黃石

遺傳學學士，復旦大學生物系遺傳學專業, 1979-1983；

Ph.D. Biochemistry, University of California，Davis, 1984-1988；

Postdoctoral Fellow, University of California，San Diego, 1989-1992；

Assistant Professor, The Burnham Institute for Medical Research, 1992-1998；

Associate Professor, The Burnham Institute for Medical Research, 1998-2008；

Professor, State Key Laboratory of Medical Genetics, CSU, 2009-present。

黃石博士是中南大學醫學遺傳學國家重點實驗室教授。他在解放軍軍事醫學科學院長大，他的父親是那裏的教授。他童年的愛好開始是運動，後來是純粹藝術。由於1978年報考中央美術學院失利，他的興趣轉向了自然科學。他1979至1983年在復旦大學獲得遺傳學學士學位。他是CUSBEA第三期（1984）公派出國留學生，於1988年獲得加州大學戴維斯分校博士學位。隨後在加州大學聖地亞哥分校完成博士後工作，並於1992年被任命為美國聖地亞哥Burnham Institute 助理教授（assistant professor），1998年升為副教授（associate professor）。2009年回國後至今擔任中南大學教授。

早年對藝術的研習培養了他的審美觀， 使他在自然科學研究中， 更關注能發揮創造性的課題。黃石教授的實驗室首先發現了RIZ腫瘤基因和PRDM家族組蛋白甲基轉移酶，並確定了它通過表觀遺傳學調節在高肉低蔬菜飲食（西方式飲食）增加癌症患病風險中的作用。從2003年起，黃石教授開始了他對遺傳和表觀遺傳在生物複雜性進化中相互關係的原創性研究。他在世界上首次提出了種內變異度上限理論（maximum genetic diversity theory），這一理論解決了主流進化理論不能解釋分子進化中的遺傳等距離現象以及不能解釋複雜疾病的遺傳機制這些重要問題。 ^[1] 

1. 黃益敏，夏夢穎， 黃石 （2013）遺傳多樣性上限假説所揭示的進化歷程 《遺傳》，Hereditas (Beijing), 35:599-606. Yimin Huang, Mengying Xia, and Shi Huang (2013) The evolutionary process unveiled by the maximum genetic diversity hypothesis. Hereditas, 35:599-606. pdf in Chinese；

2. Zhu, Z., Lu, Q., Yuan, D., Li, Y., Man, X., Zhu, Y., and Huang, S. (2013) Role of genetic polymorphisms intransgenerational inheritance of inherent as well as acquired traits in budding yeast. arXiv:1302.7276 ；

3. Hu, T., Long , M., Yuan D., Zhu Z., Huang, Y., and Huang, S. (2013) The genetic equidistance result: misreading by the molecular clock and neutral theory and reinterpretation nearly half of a century later. Sci China Life Sci, 56:254-261 (in English). 胡濤波，龍孟平，袁德健， 朱作斌， 黃益敏， 黃石 （2013） 遺傳等距離結果: 分子鐘和中性理論的誤讀及其近半世紀後的重新解謎 《中國科學：生命科學》 43: 275-282；

4. Yuan, D, Zhu, Z., and Huang, S. (2012) A more complete reinterpretation of molecular evolution nearly half of a century later supports the multiregional hypothesis rather than the out of Africa hypothesis. News magazine from the Chinese Academy of Social Sciences, Issue 389, (in Chinese). 袁德健 朱作斌 黃石 分子進化遲到近半世紀的完整解讀：支持“多地區起源説”而不是“出非洲説” 《中國社會科學報》2012年12月7日第389期；

5. Yuan, D., Zhu, Z., Tan, X., Liang, J., Zeng, C., Zhang, J., Chen, J., Ma, L., Dogan, A., Brockmann, G., Goldmann, G., Medina,E., Rice, A.D., Moyer, R.W., Man, X., Yi, K., Li, Y., Lu, Q., Huang, Y., Wang, D., Yu, J., Guo, H., Xia, K., and Huang, S. (2012) Methods for scoring the collective effects of SNPs: Minor alleles of common SNPs quantitatively affect traits/diseases and are under both positive and negative selection；.

6. Huang, S. (2012) Primate phylogeny: molecular evidence for a pongid clade excluding humans and a prosimian clade containing tarsiers. Sci China Life Sci, 55: 709-725. pdf；

7. Huang, S. (2010) The overlap feature of the genetic equidistance result, a fundamental biological phenomenon overlooked for nearly half of a century. Biological Theory, 5: 40-52. pdf；

8. Huang, S. (2009) Inverse relationship between genetic diversity and epigenetic complexity. Preprint available, Nature Precedings；

9. Huang, S. (2009) Molecular evidence for the hadrosaur B. canadensis as an outgroup to a clade containing the dinosaur T. rex and birds. Rivista di Biologia / Biology Forum, 102: 20-22. pdf；

10. Huang, S. (2008) The genetic equidistance result of molecular evolution is independent of mutation rates. J. Comp. Sci. Syst. Biol., 1: 92-102. pdf；

11. Huang, S. (2008) Ancient fossil specimens are genetically more distant to an outgroup than extant sister species are. Rivista di Biologia / Biology Forum, 101: 93-108. pdf；

12. Huang, S. (2008) Histone methylation and the initiation of cancer. Cancer Epigenetics, Ed. Tollefsbol, T., CRC Books. pdf；

13. Zhou, W., Alonso, S., Takai, D., Lu, S.C., Yamamoto, F., Perucho, M., and Huang, S. (2008) Requirement of RIZ1 for cancer prevention by methyl-balanced diet. PLoS One, 3: e3390. doi:10.1371/journal.pone.0003390. pdf；

14. Deng, Q. and Huang, S. (2004) PRDM5 is silenced in human cancers and has growth suppressive activities. Oncogene. 23, 4903-4910.；

15. Carling, T., Kim, K.-C., Yang, X., Gu, J., Piao, Z., Zhang, X., and Huang, S. (2004) A histone methyltransferase is required for maximal response to female sex hormones. Mol. Cell. Biol., 24, 7032-7042；

16. Kim, K.-C., Geng, L., and Huang, S. (2003). Inactivation of a histone methyltransferase by mutations in human cancersCancer Res, 63, 7619-7623；

17. Huang, S. (2002).Histone methyltransferases, diet nutrients and tumor suppressors. Nature Reviews Cancer, 2, 469-476.pdf；

18. Steele-Perkins, G., Fang, W., Van Gele, M., Yang, X.-H., Gu, J., Carling, T., Buyse, I. M., Fletcher, J. A., Liu, J., Bronson, R.T., Chadwick, R.B., de la Chapelle, A., Zhang, X-k., Speleman, F., and Huang, S. ；(2001). Tumor formation and inactivation of RIZ1, a Rb-binding member of a nuclear protein methyltransferase superfamily. Genes Dev. 15: 2250-2262. ^[2]  ；

CUSBEA Scholar, Class III, 1984；

Pew Scholar in the Biomedical Sciences, 1993；

Furong Scholar 芙蓉學者, 2010。