李揚

1992年本科畢業於山東大學生化專業，1999年華東師範大學生理學碩士畢業，2002年中國科學院上海藥物研究所藥理學博士畢業。2002年7月至2009年9月先後在美國德克薩斯大學聖安東尼奧醫學中心和達拉斯西南醫學中心從事研究工作。2009年9月入選中國科學院百人計劃，在上海藥物研究所擔任課題組長。

離子通道和受體是重要的膜蛋白，不僅發揮重要的生理功能，也是主要的藥物作用靶點。我們綜合電生理學、藥理學和結構生物學等技術手段，研究受體與離子通道的調控機制，開展鉀通道的結構與功能研究。最近針對抑鬱症等神經系統疾病，我們進一步開展了動物行為學和在體電生理學研究，從天然產物中篩選和發現新的抗抑鬱藥物；同時“以藥效測機制”開展藥理學機制研究。

代表論著：

Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. Proc Natl Acad Sci U S A.

Ning Shia,1, Weizong Zenga,1, Sheng Yeb, Yang Lic* and Youxing Jianga*. Crucial Points within the Pore as Determinants of K+ Channel Conductance and Gating，JOURNAL OF MOLECULAR BIOLOGY.

Derebe MG, Zeng W, Li Y, Alam A, Jiang Y. Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.

Sheng Ye1, Yang Li2 & Youxing Jiang3,4 Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nature structural & molecular biology.

Li Y, Berke I, Chen L, Jiang Y. Gating and inward rectifying properties of the MthK K+ channel with and without the gaing ring. J. Gen. Physiol.

Ye S, Li Y, Chen L, Jiang Y. Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K+ Channels. Cell.

Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS. Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing. EMBO J.

Li Y, Gamper N, Hilgemann DW, Shapiro MS. Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.J. Neurosci.

Gamper N, Li Y, Shapiro MS. Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin. Mol Biol Cell.

Li Y, Langlais P, Gamper N, Liu F, Shapiro MS. Dual phosphorylations underlie modulation of unitary KCNQ K+ channels by Src tyrosine kinase. J. Biol.

Li Y, Gamper N, Shapiro MS. Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent. J. Neurosci.

Liu, H.; Li, Y.; Song, M.; Tan, X.; Cheng, F.; Zheng, S.; Shen, J.; Luo, X.; Ji, R.; Yue, J.; Hu, G.; Jiang, H.; Chen, K. Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing. Chem. Biol.

Liu H, Gao ZB, Yao Z, Zheng S, Li Y, Zhu W, Tan X, Luo X, Shen J, Chen K, Hu GY, Jiang H. Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay.

Yang Li, Guo-Yuan Hu. Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons. Neuroscience Letters.

Yang Li, Guo-Yuan Hu Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons. Neuroscience Letters ^[1]  .