黃世亮

（1）選擇性靶向Top IIa的ATPase的新型抗腫瘤曼宋酮類化合物的設計、合成及機制研究(21272288/B020601),國家自然科學基金，2013.1-2016.12.

（2）基於FP和TR-FRET高通量篩選技術：靶向Top IIa ATPase新先導物的發現及結構改造（2015A030313120）,省自然科學基金面上項目，2014年10月至 2017年9月

（3）選擇性靶向Top IIα的ATPase的新型抗腫瘤曼宋酮類化合物的設計、合成及機制研究(21272288), 國家自然科學基金，2013.1-2016.12.

（4） 靶向TopIIα ATPase位點的新型曼宋酮類化合物的設計、合成及機制研究,藥用資源化學與藥物分子工程教育部重點實驗室資助課題（CMEMR2012-B02）, 2012.6-2015.5

（5） 基於mRNA 5’UTR G-四鏈體調控β-分泌酶的抗阿爾茨海默症先導化合物的發現與分子機制研究（81273433/H3007），國家自然科學基金，參與人，2013.1-2016.12

（6）基於TOPII的ATP活性位點的新曼宋酮F類似物的設計、合成與活性研究（A2011155）,廣東省醫學研究基金，2011-2013

（7）新型抗腫瘤天然產物Mansonone F衍生物的合成、構效關係和作用機制研究(30701050), 國家自然科學基金, 2008.1-2010.12

（8） 曼宋酮F衍生物的抗腫瘤作用構效關係和作用機制研究(7301303), 廣東省自然科學基金, 2007.10-2009.10

（9）具抗菌和抗腫瘤作用的天然產物曼宋酮 E、F的結構改造及活性篩選 (B2007033), 廣東省醫學科研基金, 2007.9-2009.9

(1)Xie, H.-T.; Zhou, D.-C.; Mai, Y.-W.; Huo, L.; Yao, P.-F.; Huang, S.-L.*; Wang, H.-G.; Huang, Z.-S.; Gu, L.-Q. Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities.RSC Adv. 2017, 7, 20919-20928.

(2)Li, P. H.; Zeng, P.; Chen, S. B.; Yao, P. F.; Mai, Y. W.; Tan, J. H.; Ou, T. M.; Huang, S. L.*; Li, D.; Gu, L. Q.; Huang, Z. S.*Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.J Med. Chem. 2016, 59, 238-52.

(3)Zhai, P.; Xia, C. L.; Tan, J. H.; Li, D.; Ou, T. M.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Syntheses and evaluation of asymmetric curcumin analogues as potential multifunctional agents for the treatment of Alzheimer's disease.Current Alzheimer research2015, 12, 403-14.

(4)Yao, B. L.; Mai, Y. W.; Chen, S. B.; Xie, H. T.; Yao, P. F.; Ou, T. M.; Tan, J. H.; Wang, H. G.; Li, D.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.Eur. J. Med. Chem.2015, 92, 540-53.

(5)Zhuo, S. T., Li, C. Y., Hu, M. H., Chen, S. B., Yao, P. F.,Huang, S. L.,* Ou, T. M., Tan, J. H., An, L. K., Li, D., Gu, L. Q., and Huang, Z. S.* Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II,Org. Biomol. Chem.2013,11(24), 3989-4005.

(2)Huang, Z. H., Zhuo, S. T., Li, C. Y., Xie, H. T., Li, D., Tan, J. H., Ou, T. M., Huang, Z. S., Gu, L. Q., andHuang, S. L.*Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors,Eur. J. Med. Chem.2013,68C, 58-71.

(3)Chen, Y. P., Zhang, Z. Y., Li, Y. P., Li, D.,Huang, S. L.,* Gu, L. Q., Xu, J., and Huang, Z. S. Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase,Eur. J. Med. Chem.2013,66, 22-31.

(4)Li, Y. P., Weng, X., Ning, F. X., Ou, J. B., Hou, J. Q., Luo, H. B.,* Li, D., Huang, Z. S.,Huang, S. L.,*and Gu, L. Q.3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method,J. Mol. Graph. Model.2013,41, 61-67.

(5)Li, Y.-P., Ning, F.-X., Yang, M.-B., Li, Y.-C., Nie, M.-H., Ou, T.-M., Tan, J.-H.,Huang, S.-L.,* Li, D., Gu, L.-Q., Huang, Z.-S.Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.Eur. J. Med. Chem., 2011.46(5): 1572-1581

(6)Fang Xian Ning, Xiang Weng,Shi Liang Huang,* Li Jun Gu, Zhi Shu Huang, * Lian Quan Gu.A facile and efficient method for hydroxylation of azabenzanthrone compounds.Chin. Chem. Lett.2011,22(1), 41-44

(7)Wei-bin Wu, Jie-bin Ou, Zhi-shu Huang, Shuo-bin Chen, Tian-miao Ou, Jia-heng. Tan, Ding Li, Liu-lan. Shen,Shi-liang Huang*, Lian-quan Gu and Zhi-shu Huang,Eur. J. Med. Chem.2011,46, 3339-3347.

(8)Zhong Liu,Shi-Liang Huang, Man-Mei Li, Zhi-Shu Huang, Kin Sing Lee*, Lian-Quan Gu*. Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.Chem-Bio. Interac.2009, 177(1), 48-57

(9)Hua-pei Jian, Xing-yuan Wang, Zhi-shu Huang,Shi-liang Huang,*, Lian-quan Gu. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines.Heterocycles.2008,75(7),1773-1778.

(10)Shi-Liang Huang, Yi Luo, Zhi-Shu Huang, Xing-Yuan Wang, Xian-Zhang Bu, Pei-Qing Liu, Lin Ma, Bing-Fen Xie, Zong-Chao Liu, Yue-Ming Li, Albert S. C. Chand, Lian-Quan Gu. Synthesis and Cytotoxicity of 9-Substitued benzo[de] chromene -7,8-dione and 5-benzyl -9- Substitued benzo[de]chromene-7,8-dione.Synthetic Communications.2006, 36(18), 2667-2684.

(11)Shi Liang Huang, Yi Luo, Zhi Shu Huang, Xian Zhang Bu, Pei Qing Liu, Lin Ma, Yue Ming Li, Albert S. C. Chan, Lian Quan Gu. The Mechanism on Cyclization, Debenzylation and Oxidation of 1-[1- (Benzyloxy)-3- methylnaphthalen-4- yloxy]propan-2-one.Chin. Chem. Lett.2006, 17(6), 769-772. ^[1]