thymidine duplexes. Luminescence, 2015, 30:631-636. (SCI, IF=1.518)

5. Dan Zhong, Yan Zhuo, Yuanjiao Feng, Xiaoming Yang*. Employing carbon dots modified with vancomycin for assaying Gram-positive bacteria like Staphylococcus aureus. Biosensors and Bioelectronics, 2015, 74:546-553. (SCI, IF=6.409)

6. Yawen Luo, Hong Miao, Xiaoming Yang*. Glutathione-stabilized Cu nanoclusters as fluorescent probes for sensing pH and vitamin B1. Talanta, 2015, 144:488-495. (SCI, IF=3.545)

7. Yan Zhuo, Dan Zhong, Hong Miao, Xiaoming Yang*. Reduced carbon dots employed for synthesizing metal nanoclusters and nanoparticles. RSC Advances, 2015, 5:32669-32674. (SCI, IF=3.84)

8. Yuanjiao Feng, Dan Zhong, Hong Miao, Xiaoming Yang*. Carbon dots derived from rose flowers for tetracycline sensing.Talanta, 2015, 140:128-133. (SCI, IF=3.545)

9. Yan Zhuo, Hong Miao, Dan Zhong, Shanshan Zhu, Xiaoming Yang*. One-step synthesis of high quantum-yield and excitation-independent emission carbon dots for cell imaging. Materials Letters, 2015, 139:197-200. (SCI, IF=2.489)

10. Xiaoming Yang*, Yan Zhuo, Shanshan Zhu, Yawen Luo, Yuanjiao Feng and Yan Xu. Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters’ fluorescence. Biosensors and Bioelectronics, 2015, 64:345-351. (SCI, IF=6.409)

11. Xiaoming Yang*, Yuanjiao Feng, Shanshan Zhu, Yawen Luo, Yan Zhuo and Yao Dou. One-step synthesis and applications of fluorescent Cu nanoclusters stabilized by L-Cysteine in aqueous solution. Analytica Chimica Acta, 2014, 847:49-54. (SCI, IF=4.513)

12. Xiaoming Yang*, Yawen Luo, Yan Zhuo, Yuanjiao Feng and Shanshan Zhu. Novel synthesis of gold nanoclusters templated with L-tyrosine for selective analyzing tyrosinase. Analytica Chimica Acta, 2014, 840:87-92. (SCI, IF=4.513)

13. Xiaoming Yang*, Yan Zhuo, Shanshan Zhu, Yawen Luo, Yuanjiao Feng and Yao Dou. Novel and green synthesis of high-fluorescent carbon dots originated from honey for sensing and imaging. Biosensors and Bioelectronics, 2014, 60:292-298. (SCI, IF=6.409)

14. Yan Xu, Xiaoming Yang*, Shanshan Zhu and Yao Dou. Selectively fluorescent sensing of Cu based on Lysine-functionalized gold nanoclusters. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 450: 115-120. (SCI, IF=2.752)

15. Xiaoming Yang*, Yawen Luo, Shanshan Zhu, Yuanjiao Feng, Yan Zhuo and Yao Dou. One-pot synthesis of high fluorescent carbon nanoparticles and their applications as probes for detection of tetracyclines. Biosensors and Bioelectronics, 2014, 56: 6-11.(SCI, IF=6.409)

16. Xiaoming Yang*, Shanshan Zhu, Yao Dou, Yan Zhuo, Yawen Luo and Yuanjiao Feng. Novel and remarkable enhanced-fluorescence system based on gold nanoclusters for detection of tetracycline. Talanta, 2014, 122: 36-42. (SCI, IF=3.545)

17. Xiaoming Yang*, Lei Yang, Yao Dou and Shanshan Zhu. Synthesis of highly fluorescent lysine-stabilized Au nanoclusters for sensitive and selective detection of Cu ion. Journal of Materials Chemistry C, 2013, 6748-6751. (SCI, IF=4.696)

18. Xiaoming Yang*, Yao Dou and Shanshan Zhu. Highly sensitive detection of superoxide dismutase based on an immunoassay with surface-enhanced fluorescence. Analyst, 2013, 138:3246-3252. (SCI, IF=4.107)

19. Yao Dou and Xiaoming Yang*. Novel high-sensitive fluorenscent detection of deoxyribonuclease I based on DNA-templated gold/silver nanoclusters. Analytica Chimica Acta, 2013, 784:53-58. (SCI, IF=4.513)

20. Yao Dou, Xiaoming Yang*, Zhongde Liu and Shanshan Zhu. Homocysteine-functionalized silver nanoparticles for selective sensing of Cu ions and Lidocaine hydrochloride. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2013, 423:20-26. (SCI, IF=2.752)

21. Xiaoming Yang*, Hongchang Li, Anping Deng and Xiaoqi Liu. Plk1 phosphorylation of topors is involved in its degradation. Molecular Biology Reports, 2010, 37:3023-3028. (SCI, IF=2.024)

22. Xiaoming Yang, Hongchang Li, Zinan Zhou, Wen-Hong Wang, Anping Deng, Ourania Andrisani and Xiaoqi Liu*. Plk1-mediated phosphorylation of topors regulates P53 stability. Journal of Biological Chemistry, 2009, 284:18558-18592. (SCI, IF=4.573)

23. Xiaoming Yang, Hongchang Li, Shawn Liu, Anping Deng and Xiaoqi Liu*. CDC2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. Journal of Biological Chemistry, 2009, 284:28775-28782. (SCI, IF=4.573)

24. Jiabin Tang, Xiaoming Yang and Xiaoqi Liu*. Phophorylation of PLK1 at Ser-326 regulates its functions during mitotic progression. Oncogene, 2008, 27:6635-6645. (SCI, IF=8.559)

25. Zhao-Qiu Wu, Xiaoming Yang , Gregory Weber and Xiaoqi Liu*. PLK1 Phosphorylation of TRF1 is essential for its binding to telomers. Journal of Biological Chemistry, 2008, 283:25503-25513. (SCI, IF=4.573)

26. Hongchang Li, X Shawn Liu, Xiaoming Yang, Bing Song, Yun Wang and Xiaoqi Liu*. Polo-like kinase 1 Phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(33):14633-14638. (SCI, IF=9.809)

27. Hongchang Li, X Shawn Liu, Xiaoming Yang, Yingmin Wang, Yun Wang, Jerrold R Turner and Xiaoqi Liu*. Phosphorylation of CLIP-170 by PLK1 and CK2 promotes timely formation of kinetochore-microtubule attachments. EMBO J. 2010, 29:2953-2965. (SCI, IF=10.740)

28. Xiaoling Qi, Xiaoming Yang, Bin Wang, Hong Yang and Anping Deng*. Development of a broad selective molecularly imprinted polymers based solid phase extraction of contraceptive drug levonorgestrel from water samples. Intern. J. Environm. Anal. Chem. 2012, 92,268-278. (SCI, IF=1.24)

29. Weiwei Xing, Li He, Hong Yang, Chengjun Sun, Dawei Li, Xiaoming Yang, Yuan Li and Anping Deng*. Development of a sensitive and group-specific polyclonal antibody-based enzyme-linked immunosorbent assay (ELISA) for detection of malachite green and leucomalachite green in water and fish samples. J Sci Food Agric. 2009, 89:2165-2173. (SCI, IF=1.879) ^[2]