趙冰

2005-2008年就讀於中國農業大學生命科學試驗班並獲得學士學位。

2008-2013年就讀於清華大學生命科學學院並獲得博士學位。

2013-2015年於清華-北大生命科學聯合中心進行博士後研究。

2015-2017年於美國辛辛那提兒童醫院醫學中心從事博士後研究。

2017-2023年任復旦大學生命科學學院研究員、長聘研究員、PI、博士生導師。 ^[2] 

2023年至今任南昌大學研究員、類器官研究院執行院長。 ^[1] 

研究成體幹細胞命運決定機制，發展類器官培育新策略。以第一/通訊作者身份於國際權威期刊 Cell Research、Nature Communications、Advanced Science、Protein & Cell、Developmental Cell 等發表系列性研究論文，為再生生物學和類器官技術發展提供重要基礎。代表性研究成果獲 Nature News 專訪報道、Nature 官網主頁高亮，獲國際權威綜述期刊 Nature Reviews Molecular Cell Biology、NatureReviews Gastroenterology & Hepatology 等高度評價。

2018年創立復旦大學類器官中心；2021年創立伯楨生物；2023年創立南昌大學類器官研究院。致力於推進類器官技術標準化和產業轉化，開拓醫藥應用新場景。主編或參編“十四五”國家重點研發、國家博士後創新創業、上海市重點、廣東省重點等多個省部級以上類器官重點專項項目指南；作為中國細胞生物學學會標準工作委員會委員，牽頭制定多項類器官相關標準及培養規範；主筆類器官質量控制中國專家共識；主辦中國細胞生物學學會年度類器官大會；促進藥審藥評鼓勵意見出台。多維度打造類器官產業轉化和醫藥應用行業新生態。

贛鄱俊才·高校領軍人才 江西省委組織部 2023

復星醫藥獎教金（一等） 復旦大學 2020 2021 2022

“東方學者”特聘教授 上海市教委 2019

上海市青年拔尖人才 上海市委組織部、人社局 2018

上海市青年科技啓明星（A類） 上海市科委 2018

生命科學學院院長獎 復旦大學 2018

AMGEN Postdoctoral Award AMGEN 2015

北京市優博 北京市教委 2013

第八屆國務院學位辦生物學、生物工程學科評議組副秘書長

中國細胞生物學學會標準工作委員會委員

中國細胞生物學學會細胞結構與細胞行為分會副秘書長、委員

中國細胞生物學學會發育生物學分會委員

中國細胞生物學學會細胞治療研究與應用分會委員

中國生物醫學工程學會類器官與器官芯片分會委員

中國微生物學會第十二屆理事會委員（細胞因子與干擾素專業委員會）

《Cell Transplantation》、《遺傳》雜誌編委 ^[3] 

《Cell Regeneration》幹細胞信號調控專刊客座主編

《Organs-on-a-Chip》類器官專刊客座主編

復旦大學生物學博士後流動站專家委員

1. Chen J, Zhang J, Yang L and Zhao B*. (2023) Facile suspension culture protocol of the liver biliary organoids. Bio-Design and Manufacturing, 6:74–81. (*corresponding author)

2. Chen Z, Chen C, Xiao L, Tu R, Yu M, Wang D, Kang W, Han M, Huang H, Liu H, Zhao B* and Qing G*. (2023) HILPS, a novel long non-coding RNA essential for global oxygen sensing in human. Science Advances (綜合1區Top), 24;9(47):eadi1867.

3. Liang J, Wei J, Cao J, Qian J, Gao R, Li X, Wang D, Gu Y, Dong L, Yu J, Zhao B* and Wang X*. (2023) In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation. Genome Biology (生物1區Top), 24:251.

4. Luo Z, Wang B, Luo F, Guo Y, Jiang N, Wei J, Wang X, Tseng Y, Chen J, Zhao B* and Liu J*. (2023) Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening. BMC Medicine (醫學1區Top), 21:336.

5. Wang W, Yang J, Kang P, Bai J, Feng X, Huang L, Zhang Y, Wu Y, Tang B, Wang H, Jiang J, Li M, Zhao B* and Yang X. (2023) Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis. Virologica Sinica, doi: 10.1016/j.virs.2023.09.005.

6. Xu Y, Hu J, Lv Q, Shi C, Qiu M, Xie L, Liu W, Yang B, Shan W, Cheng Y, Zhao B* and Chen X*. (2023) Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt/β-catenin signaling pathway. Stem Cell Research & Therapy, 14:159.

7. Jiang C, Wang D, Ni C, Li X, Liu X, Ge X, Chen D, Dzakah E and Zhao B*. (2023) Generation of cynomolgus monkey airway, liver ductal, and kidney organoids with pharmacokinetic functions. Organs on a Chip, 100031.

8. Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J, Xu S and Zhao B*. (2022) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science (綜合1區Top), 9:2202505.

9. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X and Zhao B*. (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Advanced Science (綜合1區Top), 9:2105568.

10. Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J and Zhao B*. (2022) Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein & Cell (生物1區Top), 13:683-688.

11. Ren X, Liang J, Zhang Y, Jiang N, Xu Y, Qiu M, Wang Y, Zhao B* and Chen X*. (2022) Single-cell transcriptomic atlas highlights origin and pathological process of human endometrioid endometrial carcinoma. Nature Communications (綜合1區Top), 13:6300.

12. Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B*, Jiang N*, Li R* and Lin X*. (2022) Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Developmental Cell (生物1區Top), 57:901–913. (Cover Story)

13. Meng F, Shen C, Yang L, Ni C, Huang J, Lin K, Cao Z, Xu S, Cui W, Wang X, Zhou B, Xiong C, Wang J and Zhao B*. (2022) Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal. Cell Regeneration (高起點，chief editor：Ye-Guang Chen), 11:39.

14. Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan D, Zhou Z, Song Y, Liu H*, Zhao B* and Lin X*. (2022) Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. Journal of Biological Chemistry, 298:102490.

15. Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B* and Lin X*. (2021) Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology (醫學1區Top), 14:873-886. (Cover Story and 2021 Editor’s Choice)

16. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia (醫學1區Top), 34:3348-3358.

17. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R and Lin X. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell (生物1區Top), 11:771-775. (Highlighted by Nature)

18. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, 12: 618-629.

19. Zhao B*, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X. (2019) Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nature Communications (綜合1區Top), 10:1071.

20. Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X, Ling C and Zhao B*. (2019) Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry, 294:14096-14104.

21. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG. (2015) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications (綜合1區Top), 6:7166.

22. Cui HK#, Zhao B#, Li Y, Guo Y, Hu H, Liu L* and Chen YG*. (2013) Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling. Cell Research (生物1區Top), 23:581-584. (# co-first author)

23. Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG. (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. Cell Research (生物1區Top), 22:1467-1478.

24. Li Y, Gao X, Ni C, Zhao B* and Cheng X*. (2023) The application of patient-derived organoid in the research of lung cancer. Cellular Oncology (醫學1區Top), 46:503–519.

25. Wei J, Zhang W and Zhao B*. (2023) Human liver organoid: modeling liver steatosis and beyond. Cell Regeneration, 12:17.

26. Liang J, Li X, Dong Y and Zhao B*. (2022) Modeling human organ development and diseases with fetal tissue-derived organoids. Cell Transplantation, 31:1–15.

27. Lv T, Meng F, Yu M, Huang H, Lin X and Zhao B*. (2021) Defense of COVID‐19 by human organoids. Phenomics,1:113–128.

28. Zhao B and Chen YG. (2014) Regulation of TGF-β signal transduction. Scientifica, 2014:874065.