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劉亞平
(廣州醫科大學附屬腦科醫院睡眠與節律醫學中心教授)
鎖定
劉亞平人物經歷
本科畢業於南方醫科大學
碩士畢業於暨南大學
劉亞平研究方向
- 基於大樣本人羣隊列,探究快眼動睡眠行為障礙向alpha突觸核蛋白病進展的生物學機制(如腸道微生物學、遺傳學、神經免疫學、以及神經影像學機制等)
劉亞平研究項目
- PI, Health and Medical Research Fund (08191416). Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study. HK$ 1,122,120. 01/12/2021-30/11/2024.
- PI, Knowledge Transfer Project Fund (KPF21GWP26). Risk screening for prodromal Parkinson’s disease in elderly using smartphone. The Chinese University of Hong Kong. HK$ 395,380. 01/04/2021-31/03/2023
- PI, Direct Grant for Research (2020.084). Impact of Long COVID–Neurodegenerative Perspective. CUHK. HK$ 149,000. 30/06/2021-29/06/2022.
- Co-PI, Collaborative Research Fund (C4044-21GF). Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort. HK$ 7,214,620. 01/04/2022-31/03/2025.
- Co-PI, Collaborative Research Fund (C4061-21GF). Neuropsychiatric ‘long-COVID’ in adult patients. HK$ 3,251,480. 01/04/2022-31/03/2023.
- Co-I, General Research Fund (14108722). Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing. HK$ 1,300,000. Starts in 2023.
- Co-I, Health and Medical Research Fund (18190931). AI-Based Day and Night Digital Phenotyping of Rapid Eye Movement (REM) Sleep Behaviors Disorder (RBD) and its Prediction towards α-Synucleinopathy. HK$ 1,495,330. Starts in 2023.
- Co-I, Health and Medical Research Fund (09202766). Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease. HK$ 1,413,200. 01/08/2022-31/07/2025.
- Co-I, Health and Medical Research Fund (18190221). Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration. HK$ 1,104,304. 01/10/2021-31/03/2024.
- Co-I, General Research Fund (14116121). Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. HK$ 1,130,208. 01/01/2022-31/12/2025.
- Co-I, Health and Medical Research Fund (06170676). A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases. HK$ 1,250,616. 01/07/2019-30/06/2022.
劉亞平科研成果
發表SCI文章代表作:(*表示通訊作者,#表示共同第一作者)
- Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK*, Liu Y*. Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.J Sleep Res. 2022:e13791.
- Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK*.Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.Neurology. 2022;99(6):e627-e637.
- Liu Y#, Partinen E#, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M*, Wing YK*.Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.J Sleep Res. 2022:10.1111/jsr.13613.
- Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT*.Longitudinal changes in Parkinson’s disease symptoms with and without REM sleep behavior disorder: the Oxford Discovery Cohort study.Mov Disord. 2021;36(12):2821-2832.
- Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MW, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok VCT, Wing YK*.Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.Mov Disord. 2020;35(11):2077-2085.
- Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen J, Mok VCT, Wing YK*, Zhang J*.Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.Ann Neurol. 2020;88(4):817-829.
- Liu Y#, Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK*.A case-control-family study of idiopathic rapid eye movement sleep behavior disorder.Ann Neurol. 2019;85(4):582-592.
- Liu Y, Zhang J*, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK.Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.Sleep Med. 2019;56:128-134.
- Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK*.Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.Sleep Med. 2018, 24;53:1-8.
劉亞平獲獎情況
劉亞平學術任職
Clinical Neurophysiology、Brain imaging and behavior、Translational Psychiatry 、Sleep medicine等學術期刊審稿人(Peer review)
[8]
劉亞平擅長領域
- 參考資料
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- 1. 廣州醫科大學附屬腦科醫院劉亞平課題組招聘-廣州醫科大學研究生院 .廣州醫科大學研究生院[引用日期2023-06-20]
- 2. 香港中文大學精神科學系官網個人介紹 .香港中文大學精神科學系官網[引用日期2023-06-20]
- 3. 廣州醫科大學附屬腦科醫院-個人介紹 .廣州醫科大學附屬腦科醫院官網[引用日期2023-06-20]
- 4. 研究之門個人文章列表 .研究之門官網[引用日期2023-06-20]
- 5. 劉亞平 - The Chinese University of Hong Kong | 科研之友 .科研之友個人學術成果網頁[引用日期2023-06-20]
- 6. Lee Hysan博士後名單介紹 .牛津大學納菲爾德臨牀神經科學系新聞[引用日期2023-06-20]
- 7. World Sleep 2017 Awards .世界睡眠大會官網[引用日期2023-06-20]
- 8. ORCID .ORCID個人學術登記[引用日期2023-06-20]
- 9. 快速眼動睡眠行為障礙與帕金森病發病及防治的關係 .萬方數據知識服務平台[引用日期2023-06-27]
- 10. 失眠與抑鬱關係2008-2013年研究進展及存在問題--《中國心理衞生雜誌》2015年02期 .知網[引用日期2023-06-27]
- 11. 失眠障礙的神經影像學研究進展--《中國神經精神疾病雜誌》2015年01期 .知網[引用日期2023-06-27]
- 12. 非恢復性睡眠的研究現狀--《實用醫學雜誌》2012年07期 .知網[引用日期2023-06-27]
- 13. 原發性失眠患者與有失眠症狀抑鬱症患者的血清神經肽Y和P物質水平--《中國心理衞生雜誌》2012年07期 .知網[引用日期2023-06-27]
- 14. 抑鬱症動物模型的回顧與展望--《廣東醫學》2011年07期 .知網[引用日期2023-06-27]
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