陳增萍

2002.10-2008.11 英國鈕卡斯爾大學化工與先進材料學院，博士後。

1998.09-2001.05 湖南大學化學化工學院，理學博士；

1995.09-1998.06 湖南大學化學化工學院，理學碩士；

1991.09-1995.06 湖南大學化學化工學院，理學學士； ^[1] 

2008.12- 現在 湖南大學化學化工學院，教授、博士生導師。

2001.06- 2002.09 湖南大學化學化工學院，講師。 ^[1] 

英國斯特斯克萊德大學（University of Strathclyde）純粹與應用化學系榮譽教師 ^[1] 

Editorial Advisory Board Member of "Chemometrics and Intelligent Laboratory Systems"

目前主要從事複雜體系波譜定量分析理論和應用方面的研究，研究內容主要包括：複雜生物體系質譜定量分析技術、表面增強拉曼光譜定量分析技術、熒光化學生物傳感技術、化學計量學理論和方法等。所獲得的研究成果可望為臨牀疾病診斷、生物醫學研究、食品和藥品安全檢測、以及環境監測和保護等領域提供重要的工具。 ^[1] 

1. 國家自然科學基金，基於分子探針技術的化學計量學定量分析理論及其應用研究，2018.1-2021.12。

2. 國家自然科學基金，非均相體系熒光化學生物傳感技術中的化學計量學理論及應用研究，2015.1-2018.12。

3. 國家自然科學基金，具有普適性的表面增強拉曼光譜定量分析技術的研究，2013.1-2016.12。

4. 國家自然科學基金，複雜多相體系拉曼光譜定量分析的化學計量學方法研究，2011.1-2013.12。

5. 科技部重大科學儀器設備開發專項子任務，SHINERS粒子模型設計與理論研究，2011.9-2015.8。

6. 湖南省自然科學基金，複雜非均相體系熒光化學生物傳感定量分析理論及應用研究，2016.1-2017.12。

7. 教育部博士點基金（博導類），複雜非均相體系原位光譜定量分析基礎理論研究，2014.1-2016.12。

8. 教育部新世紀人才計劃，化學計量學，2013.1-2014.12。 ^[1] 

Shi, C.X.; Chen, Z.P.*; Chen, Y.; Liu, Q.; Yu, R.Q. Quantification of dopamine in biological samples by surface-enhanced Raman spectroscopy: comparison of different calibration models, Chemometrics and Intelligent Laboratory Systems, 2017, 169, 87-93

Zuo, Q.; Xiong, S.; Chen, Z.P.*; Chen, Y.; Yu, R.Q. A novel calibration strategy based on background correction for quantitative circular dichroism spectroscopy, Talanta, 2017, 174, 320-324

Kong, J.J.; Chen, Z.P.*; Chen, Y.; Yan, X.F.; Yu, R.Q. Direct DNA quantification in cell lysates by fluorometric method in combination with an advanced chemometric model, Chemometrics and Intelligent Laboratory Systems, 2016, 151, 9-14

Hu, Y.L.; Chen, Z.P.*; Chen, Y.; Shi, C.X.; Yu, R.Q. Generalized multiple internal standard method for quantitative liquid chromatography mass spectrometry, Journal of Chromatography A, 2016, 1445, 112-117

Yan, X.F.; Chen, Z.P.*; Cui, Y.Y.; Hu, Y.L.; Yu, R.Q. Quantitative generalized ratiometric fluorescence spectroscopy for turbid media based on probe encapsulated by biologically localized embedding, Analytica Chimica Acta, 2016, 921, 38-45

Chen, Y.; Chen, Z.P.*; Zuo, Q.; Shi, C.X.; Yu, R.Q. Surface-enhanced Raman spectroscopy based on conical holed enhancing substrates, Analytica Chimica Acta, 2015, 887, 45-50

Yan, X.F.; Chen, Z.P.*; Kong, J.J.; Hu, Y.L.; Chen, Y.; Yu, R.Q. Determination of free Mg2+ in turbid samples with the coexistence of interfering Ca2+ using extended quantitative fluorescence model, Chemometrics and Intelligent Laboratory Systems, 2015, 147, 41-46 ^[1] 

Shi, C.X.; Chen, Z.P.*; Chen, Y.; Yu, R.Q. Quantitative analysis of hormones in cosmetics by LC-MS/MS combined with an advanced calibration model, Analytical Methods, 2015, 7, 6804-6809

Long, S.Y.; Chen, Z.P.*; Chen, Y.; Yu, R.Q. Quantitative detection of captopril in tablet and blood plasma samples by the combination of surface-enhanced Raman spectroscopy with multiplicative effects model, Journal of Raman Spectroscopy, 2015, 46, 605-609

Chen, Y.; Chen, Z.P.*; Jin, J.W.; Yu, R.Q. Quantitative determination of ametryn in river water using surface-enhanced Raman spectroscopy coupled with an advanced chemometric model, Chemometrics and Intelligent Laboratory Systems, 2015, 142, 166-171

Chen, Y.; Chen, Z.P.*; Long, S.Y.; Yu, R.Q. Generalized ratiometric indicator based surface-enhanced Raman spectroscopy for the detection of Cd2+ in environmental water samples, Analytical Chemistry, 2014, 86, 12236-12242

Du, H.L.; Chen, Z.P.*; Song, M.; Chen, Y.; Yu, R.Q. Novel calibration model maintenance strategy for solving the signal instability in quantitative liquid chromatography–mass spectrometry, Journal of Chromatography A, 2014, 1338, 44-50

Jin, J.W.; Chen, Z.P.*; Song, J.; Xia, T.H.; Yu, R.Q. Determination of glucose in plasma by dry film-based near infrared spectroscopy: correcting the thickness variations of dry films without applying an internal standard, Chemometrics and Intelligent Laboratory Systems, 2014, 135, 63-69

Song, M.; Chen, Z.P.*; Chen, Y.; Jin, J.W. Multiplicative effects model with internal standard in mobile phase for quantitative liquid chromatography-mass spectrometry, Talanta, 2014, 125, 347-351.

Xia, T.H.; Chen, Z.P.*; Chen, Y.; Jin J.W.; Yu, R.Q. Improving the quantitative accuracy of surface enhanced Raman spectroscopy by the combination of microfluidics with a multiplicative effects model, Analytical Methods, 2014, 6, 2363-2370

Song, J.; Chen, Z.P.*; Jin, J.W.; Chen, Y.; Yu, R.Q. Quantitative surface-enhanced Raman spectroscopy based on the combination of magnetic nanoparticles with an advanced chemometric model, Chemometrics and Intelligent Laboratory Systems, 2014, 135, 31-36

Chen, Y.; Chen, Z.P.*; Yang J.; Jin, J.W.; Zhang, J.; Yu, R.Q. Quantitative fluorescence spectroscopy in turbid media: a practical solution to the problem of scattering and absorption, Analytical Chemistry, 2013, 85, 2015-2020

Yang, J.; Chen, Z.P.*; Zhang, J.; Jin, J.W.; Chen, Y. Quantitative Raman spectrometry: the accurate determination of analytes in solution phase of turbid media, Chemometrics and Intelligent Laboratory Systems, 2013, 126, 6-10

Zhang, J.; Liu S.Z.; Yang, J.; Song, M.; Song, J.; Du, H.L.; Chen, Z.P.* Quantitative spectroscopic analysis of heterogeneous systems: chemometric methods for the correction of multiplicative light scattering effects, Review in Analytical Chemistry , 2013, 32(2), 113-125

Chen, Z.P*; Li, L.M.; Jin, J.W.; Nordon, A.; Littlejohn, D.; Yang, J.; Zhang, J.; Yu, R.Q. Quantitative analysis of powder mixtures by Raman spectrometry: the influence of particle size and its correction, Analytical Chemistry, 2012, 84, 4088-4094

Jin, J.W.; Chen, Z.P.*; Li, L.M.; Steponavicius, R.; Thennadil, S.N.; Yang, J.; Yu, R.Q. Quantitative spectroscopic analysis of heterogeneous mixtures: the correction of multiplicative effects caused by variations in physical properties of samples, Analytical Chemistry, 2012, 84, 320-326

Chen Z.P.*; Zhong L.J.; Nordon A.; Littlejohn D.; Holden M.; Fazenda M.; Harvey L.; McNeil B.; O’Kennedy R. Calibration of multiplexed fibre-optic spectroscopy, Analytical Chemistry, 2011, 83, 2655-2659

Chen Z.P.*; Li L.M.; Yu R.Q.; Littlejohn D.; Nordon A.; Morris J.; Dann A.S.; Jeffkins P.A.; Richardson M.D.; Stimpson S.L. Systematic prediction error correction: a novel strategy for maintaining the predictive abilities of multivariate calibration models, Analyst, 2011, 136, 98-106

Chen Z.P.; Lovett D.; Morris J. Process analytical technologies and real time process control a review of some spectroscopic issues and challenges, Journal Process Control, 2011, 21, 1467-1482

Du W.; Chen Z.P.*; Zhong L.J.; Wang S.X.; Yu R.Q.; Nordon A.; Littlejohn D.; Holden M. Maintaining the predictive abilities of multivariate calibration models by spectral space transformation, Analytica Chimica Acta, 2011, 690, 64-70

Chen, Z.P.*; Morris, J. Borissova, A.; Khan, S.; Mahmud, T.; Penchev, R.; Roberts, K. On-line monitoring of batch cooling crystallisation of organic compounds using ATR-FTIR spectroscopy coupled with an advanced chemometric calibration method, Chemometrics and Intelligent Laboratory Systems, 2009, 96, 49-58

Chen, Z.P.; Morris, J. Process analytical technology and compensating for nonlinear effects in process spectroscopic data for improved process monitoring and control, Biotechnology Journal, 2009, 4, 610-619

Chen, Z.P.*; Fevotte, G.; Caillet, A.; Littlejohn, D.; Morris, J. Advanced calibration strategy for in-situ quantitative monitoring of phase transition processes in suspensions using FT-Raman spectroscopy, Analytical Chemistry, 2008, 80, 6658-6665

Chen, Z.P.*; Morris, J. Improving the linearity of spectroscopic data subjected to fluctuations in external variables by the extended loading space standardization, Analyst, 2008, 133, 914-922

Chen, Z.P.; Lovett, D.; Morris, J. Process analytical technologies (PAT)-the impact for process systems engineering, Computer Aided Chemical Engineering, 2008, 25, 967-972

Chen, Z.P.; Morris, J.; Martin, E. Extracting chemical information from spectral data with multiplicative light scattering effects by optical path-length estimation and correction, Analytical Chemistry, 2006, 78, 7674-7681

Chen, Z.P.; Morris, J.; Martin, E. Correction of temperature-induced spectral variations by loading space standardization, Analytical Chemistry, 2005, 77, 1376-1384

Chen, Z.P.; Morris, J.; Martin, E.; Hammond, R.B.; Lai, X.J.; Ma, C.Y.; Purba, E.; Roberts, K.J.; Bytheway, R. Enhancing the signal-to-noise ratio of X-ray diffraction profiles by smoothed principal component analysis, Analytical Chemistry, 2005, 77, 6563-6570

Chen, Z.P.; Morris, J.; Martin, E.; Yu, R.Q.; Liang, Y.Z.; Gong, F. Recursive evolving spectral projection for revealing the concentration windows of overlapping peaks in two-way chromatographic experiments, Chemometrics and Intelligent Laboratory Systems, 2004, 72, 9-19

Chen, Z.P.; Yu, R.Q. Mitigating model deficiency in three-way data analysis by the combination of background constraining and iterative correcting techniques, Analytica Chimica Acta, 2003, 487, 171-180

Chen, Z.P.; Wu, H.L.; Li, Y.; Yu, R.Q. On self-weighted alternating trilinear decomposition algorithm-the property of being insensitive to the excess factors used in calculation, Journal of Chemometrics, 2001, 15, 427-438

Chen, Z.P.; Li, Y.; Yu, R.Q. Pseudo alternating least squares algorithm for trilinear decomposition, Journal of Chemometrics, 2001, 15, 149-167

Chen, Z.P.; Liu, Z. Cao, Y. Z.; Yu, R.Q. Efficient way to estimate the optimum number of factors for trilinear decomposition, Analytica Chimica Acta, 2001, 444, 295-307

Chen, Z.P.; Wu, H.L.; Jiang, J.H.; Li, Y.; Yu, R.Q. A novel trilinear decomposition algorithm for second orders linear calibration, Chemometrics and Intelligent Laboratory Systems, 2000, 52, 75-86

Chen, Z.P.; Wu, H.L.; Li, Y.; Yu, R.Q. Novel constrained PARAFAC algorithm for second order linear calibration, Analytica Chimica Acta, 2000, 423, 187-196

Chen, Z.P.; Jiang, J.H.; Li, Y.; Liang, Y.Z.; Yu, R.Q. Fuzzy linear discriminant analysis for chemical data sets, Chemometrics and Intelligent Laboratory Systems, 1999, 45, 295-302

Chen, Z.P.; Jiang, J.H.; Li, Y.; Yu, R.Q. Non-linear mapping using real-valued genetic algorithm, Chemometrics and Intelligent Laboratory Systems, 1999, 45, 409-418

Chen, Z.P.; Liang, Y.Z.; Jiang, J.H.; Li, Y.; Qian, J.Y.; Yu, R.Q. Determination of the number of components in mixtures using a new approach incorporating chemical information, Journal of Chemometrics, 1999, 13, 15-30

Chen, Z.P.; Jiang, J.H.; Li, Y.; Shen, H.L.; Liang, Y.Z.; Yu, R.Q. Smoothed window factor analysis, Analytica Chimica Acta, 1999, 381, 233-246 ^[1] 

陳增萍、俞汝勤. 用於維護複雜體系光譜校正模型預測能力的方法, 中國發明專利, 專利號：ZL201210243634.0（2012.05.23）

陳增萍、金競文、俞汝勤. 用於複雜非均相混合物體系的準確光譜定量分析方法，中國發明專利, 專利號：ZL201110280639.6（2013.09.04）

陳增萍、李麗梅、金競文. 一種粉末混合物的拉曼光譜準確定量分析方法，中國發明專利, 專利號：ZL201110409685.1（2013.11.20）

陳增萍、金競文、俞汝勤. 具有普適性的表面增強拉曼光譜定量分析技術，中國發明專利, 專利號：ZL201210243634.0（2014.04.16）

陳增萍，陳瑤，田中羣. 一種環境水體樣本中鎘離子含量的定量分析方法，專利號：ZL201410439838.0（2016.06.08） ^[1] 

陳增萍，陳瑤，田中羣. 一種增強SERS信號的方法及其應用，中國發明專利, 專利號：ZL201510002031.5（2017.08.04）

曾獲湖南省2002自然科學技術一等獎 ^[1]