閆志強

1. 2008/9 - 2011/7，復旦大學，藥劑學，博士

2. 2005/9 - 2008/7，瀋陽藥科大學，藥劑學，碩士

3. 2001/9 - 2005/7，瀋陽藥科大學，藥物製劑，學士

1. 新型智能遞藥系統，重點研究針對腫瘤、肝纖維化、肝硬化等疾病的靶向和環境響應遞藥系統

2. 基因治療，重點研究siRNA、shRNA的體內靶向遞送

3. 細胞免疫治療，重點研究嵌合抗原受體T細胞（CAR-T）治療

1. Zhang J, Shen H, Xu J, Liu L,Tan J, Li M, Xu N, Luo S, Wang J, Yang F, Tang J, Li Q, Wang Y, Yu L*, Yan Z*.Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by DualAntifibrotic and Anti-inflammatory Activities. ACS Nano, 2020;14(5):6305-22.

2. Zou H, Israth J, Masuma A, LuoS, Shao J, Yan Z*, Yu L*. Gene therapy for hepatocellular carcinoma usingadenoviral vectors delivering a gene encoding IL-17A-neutralizing antibodyfragments. Hum Gene Ther. 2020: doi: 10.1089/hum.2019.169.

3. Gao L, Yu J, Liu Y, Zhou J, SunL, Wang J, Zhu J, Peng H, Lu W, Yu L, Yan Z*, Wang Y*. Tumor-penetratingPeptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast AgentsNanoparticles for Tumor Theranostics. Theranostics, 2018, 7(20):4984-5000（ESI高被引論文）

4. Fan M, Li M, Gao L, Geng S,Wang J, Wang Y, Yan Z*, Yu L*. Chimeric antigen receptors for adoptive T celltherapy in acute myeloid leukaemia. J Hematol Oncol, 2017, 10(1): 151.

5. Jia Z, Gong Y, Pi Y, Liu X, GaoL, Kang L, Wang J, Yang F, Tang J, Lu W, Li Q, Zhang W, Yan Z*, Yu L*. pPBpeptide-mediated siRNA-loaded stable nucleic acid lipid nanoparticles ontargeting therapy of hepatic fibrosis. Mol Pharm, 2018, 15(1): 53-62

6. Zhou JE, Yu J, Gao L, Sun L,Peng T, Wang J, Zhu J, Lu W, Zhang L, Yan Z*, Yu L*. iNGR-Modified Liposomesfor Tumor Vascular Targeting and Tumor Tissue Penetrating Delivery in theTreatment of Glioblastoma. Mol Pharm, 2017, 14(5): 1811-1820.

7. Gao L, Wang H, Nan L, Peng T,Sun L, Zhou J, Xiao Y, Wang J, Sun J, Lu W, Zhang L, Yan Z*, Yu L, Wang Y*.Erythrocyte Membrane-Wrapped pH Sensitive Polymeric Nanoparticles for Non-SmallCell Lung Cancer Therapy. Bioconjug Chem, 2017, 28(10):2591-2598

8. Yu J, Sun L, Zhou J, Gao L, NanL, Zhao S, Peng T, Han L, Wang J, Lu W, Zhang L, Wang Y, Yan Z*, Yu L*.Self-Assembled Tumor Penetrating Peptide Modified Poly(L-gamma-glutamylglutamine)-Paclitaxel Nanoparticles Based on HydrophobicInteraction for Treatment of Glioblastoma. Bioconjug Chem, 2017,28(11):2823-2831

9. Yan Z*, Yang Y, Wei X, Zhong J,Wei D, Liu L, Xie C, Wang F, Zhang L, Lu W*, He D. Tumor-penetrating Peptidemediation: an effective strategy for improving the transport of liposomes intumor tissue. Mol Pharm, 2014, 11(1): 218-225.

10. 楊一禕, 閆志強*, 鍾建, 何丹農*, 陸偉躍, 多肽介導的腫瘤靶向納米遞藥系統, 化學進展, 2013, 25(06):1052-1060.

11. Yan Z, Wang F, Wen Z, Zhan C,Feng L, Liu Y, Wei X, Xie C, Lu W*. LyP-1-conjugated PEGylated liposomes: acarrier system for targeted therapy of lymphatic metastatic tumor. J ControlRelease, 2012, 157(1): 118-125. ^[1]