黎家

1995 美國弗吉尼亞理工大學 博士 (Ph.D. Virginia Tech)

1989 中國科學院植物所 碩士 (M.S. Institute of Botany, CAS)

1984 蘭州大學生物系 學士 (B.S. Lanzhou University) ^[1] 

1980-1984年在蘭州大學生物系學習並獲得植物生理學學士學位。

1984-1986年在湖南師範大學生物系任助教。

1986—1989年在中科院植物研究所學習並獲植物生理學碩士學位。

1990-1991年在中科院植物研究所任助研。

1991-1995年美國弗吉尼亞理工大學獲植物生理學博士學位。

1997-2002年在美國密蘇里大學哥倫比亞分校從事博士後研究。

2009年3月通過全球競聘獲任蘭州大學生命科學學院院長，全職回國工作。 ^{[1-2]  [4]} 

2021年10月據廣州大學生命科學學院消息，黎家教授受聘擔任廣州大學生命科學學院院長。 ^[3-4] 

（1）油菜素內酯的信號傳遞、合成、及代謝途徑的分子調控機制 (Brassinosteroid Signal Transduction and Homeostasis): 油菜素內酯是一類重要的植物激素，參與調控植物生長的各個階段，阻斷油菜素內酯的生物合成或信號轉導都會使植物變得極其矮小，並表現出雄性不育、推遲衰老、在黑暗培養時呈現出去黃化等的異常表型。油菜素內酯的受體是一個跨膜的亮氨酸富集型受體激酶，它的胞外特定結構域能特意與油菜素內酯相互作用從而啓動胞內一系列磷酸化、脱磷酸化反應，把信號一步步傳到細胞核中，最終改變基因的表達。在過去的十年中，本研究小組利用激活標籤遺傳學手段成功地分離到多個關鍵蛋白 ( 比如： BRS1 ， BAK1 ， AtSERK1 ， BRL1 ， BRL3 ， BEN1 等 ) ，研究表明它們參與油菜素內酯的信號轉導、合成、及代謝調控，現階段的工作主要對這些蛋白所參與的具體作用機制作深入細緻的探討。 ^[1] 

（2）用遺傳及生化手段研究擬南芥中一類亮氨酸富集型受體蛋白激酶的生物學功能 (Functional Analyses of LRR-RLKs): 細胞與細胞之間的信號轉導是高等植物生長髮育的細胞生物學基礎，受體激酶在信號轉導過程中起至關重要的作用，它們通常作為信號轉導的原初受體。過去的十幾年中我們做了大量的前期工作，克隆了擬南芥基因組中全部223個編碼亮氨酸富集型受體蛋白激酶的大多數全長 cDNA ，目前我們正在利用各種遺傳及分子生物學手段對223LRR-RLKs中尚未揭示功能的分子開展生物學功能研究。 ^[1] 

（3）受體激酶介導的植物細胞凋亡的分子機理 (RLK-Mediated Plant Cell-Death Control): 我們前面的工作已發現受體激酶 BAK1 及 BKK1 能同時參與正向調控油菜素內酯信號轉導，同時抑制細胞凋亡，同時敲除 BAK1 和 BKK1 使植物變得極其矮小，並在光下很快驅動細胞程序化凋亡，造成葉片快速死亡。我們目前正在對 BAK1 及 BKK1 調控細胞凋亡的分子機理作深入的探索。 ^[1] 

黎家教授長期從事植物激素油菜素甾醇（Brassinosteroid, BR）領域的研究，在闡明其生物合成、代謝調控及信號轉導的分子機理方面做了許多原創性工作。例如，黎家教授率先採用激活標籤技術篩選鑑定到BR共受體激酶BAK1，後又發現BAK1同時但獨立參與BR感知、植物免疫等多條信號通路並闡明了分子機理。這些成果是相關研究領域的經典之作，被國內外同行廣泛關注，BAK1也早已成為了國際植物學界的明星分子。 ^[3] 

黎家教授拓展了新的研究領域，開始關注受體激酶調控的植物根系可塑性發育過程。發現多個受體激酶在根分生組織的發育、側根的發生中起關鍵作用，並在植物根的向水性生長機制研究方面取得了突破性進展。 ^[3] 

黎家教授的成果發表在《Cell》、《Developmental Cell》、《Current Biology》、《Cell Research》、《Nature Plants》、《Proc. Natl. Acad. Sci. USA》、《Plant Cell》、《Nature Communications》、《Molecular Plant》、《Plant Physiology》、《Plant Journal》、《Current Opinion in Plant Biology》、《PLoS Genetics》等多種知名國際學術期刊上。 ^[3] 

曾獲2013-2014年度美國弗吉尼亞理工大學農學與生命科學學院傑出校友獎。後又被評為“甘肅省優秀專家”，“甘肅省領軍人才第一層次專家”等。 ^[3] 

2022年，獲得甘肅省外國專家“敦煌獎” ^[6]  。

中國植物生理學會常務理事、植物激素專業委員會主任；《Food and Energy Security》創刊副主編（Wiley-Blackwell出版社）；《Journal of Integrative Plant Biology》、《Journal of Genetics and Genomics》、《植物學報》、《遺傳》編委以及20多種國際主要學術刊物審稿人；國家自然科學基金委員會生命科學部專家評審組成員；科技部、教育部及基金委各類人才計劃終評組專家；教育部重點實驗室評審專家，國家重點實驗室評估專家組成員；蘭州大學學術委員會委員、“細胞活動與逆境適應”教育部重點實驗室主任、自然科學分委會副主任；多個國家重點實驗室、教育部重點實驗室及其他學術機構學術委員會委員等。 ^[3] 

Gou, X. and Li, J.* (2012) Activation Tagging. Methods in Molecular Biology, in press

Gou, X., Yin, H., He, K., Du, J., Yi, J., Xu S., Lin, H., Clouse, S.D., Li, J.* (2012) Genetic Evidence for an Indispensable Role of Somatic Embryogenesis Receptor Kinases in Brassinosteroid Signaling. PLoS Genetics 8(1): e1002452. (Selected by Faculty of 1000 as a "must read" paper)

Li, J.*, Du, J., He, K., and Gou, X. (2012) Cell Death Control by Receptor Kinases in Arabidopsis thaliana. In, F.E. Tax and B. Kemmerling (editors) RECEPTOR-LIKE KINASES IN PLANTS: From Development to Defense. Springer. Volume 13, pp79-91.

Wei, Z-Y and Li, J.* (2011) Receptor kinases mediated brassinosteroid signal transduction in plants. Chinese Bulletin of Life Sciences. 23 (11), 1106-1113.

An, J., Guo, Z., Gou, X., Li, J.* (2011) TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana. Plant Signaling & Behavior, 6: 1117-1118.

Li J.*（2010） Multi-tasking of somatic embryogenesis receptor-like protein kinases. Current Opinion in Plant Biology , 13: 509-514.

Guo, Z., Fujioka, S., Blancaflor, E.B., Miao, S., Gou, X., and Li, J.* (2010) TCP1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell 22, 1161-1173.

Yang, H., Gou, X., He, K., Xi, D., Du, J., Lin, H., Li, J.* (2010) Arabidopsis BAK1 and BKK1 confer reduced susceptibility to Turnip Crinkle Virus. European Journal of Plant Pathology, 127: 149-156.

Gou, X., He, K., Yang, H., Yuan, T., Lin, H., Clouse, S.D., Li, J.* (2010) Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11(1):19 [Epub ahead of print]

Li, D., Wang, L., Wang, M., Xu, Y.Y., Luo, W., Liu, Y.J., Xu, Z.H., Li, J., Chong, K. (2009) Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield. Plant Biotechnology Journal 7(8): 791-806.

Wang, X., Kota, U., He, K., Blackburn, K., Li, J. , Goshe, M.B., Huber, S.C., and Clouse, S.D. (2008) Sequential transphosphorylation of the BRI1/BAK1 receptor kinase pair impacts early events in brassinosteroid signaling. Developmental Cell 15, 220-235.

He, K., Gou, X., Powell, R.A., Yang, H., Yuan, T, Guo, Z., and Li, J.* (2008) Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaling & Behavior 3 (10), 813-815.

Clouse, S.D., Goshe, M.B., Huber, S.C. and Li, J. (2008) Functional Analysis and Phosphorylation Site Mapping of Leucine-Rich Repeat Receptor-Like Kinases. In, GK Agrawal and R Rakwal (eds) Plant Proteomics: Technologies, Strategies and Applications. John Wiley & Sons, pp 469-484.

Heese, A., Hann, D.R., Gimenez-ibanex, S., Jones, A., He, K., Li, J. , Schroeder, J.I., Peck, S.C., Rathjen, J.P. (2007) The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proc. Natl. Acad. Sci. USA 104, 12217-12222.

He, K., Gou, X., Yuan, T., Lin, H., Asami, T., Yoshida, S., Russell, S.D., Li, J.* (2007) BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell death pathways. Current Biology 17, 1109-1115.

Yuan, T., Fujioka, S., Takatsuto, S., Matsumoto, S., Gou, X.,He, K., Russell, S.D., and Li, J.* (2007) BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. The Plant Journal 51 (2), 220–233. (Selected by Faculty of 1000 as a "must read" paper)

Li, J.* and Gou, X. (2007) Brassinosteroids. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0020092]

Wang, L., Xu, Y.Y., Li, J. , Powell, R.A., Xu, Z.H., and Chong, K. (2007) Transgenic rice plants ectopically expressing AtBAK1 are semi-dwarfed and hypersensitive to 24-epibrassinolide. Journal of Plant Physiology 164(5), 655-664.

Zhou, A. and Li, J.* (2005) Arabidopsis BRS1 is an active and secreted serine carboxypeptidase. Journal of Biological Chemistry 280 (42), 35554-35561.

Xu, Y.Y., Wang, X.M., Li, J. , Li, J.H., Wu, J.S., Walker, J.C., Xu, Z.H., Chong, K. (2005) Activation of the WUS gene induces ectopic initiation of floral meristems on mature stem surface in Arabidopsis thaliana. Plant Molecular Biology 57 (6), 773-784.

Wang, X.F., Goshe, M. B., Soderblom, E., Phinney, B.S., Kuchar, J., Li, J., Asami, T., Yoshida, S., Huber, S. C., Clouse, S. D. (2005) Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase. The Plant Cell 17(6), 1685-703. (Selected by Faculty of 1000 as a "must read" paper)

Zhou, A., Wang, H., Walker, J.C., and Li, J.* (2004) BRL1, a leucine-rich repeat receptor-like protein kinase, is functionally redundant with BRI1 in regulating Arabidopsis brassinosteroid signaling. The Plant Journal 40, 399-409.

Lee, G., Li, J., Walker, J.C. and Van Doren S.R. (2003) 1H. 13C and 15N resonance assignments of the kinase interacting FHA domain of Arabidopsis thaliana kinase-associated protein phosphatase. J. Biomol NMR 25, 253-254.

Li, J. , Wen, J., Lease, K.A., Doke, J.T., Tax, F.E. and Walker, J.C. (2002) BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling. Cell 110, 213-222. (Selected by Faculty of 1000 as a "must read" paper)

Lease, K.A., Wen, J., Li, J., Doke, J.T., Liscum, E. and Walker, J.C. (2001) A mutant Arabidopsis Heterotrimeric G protein b subunit affects leaf, flower and fruit development. The Plant Cell 13, 2631-2641.

Li, J. , Lease, K.A., Tax, F.E. and Walker, J.C. (2001) BRS1, a serine carboxypeptidase, regulates BRI1 signaling in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 98, 5916-5921.

Li, J. , Lee, G., Van Doren, S.R. and Walker, J.C. (2000) The FHA domain mediates phosphorylation-dependent protein-protein interactions. J. Cell Sci. 113, 4143-4149.

Li, J. , Smith, G.P. and Walker, J.C. (1999) Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96, 7821-7826.

Lin, Q., Li, J., Smith, R.D. and Walker, J.C. (1998) Molecular cloning and chromosomal mapping of type one serine/threonine protein phosphatases in Arabidopsis thaliana. Plant Molecular Biology 37, 471-481.

Li, J. , Hegeman, C.E., Hanlon, W.R., Lacy, G.H., Denbow, D.M. and Grabau, E.A. (1997) Secretion of active recombinant phytase from soybean cell-suspension cultures. Plant Physiology 114, 1103-1111.

Li, J. and Grabau, E.A. (1996) Comparison of somatic embryogenesis and embryo conversion in commercial soybean cultivars. Plant Cell, Tissue Organ Cult. 44, 87-89. ^[1]