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郭興
（南京醫科大學神經生物學系教授）
鎖定
郭興，南京醫科大學特聘教授，博士生導師。國家優青獲得者，江蘇省特聘教授，江蘇省雙創團隊成員，現任神經生物學系副主任。主要研究方向：線粒體質量控制與神經退行性疾病。以第一或通訊作者在Journal of Clinical Investigation, EMBO molecular medicine, Nature communications，Signal Transduction and Targeted Therapy，Chemical Science等國際期刊發表多篇高水平論文。承擔國家自然科學基金優秀青年科學基金、國家自然科學基金面上項目（2項）、作為課題組長或研究骨幹參與科技部國家重點研發計劃2項。目前擔任中國生理學會青年委員會委員、中國生理學會幹細胞分會委員、江蘇省神經科學學會理事等。
[1]
- 中文名
- 郭興
- 國 籍
- 中國
- 出生日期
- 1983年
- 教學職稱
- 教授
- 執業地點
- 南京醫科大學
- 研究方向
- 神經生物學
科研方向：
近年承擔課題情況
代表性論文：
1. Liu CY*, Fu ZX*, Wu SS*, Wang XS*, Zhang SR*, Chu C*, Hong Y, Wu WB, Chen SQ, Jiang YQ, Wu Y, Song YB, Liu Y#, Guo X#. Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington’s disease. EMBO Molecular Medicine. 2022 Jul 7;14(7):e15851. doi: 10.15252/emmm.202215851 . Epub 2022 Jun 7. PMID: 35670111 ; PMCID: PMC9260212 .
[7]
2. Lu KQ*, Hong Y*, Tao MD*, Shen LP*, Zheng ZL, Fang KH, Yuan F, Xu M, Wang C, Zhu DY, Guo X#, Liu Y#. Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C. EMBO Molecular Medicine. 2022 Nov 14;e16364. doi: 10.15252/emmm.202216364 . PMID: 36373384 .
[8]
3. Zhu WY*, Tao MD*, Hong Y, Wu SS, Chu C, Zheng ZL, Han X, Zhu Q, Xu M, Ewing AG#, Guo X#, Liu Y#. Dysfunction of vesicular storage in young-onset Parkinson’s patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry. Chemical Science. 2022 May 11;13(21):6217-6223. doi: 10.1039/d2sc00809b . eCollection 2022 Jun 1. PMID: 35733907 ; PMCID: PMC9159080 .
[9]
4. Tang XY*, Wu SS*, Wang D, Chu C, Hong Y, Tao MD, Hu H, Xu M, Guo X#, Liu Y#. Human organoids in basic research and clinical applications. Signal Transduction and Targeted Therapy. 2022 May 24;7(1):168. doi: 10.1038/s41392-022-01024-9 . PMID: 35610212 ; PMCID: PMC9127490 .
[10]
5. Tang XY*, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XY, Liu CY, Fang KH, Han X, Wang S, Wang X, Xu M, Bhattacharyya A, Guo X#, Lin M#, Liu Y#. DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. Journal of Clinical Investigation. 2021 Jun 15;131(12): e135763. doi: 10.1172/JCI135763 . PMID: 33945512 ; PMCID: PMC8203468 .
[11]
6. Xu L*, Huo HQ, Lu KQ, Tang XY, Hong Y, Han X, Fu ZX, Fang KH, Xu M, Guo X#, Liu Y#. Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids. BBA-Molecular Basis of Disease. 2022 Jun 1;1868(6):166388. doi: 10.1016/j.bbadis.2022.166388 . Epub 2022 Mar 15. PMID: 35301086 .
[12]
7. Fu ZX*, Liu F*, Liu CY*, Jin BF, Jiang YQ, Tang ML, Qi X#, Guo X#. Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability. BBA-Molecular Basis of Disease. 2019 Jun 1;1865(6):1428-1435. doi: 10.1016/j.bbadis.2019.02.015 . Epub 2019 Feb 23. PMID: 30802639 ; PMCID: PMC6502650 .
[13]
8. Guo X*, Disatnik MH*, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X#. Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. Journal of Clinical Investigation. 2013 Dec;123(12):5371-5388. doi: 10.1172/JCI70911 . Epub 2013 Nov 15. PMID: 24231356 ; PMCID: PMC3859413 .
[14]
9. Guo X*, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X#. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nature Communications. 2016 Aug 26;7:12646. doi: 10.1038/ncomms12646 . PMID: 27561680 ; PMCID: PMC5007466 .
[15]
- 參考資料
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- 1. 郭興 ．南京醫科大學基礎醫學院[引用日期2022-12-30]
- 2. 郭興 ．南京醫科大學基礎醫學院[引用日期2022-12-30]
- 3. 郭興 ．南京醫科大學基礎醫學院[引用日期2022-12-30]
- 4. 郭興 ．南京醫科大學基礎醫學院[引用日期2022-12-30]
- 5. 郭興 ．南京醫科大學基礎醫學院[引用日期2022-12-30]
- 6. 郭興 ．南京醫科大學基礎醫學院[引用日期2022-12-30]
- 7. Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease - PubMed ．PubMed[引用日期2022-12-30]
- 8. Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C - PubMed ．PubMed[引用日期2022-12-30]
- 9. Dysfunction of vesicular storage in young-onset Parkinson's patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry - PubMed ．PubMed[引用日期2022-12-30]
- 10. Human organoids in basic research and clinical applications - PubMed ．PubMed[引用日期2022-12-30]
- 11. DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome - PubMed ．PubMed[引用日期2022-12-30]
- 12. Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids - PubMed ．PubMed[引用日期2022-12-30]
- 13. Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability - PubMed ．PubMed[引用日期2022-12-30]
- 14. Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration - PubMed ．PubMed[引用日期2022-12-30]
- 15. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease - PubMed ．PubMed[引用日期2022-12-30]
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