孫慧

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學　位：博士

科研方向：抗病毒、抗腫瘤藥物篩選

學習簡歷

1990-1994 華中農業大學，獲學士學位；

1994-1997 南京農業大學，獲碩士學位；

1997-2000 福建農業大學，獲博士學位；師從謝聯輝院士、林奇英研究員，從事藥用真菌抗病毒活性成分研究。

工作經歷

2000－2002 武漢大學生命科學學院做博士後工作，從事藥用真菌抗病毒、抗腫瘤成分研究。

2002.9－2011.10 武漢大學副教授。

2011.11- 武漢大學教授。

教學工作

2004- 本科生免疫學

2004- 研究生腫瘤分子生物學

2009- 2010本科生病毒學

科研方向：

1. 抗病毒、抗腫瘤藥物篩選。

2. 半乳糖凝集素家族在腫瘤發生中的作用。

主持課題：

國家“重大專項”1項，“863”課題1項，國家自然科學基金3項

主持國家“11.5”重大專項1項：

2種藥用真菌活性蛋白作為抗腫瘤候選藥物的研究（2008.12-2010.12，NO. 2009ZX09103-676）

主持“863”專項課題1項：

藥用真菌抗腫瘤蛋白作為抗腫瘤藥物、抗腫瘤藥物設計前體的開發研究(2006.12-2008.12, NO.2006AA02Z135)

主持國家自然科學基金3 項：

1. 楊樹菇中抗腫瘤活性蛋白質成分

2. 藥用真菌(楊樹菇，A. aegerita)galectin-1 對大鼠的雄性生殖毒性

3. 半乳糖凝集素AAL在擔子菌楊樹菇（Agrocybe aegerita）子實體形成過程中的作用

獲批專利3項：

1. 一種真菌半乳糖凝集素蛋白活性的多肽、其編碼序列及製備方法和應用

2. 一種真菌硫氧還蛋白的多肽、編碼序列及製備方法和應用

3. 一種真菌泛素交聯酶活性的多肽、其編碼序列及製備方法和應用

1.Yin YL, Yu GJ, Chen YJ, Jiang Sh, Wang M, Jin YX, Lan XQ, Liang Y, Sun H*, Genome-wide transcriptome and proteome analysis on different developmental stages of Cordyceps militaris, 2013, PLOS ONE, in press

2.Wang M, Gu B, Huang J, Chen Y, Jiang Sh, Yin Y, PanY, Yu G, Li Y, Barry Hon Cheung Wong, Liang Y,Sun H*，Integration of Transcriptome and Proteome Analyses in Two Development Stages of Agrocybe aegerita, 2013, PLOS ONE, in press

3.Yu GJ, Wang M, Huang J, Yin Y, Chen Y, Jiang Sh, Jin, Lan X, Liang Y, Sun Hui*, Deep insight into the Ganoderma lucidum by comprehensive analysis of its transcriptome, PLoS One. 2012; 7(8):e44031.

4.Jiang SH, Chen YJ, Wang M, Yin YL, Pan YF, Gu BL, Yu GJ, Li YM, Barry Hon Cheung Wong, Liang Y,Sun H*, A Novel lectin from Agrocybe aegerita with high binding selectivity toward terminal N-acetylglucosamine. Biochemical Journal, 2012, Apr 15;443(2):369-78

5.Chen Y, Jiang S, Jin Y, Yin Y, Yu G, Lan X, Cui M, Liang Y, Wong BH, Guo L, Sun H*. Purification and characterization of an antitumor protein with deoxyribonuclease activity from edible mushroom Agrocybe aegerita. Mol Nutr Food Res. 2012 Nov;56(11):1729-38.

6.Liang Y, Chen YJ, Liu HH, Luan R, Che T, Jiang Sh, Xie DY, Sun Hui*, The tumor rejection effect of protein components from medicinal fungus, Biomedicine & Preventive Nutrition, 2011,245-254.

7.Luan R, Liang Y, Chen YJ, Liu HH, Jiang Sh, Che T, Barry Wong, Sun H*, Opposing developmental functions of Agrocybe aegerita galectin (AAL) during mycelia differentiation, Fungal Biology (mycological research), 2010, 114, 8: 599-608.

8.Feng L, Sun H, Zhang Y, Li D F, Wang D C，Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenrich antigen, FASEB J. 2010; 24: 3861-3868

9.Liang Y, Lin JC, Wang K, Chen YJ, Liu HH, Luan R, Jiang S, Che T, Zhao Y, Li DF, Wang DC, Guo L, Sun H*. A nuclear ligand MRG15 involved in the proapoptotic activity of medicinal fungal galectin AAL (Agrocybe aegerita lectin). Biochim Biophys Acta. 2010; 1800(4): 474-480

10.Xue Y, Zhou Y, Wu T, Zhu T, Ji X, Kwon YS, Zhang C, Yeo G, Black DL,Sun H, Fu XD, Zhang Y. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell. 2009 Dec 25;36(6):996-1006

11.Liang Y, Feng L, Tong X, Wang K, Li de F, Lin JC, Tang ZJ, Liu HH, Jiang S, Guo L, Wang D C*, Sun H*. Importance of nuclear localization for the apoptosis-induced activity of a fungal galectin AAL (Agrocybe aegerita lectin)，BBRC.2009. 386(3):437-42

12.Yang N, Li DF, Feng L, Xiang Y, Liu W,Sun H*, Wang DC*，Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita.J Mol Biol. 2009 Apr 3;387(3):694-705.

13.Yang N, Liang Y, Xiang Y, Sun H*, Wang DC*, Crystallization and preliminary crystallographic studies of an antitumour lectin from the edible mushroom Agrocybe aegerita. Protein and Peptide Letters. 2005, 12(7):705-7.（Equal corresponding author）

14.Yang N, Tong X, Xiang Y, Sun H*, Wang DC*, Molecular character of an antitumour lectin from the edible mushroom Agrocybe aegerita. The Journal of Biochemistry. 2005 (138), 145-150.（Equal corresponding author）

15.Yang N, Tong X, Zhang Y, Sun H*, Wang DC*, Crystallization and preliminary crystallographic studies of the recombinant antitumour lectin from the edible mushroom Agrocybe aegerita. Biochimica et Biophysica Acta: Proteins and Proteomics. 2005, 209-212（Equal corresponding author）

16.Zhao Chen Guang*, Sun Hui*, Xin Tong, Qi Yi Peng, An antitumor lectin from edible mushroom Agrocybe aegerita, Biochemical Journal, 2003 (374): 321-327 （Equal first author）

17.Sun Hui, Zhao Chen Guang, Xin Tong, Qi Yi Peng, A Lectin with Mycelia Differentiation and Antiphytovirus Activities from the Edible Mushroom Agrocybe aegerita. Journal of Biochemistry and Molecular Biology, 2003，36（2）：214- 222 ^[2]