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巢暉

（中山大學教授）

鎖定
巢暉，男，1970年3月出生，籍貫湖南汨羅，理學博士，中山大學教授、博士生導師。 [1] 
中文名
巢暉
出生地
湖南汨羅
畢業院校
中山大學
學位/學歷
博士
任職院校
中山大學

目錄

  1. 1 人物經歷
  2. ▪ 教育經歷
  3. ▪ 工作經歷
  4. 2 講授課程
  1. 3 學術成果
  2. ▪ 科研項目
  3. ▪ 論著一覽
  4. ▪ 相關成果
  1. 4 獲獎情況

巢暉人物經歷

巢暉教育經歷

學士（1988-1992）：湘潭師範學院（現為湖南科技大學）化學系
碩士（1994-1997）：南開大學化學學院
博士（1997-2000）：中山大學化學與化學工程學院
訪問學者 (2000-2003)：香港科技大學化學系
博士後（2004-2005）：美國Texas A&M大學化學系 [1] 

巢暉工作經歷

講師（2000-2002）：中山大學化學與化學工程學院
副教授（2002-2007）：中山大學化學與化學工程學院
教授（2007-2016）：中山大學化學與化學工程學院
教授（2016-至今）：中山大學化學學院
  2002年6月：被遴選為中山大學無機化學專業、化學生物學專業碩士生導師
  2006年11月：被遴選為中山大學無機化學專業博士生導師
  2008年10月：被批准為中山大學化學生物學專業博士生導師
  2005年-至今：生物無機與合成化學教育部重點實驗室固定研究人員 [1] 

巢暉講授課程

1. 本科生：《化學學習與研究》、《無機化學》、《無機化學實驗》、《普通化學》、《現代化學》（逸仙班）、《化學生物學實驗》、《今日化學》、《化學前沿》（基礎學科拔尖學生培養實驗班）
2. 研究生：《配位化學》、《化學前沿進展》 [1] 

巢暉學術成果

巢暉科研項目

  承擔國家自然科學基金（包括國家傑出青年科學基金項目、重大研究計劃培育項目、面上項目、青年項目）、973計劃課題、教育部新世紀優秀人才支持計劃項目、教育部創新團隊項目（核心成員）、教育部科學技術研究重點項目、教育部高校博士點基金博導類課題、教育部留學回國人員科研啓動基金、廣東省自然科學基金團隊項目（核心成員）、廣東省自然科學基金自由項目、國家重點實驗室開放基金和中山大學青年教師重點培育計劃等20多項課題研究。 [1] 

巢暉論著一覽

1. Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao*, Zhe-Sheng Chen*, "The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials",Chem. Soc. Rev., 46 (2017) 5771-5804.(Inside front cover)
2. Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”,Coord. Chem. Rev., 2018, DOI: 10.1016/j.ccr.2017.10.022.
3. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke,Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”,Coord. Chem. Rev., 363 (2018) 17–28.
4. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”,Coord. Chem. Rev., 310 (2016) 16-40.
5. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”,Coord. Chem. Rev., 281 (2014) 100-113.
6. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”,Curr. Opin. Chem. Biol., 43 (2018) 51-57.
7. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang,Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”,Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
8. Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells",Angew. Chem. Int. Ed., 56 (2017) 14898-14902.(VIP Article,Inside front cover)
9. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser,* Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”,Angew. Chem. Int. Ed., 54 (2015) 14049-14052.(VIP Article)
10. Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Zhe-Sheng Chen, Liangnian Ji, Hui Chao*, “Oncosis-inducing cyclometalated iridium(III) complexes”,Chem. Sci., 9 (2018) 5183–5190.
11. Guanying Li, Yu Chen,Jinquan Wang, Qian Lin, Jing Zhao, Liangnian Ji, Hui Chao*, “A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”,Chem. Sci., 4 (2013) 4426-4433.
12. Huaiyi Huang†, Liang Yang† (†equal contributors), Pingyu Zhang, Kangqiang Qiu, Juanjuan Huang, Yu Chen, JiaJie Diao, Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, "Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes",Biomaterials, 83 (2016) 321-331.
13. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang,Lei Jiang,Gilles Gasser,Liangnian Ji,Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”,Biomaterials, 63 (2015) 102-114.
14. Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivativesin vivousing a two-photon phosphorescent probe”,Biomaterials, 63 (2015) 128-136.
15. Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for theimaging of nitric oxide in mitochondria”,Biomaterials, 58 (2015) 72-81.
16. Jiangping Liu, Yu Chen, Guanying Li, Pingyu Zhang, Chengzhi Jin, Leli Zeng, Liangnian Ji, Hui Chao*, "Ruthenium(II) polypyridyl complexes asmitochondria-targeted two-photon photodynamic anticancer agents",Biomaterials, 56 (2015) 140-153.
17. Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”,Biomaterials, 53 (2015) 522-531.
18. Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu,Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”,Biomaterials, 53 (2015) 285-295.
19. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”,Biomaterials, 35 (2014) 9003-9011.
20. Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking”,Biomaterials, 35 (2014) 2-13.
21. Kangqiang Qiu, Jinquan Wang, Cuilan Song, Lili Wang, Hongyi Zhu, Huaiyi Huang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Crossfire for two-photon photodynamic therapy with fluorinated ruthenium(II) photosensitizers”,ACS Appl. Mater. Interfaces, 9 (2017) 18482-18492.
22. Kangqiang Qiu, Huaiyi Huang, Bingyang Liu, Yukang Liu, Ziyi Huang, Yu Chen, Liangnian Ji, Hui Chao*, "Long-Term Lysosomes Tracking with A Water-Soluble Two-Photon Phosphorescent Iridium(III) Complex",ACS Appl. Mater. Interfaces, 8 (2016) 12702-12710.
23. Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”,ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.
24. Cheng Ouyang,Lei Chen, Thomas W. Rees, Yu Chen* Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, “A mitochondria-targeting hetero-binuclear Ir(III)-Pt(II) complex induces necrosis in cisplatin-resistant tumor cells”,Chem. Commun., 2018, DOI: 10.1039/C8CC02795A.
25. Kangqiang Qiu†, Libing Ke† (†equal contributors), Xuepeng Zhang, Yukang Liu, Thomas W. Rees, Liangnian Ji, Jiajie Diao*, Hui Chao*, “Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes”,Chem. Commun., 54 (2018) 2421-2424.
26. Pingyu Zhang*, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang*, Hui Chao*, “NIR phosphorescent osmium(II) complex as lysosome tracking reagent andphotodynamictherapeutics”,Chem. Commun., 53 (2017) 12341-12344.
27. Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Rational design of NIR-emitting iridium(III) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation”,Chem. Commun., 53 (2017) 10374-10377.
28. Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji, Hui Chao*, “Enhanced cancer therapy by marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes”,Chem. Commun., 53 (2017) 9878-9881.
29. Jiangping Liu†, Chengzhi Jin† (†equal contributors), Bo Yuan, Xingguo Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Selectively Lighting Up Two-Photon Photodynamic Activity in Mitochondria with AIE-Active Iridium(III) Complexes”,Chem. Commun., 53 (2017) 2052-2055.
30. Leli Zeng†, Shi Kuang† (†equal contributors), Guanying Li, Chengzhi Jin, Liangnian Ji, Hui Chao*, “A GSH-activatableruthenium(II)-azo photosensitizerfor two-photon photodynamic therapy”,Chem. Commun., 53 (2017) 1977-1980.
31.Bole Yu,Ying Chen,Mei Hong,Pingping Duan,Shifeng Gan,Hui Chao*,Zujin Zhao*,Jing Zhao*, "Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties",Chem Commun., 51 (2015) 14365-14368.
32. Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”,Chem. Commun., 50 (2014) 2123-2125.
33. Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li,Chunyuan Liu,Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”,Chem. Commun., 49 (2013) 11095-11097.
34. Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”,Chem. Commun., 49 (2013) 2040-2042.
35. Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as atracking non-viral gene vector”,Chem. Commun., 49 (2013) 810-812.
36. Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”,Chem. Commun., 48 (2012) 10781-10783.
37. Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji and Hui Chao*, "Targeting Nucleus DNA with a Cyclometalated Dipyridophenazine Ruthenium(II) Complex",J. Med. Chem., 57 (2014) 8971-8983.(Highlight as Highly Cited Article of 2014 of J Med Chem)
38. Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao* and Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”,J. Med. Chem., 56 (2013) 6531-6535.
39. Shanshan Zou, Guanying Li, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Yu Chen, Liangnian Ji, Hui Chao*, “Interfering DNA high-order structures with chiral ruthenium(II) complexes”,Chem. Eur. J.,24 (2018) 690-698.
40. Jeannine Hess†, Huaiyi Huang† (†equal contributors),Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao*, Gilles Gasser*, "Evaluation of the medicinal potential of two ruthenium(II) polypyridine complexes as one- and two-photon photodynamic therapy photosensitizers",Chem. Eur. J.,23 (2017) 9888-9896.(VIP Article, Highlight on ChemistryViews “Fighting Cancer with Ruthenium Complexes”)
41. Lingli Sun, Yu Chen, Shi Kuang, Guanying Li, Ruilin Guan, Jiangping Liu, Liangnian Ji, Hui Chao*, “Iridium(III) Anthraquinone Complexes asTwo-photon Phosphorescence Probes for Mitochondria Imaging and Tracking under Hypoxia”,Chem. Eur. J., 22 (2016) 8955-8965.(Hot paper).
42. Leli Zeng, Yu Chen, Huaiyi Huang, Jinquan Wang, Donglei Zhao, Liangnian Ji, Hui Chao*, “Cyclometalated Ruthenium(II)Anthraquinone Complexes ExhibitStrong Anticancer Activity inHypoxic Tumor Cells”,Chem. Eur. J., 21 (2015) 15308-15319. (Hot paper, Highlight on ChemistryViews “Combating Drug Resistance in Hypoxic Tumor Cells”)
43. Chengzhi Jin, Jiangping Liu, Yu Chen, Leli Zeng, Ruilin Guan, Cheng Ouyang, Liangnian Ji, Hui Chao*, “Cyclometalated Iridium(III) Complexes as Two-Photon Phosphorescent Probes for Specific Mitochondrial Dynamics Tracking in Living Cells”,Chem. Eur. J. 21 (2015) 12000-12010.(Highlight as Frontispiece)
44. Li Xu†, Xiang Chen† (†equal contributors), Jingheng Wu, Jinquan Wang, Liangnian Ji, Hui Chao*, “Dinuclear Ruthenium(II) Complexes that Induce and Stabilize G-quadruplex DNA”,Chem. Eur. J., 21 (2015) 4008-4020.
45. Bole Yu, Cheng Ouyang, Kangqiang Qiu, Jing Zhao, Liangnian Ji, Hui Chao*, “Lipophilic Tetranuclear Ruthenium(II) Complexes asTwo-Photon Luminescent Tracking Non-Viral Gene Vectors”,Chem. Eur. J., 21 (2015) 3691-3700.
46. Huaiyi Huang, Pingyu Zhang, Hongmin Chen, Liangnian Ji, Hui Chao*, “A Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities on 2D and 3D Cancer Models”,Chem. Eur. J., 21 (2015) 715-725.
47. Pingyu Zhang†,Lingmin Pei†, Yu Chen† (†equal contributors), Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji and Hui Chao*, “A dinuclear ruthenium(II) complex as a one- and two-photon luminescent probe for biological Cu2+detection”,Chem. Eur. J., 19 (2013) 15494-15503.(Highlight as Frontispiece) [1] 

巢暉相關成果

先後在《Chem.Soc. Rev》、《Coord.Chem. Rev》、《PNAS》、《Angew. Chem. Int. Ed.》、《Chem. Sci.》、《Biomaterials》、《ACS Appl. Mater. Interfaces》、《Chem. Commun.》、《J. Med. Chem.》、《Chem. Eur. J》等國際期刊發表第一作者或通訊作者SCI論文163篇，論文被引用4600多次。參編著作 “Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine” (德國 John Wiley & Son出版公司出版, 2005年)和“生物無機化學導論”（第三版）（科學出版社，2010年）。申請中國發明專利16件, 授權12件。目前擔任中國化學會化學生物學專業委員會委員、《Scientific Reports》編委、《Journal of Inorganic Biochemistry》編委、《大學化學》編委。 [1] 

巢暉獲獎情況

2001年獲中國高校自然科學獎二等獎（第九完成人）
2005年獲中國化學會“青年化學獎”
2006年入選教育部“新世紀優秀人才支持計劃”
2006年入選廣東省高等學校“千百十工程”人才培養計劃（校級）
2007年獲 中山大學化學與化工學院“53獎教金”
2011年獲廣東省科學技術獎一等獎（第二完成人）
2011年被評為中山大學校級教學名師
2012年獲國家自然科學獎二等獎（第三完成人）
2012年獲中山大學第七屆校級教學成果獎一等獎（第一完成人）
2012年獲中山大學第七屆校級教學成果獎一等獎（第四完成人）
2012年被評為南粵優秀教師（廣東省）
2013年獲中山大學化學與化工學院“芙蘭勵教獎”
2014年獲廣東省教育教學成果獎（高等教育）一等獎（第一完成人）
2014年獲廣東省教育教學成果獎（高等教育）二等獎（第四完成人）
2014年獲中山大學化學與化工學院“施開良教學管理創新獎”
2014年獲寶鋼優秀教師獎
2015年獲“國家傑出青年科學基金”
2016年入選廣東特支計劃“百千萬工程領軍人才”
2017年獲中山大學第八屆校級教學成果獎二等獎（第一完成人）
2017年獲中山大學第八屆校級教學成果獎一等獎（第五完成人）
2017年獲廣東省教育教學成果獎（高等教育）一等獎（第五完成人） [1] 
參考資料