李昂

2000.09-2004.06 北京大學化學與分子工程學院，理學學士，導師：楊震教授。

2004.07-2009.11 The Scripps Research Institute，California，USA，Ph.D.，導師：Prof. K. C. Nicolaou。

2010.01-2010.09 Institute of Chemical and Engineering Sciences，Singapore，research fellow，導師：Prof. K. C. Nicolaou。

2010.09-2019.11中國科學院上海有機化學研究所研究員。 ^[2] 

2019.11- 中國科學院上海有機化學研究所副所長。 ^[3] 

活性天然產物的化學合成 ^[4] 

天然產物合成對化學學科的發展和小分子藥物的創制起到了重要推動作用，是國際上非常活躍的研究領域。李昂博士在此領域取得了具有國際影響力的成績，系統地發展了針對擁擠環系的合成策略，完成了14類90多個天然產物的全合成，其中45個為首次合成。他的一項代表性工作是虎皮楠生物鹼的全合成。這類分子在過去30多年裏引起了國際全合成界的廣泛關注和激烈競爭。他完成了該家族多個成員的集合式合成，其中含有11個環和19個手性中心的hybridaphniphylline B的合成代表了該領域繼Heathcock傑出工作後的一項突破。 ^[4] 

2022年11月，榮獲第十七屆中國青年科技獎。 ^[6] 

2020 第二屆“科學探索獎”獲得者 ^[1] 

2017 Asian International Symposium Distinguished Lectureship Award, Chemical Society of Japan

2017 Tetrahedron Young Investigator Award for Organic Synthesis

2016 CAPA Distinguished Faculty Award

2016 ChemComm Emerging Investigator Lectureship

2015 The National Science Fund for Distinguished Young Scholars

2015 WuXi PharmaTech Life Science and Chemistry Award

2015 Roche Chinese Young Investigators Award

2013 Asian Core Program Lectureship Award

2013 Chinese Chemical Society Wei-Shan Award for Synthetic Chemistry

2013 China Pharmaceutical Association–Servier Youth Medicinal Chemist Award

2013 Thieme Chemistry Journal Award

2012 Asian Core Program Lectureship Award

2009 Eli Lilly Graduate Fellowship

2007 Chinese Government Award for Outstanding Graduate Students Abroad

2007 Bristol-Myers Squibb Graduate Fellowship in Organic Synthesis ^[2] 

(1) P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,* A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 142 (2020), DOI: 10.1021/jacs.9b09699

(2) S. Zhou, K. Xia, X. Leng, A. Li,* Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc. 141 (2019), DOI: 10.1021/jacs.9b05818

(3) X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed. 58 (2019), DOI: 10.1002/anie.201901086

(4) Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b05070

(5) S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b03712

(6) W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b01681

(7) Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 57(2018), DOI:10.1002/ange.201711482

(8) J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc. 139 (2017), DOI: 10.1021/jacs.7b09186

(9) Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 139 (2017), DOI: 10.1021/jacs.7b01718

(10) H. Li, Q. Chen, Z. Lu, A. Li,* Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc. 138 (2016), DOI: 10.1021/jacs.6b10880

(11) P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 55 (2016), DOI:10.1002/ange.201601915

(12) Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 138 (2016), DOI: 10.1021/jacs.6b00764

(13) M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole. Angew. Chem. Int. Ed. 55 (2016), DOI:10.1002/ange.201510568

(14) Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc. 137 (2015), DOI: 10.1021/jacs.5b09198

(15) S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,* Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed. 54 (2015), DOI: 10.1002/ange.201501021

(16) M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun. 6 (2015), DOI：10.1038/ncomms7445

(17) Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun. 6 (2015), DOI:10.1038/ncomms7096

(18) J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 136 (2014), DOI:10.1021/ja5092563

(19) Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed. 53 (2014), DOI: 10.1002/anie.201406626

(20) Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed. 53 (2014), DOI: 10.1002/anie.201404191

(21) J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 136 (2014), DOI：10.1021/ja503972p

(22) Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed. 52 (2013), DOI: 10.1002/anie.201303334

(23) Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum alkaloid daphenylline. Nat. Chem. 5 (2013), DOI: 10.1038/nchem.1694

(24) M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc. 134 (2012), DOI:10.1021/ja302765m

(25) J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 134 (2012), DOI:10.1021/ja211444m ^[4]