吳建國

2010-2016年於北京大學生命科學學院李毅教授和清華大學生命學院戚益軍教授實驗室從事博士後研究工作，並榮獲北京大學-清華大學生命科學聯合中心優秀博士後；羅氏優秀博士。

主要從事水稻抗病毒和病毒致病相關研究，其研究成果在eLife, Nature Plants, PLoS Pathogens和Molecular Plant等雜誌上發表SCI論文20篇，累計影響因子＞100，5年內文章累計被引用近500次。主持國家自然科學基金優秀青年基金、面上基金、“973”和“863”計劃項目子課題的研究。擔任中植物病理學會植物與病原互作委員會秘書長；中國植物病理學會青年學術委員會副主任。Annals of Phytopathology編委；《激光生物學報》常務編委等。 ^[2] 

國家優秀青年基金獲得者；

教育部霍英東基金獲得者；

中國植物病理學會-青年植物病理學家獎獲得者；

福建省五四青年獎章獲得者；嚴家顯最高獎教金獲得者；

福建農林大學 “金山學者”拔尖人才。2012年獲福建省“優秀博士論文二等獎”。

2013年入選福建省高校傑出青年科研人才培育計劃;

2014年入選福建省青年拔尖人才。

2017年福建省新世紀優秀人計劃，

2018年福建省領軍人才-拔尖人才。

2020年8月，入選2020年度國家傑出青年科學基金建議資助項目申請人名單。 ^[3] 

2021年2月1日，被授予“第十五屆福建青年科技獎”稱號。 ^[1] 

1. 基於RNA沉默的水稻抗病毒和病毒致病機制；

2. Small RNA的跨界（昆蟲-病毒-植物-微生物）調控；

3. 病毒與宿主的相互作用以及病毒對宿主發育的影響；

4. 水稻抗病毒資源的篩選和抗病毒基因的克隆； ^[2] 

2020年國家傑出青年基金項目；

2019年國家自然基金海峽聯合基金重點項目；

2018年福建省高校領軍人才-拔尖人才項目；

2017年國家優秀青年基金項目；

2017年國家自然基金面上項目；

2012年國家自然基金面上項目； ^[2] 

（1） Shanshan Zhao, Yuansheng Wu, Jianguo Wu*. Arms race between rice and viruses: an review of viral proteins and plant factors. Current Opinion in Virology, 2021,47:38–44.

（2） Lu Wang#, Huiting Xie#, Xiaoyuan Zheng, Jiasheng Chen, Shuai Zhang*, Jianguo Wu*. Recent advances and emerging trends in antiviral defence networking in rice. The Crop Journal, 2021,Revision.

（3） Shuai Zhang#, Xiaoqing Wu #, Huiting Xie, Shanshan Zhao, Jianguo Wu*. Multifaceted roles of RNA polymerase IV in plant growth and development, Journal of Experimental Botany，2020, 71(19): 5725–5732.

（4） Chao Zhang#, Ying Wei#, Le Xu#, Kangcheng Wu#, Liang Yang, Chaonan Shi, Guoyi Yang, Dong Chen, Feifei Yu, Qi Xie, Yi Li, Shouwei Ding, Jianguo Wu*. A Bunyavirus-Inducible Ubiquitin Ligase Targets RNA Polymerase IV for Degradation during Viral Pathogenesis in Rice, Molecular Plant, 2020, 13(6):836-850.（封面論文）

（5） Le Xu, Kun Yuan, Meng Yuan, Xiangbing Meng, Min Chen, Jianguo Wu, Jiayang Li*, Yijun Qi*. Regulation of Rice Tillering by RNA-directed DNA Methylation at Miniature Inverted-repeat Transposable Elements, Molecular Plant, 2020, 13(6)851-863.

（6） Chao Zhang^#, Dong Chen^#, Guoyi Yang, Xiyuan Yu, Jianguo Wu*. Rice Stripe Mosaic Virus-encoded P4 Is A Weak Suppressor of Viral RNA Silencing and is Required for Disease Symptom Development. Molecular Plant-Microbe Interactions, 2020, 33(3):412-422.（封面論文）

（7） Jiaqi Qin, Ci Wang, Leqi Wang, Shanshan Zhao* and Jianguo Wu*. Defense and counter-defense in rice–virus interactions. Phytopathology Research, 2019,1:34.

（8） Baogang Zhang^#, Wenji Li^#, Jialin Zhang, Lu Wang and Jianguo Wu*. Roles of small RNAs in virus-plant interactions. Viruses, 2019, 11(9), 827.

（9） Shengze Yao^#, Zhirui Yang^#, Rongxin Yang, Yu Huang, Ge Guo, Xiangyue Kong, Ying Lan, Tong Zhou, He Wang, Wenming Wang, Xiaofeng Cao, Jianguo Wu*, Yi Li*. Transcriptional regulation of miR528 by OsSPL9 orchestrates antiviral response in rice. Molecular Plant, 2019,12(8):1114-1122. （封面論文）

（10） Lijia Zheng, Chao Zhang, Jianguo Wu* and Yi Li*.Detecting the interaction of double-stranded RNA binding protein, viral protein and primary miRNA transcript by co-immunoprecipitation in planta.Bio-protocol, 2018, 8,09, 2840.

（11） Chao Zhang, Chaonan Shi, Dong Chen and Jianguo Wu*.Rice ragged stunt virus propagation and infection on rice plants. Bio-protocol, 2018, 8,20, 3060.

（12） Zhaoyun Wang, Yeqiang Xia, Siyuan Lin, Yanru Wang, Baohuan Guo, Xiaoning Song, Shaochen Ding, Liyu Zheng, Ruiying Feng, Shulin Chen, Yalin Bao, Cong Sheng, Xin Zhang,Jianguo Wu, Dongdong Niu, Hailing Jin and Hongwei Zhao. Osa-miR164a targets OsNAC60 and negatively regulates rice immunity against the blast fungus Magnaporthe oryzae. The Plant Journal, 2018, 95(4): 584-597.

（13） Jianguo Wu^#, Rongxin Yang^#, Zhirui Yang^#, Shengze Yao, Shanshan Zhao, Yu Wang, Pingchuan Li, Xianwei Song, Lian Jin, Tong Zhou, Ying Lan, Lianhui Xie, Xueping Zhou, Chengcai Chu, Yijun Qi, Xiaofeng Cao* and Yi Li*. ROS accumulation and antiviral defence control by microRNA528 in rice. Nature Plants, 2017, 3, 16203. （高被引論文）

（14） Shanshan Zhao, Wei Hong, Jianguo Wu, Yu Wang, Shaoyi Ji, Shuyi Zhu, Chunhong Wei, Jinsong Zhang, Yi Li*, A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection. eLife, 2017,6:e27529.

（15） Lijia Zheng, Chao Zhang, Chaonan Shi, Zhirui Yang, Yu Wang, Tong Zhou, Feng Sun, Hong Wang, Shanshan Zhao, Qingqing Qin, Rui Qiao, Zuomei Ding, Chunhong Wei, Lianhui Xie*, Jianguo Wu*, Yi Li*. Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice.PLoS Pathogens, 2017,13(10): e1006662.

（16） Chao Zhang^#, Zuomei Ding^#, Kangcheng Wu^#, Liang Yang, Yang Li, Zhen Yang, Shan Shi, Xiaojuan Liu, Shanshan Zhao, Zhirui Yang, Yu Wang, Luping Zheng, Juan Wei, Zhenguo Du, Aihong Zhang, Hongqin Miao, Yi Li, Zujian Wu* andJianguo Wu*.Suppression of jasmonic acid-mediated defense by viral-inducible microRNA319 facilitates virus infection in rice.Molecular Plant, 2016, 9:1372-1384.

（17） Lian Jin^#, Qingqing Qin, Yu Wang, Yingying Pu, Lifang Liu, Xing Wen, Shaoyi Ji,Jianguo Wu, Chunhong Wei, Biao Ding and Yi Li*. Rice dwarf virus P2 protein hijacks auxin signaling by directly targeting the rice OsIAA10 protein, enhancing viral infection and disease development. PLOS Pathogens,2016, 12(9): e1005847.

（18） Jianguo Wu^#, Zhirui Yang^#, Yu Wang, Lijia Zheng, Ruiqiang Ye, Yinghua Ji, Shanshan Zhao, Shaoyi Ji, Ruofei Liu, Le Xu, Hong Zheng, Yijun Zhou, Xin Zhang, Xiaofeng Cao, Lianhui Xie, Zujian Wu*, Yijun Qi* and Yi Li*. Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA. eLife,2015, 4:e05733.

（19） Chao Zhang^#, Xiaojuan Liu^#, Kangcheng Wu, Luping Zheng, Zuomei Ding, Fei Li, Peng Zou, Liang Yang, Jianguo Wu* and Zujian Wu*. Rice grassy stunt virus nonstructural protein p5 serves as a viral suppressor of RNA silencing and interacts with nonstructural protein p3.Archives of Virology, 2015, 160(11): 2769-2779.

（20） Chao Zhang^#, Zujian Wu Yi Li and Jianguo Wu*.Biogenesis, function and applications of virus-derived small RNAs in plants.Frontiers in Microbiology, 2015, 6:1237.

（21） Luping Zheng^#, Zhenguo Du^#,Chen Lin, Qianzhuo Mao, Kangcheng Wu, Jianguo Wu, Taiyun Wei, Zujian Wu* and Lianhui Xie*.Rice stripe tenuivirus p2 may recruit or manipulate nucleolar functions through an Interaction with fibrillarin to promote virus systemic movement. Molecular Plant Pathology, 2015,16 (9): 921–930.

（22） Liang Yang^#, Zhenguo Du^#, Feng Gao, Kangcheng Wu, Lianhui Xie, Yi Li, Zujian Wu* and Jianguo Wu*.Transcriptome profiling confirmed correlations between symptoms and transcriptional changes in RDV infected rice and revealed nucleolus as a possible target of RDV manipulation.Virology Journal, 2014, 11:81.

（23） Jang-Kyun Seo^#,Jianguo Wu, Yifan Lii, Yi Li* and Hailing Jin*.Contribution of small RNA pathway components in plant immunity.Molecular Plant-Microbe Interactions, 2013, 26(6):617-25.

（24） Peng Du^#, Jianguo Wu^#, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei and Yi Li*. Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. PLoS Pathogens, 2011,7(8): e1002176.

（25） Zhenguo Du^#, Donglai Xiao^#,Jianguo Wu^#, Dongsheng Jia, Zhengjie Yuan, Ying Liu, Liuyang Hu, Zhao Han, Taiyun Wei, Qiying Lin, Zujian Wu*and Lianhui Xie*. P2 of Rice stripe virus (RSV) interacts with OsSGS3 and is a silencing suppressor.Molecular Plant Pathology,2011, 12(8):808-14.

（26） Jianguo Wu^#, Chunzheng Wang, Zhengguo Du, Lijun Cai, Meiqun Hu, Zujian Wu*, Yi Li*and Lianhui Xie*.Identification of Pns12 as the second silencing suppressor of rice gall dwarf virus. Science China Life Sciences,2011,54 (3): 201-208.（封面論文）

（27） Jianguo Wu^#, Zhenguo Du^#, Chunzheng Wang, Lijun Cai, Meiqun Hu, Qiying Lin, Zujian Wu*, Yi Li* and Lianhui Xie*. Identification of Pns6, a putative movement protein of RRSV, as a silencing suppressor. Virology Journal, 2010, 7:335.

（28） Zujian Wu^#,JianguoWu^#, Scott Adkins, Lianhui Xie* and Weimin Li*. Rice ragged stunt virus segment S6-encoded nonstructural protein Pns6 complements cell-to-cell movement of tobacco mosaic virus-based chimeric virus. Virus Research, 2010,152:176-179.

（29） Chunzheng Wang^#, Feng Gao, Jianguo Wu,Jianli Dai, Chunhong Wei and Yi Li*.Arabidopsis Putative Deacetylase AtSRT2 Regulates Basal Defense by Suppressing PAD4, EDS5 and SID2 Expression.Plant andCell Physiology,2010, 51(8): 1291-1299.

（30） Junwei Guo^#, Fangli Ren,Yinyin Wang, Shan Li, Zhengrong Gao, Xiaoyan Wang, Hongxiu Ning, Jianguo Wu, Yi Li, Zhao Wang, Shek Man Chim, Jiake Xu and Zhijie Chang*.miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression.Journal of Bone and Mineral Research, 2012, 27(7):1607–1618 IF: 7.056. ^[2]