谷楊楠

2003-2007年，西安交通大學 生物工程 學士

2007-2013年，美國印第安納大學 分子細胞發育生物學 博士

2011-2013年，美國印第安納大學 應用統計學 碩士

2013-2015年，美國杜克大學-霍華德休斯醫學院 博士後

2015-2017年，美國杜克大學-霍華德休斯醫學院 高級研究助理

2017年至今， 清華大學生命科學學院, 清華-北大聯合生命科學中心 助理教授，研究員，博士生導師 ^[1] 

植物在與微生物長達幾億年的共存互作過程中演化出了極其複雜和精密的免疫系統。有別於具有專職免疫細胞的動物，植物的每一個細胞都可以啓動免疫反應，甚至可以精確地調用和改變細胞的其他生理過程來實現多樣化的免疫結果，是一個具有高度研究價值的系統。

實驗室致力於研究植物的免疫調控機制。我們利用分子，細胞，遺傳，生化，生統，生物信息學等綜合手段主攻此過程中免疫分子和信號是如何利用細胞內膜轉運系統以及核質穿梭來啓動，控制和終止抗病反應的。我們同時也關注細胞核膜上的大分子複合體（如核孔複合體）以及全新的跨膜蛋白對植物細胞免疫的調控作用。 ^[1] 

1. Gu, Y. (2017). Nuclear pore complex: a strategic platform for regulating cell signaling New Phytologist (Tansley Insight) DOI-10.1111/nph.1475.

2. Gu, Y.*, Zavaliev, R and Dong, X. (2017). Membrane trafficking in plant immunity. Molecular Plant 10: 1026-1034. *Corresponding author

3. Gu, Y., Zebell, S., Liang, Z., Wang, S., Kang, B. and Dong, X. (2016). Nuclear pore permeabilization is a convergent signaling event in effector-triggered immunity. Cell 166: 1526-1538.

Highlighted by commentary "Gating immunity and death at the nuclear pore complex", Cell (2016) 166: 1364-1366.

4. Liu, L., Sonbol, FM., Huot, B., Gu, Y., Withers, J., Mwimba, M., Yao, J., He, S.Y. and Dong, X. (2016). Salicylic acid receptors activate jasmonic acid signalling through a noncanonical pathway to promote effector-triggered immunity; Nature Communications 7: 13099.

5. Gu, Y. and Dong X. (2015). Stromules: signal conduits for plant immunity. Developmental Cell 34: 3-4.

6. Saleh, A., Withers, J., Mohan, R., Marques, J., Gu, Y., Yan, S., Zavaliev, R., Nomoto, M., Tada, Y. and Dong, X. (2015). Posttranslational modifications of the master transcriptional regulator NPR1 enable dynamic but tight control of plant immune responses; Cell Host-Microbe 18: 169-182.

7. Pauwels, L., Ritter, A., Goossens, J., Durand, A.N., Liu, H., Gu, Y., Geerinck, J., Boter, M., Bossche, R.V., De Clercq, R., Van Leene, J., Gevaert, K., De Jaeger, G., Solano, R., Stone, S., Innes, R.W., Callis, J. and Goossens, A. (2015). The RING E3 ligase KEEP ON GOING modulates Jasmonate ZIM-domain 12 stability. Plant Physiology 169: 1405-1417.

8. Wang, S.#, Gu, Y.#, Zebell, S.#, Anderson, L.K., Wang, W., Mohan, R., and Dong, X. (2014). A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host-Microbe 16: 787-794. #Co-first authorship.

Highlighted by commentary "Co-opting the cell-cycle machinery for plant immunity", Cell Host-Microbe (2014) 16: 707-709.

9. Serrano, I.#, Gu, Y.#, Qi, D., Dubiella, U. and Innes, R.W. (2014). The Arabidopsis EDR1 protein kinase negatively regulates the ATL1 E3 ubiquitin ligase to suppress cell death. Plant Cell 26: 4532-4546. #Co-first authorship. ？

10. Gu, Y. and Innes, R.W. (2012). The Keep On Going (KEG) protein of Arabidopsis regulates intracellular protein trafficking and is degraded during fungal infection. Plant Cell 24: 4717-4730.

Highlighted by research spotlight, IS-MPMI Reporter (2013) 1: 7

11. Gu, Y. and Innes, R.W. (2011). The Keep On Going (KEG) protein of Arabidopsis physically interacts with the Enhanced Disease Resistance 1 (EDR1) protein and recruits it to early endosomes; Plant Physiology 115: 1827-1838.

12. Christiansen, K.M., Gu, Y., Rodibaugh, N.L. and Innes R.W. (2011). Negative regulation of defense signaling pathways by the EDR1 protein kinase. Molecular Plant Pathology 12: 746–758. ^[1]