伍一軍

主要研究在於環境有害化學物質的神經毒性機制、神經病靶標酯酶引發遲發性神經毒性的分子機理、低劑量環境化學物質的致癌機理、溶血卵磷脂及泛蛋白調節在神經毒性發生過程中的作用等。先後主持中國科學院重點項目、國家自然科學基金項目、中科院生物特別支持項目、院創新項目和國際合作項目，並承擔中科院創新重大項目和國家863專題項目 ^[3]  。

先後主持承擔國家自然科學基金項目、中科院生物特別支持項目、國際合作項目、國家863計劃項目、國家973計劃項目（子課題），中國科學院知識創新工程重大項目（專題）、國家科技支撐計劃重大項目等多項課題。目前在研任務主要是承擔國家973計劃項目、國家自然科學基金項目以及中國科學院戰略性先導專項等科研項目。 ^[4] 

1.Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit interacts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.

2. XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced Ca2+response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80(6):886-892.

3.XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett, 2007, 424:22-26.

4.Chen R, Chang PA, Long DX, Yang L, Wu YJ. Down-regulation of neuropathy target esterase by protein kinase C activation with PMA stimulation. Mol Cell Biochem. 2007, 302:179-185.

5.Yang L, Liu J, Wu YJ, Li W, Gao XW, Leng XF. Oral administrations of methamidophos and TOCP have different effects on in vitro protein phosphorylation levels from subcellular fractions of hen brain. Pestic Biochem Physiol 2007, 88(1):20-25.

6.Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the nhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate. Environ Toxicol Pharmacol. 2007, 24(1):67-71.

7.Chang P-A, Long D-X, Wu Y-J. Molecular cloning and expression of chicken neuropathy target esterase activity domain. Toxicol. Lett. 2007, 174(1-3):42-48.

8.Chang PA, Long DX, Wu YJ. Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase. Mol Cell Biochem. 2007, 306:25-32

9. Q, Chen R, Li W, Qiao C-L, Wu Y-J. A genetically engineered Escherichia coli, expressing the fusion protein of green fluorescent protein and carboxylesterase B1, can be easily detected in the environment following degradation of pesticide residues. Biotechnol Lett. 2007, 29(9): 1357-1362.

10.W, Wu Y-J,Qin D-M,Ma Y,Sun Y-J,Qiu S-P.A method for quantifying azoxystrobin residues in grapes and soil using a gas chromatography capture detector. Chromatographia.2008, 67:761-766.

11.W, Qiu S-P, Wu Y-J. Triazophos residues and dissipation rates in wheat crops and soil. Ecotoxicol Environ Saf. 2008, 69:312-316.

12.Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159(1): 65-72.

13.Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39(5): 429-440.

14.Chang PA, Wu YJ. Effect of tri-o-cresyl phosphate on cytoskeleton in human neuroblastoma SK-N-SH cell. Mol Cell Biochem. 2006, 290: 145-151.

15.Chang PA, Chen R, Wu YJ. Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) cell line. Mol Brain Res 2005, 151: 30-38.

16.Chang PA, Wu YJ, Chen R, Li M, Li W, Qin QL. Inhibition of neuropathy target esterase expressing by antisense RNA does not affect neural differentiation in human neuroblastoma (SK-N-SH) cell line. Mol Cell Biochem 2005, 272: 47-54.

17.Chang P-A, Wu Y-J. Inhibition of the expression of neuropathy target esterase in human neuroblastoma cell SH-SY5Y by antisense RNA and RNA interference. Acta Biochimica et Biophysica Sinica. 2004, 36(2):156.

18.Wu YJ, Harp P, Yan XR, Pope CN. Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterase. Chem-Biol Interact. 2003, 142(3):255-268.

19.Nozell S, Wu YJ, McNaughton K, Liu G, Willis A, Park JS, Chen XB. Characterization of p73 functional domains necessary for transactivation and growth suppression. Oncogene, 2003, 22:4333-4347.

20.Wu YJ, Chang PA, Li M, Li YX, Li W. Effect of tri-O-cresyl phosphate and methamidophos on 45CA uptake by brain synaptosomes in hens. Pestic Biochem Physiol. 2003, 77(1):18-23.

1.常平安，陳瑞，李薇，伍一軍. 構建人神經病靶標酯酶RNAi表達載體抑制哺乳動物細胞中NTE的表達. 中華勞動衞生職業病雜誌, 2006，24(1)：27-30.

2.常平安，伍一軍. 有機磷引起的遲發性神經病的發生機制.中華勞動衞生職業病雜誌, 2006，24(6)：382-384.

3.劉傑，高希武，伍一軍. 化學殺蟲劑對松墨天牛體內代謝酶的作用. 農藥, 2006，45（8）：542-544.

4.常平安，倪小敏，伍一軍. 綠色熒光蛋白標記的NTE活性域表達載體的構建及表達. 重慶郵電學學報（自然科學版）, 2006，18（3）：416-419.

5.李薇，伍一軍，仇紹萍，王睿，冷欣夫. 吡蟲啉在蘿蔔及土壤中的殘留動態研究. 農藥, 2006，45（12）：840-841.

6.龍鼎新，伍一軍，李薇，王琦，秦啓聯. 8種化學藥劑單獨及兩兩聯合染毒對松材線蟲殺滅作用試驗. 浙江林業科技, 2006, 26(5):39-42.

7.陳瑞，王仲文，伍一軍. 電離輻射引發細胞凋亡的信號通路. 世界科技研究與發展, 2005，27（1）：49-51.

8.伍一軍，楊琳，李薇. 有機磷農藥的多毒性作用. 環境與職業醫學, 2005，22（4）：367-370.

9.楊琳，劉傑，李薇，伍一軍. 甲胺磷誘發母雞遲發性神經毒性模型. 動物學雜誌,2005，40（4）：12-16.

10.常平安，陳瑞，李薇，伍一軍. NTE酯酶活性區域真核表達載體的構建及其表達. 毒理學雜誌, 2005，19（3）：169-171.

11.伍一軍，陳瑞，李薇. 昆蟲仿生. 昆蟲知識, 2005，42（1）：109-112.

12.伍一軍，常平安，李薇，秦啓聯，陳瑞，劉承芸，冷欣夫.昆蟲神經毒性酯酶活性的測定.昆蟲知識, 2005，42（4）：458-460.

13.伍一軍，陳瑞，劉承芸，李薇. 農藥殘留及其納米顆粒的毒性問題. 農藥,2005，44（8）：370-371-381.

14.常平安，伍一軍. 有機磷酸酯誘發的遲發性神經病靶標酯酶的老化機制. 中國藥理學與毒理學雜誌, 2005，19（6）：462-465.

15.伍一軍，劉傑，楊琳，李薇，高希武. 松墨天牛幼蟲體內神經毒性酯酶和乙酰膽鹼酯酶對甲胺磷敏感性的比較. 昆蟲學報,2006, 49(3):399-403.

16.陳瑞，楊琳，姚智，劉承雲，李曉華，李琴，劉傑，常平安，李薇，伍一軍. 神經病靶標酯酶調控結構域結合蛋白篩選及其在COS-7細胞中的表達. 動物學報，2005，51（5）：840-844.

17.常平安，李明，伍一軍.培養細胞在遲發性神經毒性研究中的應用.衞生毒理學雜誌，2002，16 （4）：245-247.

18.李明，常平安，李玉俠，李薇，伍一軍.兩種有機磷酸酯對人成神經細胞瘤細胞生長與鈣攝取的影響.中華勞動衞生職業病雜誌，2003，21（3）：200-202.

19.常平安，伍一軍.毒理蛋白質組學.中華預防醫學雜誌，2003，37（6）：455-457.

20.伍一軍，冷欣夫.殺蟲藥劑的神經毒理學研究進展.昆蟲學報，2003，46（3）：382-389.

21. M, Wu Y-J, Leng X-F. Effects of verapamil on brainstem microsomal protein phosphorylation in vitro in hens dosed with tri-o-cresyl phosphate. Chin J Pharmacol Toxicol 2002, 16(3): 165-171.

22.常平安，伍一軍.有機磷酸酯引起的遲發性神經病的“強化”機理.中國藥理學與毒理學雜誌,2002，16（4）：316-420.

23.伍一軍.研究生創新思維和創新能力的培養.學位與研究生教育，2003，126（7）：4-6.

24.冷欣夫、邱星輝、伍一軍.細胞色素P450酶系循環催化的新途徑.中國生物工程雜誌,2002，22（5）：49-52.

25.常平安，伍一軍. 氟丙胺磷對人成神經細胞瘤SK-N-SH細胞分化的毒性機制. 中國藥理學與毒理學雜誌，2006，20（6）：494-499.

26.常平安 , 伍一軍. 反向重複序列法構建神經病靶標酯酶RNA干涉表達質粒. 毒理學雜誌, 2007，21(1)：4-8.

27.常平安，伍一軍. 神經病靶標酯酶的特性.生命的化學，2004，24（5）：424-426.

28.李曉華，龍鼎新，侯威遠，李薇，伍一軍. 溶血卵磷脂對小鼠及雞腦突觸體內鈣離子濃度升高的影響. 動物學報, 2007, 49(3):399-403.

1. Liu J, Yang L, Li W, Gao XW, Wu YJ. Effects of Methamidophos and deltamethrin on protein phosphorylation of Monochamus alternatus Hope. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp97, China Agricultural University Press.

2. Yang L, Liu J, Li W, Wu YJ. The effect of methamidophos on protein phosphorylation of adult hen’s brain. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp95, China Agricultural University Press.

3. Liu CY, Li W, Wu YJ. Study of apoptosis induced by trichlorfon in SH-SY5Y cells. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp100, China Agricultural University Press.

4. Li Q, Chen R, Li W, Qiao CL, Liu J, Liu CY, Li XH, Yang L, Wu YJ. Construction of GFP-marked genetically engineered bacteria used to degrade the pesticide residue in the environment. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing, (Editor-in-chief: Jiang Shuren), pp124, China Agricultural University Press.

5. Li W, Wu Y-J, Qin D-M, Ma Y, Qiu S-P. Determination of fungicide azoxystrobin residues in soil. In: Proceedings of 3rd International Symposium on Pesticide and Environmental Safety & 7th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (October 9-13, 2007, Beijing, P. R. China) (Editor-in-chief: Jiang Shuren, Kenneth D. Racke), pp225-230, 2007. China Agricultural University Press.

6. Li Q, Chen R, Wu Y-J. Generation of pesticides-degrading genetically engineered bacteria expressing the protein of GFP and carboxylesterase B1. In: Proceedings of 3rd International Symposium on Pesticide and Environmental Safety & 7th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (October 9-13, 2007, Beijing, P. R. China) (Editor-in-chief: Jiang Shuren, Kenneth D. Racke), pp203-212, 2007. China Agricultural University Press.

1．伍一軍譯. 第26章 陸生動物的毒液和毒素的毒效應. 見《卡薩瑞特道爾毒理學：毒物的基礎科學》(第6版)(原著：Cartus D. Klaassen),黃吉武,周宗燦主譯.北京：人民衞生出版社，2005：827-844.

2．彭雙清、郝衞東、伍一軍. 《毒理學替代法》.北京：軍事醫學科學出版社，2009.