賈桂芳

1998-2002 中國農業大學理學院，理學學士

2003-2008 中國農業大學理學院，理學博士

2007-2012 美國芝加哥大學化學系，訪問學者、博士後

2012-2019 北京大學化學與分子工程學院，副研究員 ^[1] 

2020-至今 北京大學化學與分子工程學院特聘研究員

2021-至今 北大-清華生命科學聯合中心，PI ^[2] 

利用化學與生物學交叉學科的優勢，採用化學生物學、結構生物學、細胞生物學、分子生物學、基因組學及有機合成等研究手段，對與核酸相關的最前沿與熱點領域RNA表觀遺傳學方面展開研究，具體研究方向如下：

1.研究信使RNA的最主要修飾鹼基N6-甲基腺嘌呤對信使RNA的基因表達、剪切、轉譯等調控功能；

2.研究RNA去甲基修飾蛋白酶的對RNA的調控功能和致病機理；

3.研究N6-甲基腺嘌呤在植物中的功能與機理；

4.利用化學二硫鍵交聯技術對去甲基修飾蛋白酶與核酸複合物的結構解析和功能機理研究 ^[1]  。

1. Liu, J., Jia, G. *, Methylation modifications in eukaryotic messenger RNA, J Genet Genomics.

2. Liu, J.Z., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W., He, C. *, A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol..

3. Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., Ren, B., Pan, T., He, C.*, N6-methyladenosine-dependent regulation of messenger RNA stability. Nature.

4. Fu, Y.#, Jia, G.#, Pang, X., Wang, R. N., Wang, X., Li, C. J., Smemo, S., Dai, Q., Bailey, K. A., Nobrega, M. A., Han, K.-L., Cui, Q., He, C.*, FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat. Commun.(#co-first author)

5. Jia, G., Fu, Y., He, C.*, Reversible RNA adenosine methylation in biological regulation. Trends Genet.

6. Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, Charles J., Vågbø, Cathrine B., Shi, Y., Wang, W.-L., Song, S.-H., Lu, Z., Bosmans, Ralph P. G., Dai, Q., Hao, Y.-J., Yang, X., Zhao, W.-M., Tong, W.-M., Wang, X.-J., Bogdan, F., Furu, K., Fu, Y., Jia, G., Zhao, X., Liu, J., Krokan, Hans E., Klungland, A.*, Yang, Y.-G.*, He, C.*, ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Mol. Cell.

7. Chen, B., Ye, F., Yu, L., Jia, G., Huang, X., Zhang, X., Peng, S., Chen, K., Wang, M., Gong, S., Zhang, R., Yin, J., Li, H., Yang, Y., Liu, H., Zhang, J., Zhang, H., Zhang, A., Jiang, H., Luo, C.*, Yang, C.G.*, “Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor”, J. Am. Chem. Soc.

8. Yi, C., Chen, B., Qi, B., Zhang, W., Jia, G., Zhang, L., Li, C. J., Dinner, A. R., Yang, C. G.*, He, C.* Duplex interrogation by a direct DNA repair protein in search of base damage. Nat. Struct. Mol. Biol.

9. Jia, G.#, Fu, Y.#, Zhao, X.#, Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y. G., He, C.*, N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol.(#co-first author)

10. Yi, C., Jia, G., Hou, G., Dai, Q., Zhang, W., Zheng, G., Jian, X., Yang, C.-G., Cui, Q., He, C.*, Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature.

11. Jia, G.#, Yang, C-G.#, Yang, S., Jian, X., Yi, C., Zhou, Z., He, C.*, Oxidative demethylation of 3-meT and 3-meU in single-stranded DNA and RNA by mouse and human FTO, FEBS Lett.

12. Jia G, Lv C, Zhu W, Qiu J, Wang X, Zhou Z.*, Applicability of cloud point extraction coupled with microwave assisted back-extraction to the determination of organophosphorous pesticides in human urine by gas chromatography with flame photometry detection, J. Hazard Mater., 2008.

13. Jia G, Li L, Qiu J, Wang X, Zhu W, Sun Y, Zhou Z.*, Determination of carbaryl and its metabolite 1-naphthol in water samples by fluorescence spectrophotometer after anionic surfactant micelle-mediated extraction with sodium dodecylsulfate, Spectrochim Acta Part A Mol. Biomol. Spectrosc., 2007.

14. Lv C, Jia G, Zhu W, Qiu J, Wang X, Zhou Z.*, Enantiomeric resolution of new triazole compounds by high perform liquid chromatography, J. Sep. Sci., 2007

15. Wang X, Jia G, Qiu J, Diao J, Zhu W, Lv C, Zhou Z.*, Stereoselective degradation of fungicide Benalaxyl in soils and Cucumber plants, Chirality, 2007.

16. Qiu J, Wang Q, Zhu W, Jia G, Wang X, Zhou Z.*, Stereoselective Determination of Benalaxyl in Plasma by ChiralHigh-Performance Liquid Chromatography with Diode Array Detector and Application to Pharmacokinetic Study in Rabbits, Chirality, 2007.

17. Zhu W, Qiu J, Dang Z, Lv C, Jia G, Li L, Zhou Z.*, Stereoselective Degradation Kinetics of Tebuconazole in Rabbits, Chirality, 2007

18. Zhu W, Dang Z, Qiu J, Lv C, Jia G, Li L, Zhou Z.*, Stereoselective Toxicokinetics and Tissue Distribution of Ethofumesate in Rabbits, Chirality, 2007.

19. Jia G, Bi C, Wang Q, Qiu J, Zhou W, Zhou Z.*, Determination of Etofenprox in environmental samples by HPLC after anionic surfactant micelle-mediated extraction (coacervation extraction), Anal. Bioanal. Chem., 2006.

20. Wang Q, Qiu J, Zhu W, Jia G, Li J, Bi C, Zhou Z*, Stereoselective Degradation Kinetics of Theta-cypermethrin in Rats, Environ. Sci. Technol., 2006

21. Qiu J, Wang Q, Wang P, Jia G, Li J, Zhou, Z*, Enantioselective degradation kinetics of Metalaxyl in Rabbits, Pestic. Biochem. Physiol., 2005

22. Wang Q, Qiu J, Wang P, Jia G, Wang P, Li J, Zhou Z.*, Stereoselective Kinetic Study of Hexaconazole Enantiomers in the Rabbit, Chirality, 2005

23. Jia G, Wang P， Qiu J， Sun Y， Xiao Y, Zhou Z*, Determination of DNA with imidacloprid by a Resonance Light Scattering Technique at Nanogram Levels and Its Application，Anal. Lett.

24. Jie N*, Jia G, Hou S, Xiong Y, Dong Y. Determination of deoxyribonucleic acids by a resonance light scattering technique and its application, Spectrochim Acta Part A Mol. Biomol. Spetrosc ^[1]  .

2024年4月，經第十九屆中國青年女科學家獎評審委員會評審，賈桂芳獲得第十九屆中國青年女科學家獎。 ^[4]