陳明遠

1993.9-1998.6　南華大學醫學院 臨牀醫學學士

1998.9-2001.6　中山大學第一附屬醫院耳鼻咽喉科 碩士

2004.9-2007.6　中山大學腫瘤防治中心鼻咽科 腫瘤學博士

2001.7- 中山大學腫瘤防治中心鼻咽科　教授/主任醫師/科副主任

2009.4-2009.5　荷蘭癌症中心列文虎克醫院頭頸腫瘤外科 訪問學者

2009.6-2009.9　香港大學瑪麗醫院頭頸外科 Fellowship

2011.2-2012.3　美國馬里蘭大學醫學院 博士後

2013.9-2014.8　教育部科技司2011辦公室（北京） 借調工作

2015.2- 中山大學腫瘤防治中心鼻咽科副主任

主要從事鼻咽癌的多學科綜合治療，擅長於鼻咽癌放射治療，轉移鼻咽癌綜合治療，復發鼻咽癌微創外科治療等等。

長期專注於鼻咽癌的臨牀診療及其相關轉化研究，擅長鼻咽癌的放療、化療、手術及其綜合治療，尤其是復發、轉移、壞死鼻咽癌等難治性鼻咽癌的臨牀綜合治療。發表第一/並列第一/通訊作者高水平論文多篇，主持國家級、省部級和校級等各類科研基金項目多項，先後在美國耳鼻咽喉-頭頸外科年會、歐洲放射腫瘤年會等國際國內著名學術會議上做主題發言10餘次，主要學術貢獻有：1.在調強放療方面，通過迄今世界上最大宗（7081例）初治鼻咽癌病例回顧性分析，證明調強放療相對於傳統二維放療，可以顯著提高初治鼻咽癌的無局部復發生存率和無進展生存率。2.在後裝放射治療方面，經鼻內鏡鼻咽施源器插植，進行組織間近距離放射治療早期鼻咽癌，並取得滿意的療效。3.在復發鼻咽癌方面，率先在國內國際系統報道了經鼻內鏡鼻咽切除術治療局部復發鼻咽癌的新技術，術後聯合自主創新的帶血管蒂鼻腔粘骨膜瓣修復術進行一期傷口修復，徹底解決復發鼻咽癌腫瘤難以切除、傷口難以癒合的科學難題，從而為局部復發鼻咽癌的挽救性外科治療提供了一個創新、微創、系統的治療模式，顯著提高了局部復發鼻咽癌的生存率和生存質量。4.在鼻咽壞死方面，倡導徹底清除鼻咽壞死病灶的基礎上進行手術創面一期修復的學術觀點，徹底解決了鼻咽癌放療後鼻咽頑固性壞死的國際性治療難題。5.在轉移鼻咽癌方面，通過迄今世界上最大宗（977例）和多中心初治遠處轉移鼻咽癌病例研究，成功地將遠處轉移轉移鼻咽癌分成低危、中危和高危三個亞組，並發現在全身化療的基礎上，聯合局部區域放療有助於提高低危和中危的患者的生存率。

國家自然科學基金委初審專家，廣東省自然科學基金委評審專家；Head & Neck, Laryngoscope, Oncotarget等國際高水平雜誌審稿專家。

1、2014年度　腫瘤防治中心醫科本科教學中青年教師授課比賽一等獎

2、2014年度　中山大學醫科本科教學中青年教師授課大賽二等獎

3、實用新型專利及發明專利：血管外保護支架(第3791122號)。發明人：陳明遠。

4、陳明遠教授團隊《復發鼻咽癌的微創外科體系建立及分層治療策略創新》項目榮獲2023年中國抗癌協會科技獎一等獎 ^[8] 

1.鼻咽癌遠處轉移分子標誌物的篩選及其預測模型的構建（81572912）。國家自然科學基金面上項目，執行年限：2016.1-2019.12，經費：57萬元。

2.誘導化療聯合同時期化放療治療高轉移潛能鼻咽癌的多中心、隨機對照臨牀試驗（入庫）。廣州市科技計劃項目產學研協同創新重大專項，執行年限：2016.04.01- 2019.04.01，經費：100萬元。

3.基於鼻咽癌外泌體轉移相關蛋白標誌物的預後預測模型指導鼻咽癌誘導化療的臨牀研究(2014B020212005)。廣東省科技計劃項目公益研究與能力建設專項重點項目，執行年限：2015.01-2017.12，經費：100萬元。

4.復發/轉移鼻咽癌的綜合治療及轉化研究。中山大學腫瘤防治中心特支計劃，執行年限：2015.09-2018.09，經費：150萬。

5.循環腫瘤DNA濃度及其突變基因檢測預測鼻咽癌轉移並動態指導鼻咽癌靶向治療的研究。中山大學重大項目培育和新興、交叉學科資助計劃，執行年限：2015.09-2017.09，經費：20萬。

6.超分割調強放療對比傳統分割方式調強放療治療局部復發鼻咽癌的多中心隨機對照臨牀試驗。中山大學臨牀醫學研究5010計劃培育項目，01/01/2016– 12/31/2017，20萬。

7.缺氧誘導因子HIF1a下調轉錄因子TELB促進鼻咽癌轉移的分子機制。廣東省自然科學基金重點項目（No. S2013020012726），01/01/2014– 12/31/2016，30萬。

8.原發灶放療聯合全身化療對比單純全身化療治療化療敏感的初治遠處轉移鼻咽癌的多中心隨機對照臨牀試驗。中山大學臨牀醫學研究5010計劃常規項目，08/01/2013– 7/31/2023，200萬。

9.血管外保護支架的研製及其在局部復發鼻咽癌外科治療中的應用。中山大學腫瘤中心留學人員科研啓動基金項目，10/01/2013– 9/31/2015，3萬。

10.p62SQSTM1在缺氧誘導的自噬中抑制凋亡並促進鼻咽癌轉移的分子機制。教育部“新世紀優秀人才支持計劃”（No. NCET-12-0562），01/01/2013– 12/31/2015，50萬。

11.三維細胞培養模擬臨牀缺氧狀態下HIF-1a轉錄調節Aurora激酶誘發鼻咽癌放療抵抗的分子機制。國家自然科學基金（No. 81071890），01/01/2010– 12/31/2012，33萬。

1.Qian Zhu, Xiong Zou, Rui You, Rou Jiang, Men-Xia Zhang, You-Ping Liu, Chao-Nan Qian, Hai-Qiang Mai, Ming-Huang Hong, Lin Guo*, Ming-Yuan Chen*. Establishment of an innovative staging system for extramedullary plasmacytoma. BMC Cancer. 2016 Oct 8;16(1):777.

2.Meng-Xia Zhang, Yi-Jun Hua, Hai-Yun Wang, Ling Zhou, Hai-Qiang Mai, Xiang Guo, Chong Zhao, Wen-Lin Huang, Ming-Huang Hong*, Ming-Yuan Chen*. Long Term Prognostic Implication and therapeutic target role of Hexokinase II in Patients with Nasopharyngeal Carcinoma. Oncotarget. 2016 19;7(16):21287-97.

3.Jiang R, You R, Pei XQ, Zou X, Zhang MX, Wang TM, Sun R, Luo DH, Huang PY, Chen QY, Hua YJ, Tang LQ, Guo L, Mo HY, Qian CN, Mai HQ, Hong MH, Cai HM*, Ming-Yuan Chen*. Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients' survival. Oncotarget. 2016, 19;7(3):3645-57.

4.Deng CC, Xu M, Li J, Luo XL, Zhu YJ, Jiang R, Zhang MX, Lei JJ, Lian YF, Zou X, You R, Chen LZ, Feng QS, Bei JX, Ming-Yuan Chen*, Zeng YX*. Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity. Cancer Prev Res (Phila). 2016, 9(2):180-8.

5.Sang Y#, Chen MY#, Luo D#, Zhang RH, Wang L, Li M, Luo R, Qian CN, Shao JY, Zeng YX, Kang T. TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma. Oncotarget. 2015 Oct 6;6(30):29240-53.

6.Zhang MX, Li J, Shen GP, Zou X, Xu JJ, Jiang R, You R, Hua YJ, Sun Y, Ma J, Hong MH, Chen MY*. Intensity-modulated radiotherapy prolongs the survival of patients with nasopharyngeal carcinoma compared with conventional two-dimensional radiotherapy: A 10-year experience with a large cohort and long follow-up. Eur J Cancer. 2015 Nov;51(17):2587-95.

7.Jiang R, Cai XY, Yang ZH, Yan Y, Zou X, Guo L, Sun R, Luo DH, Chen QY, Huang PY, Xiang YQ, Lu X, Wang L, Xia WX, Mai HQ, Chen MY*. Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma. Chin J Cancer. 2015 Jun 10;34(6):237-46.

8.Rui You, Xiong Zou, Rou Jiang, Lin-Quan Tang, Wei-Dong Zhang, Li Li, Meng-Xia Zhang, Guo-Ping Shen, Ling Guo, Xiang Guo, Chao-Nan Qian, Hai-Qiang Mai, Jun Ma, Ming-Huang Hong, Ming-Yuan Chen*. New Surgical Staging System for Patients with Recurrent Nasopharyngeal Carcinoma based on the AJCC/UICC rTNM Classification System. European Journal of Cancer. 2015 Sep;51(13):1771-9.

9.Rui You, Xiong Zou, Yi-Jun Hua, Fei Han, Li Li, Chong Zhao, Ming-Huang Hong, Ming-Yuan Chen*. Salvage Endoscopic Nasopharyngectomy is Superior to Intensity-Modulated Radiation Therapy for Local Recurrence of Selected T1-T3 Nasopharyngeal Carcinoma --- a Case-Matched Comparison. Radiotherapy & Oncology. 2015 Jun;115(3):399-406.

10.Rou Jiang, Xiong Zou, Wen Hu, Yu-Ying Fan, Yue Yan, Meng-Xia Zhang, Rui You, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Pei-Yu Huang, Yi-Jun Hua, Ling Guo, Ming-Yuan Chen*. The elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients. Tumor Biology. 2015 Sep;36(10):7775-87.

11.Rou Jiang, Zhong-Han Yang, Xiu-Yu Cai, Yue Yan, Xiong Zou, Ling Guo, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Pei-Yu Huang, Yan-Qun Xiang, Xing Lu, Lin Wang, Wei-Xiong Xia, Hai-Qiang Mai, Ming-Yuan Chen*. The elevated peripheral blood lymphocyte/monocyte ratio predicts favorable prognosis in metastatic nasopharyngeal carcinoma. Chinese Journal of Cancer. 2015 Jun 10;34(1):23.

12.Jing Li, Xiong Zou, Yun-Long Wu, Jing-Cui Guo, Jing-Ping Yun, Miao Xu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Yi-Xin Zeng, Ming-Yuan Chen*. A comparison between the sixth and seventh editions of the UICC/AJCC staging system for nasopharyngeal carcinoma in a Chinese cohort. PLoS One. 2014 Dec 23;9(12):e116261.

13.Xiong Zou, Fei Han, Wen-Juan Ma, Man-Quan Deng, Rou Jiang, Lin Guo, Qing Liu, Hai-Qiang Mai, Ming-Huang Hong, Ming-Yuan Chen*. Salvage endoscopic nasopharyngectomy and intensity-modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma. Head Neck. 2015 Aug;37(8):1108-15.

14.Rou Jiang, Zhong-Han Yang, Dong-Hua Luo, Lin Guo, Rui Sun, Qiu-Yan Chen, Pei-Yu Huang, Fang Qiu, Xiong Zou, Ka-Jia Cao, Hai-Qiang Mai, Xiang Guo, Chao-Nan Qian, Ming-Huang Hong, Ming-Yuan Chen*. Elevated apolipoprotein A-I levels are associated with favorable prognosis in metastatic nasopharyngeal carcinoma. Med Oncol. 2014 Aug;31(8):80.

15.Yi Sang, Li Wang, Jian-Jun Tang, Mei-Fang Zhang, Meng-Xia Zhang, Xia Liu, Ru-Hua Zhang, Tie-Bang Kang, Ming-Yuan Chen*. Oncogenic roles of carbonic anhydrase IX in human nasopharyngeal carcinoma. Int J Clin Exp Pathol. 2014, 7(6):2942-9.

16.Xiang-Bo Wan, Rou Jiang, Fang-Yun Xie, Zhen-Yu Qi, Ai-Ju Li, Wei-Jun Ye, Yi-Jun Hua, Yu-Liang Zhu, Xiong Zou, Ling Guo, Hai-Qiang Mai, Xiang Guo, Ming-Huang Hong, Ming-Yuan Chen*. Endoscope-guided Interstitial Intensity -Modulated Brachytherapy and Intracavitary Brachytherapy as Boost Radiation for Primary Early T Stage Nasopharyngeal Carcinoma. PLoS One. 2014 Mar 3;9(3):e90048. 2014.

17.Ming-Yuan Chen; Yi-Jun Hua; Hai-Qiang Mai, et al. Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis (PRNN). Chin J Cancer. 2013, 32(10):533-8.

18.Chen Mingyuan*, Jiang Rou, Guo Ling, Zou Xiong, Liu Qin, Sun Rui, Qiu Fang, Xia Zongjun, Huang Haiqiang, Zhang Li, Hong Minghuang, Mai Haiqiang, Qian Chaonan. Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis. Chin J Cancer. 2013, 32(11):604-13.

19.Ming-Yuan Chen*, Rou Jiang, Ling Guo, Pei-Yu Huang, Dong-Hua Luo, Xiong Zou, Men-Xia Zhang, Rui Sun, Yi-Jun Hua, Xing Lv, Lin Wang, Hai-Qiang Mai, Ming-Huang Hong. Impact of Local Radiotherapy of Bone Lesions on the Survival Risk in Nasopharyngeal Carcinoma Patients with Bone Metastasis. Journal of Sun Yat-Sen university (Medical sciences). 2013, 34(6):979-985.

20.Jing Li, Rou Jiang, Wu-Shen Liu, Qing Liu, Miao Xu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Ming-Yuan Chen*, Yi-Xin Zeng*. A Large Cohort Study Reveals the Association of Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio with Favorable Prognosis in Nasopharyngeal Carcinoma. PLoS One. 2013 Dec 27;8(12):e83069.

21.Wang Tiantian#, Cao Qinghua#, Chen Mingyuan#, Xia Qing, Fan Xingjuan, Ma Xiaokun, Lin Qu, Jia Changchang, Dong Min, Ruan Danyun, Lin Zexiao, Wen Jingyun, Wei Li, Li Xing, Chen Zhanhong, Wang Lei, Wu Xiangyuan, Wan Xiangbo. Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma. PLoS One. 2013 Nov 26;8(11):e80317.

22.Ming-Yuan Chen; Yi-Jun Hua; Xiang-Bo Wan; Rui Sun; Pei-Yu Huang; Yan-Qun Xiang; Ling Guo; Hao-Yuan; Yue Yang; Ming-Huang Hong. A posteriorly pedicled middle turbinate mucoperiosteal flap resurfacing nasopharynx after endoscopic nasopharyngectomy for recurrent NPC. Otolaryngology-Head and Neck Surgery, 2012, 146(3):409-11.

23.Ming-Yuan Chen*, Sun-Lan Wang, Yu-Liang Zhu, Fang Qiu, Yan-Qiu Chen, Rou Jiang, Ca-Jia, Chao, Hai-Qiang Mai, Ming-Huang Hong*. Use of a posterior pedicle nasal septum and floor mucoperiosteum flap to resurface the nasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma. Head & Neck, 2012, 34(10):1383-8.

24.Xiang-Bo Wan#, Xin-Juan Fan#, Ming-Yuan Chen#, Jin Xiang, Pei-Yu Huang, Ling Guo, Xiang-Yuan Wu, Jie Xu, Zi-Jie Long, Yan Zhao, Wei-Hua Zhou, Hai-Qiang Mai, Quentin Liu, Ming-Huang Hong. Elevated Beclin 1 expression is correlated with HIF-1a in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy, 2010, 6(3):395-404.